EA024492B1 - Антитела, специфически связывающиеся с baffr, и их применение - Google Patents
Антитела, специфически связывающиеся с baffr, и их применение Download PDFInfo
- Publication number
- EA024492B1 EA024492B1 EA201100191A EA201100191A EA024492B1 EA 024492 B1 EA024492 B1 EA 024492B1 EA 201100191 A EA201100191 A EA 201100191A EA 201100191 A EA201100191 A EA 201100191A EA 024492 B1 EA024492 B1 EA 024492B1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- antibody
- variable region
- zeo
- cells
- sequence
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2878—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/55—Fab or Fab'
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/74—Inducing cell proliferation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Immunology (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Biophysics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Rheumatology (AREA)
- Physical Education & Sports Medicine (AREA)
- Transplantation (AREA)
- Oncology (AREA)
- Pain & Pain Management (AREA)
- Neurosurgery (AREA)
- Hematology (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP08160671 | 2008-07-17 | ||
| EP09160326 | 2009-05-15 | ||
| PCT/EP2009/059030 WO2010007082A1 (en) | 2008-07-17 | 2009-07-15 | Compositions and methods of use for therapeutic antibodies |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| EA201100191A1 EA201100191A1 (ru) | 2011-08-30 |
| EA024492B1 true EA024492B1 (ru) | 2016-09-30 |
Family
ID=41073830
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EA201100191A EA024492B1 (ru) | 2008-07-17 | 2009-07-15 | Антитела, специфически связывающиеся с baffr, и их применение |
Country Status (40)
Families Citing this family (39)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2009023184A2 (en) * | 2007-08-10 | 2009-02-19 | Protelix, Inc. | Universal fibronectin type iii binding-domain libraries |
| US8470966B2 (en) | 2007-08-10 | 2013-06-25 | Protelica, Inc. | Universal fibronectin type III binding-domain libraries |
| US8680019B2 (en) * | 2007-08-10 | 2014-03-25 | Protelica, Inc. | Universal fibronectin Type III binding-domain libraries |
| WO2012076670A2 (en) * | 2010-12-10 | 2012-06-14 | Novartis Ag | Antibody formulation |
| JP2012153788A (ja) * | 2011-01-25 | 2012-08-16 | Nitto Denko Corp | 光学用粘着シート |
| ES2989943T3 (es) * | 2011-05-13 | 2024-11-28 | Astellas Pharma Inc | Anticuerpos para el tratamiento de un cáncer que expresa la Claudina 6 |
| US9216219B2 (en) | 2012-06-12 | 2015-12-22 | Novartis Ag | Anti-BAFFR antibody formulation |
| WO2015100246A1 (en) | 2013-12-24 | 2015-07-02 | Ossianix, Inc. | Baff selective binding compounds and related methods |
| EA033604B1 (ru) | 2014-01-31 | 2019-11-08 | Boehringer Ingelheim Int | Молекула анти-baff антитела, фармацевтическая композиция, содержащая эту молекулу, способы ее применения и кодирующий ее изолированный полинуклеотид |
| MA41044A (fr) | 2014-10-08 | 2017-08-15 | Novartis Ag | Compositions et procédés d'utilisation pour une réponse immunitaire accrue et traitement contre le cancer |
| EP4245376A3 (en) | 2014-10-14 | 2023-12-13 | Novartis AG | Antibody molecules to pd-l1 and uses thereof |
| MA41459A (fr) | 2015-02-03 | 2017-12-12 | Als Therapy Development Inst | Anticorps anti-cd40l et méthodes pour traiter des maladies ou des troubles liés aux cd40l |
| EP3328418A1 (en) | 2015-07-29 | 2018-06-06 | Novartis AG | Combination therapies comprising antibody molecules to pd-1 |
| EP3878465A1 (en) | 2015-07-29 | 2021-09-15 | Novartis AG | Combination therapies comprising antibody molecules to tim-3 |
| HRP20211058T8 (hr) | 2015-07-29 | 2021-11-26 | Novartis Ag | Kombinirane terapije koje sadrže molekule antitijela protiv lag-3 |
| ES2986067T3 (es) | 2015-12-17 | 2024-11-08 | Novartis Ag | Moléculas de anticuerpos frente a PD-1 y usos de las mismas |
| AU2017204936B2 (en) | 2016-02-10 | 2019-06-27 | Novartis Ag | Use of inhibitors of the activity or function of PI3K for the treatment of primary Sjogren's Syndrome |
| EP4628094A3 (en) * | 2016-06-06 | 2025-12-31 | City of Hope | BAFF-R ANTIBODIES AND THEIR USES |
| IL317134A (en) | 2016-12-21 | 2025-01-01 | Teneobio Inc | An antibody containing only heavy chains that binds a human B-cell maturation antigen, a pharmaceutical composition containing the same, its use in the treatment of B-cell disorders and a method for its preparation |
| US11197928B2 (en) | 2017-01-13 | 2021-12-14 | Board Of Regents, The University Of Texas System | Sustained production of high affinity antigen specific antibody by high dose BAFF receptor-targeting mAb-siRNA conjugate |
| KR102840867B1 (ko) * | 2017-05-24 | 2025-07-30 | 에이엘에스 테라피 디벨럽먼트 인스티튜트 | 치료용 항-cd40 리간드 항체 |
| KR20250007003A (ko) | 2017-06-20 | 2025-01-13 | 테네오바이오, 인코포레이티드 | 항-bcma 중쇄-단독 항체 |
| BR112020024074A2 (pt) * | 2018-07-20 | 2021-02-17 | Teneobio, Inc. | anticorpos de cadeia pesada com ligação a cd19 |
| US20220220210A1 (en) * | 2019-03-29 | 2022-07-14 | Chugai Seiyaku Kabushiki Kaisha | Anti-il-6 receptor antibody-containing inhibitor for inhibiting deterioration of bbb function |
| JP7489407B2 (ja) | 2019-05-21 | 2024-05-23 | ノバルティス アーゲー | Ｃｄ１９結合分子及びその使用 |
| KR20220093347A (ko) | 2019-11-06 | 2022-07-05 | 노파르티스 아게 | 쇼그렌 증후군의 치료 |
| CN112813099A (zh) * | 2019-11-15 | 2021-05-18 | 上海细胞治疗集团有限公司 | 一种在活化的t细胞中具有高活性的启动子 |
| WO2022031568A1 (en) | 2020-08-04 | 2022-02-10 | Novartis Ag | Treatment of cll |
| AU2021320129B2 (en) | 2020-08-04 | 2025-12-18 | Novartis Ag | Treatment of B cell malignancies |
| CN114149504B (zh) * | 2020-09-07 | 2024-01-12 | 白先宏 | Baff-r结合分子及其应用 |
| IL302412A (en) * | 2020-11-06 | 2023-06-01 | Novartis Ag | Anti-CD19 and B-cell targeting agent combination therapy for the treatment of B-cell malignancies |
| CN115073598B (zh) * | 2021-03-15 | 2024-02-20 | 盛禾(中国)生物制药有限公司 | 一种抗baffr抗体及其应用 |
| TW202302147A (zh) | 2021-05-04 | 2023-01-16 | 瑞士商諾華公司 | 使用抗baffr抗體治療狼瘡腎炎 |
| IL308044A (en) | 2021-05-04 | 2023-12-01 | Novartis Ag | Treatment of systemic lupus erythematosus using antibuffer antibodies |
| AR127163A1 (es) * | 2021-09-29 | 2023-12-27 | Dragonfly Therapeutics Inc | Anticuerpos dirigidos a baff-r y uso de estos |
| AU2024239150A1 (en) | 2023-03-21 | 2025-10-02 | Biograph 55, Inc. | Cd19/cd38 multispecific antibodies |
| WO2025058962A1 (en) * | 2023-09-11 | 2025-03-20 | Absci Corporation | High-throughput methods for kinetic characterization, quantifying and optimizing antibodies and antibody fragments expression in bacteria |
| WO2025131888A1 (en) | 2023-12-19 | 2025-06-26 | Basf Se | Modified alkoxylated polyalkylene imines or modified alkoxylated polyamines |
| WO2025221674A1 (en) * | 2024-04-15 | 2025-10-23 | Eli Lilly And Company | Baffr x cd3 bispecific antibodies and methods of use |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2006073941A2 (en) * | 2004-12-31 | 2006-07-13 | Genentech, Inc. | Polypeptides that bind br3 and uses thereof |
| WO2008008482A2 (en) * | 2006-07-13 | 2008-01-17 | Genentech, Inc. | Altered br3-binding polypeptides |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100447244C (zh) * | 1999-08-17 | 2008-12-31 | 比奥根艾迪克Ma公司 | Baff受体(bcma),一种免疫调节剂 |
| UA83458C2 (uk) | 2000-09-18 | 2008-07-25 | Байоджен Айдек Ма Інк. | Виділений поліпептид baff-r (рецептор фактора активації в-клітин сімейства tnf) |
-
2009
- 2009-07-15 SI SI200931293T patent/SI2315780T1/sl unknown
- 2009-07-15 DK DK09797499.2T patent/DK2315780T3/en active
- 2009-07-15 GE GEAP200912063A patent/GEP20146129B/en unknown
- 2009-07-15 MY MYPI2010005960A patent/MY158980A/en unknown
- 2009-07-15 KR KR1020117001052A patent/KR101314369B1/ko active Active
- 2009-07-15 HR HRP20151227TT patent/HRP20151227T1/hr unknown
- 2009-07-15 BR BRPI0915928A patent/BRPI0915928B8/pt active IP Right Grant
- 2009-07-15 PT PT97974992T patent/PT2315780E/pt unknown
- 2009-07-15 CA CA2730063A patent/CA2730063C/en active Active
- 2009-07-15 UY UY0001031987A patent/UY31987A/es active IP Right Grant
- 2009-07-15 SG SG2013062567A patent/SG193805A1/en unknown
- 2009-07-15 RS RS20150667A patent/RS54299B1/sr unknown
- 2009-07-15 MX MX2011000616A patent/MX2011000616A/es active IP Right Grant
- 2009-07-15 JP JP2011517915A patent/JP5767109B2/ja active Active
- 2009-07-15 PE PE2011000038A patent/PE20110563A1/es active IP Right Grant
- 2009-07-15 ES ES09797499.2T patent/ES2547270T3/es active Active
- 2009-07-15 AR ARP090102678A patent/AR072749A1/es active IP Right Grant
- 2009-07-15 WO PCT/EP2009/059030 patent/WO2010007082A1/en not_active Ceased
- 2009-07-15 EP EP09797499.2A patent/EP2315780B8/en active Active
- 2009-07-15 KR KR1020137019574A patent/KR101545795B1/ko active Active
- 2009-07-15 US US12/503,175 patent/US8106163B2/en active Active
- 2009-07-15 HU HUE09797499A patent/HUE025778T2/en unknown
- 2009-07-15 PL PL09797499T patent/PL2315780T3/pl unknown
- 2009-07-15 AU AU2009272771A patent/AU2009272771B2/en active Active
- 2009-07-15 CN CN200980127408.2A patent/CN102119174B/zh active Active
- 2009-07-15 EA EA201100191A patent/EA024492B1/ru not_active IP Right Cessation
- 2009-07-15 NZ NZ590057A patent/NZ590057A/xx unknown
- 2009-07-16 JO JOP/2009/0267A patent/JO3149B1/ar active
- 2009-07-16 TW TW098124126A patent/TWI508742B/zh active
-
2010
- 2010-12-13 ZA ZA2010/08952A patent/ZA201008952B/en unknown
- 2010-12-21 CR CR11863A patent/CR11863A/es unknown
-
2011
- 2011-01-06 IL IL210485A patent/IL210485A/en active IP Right Grant
- 2011-01-14 CL CL2011000086A patent/CL2011000086A1/es unknown
- 2011-01-14 MA MA33525A patent/MA32481B1/fr unknown
- 2011-01-14 DO DO2011000016A patent/DOP2011000016A/es unknown
- 2011-01-14 NI NI201100017A patent/NI201100017A/es unknown
- 2011-01-17 SV SV2011003807A patent/SV2011003807A/es unknown
- 2011-01-17 EC EC2011010761A patent/ECSP11010761A/es unknown
- 2011-01-17 CU CUP2011000013A patent/CU23878B1/es active IP Right Grant
- 2011-02-17 SM SM201100010T patent/SMP201100010B/it unknown
- 2011-12-15 US US13/326,569 patent/US9382326B2/en active Active
- 2011-12-15 US US13/326,514 patent/US9340620B2/en active Active
-
2015
- 2015-04-10 JP JP2015081099A patent/JP6077587B2/ja active Active
- 2015-10-19 CY CY20151100934T patent/CY1116800T1/el unknown
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2006073941A2 (en) * | 2004-12-31 | 2006-07-13 | Genentech, Inc. | Polypeptides that bind br3 and uses thereof |
| WO2008008482A2 (en) * | 2006-07-13 | 2008-01-17 | Genentech, Inc. | Altered br3-binding polypeptides |
Non-Patent Citations (5)
| Title |
|---|
| EISENBERG R: "Combination biologics: 1 Stone, 2 birds", BLOOD, AMERICAN SOCIETY OF HEMATOLOGY, US, vol. 110, no. 12, 1 December 2007 (2007-12-01), US, pages 3817, XP002509034, ISSN: 0006-4971, DOI: 10.1182/blood-2007-08-107904 * |
| LEE CHINGWEI V ET AL: "Synthetic anti-BR3 antibodies that mimic BAFF binding and target both human and murine B cells.", BLOOD, AMERICAN SOCIETY OF HEMATOLOGY, US, vol. 108, no. 9, 1 November 2006 (2006-11-01), US, pages 3103 - 3111, XP002509032, ISSN: 0006-4971, DOI: 10.1182/blod-2006-03-011031 * |
| LIN WEI YU ET AL: "Anti-BR3 antibodies: a new class of B-cell immunotherapy combining cellular depletion and survival blockade.", BLOOD, AMERICAN SOCIETY OF HEMATOLOGY, US, vol. 110, no. 12, 1 December 2007 (2007-12-01), US, pages 3959 - 3967, XP002509033, ISSN: 0006-4971, DOI: 10.1182/blood-2007-04-088088 * |
| NG LAI GUAN, ET AL: "B cell-activating factor belonging to the TNF family (BAFF)-R is the principal BAFF receptor facilitating BAFF costimulation of circulating T and B cells.", THE JOURNAL OF IMMUNOLOGY, THE AMERICAN ASSOCIATION OF IMMUNOLOGISTS, US, vol. 173, no. 2, 15 July 2004 (2004-07-15), US, pages 807 - 817, XP002509036, ISSN: 0022-1767 * |
| ZHANG XIN ET AL: "BAFF supports human B cell differentiation in the lymphoid follicles through distinct receptors.", INTERNATIONAL IMMUNOLOGY., OXFORD UNIVERSITY PRESS., GB, vol. 17, no. 6, 1 June 2005 (2005-06-01), GB, pages 779 - 788, XP002509035, ISSN: 0953-8178, DOI: 10.1093/intimm/dxh259 * |
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| EA024492B1 (ru) | Антитела, специфически связывающиеся с baffr, и их применение | |
| US20240425602A1 (en) | Compositions and methods for increasing muscle growth | |
| RU2440134C2 (ru) | Гетеродимерные полипептиды il-17 a/f и возможности их лечебного применения | |
| CN103619353B (zh) | Fc受体结合蛋白 | |
| UA125382C2 (uk) | Антитіла проти людського vista та їх застосування | |
| EA016609B1 (ru) | Рекомбинантные моновалентные антитела и способы их получения | |
| UA127965C2 (uk) | Спосіб лікування запальних станів | |
| EA012835B1 (ru) | Антитела против фактора роста эндотелия сосудов (vegf) и способы их применения | |
| EA027575B1 (ru) | Антитело или его антигенсвязывающий фрагмент, связывающий человеческий белок с5, содержащая их композиция, нуклеиновая кислота, кодирующая антитело или его антигенсвязывающий фрагмент, содержащие эту кислоту вектор и клетка-хозяин и применение антитела или его антигенсвязывающего фрагмента | |
| EA018756B1 (ru) | Антитела к склеростину, композиции, их содержащие, и их применение | |
| EA024701B1 (ru) | Антитела, связывающие cd27 человека, и их применение | |
| EA019636B1 (ru) | Связывающие белки, включающие антитела, производные антител и фрагменты антител, которые специфически связываются с cd154, и их применения | |
| UA122676C2 (uk) | Біспецифічна антигензв'язувальна молекула проти folr1 і cd3, що активує t-клітини | |
| EA030313B1 (ru) | СПОСОБ СНИЖЕНИЯ УРОВНЕЙ IgM, IgG И IgA У МЛЕКОПИТАЮЩИХ И КОМПОЗИЦИЯ ДЛЯ ОСУЩЕСТВЛЕНИЯ ЭТОГО СПОСОБА | |
| SG192496A1 (en) | Prostaglandin e2 binding proteins and uses thereof | |
| SA518391711B1 (ar) | تركيبات ملقحة بجسم مضاد سيتوكين وطرق استخدامها للتنظيم المناعي | |
| ES3054462T3 (en) | Antibody against activin receptor type ii receptor for use in treating heart failure | |
| JP2010229156A (ja) | 早期活性化分子のターゲティングに基づく免疫調節 | |
| US20240254244A1 (en) | ANTI-HUMAN INTERFERON a RECEPTOR 1 MONOCLONAL ANTIBODY AND APPLICATION THEREOF | |
| US20260098101A1 (en) | Anti-human interleukin 36 receptor monoclonal antibody and use thereof | |
| JP2011148829A (ja) | 早期活性化分子のターゲティングに基づく免疫調節 | |
| HK1195260B (en) | Fc receptor binding proteins |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MM4A | Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s) |
Designated state(s): AM AZ KG MD TJ TM |
|
| MM4A | Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s) |
Designated state(s): BY |