EA018620B1 - ПРОИЗВОДНЫЕ ТИЕНОТРИАЗОЛОДИАЗЕПИНА, АКТИВНЫЕ В ОТНОШЕНИИ Apo A1 - Google Patents
ПРОИЗВОДНЫЕ ТИЕНОТРИАЗОЛОДИАЗЕПИНА, АКТИВНЫЕ В ОТНОШЕНИИ Apo A1 Download PDFInfo
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- EA018620B1 EA018620B1 EA201100698A EA201100698A EA018620B1 EA 018620 B1 EA018620 B1 EA 018620B1 EA 201100698 A EA201100698 A EA 201100698A EA 201100698 A EA201100698 A EA 201100698A EA 018620 B1 EA018620 B1 EA 018620B1
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
- C07D495/14—Ortho-condensed systems
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
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- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Applications Claiming Priority (2)
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| EP08167982 | 2008-10-30 | ||
| PCT/EP2009/064243 WO2010049466A1 (en) | 2008-10-30 | 2009-10-29 | Thienotriazolodiazepine derivatives active on apo a |
Publications (2)
| Publication Number | Publication Date |
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| EA201100698A1 EA201100698A1 (ru) | 2011-12-30 |
| EA018620B1 true EA018620B1 (ru) | 2013-09-30 |
Family
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| EA201100698A EA018620B1 (ru) | 2008-10-30 | 2009-10-29 | ПРОИЗВОДНЫЕ ТИЕНОТРИАЗОЛОДИАЗЕПИНА, АКТИВНЫЕ В ОТНОШЕНИИ Apo A1 |
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| US (1) | US8569288B2 (cg-RX-API-DMAC7.html) |
| EP (1) | EP2362876B1 (cg-RX-API-DMAC7.html) |
| JP (1) | JP5490811B2 (cg-RX-API-DMAC7.html) |
| KR (1) | KR101633742B1 (cg-RX-API-DMAC7.html) |
| CN (1) | CN102292341B (cg-RX-API-DMAC7.html) |
| AU (1) | AU2009309691B2 (cg-RX-API-DMAC7.html) |
| BR (1) | BRPI0914406A2 (cg-RX-API-DMAC7.html) |
| CA (1) | CA2741934C (cg-RX-API-DMAC7.html) |
| EA (1) | EA018620B1 (cg-RX-API-DMAC7.html) |
| ES (1) | ES2448567T3 (cg-RX-API-DMAC7.html) |
| WO (1) | WO2010049466A1 (cg-RX-API-DMAC7.html) |
Families Citing this family (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK2118074T3 (en) | 2007-02-01 | 2014-03-10 | Resverlogix Corp | Compounds for the prevention and treatment of cardiovascular diseases |
| CN102427813A (zh) | 2009-03-18 | 2012-04-25 | 雷斯韦洛吉克斯公司 | 新的抗炎剂 |
| EP2421533B1 (en) | 2009-04-22 | 2018-10-17 | Resverlogix Corp. | Novel anti-inflammatory agents |
| US9301962B2 (en) | 2010-05-14 | 2016-04-05 | Baylor College Of Medicine | Male contraceptive compositions and methods of use |
| BR122014024883A2 (pt) | 2010-05-14 | 2019-08-20 | Dana-Farber Cancer Institute, Inc. | Compostos no tratamento de neoplasia |
| WO2011143651A1 (en) * | 2010-05-14 | 2011-11-17 | Dana-Farber Cancer Institute, Inc. | Compositions and methods for modulating metabolism |
| CN103154246B (zh) | 2010-05-14 | 2015-11-25 | 达那-法伯癌症研究所 | 用于治疗白血病的组合物和方法 |
| WO2012075456A1 (en) | 2010-12-02 | 2012-06-07 | Constellation Pharmaceuticals | Bromodomain inhibitors and uses thereof |
| AR084070A1 (es) | 2010-12-02 | 2013-04-17 | Constellation Pharmaceuticals Inc | Inhibidores del bromodominio y usos de los mismos |
| US9422292B2 (en) | 2011-05-04 | 2016-08-23 | Constellation Pharmaceuticals, Inc. | Bromodomain inhibitors and uses thereof |
| WO2012174487A2 (en) | 2011-06-17 | 2012-12-20 | Constellation Pharmaceuticals, Inc. | Bromodomain inhibitors and uses thereof |
| WO2013184878A1 (en) | 2012-06-06 | 2013-12-12 | Constellation Pharmaceuticals, Inc. | Benzo [b] isoxazoloazepine bromodomain inhibitors and uses thereof |
| TWI602820B (zh) | 2012-06-06 | 2017-10-21 | 星宿藥物公司 | 溴域抑制劑及其用途 |
| EP3024327B1 (en) | 2013-07-25 | 2019-09-04 | Dana-Farber Cancer Institute, Inc. | Inhibitors of transcription factors and uses thereof |
| EP3066101B1 (en) | 2013-11-08 | 2020-07-29 | Dana-Farber Cancer Institute, Inc. | Combination therapy for cancer using bromodomain and extra-terminal (bet) protein inhibitors |
| RU2016134947A (ru) | 2014-01-31 | 2018-03-01 | Дана-Фарбер Кансер Институт, Инк. | Производные диаминопиримидин бензолсульфона и их применение |
| WO2015117087A1 (en) | 2014-01-31 | 2015-08-06 | Dana-Farber Cancer Institute, Inc. | Uses of diazepane derivatives |
| MX377534B (es) | 2014-02-28 | 2025-03-10 | Tensha Therapeutics Inc | Compuestos para usarse en el tratamiento de hiperinsulinemia. |
| JP6682522B2 (ja) | 2014-06-20 | 2020-04-15 | コンステレーション・ファーマシューティカルズ・インコーポレイテッドＣｏｎｓｔｅｌｌａｔｉｏｎ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ，Ｉｎｃ． | ２−（（４ｓ）−６−（４−クロロフェニル）−１−メチル−４ｈ−ベンゾ［ｃ］イソオキサゾロ［４，５−ｅ］アゼピン−４−イル）アセトアミドの結晶形態 |
| WO2016022902A1 (en) | 2014-08-08 | 2016-02-11 | Dana-Farber Cancer Institute, Inc. | Diazepane derivatives and uses thereof |
| MX2017001757A (es) | 2014-08-08 | 2017-05-30 | Dana Farber Cancer Inst Inc | Derivados de dihidropteridinona y sus usos. |
| US10124009B2 (en) | 2014-10-27 | 2018-11-13 | Tensha Therapeutics, Inc. | Bromodomain inhibitors |
| EP3268007B1 (en) | 2015-03-13 | 2022-11-09 | Resverlogix Corp. | Compositions and therapeutic methods for the treatment of complement-associated diseases |
| AU2016276963C1 (en) | 2015-06-12 | 2021-08-05 | Dana-Farber Cancer Institute, Inc. | Combination therapy of transcription inhibitors and kinase inhibitors |
| CR20180199A (es) | 2015-09-11 | 2018-05-25 | Dana Farber Cancer Inst Inc | Acetamida tienotriazolodiazepinas y usos de las mismas |
| BR112018004618A2 (pt) | 2015-09-11 | 2018-09-25 | Dana-Farber Cancer Institute, Inc. | ciano tienotriazoldiazepinas e usos das mesmas |
| BR112018009798A8 (pt) * | 2015-11-25 | 2019-02-26 | Dana Farber Cancer Inst Inc | inibidores de bromodomínio bivalentes e usos dos mesmos |
| EA202092635A1 (ru) | 2018-06-13 | 2021-03-23 | Дибли Аг | Получение конденсированных производных триазепина и их применение в качестве ингибиторов bet |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4155913A (en) * | 1973-02-08 | 1979-05-22 | Hoffmann-La Roche Inc. | Thienotriazolodiazepine derivatives |
| US4960770A (en) * | 1987-05-28 | 1990-10-02 | Yoshitomi Pharmaceutical Industries, Ltd. | 2-alkyl thieno(triazolo)diazepine compounds and pharmaceutical uses thereof |
| EP0176927B1 (de) * | 1984-10-01 | 1993-09-08 | Boehringer Ingelheim Kg | Diazepine enthaltende pharmazeutische Zusammensetzungen mit Plättchen aktivierender Faktor (PAF)-antagonistischer Wirkung |
| US5854238A (en) * | 1995-09-09 | 1998-12-29 | Hoffmann-La Roche Inc. | Use of a thienotriazolodiazephine to increase apolipoprotein A-I levels |
| US6444664B1 (en) * | 1997-04-18 | 2002-09-03 | Nederlandse Organisatie Voor Toegepast - Natuurweten Schappelijk Onderzoek (Tno) | Method for controlling the plasma level of lipoproteins to treat alzheimeris disease |
-
2009
- 2009-10-29 CA CA2741934A patent/CA2741934C/en not_active Expired - Fee Related
- 2009-10-29 EA EA201100698A patent/EA018620B1/ru not_active IP Right Cessation
- 2009-10-29 KR KR1020117012290A patent/KR101633742B1/ko not_active Expired - Fee Related
- 2009-10-29 US US13/126,600 patent/US8569288B2/en not_active Expired - Fee Related
- 2009-10-29 EP EP09740899.1A patent/EP2362876B1/en not_active Not-in-force
- 2009-10-29 AU AU2009309691A patent/AU2009309691B2/en not_active Ceased
- 2009-10-29 ES ES09740899.1T patent/ES2448567T3/es active Active
- 2009-10-29 WO PCT/EP2009/064243 patent/WO2010049466A1/en not_active Ceased
- 2009-10-29 CN CN200980150891.6A patent/CN102292341B/zh not_active Expired - Fee Related
- 2009-10-29 BR BRPI0914406A patent/BRPI0914406A2/pt active Search and Examination
- 2009-10-29 JP JP2011533714A patent/JP5490811B2/ja not_active Expired - Fee Related
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4155913A (en) * | 1973-02-08 | 1979-05-22 | Hoffmann-La Roche Inc. | Thienotriazolodiazepine derivatives |
| EP0176927B1 (de) * | 1984-10-01 | 1993-09-08 | Boehringer Ingelheim Kg | Diazepine enthaltende pharmazeutische Zusammensetzungen mit Plättchen aktivierender Faktor (PAF)-antagonistischer Wirkung |
| US4960770A (en) * | 1987-05-28 | 1990-10-02 | Yoshitomi Pharmaceutical Industries, Ltd. | 2-alkyl thieno(triazolo)diazepine compounds and pharmaceutical uses thereof |
| US5854238A (en) * | 1995-09-09 | 1998-12-29 | Hoffmann-La Roche Inc. | Use of a thienotriazolodiazephine to increase apolipoprotein A-I levels |
| US6444664B1 (en) * | 1997-04-18 | 2002-09-03 | Nederlandse Organisatie Voor Toegepast - Natuurweten Schappelijk Onderzoek (Tno) | Method for controlling the plasma level of lipoproteins to treat alzheimeris disease |
Also Published As
| Publication number | Publication date |
|---|---|
| AU2009309691B2 (en) | 2015-04-02 |
| ES2448567T3 (es) | 2014-03-14 |
| BRPI0914406A2 (pt) | 2015-10-20 |
| CN102292341B (zh) | 2014-09-10 |
| AU2009309691A1 (en) | 2010-05-06 |
| US20110230460A1 (en) | 2011-09-22 |
| JP2012506896A (ja) | 2012-03-22 |
| US8569288B2 (en) | 2013-10-29 |
| KR20110091523A (ko) | 2011-08-11 |
| EP2362876A1 (en) | 2011-09-07 |
| CN102292341A (zh) | 2011-12-21 |
| CA2741934A1 (en) | 2010-05-06 |
| WO2010049466A1 (en) | 2010-05-06 |
| CA2741934C (en) | 2016-09-13 |
| EP2362876B1 (en) | 2013-12-11 |
| JP5490811B2 (ja) | 2014-05-14 |
| KR101633742B1 (ko) | 2016-06-27 |
| EA201100698A1 (ru) | 2011-12-30 |
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