EA020915B1 - Новые соединения, обладающие функцией антикоагулянтов, фармацевтические композиции на их основе для лечения тромботических состояний и плазмозамещающий раствор для коррекции гиперкоагуляционных нарушений при гемодилюции - Google Patents
Новые соединения, обладающие функцией антикоагулянтов, фармацевтические композиции на их основе для лечения тромботических состояний и плазмозамещающий раствор для коррекции гиперкоагуляционных нарушений при гемодилюции Download PDFInfo
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- EA020915B1 EA020915B1 EA201000064A EA201000064A EA020915B1 EA 020915 B1 EA020915 B1 EA 020915B1 EA 201000064 A EA201000064 A EA 201000064A EA 201000064 A EA201000064 A EA 201000064A EA 020915 B1 EA020915 B1 EA 020915B1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- plasma
- thrombin
- coagulation
- alkyl
- hydrogen
- Prior art date
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/08—Plasma substitutes; Perfusion solutions; Dialytics or haemodialytics; Drugs for electrolytic or acid-base disorders, e.g. hypovolemic shock
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/73—Unsubstituted amino or imino radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D277/38—Nitrogen atoms
- C07D277/40—Unsubstituted amino or imino radicals
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Cardiology (AREA)
- Oncology (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Communicable Diseases (AREA)
- Heart & Thoracic Surgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Thiazole And Isothizaole Compounds (AREA)
- Pyridine Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
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| RU2007124202/04A RU2353619C2 (ru) | 2007-06-28 | 2007-06-28 | Новые соединения, обладающие функцией антикоагулянтов, фармацевтические композиции на их основе для лечения тромботических состояний и плазмозамещающий раствор для коррекции гиперкоагуляционных нарушений при гемодилюции |
| PCT/RU2008/000401 WO2009002229A2 (en) | 2007-06-28 | 2008-06-27 | New anticoagulant compounds, pharmaceutical compositions on their basis to treat thrombotic conditions, and plasma-substituting solution to correct hypercoagulation defects of hemodilution |
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| EA201000064A1 EA201000064A1 (ru) | 2010-06-30 |
| EA020915B1 true EA020915B1 (ru) | 2015-02-27 |
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| EP (1) | EP2178839A2 (enExample) |
| JP (1) | JP2010531353A (enExample) |
| KR (1) | KR20100028122A (enExample) |
| CN (1) | CN101848894B (enExample) |
| AU (1) | AU2008269258B2 (enExample) |
| CA (1) | CA2692363A1 (enExample) |
| EA (1) | EA020915B1 (enExample) |
| RU (1) | RU2353619C2 (enExample) |
| UA (1) | UA98969C2 (enExample) |
| WO (1) | WO2009002229A2 (enExample) |
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| RU2354647C2 (ru) * | 2007-06-28 | 2009-05-10 | Общество С Ограниченной Ответственностью "Бионика" | Новые соединения, обладающие функцией ингибиторов тромбина, и фармацевтические композиции на их основе |
| RU2353619C2 (ru) * | 2007-06-28 | 2009-04-27 | Общество С Ограниченной Ответственностью "Бионика" | Новые соединения, обладающие функцией антикоагулянтов, фармацевтические композиции на их основе для лечения тромботических состояний и плазмозамещающий раствор для коррекции гиперкоагуляционных нарушений при гемодилюции |
| EA021562B1 (ru) * | 2012-08-15 | 2015-07-30 | Общество С Ограниченной Ответственностью "Гематологическая Корпорация" | Устройство мониторинга пространственного свертывания крови и ее компонентов |
| JP6382997B2 (ja) * | 2014-02-07 | 2018-08-29 | エクセセーラ ファーマシューティカルズ インコーポレイテッド | 治療用化合物および組成物 |
| RU2685261C1 (ru) * | 2018-04-05 | 2019-04-17 | Общество с ограниченной ответственностью "ФК ЛАБОРАТОРИЗ" | Вещество 4-амино-1-{ 2-[3-метил-5-(бензолсульфонилокси)фенокси] этил} -пиридиний хлорид, обладающее свойствами биологически активного агента, влияющими на естественно текущие процессы свертываемости крови млекопитающих, антикоагулянт на его основе и способ его получения путем химического синтеза |
| WO2020256429A1 (ko) * | 2019-06-19 | 2020-12-24 | 주식회사 엘지화학 | 인돌 또는 인다졸 화합물의 제조방법 |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3407229A (en) * | 1964-09-09 | 1968-10-22 | Baxter Laboratories Inc | Phenylcarbamoylethylthiopseudoureas |
| JPH05134337A (ja) * | 1991-11-08 | 1993-05-28 | Konica Corp | ハロゲン化銀写真感光材料 |
| US5886191A (en) * | 1997-08-18 | 1999-03-23 | Dupont Pharmaceuticals Company | Amidinoindoles, amidinoazoles, and analogs thereof |
| US20050159457A1 (en) * | 2000-10-06 | 2005-07-21 | Wenxi Pan | Aminopyridinyl-, aminoguanidinyl- and alkoxyguanidinyl-substituted phenyl acetamides as protease inhibitors |
| WO2005094828A1 (en) * | 2004-03-02 | 2005-10-13 | F. Hoffmann-La Roche Ag | 4- (sulfanyl-pyrimidin-4-ylmethyl) -morpholine derivatives and related compounds as gaba receptor ligands for the treatment of anxiety, depression and epilepsy |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5089634A (en) * | 1984-08-20 | 1992-02-18 | Georgia Tech Research Corporation | Isocoumarins with cationic substituents |
| JPH0341065A (ja) * | 1989-07-06 | 1991-02-21 | Morishita Pharmaceut Co Ltd | アリールオキシアルキルイソチオウレア臭化水素酸塩類 |
| TW257757B (enExample) * | 1993-03-03 | 1995-09-21 | Boehringer Mannheim Gmbh | |
| IL109319A0 (en) * | 1993-04-27 | 1994-07-31 | Du Pont Merck Pharma | Amidino and guanidino substituted boronic acid compounds |
| US5510369A (en) * | 1994-07-22 | 1996-04-23 | Merck & Co., Inc. | Pyrrolidine thrombin inhibitors |
| DE4430757A1 (de) * | 1994-08-30 | 1996-03-07 | Boehringer Mannheim Gmbh | Neue 4-Aminopyridazine, Verfahren zu ihrer Herstellung sowie diese Verbindungen enthaltende Arzneimittel |
| US5792769A (en) * | 1995-09-29 | 1998-08-11 | 3-Dimensional Pharmaceuticals, Inc. | Guanidino protease inhibitors |
| EP0906091B1 (en) * | 1996-03-29 | 2006-10-04 | Ortho-McNeil Pharmaceuticals, Inc. | Amidinohydrazones as protease inhibitors |
| GB9613718D0 (en) * | 1996-06-29 | 1996-08-28 | Thrombosis Res Inst | Thrombin inhibitors |
| EP0927035A4 (en) * | 1996-09-13 | 2002-11-13 | Merck & Co Inc | THROMBIN INHIBITORS |
| US5792799A (en) * | 1996-10-10 | 1998-08-11 | Athena Neurosciences, Inc. | Parenteral delivery of MAO A inhibitors |
| JP4896387B2 (ja) * | 2003-09-30 | 2012-03-14 | 武田薬品工業株式会社 | チアゾリン誘導体およびその用途 |
| RU2300385C1 (ru) * | 2005-12-27 | 2007-06-10 | Елена Ивановна Синауридзе | Раствор для коррекции первичных нарушений гемостаза плазмозамещающими растворами нового состава |
| RU2008152788A (ru) * | 2006-05-31 | 2010-07-10 | Эбботт Лэборетриз (Us) | Новые соединения в качестве лигандов каннабиноидных рецепторов и их применение |
| RU2353619C2 (ru) * | 2007-06-28 | 2009-04-27 | Общество С Ограниченной Ответственностью "Бионика" | Новые соединения, обладающие функцией антикоагулянтов, фармацевтические композиции на их основе для лечения тромботических состояний и плазмозамещающий раствор для коррекции гиперкоагуляционных нарушений при гемодилюции |
| RU2354647C2 (ru) * | 2007-06-28 | 2009-05-10 | Общество С Ограниченной Ответственностью "Бионика" | Новые соединения, обладающие функцией ингибиторов тромбина, и фармацевтические композиции на их основе |
-
2007
- 2007-06-28 RU RU2007124202/04A patent/RU2353619C2/ru not_active IP Right Cessation
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2008
- 2008-06-27 WO PCT/RU2008/000401 patent/WO2009002229A2/en not_active Ceased
- 2008-06-27 EA EA201000064A patent/EA020915B1/ru not_active IP Right Cessation
- 2008-06-27 KR KR1020107002061A patent/KR20100028122A/ko not_active Abandoned
- 2008-06-27 UA UAA201000790A patent/UA98969C2/ru unknown
- 2008-06-27 CA CA002692363A patent/CA2692363A1/en not_active Abandoned
- 2008-06-27 US US12/666,250 patent/US8426433B2/en not_active Expired - Fee Related
- 2008-06-27 JP JP2010514672A patent/JP2010531353A/ja active Pending
- 2008-06-27 CN CN200880104823.1A patent/CN101848894B/zh not_active Expired - Fee Related
- 2008-06-27 AU AU2008269258A patent/AU2008269258B2/en not_active Ceased
- 2008-06-27 EP EP08794029A patent/EP2178839A2/en not_active Withdrawn
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Also Published As
| Publication number | Publication date |
|---|---|
| AU2008269258A8 (en) | 2010-03-25 |
| UA98969C2 (ru) | 2012-07-10 |
| RU2007124202A (ru) | 2009-01-10 |
| US8426433B2 (en) | 2013-04-23 |
| US20110003826A1 (en) | 2011-01-06 |
| AU2008269258B2 (en) | 2012-12-13 |
| KR20100028122A (ko) | 2010-03-11 |
| CA2692363A1 (en) | 2008-12-31 |
| CN101848894A (zh) | 2010-09-29 |
| CN101848894B (zh) | 2014-08-20 |
| JP2010531353A (ja) | 2010-09-24 |
| AU2008269258A1 (en) | 2008-12-31 |
| WO2009002229A2 (en) | 2008-12-31 |
| WO2009002229A3 (en) | 2009-03-12 |
| EA201000064A1 (ru) | 2010-06-30 |
| RU2353619C2 (ru) | 2009-04-27 |
| EP2178839A2 (en) | 2010-04-28 |
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