EA015715B1 - Твердая дисперсия, фармацевтическая композиция, включающая такую дисперсию, способ ее получения и применение для предотвращения и лечения заболеваний, связанных с бензодиазепиновыми рецепторами периферического типа - Google Patents
Твердая дисперсия, фармацевтическая композиция, включающая такую дисперсию, способ ее получения и применение для предотвращения и лечения заболеваний, связанных с бензодиазепиновыми рецепторами периферического типа Download PDFInfo
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- EA015715B1 EA015715B1 EA200800713A EA200800713A EA015715B1 EA 015715 B1 EA015715 B1 EA 015715B1 EA 200800713 A EA200800713 A EA 200800713A EA 200800713 A EA200800713 A EA 200800713A EA 015715 B1 EA015715 B1 EA 015715B1
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- Eurasian Patent Office
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- prevention
- treatment
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Applications Claiming Priority (2)
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| PCT/US2006/033022 WO2007027494A2 (en) | 2005-08-29 | 2006-08-24 | Morphous solid dispersions of 7-chloro-n,n, 5-trimethyl-4-oxo-3-phenyl-3, 5,-dihydro-4h-pyridazino [4, 5-b] indole-1-acetamide |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2767872C2 (ru) * | 2017-07-04 | 2022-03-22 | Цзянсу Хэнжуй Медсин Ко., Лтд. | Фармацевтическая композиция и способ ее получения |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2882684T3 (es) | 2006-04-07 | 2021-12-02 | Vertex Pharma | Preparación de moduladores de transportadores del casete de unión a ATP |
| USRE50453E1 (en) | 2006-04-07 | 2025-06-10 | Vertex Pharmaceuticals Incorporated | Indole derivatives as CFTR modulators |
| WO2008138755A2 (en) * | 2007-05-11 | 2008-11-20 | F. Hoffmann-La Roche Ag | Pharmaceutical compositions for poorly soluble drugs |
| AU2009223014A1 (en) * | 2008-03-11 | 2009-09-17 | Dr. Reddy's Laboratories Ltd. | Preparation of lenalidomide |
| AU2009283039A1 (en) * | 2008-08-18 | 2010-02-25 | Sanofi-Aventis U.S. Llc | Process for preparing polymorph of 7-chloro-N, N,5-trimethyl-4-oxo-3-phenyl-3,5-dihydr0-4H-pyridazin0[4,5-b]indole-1-acetamide |
| ES2845449T3 (es) * | 2010-03-25 | 2021-07-26 | Vertex Pharma | Dispersión sólida de forma amorfa de (R)-1(2,2-difluorobenzo[d][1,3]dioxol-5-il)-N-(1-(2,3-dihidroxipropil)-6-fluoro-2(1-hidroxi-2-metilpropan-2-il)-1h-indol-5il)-ciclopropanocarboxamida |
| US8802868B2 (en) | 2010-03-25 | 2014-08-12 | Vertex Pharmaceuticals Incorporated | Solid forms of (R)-1(2,2-difluorobenzo[D][1,3]dioxo1-5-yl)-N-(1-(2,3-dihydroxypropyl-6-fluoro-2-(1-hydroxy-2-methylpropan2-yl)-1H-Indol-5-yl)-Cyclopropanecarboxamide |
| IN2012DE00674A (enExample) | 2012-03-07 | 2015-08-21 | Nat Inst Of Pharmaceutical Education And Res Niper | |
| KR101986683B1 (ko) * | 2012-12-13 | 2019-06-10 | 한미약품 주식회사 | 테트라졸 유도체를 활성 성분으로 포함하는 용해도가 개선된 고체 분산체 |
| CN105493092A (zh) * | 2013-08-30 | 2016-04-13 | 慧与发展有限责任合伙企业 | 实时移动与模式分布的比较 |
| WO2015141662A1 (ja) | 2014-03-18 | 2015-09-24 | 武田薬品工業株式会社 | 固体分散体 |
| PT3131582T (pt) | 2014-04-15 | 2018-10-08 | Vertex Pharma | Composições farmacêuticas para o tratamento de doenças mediadas pelo regulador de condutância transmembranar da fibrose quística |
| US10246461B2 (en) | 2016-02-29 | 2019-04-02 | Genentech, Inc. | Dosage form compositions comprising an inhibitor of bruton's tyrosine kinase |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6395729B1 (en) * | 1999-01-26 | 2002-05-28 | Sanofi-Synthelabo | Use of pyridazino[4,5-b]indole-1-acetamide derivatives for preparing medicines for treating diseases related to the dysfunction of peripheral benzodiazepin receptors |
| FR2829939A1 (fr) * | 2001-09-21 | 2003-03-28 | Sanofi Synthelabo | Utilisation du 7-chloro-n,n,5-trimethyl-4-oxo-3-phenyl-3,5- dihydro-4h-pyridazino(4,5-b)indole-1-acetamide pour la preparation de medicaments destines au traitement de la polyarthrite rhumatoide |
| WO2005034999A2 (en) * | 2003-10-10 | 2005-04-21 | Bvm Holding Co. | Composition comprising association complex of a pharmaceutical and a poloxamer |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5091381A (en) * | 1991-04-12 | 1992-02-25 | Biomeasure, Inc. | 2H-1,3,4-benzotriazepin-2-ones |
| TW487582B (en) * | 1995-08-11 | 2002-05-21 | Nissan Chemical Ind Ltd | Method for converting sparingly water-soluble medical substance to amorphous state |
| FR2766823B1 (fr) * | 1997-07-30 | 1999-10-08 | Synthelabo | Derives de 4-oxo-3,5-dihydro-4h-pyridazino[4,5-b] indole-1-acetamide, leur preparation et leur application en therapeutique |
| ATE364374T1 (de) * | 1997-08-11 | 2007-07-15 | Pfizer Prod Inc | Feste pharmazeutische dispersionen mit erhöhter bioverfügbarkeit |
| AUPP278498A0 (en) * | 1998-04-03 | 1998-04-30 | Australian Nuclear Science & Technology Organisation | Peripheral benzodiazepine receptor binding agents |
| EP1027885B1 (en) * | 1999-02-09 | 2008-07-09 | Pfizer Products Inc. | Basic drug compositions with enhanced bioavailability |
| ES2307482T3 (es) * | 1999-02-10 | 2008-12-01 | Pfizer Products Inc. | Dispersiones farmaceuticas solidas. |
| EP1027887B1 (en) * | 1999-02-10 | 2008-08-13 | Pfizer Products Inc. | Matrix controlled release device |
| EP1120109A3 (en) * | 2000-01-24 | 2002-07-10 | Pfizer Products Inc. | Rapidly disintegrating and fast dissolving solid dosage form |
| CL2004001884A1 (es) * | 2003-08-04 | 2005-06-03 | Pfizer Prod Inc | Procedimiento de secado por pulverizacion para la formacion de dispersiones solidas amorfas de un farmaco y polimeros. |
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- 2006-08-24 ZA ZA200801893A patent/ZA200801893B/xx unknown
- 2006-08-24 HR HRP20130533TT patent/HRP20130533T1/hr unknown
- 2006-08-24 BR BRPI0615609-6A patent/BRPI0615609A2/pt not_active IP Right Cessation
- 2006-08-24 CN CN2006800317142A patent/CN101272767B/zh not_active Expired - Fee Related
- 2006-08-24 DK DK06802215.1T patent/DK1926476T3/da active
- 2006-08-24 CA CA002619438A patent/CA2619438A1/en not_active Abandoned
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- 2006-08-24 NZ NZ566313A patent/NZ566313A/en not_active IP Right Cessation
- 2006-08-24 EA EA200800713A patent/EA015715B1/ru not_active IP Right Cessation
- 2006-08-24 KR KR1020087004952A patent/KR20080061354A/ko not_active Abandoned
- 2006-08-24 PT PT68022151T patent/PT1926476E/pt unknown
- 2006-08-24 JP JP2008529117A patent/JP5026426B2/ja not_active Expired - Fee Related
- 2006-08-24 EP EP06802215.1A patent/EP1926476B1/en active Active
- 2006-08-24 WO PCT/US2006/033022 patent/WO2007027494A2/en not_active Ceased
- 2006-08-24 ME MEP-2013-80A patent/ME01560B/me unknown
- 2006-08-24 PL PL06802215T patent/PL1926476T3/pl unknown
- 2006-08-24 UA UAA200803944A patent/UA93517C2/ru unknown
- 2006-08-24 RS RS20130288A patent/RS52914B/sr unknown
- 2006-08-24 ES ES06802215T patent/ES2414434T3/es active Active
- 2006-08-28 AR ARP060103739A patent/AR055615A1/es not_active Application Discontinuation
- 2006-08-29 TW TW095131682A patent/TWI398250B/zh not_active IP Right Cessation
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2008
- 2008-02-12 US US12/029,691 patent/US7713548B2/en not_active Expired - Fee Related
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- 2008-02-19 EC EC2008008203A patent/ECSP088203A/es unknown
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- 2008-02-28 HN HN2008000360A patent/HN2008000360A/es unknown
- 2008-03-14 NO NO20081364A patent/NO20081364L/no not_active Application Discontinuation
- 2008-03-17 MA MA30752A patent/MA29783B1/fr unknown
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
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| US6395729B1 (en) * | 1999-01-26 | 2002-05-28 | Sanofi-Synthelabo | Use of pyridazino[4,5-b]indole-1-acetamide derivatives for preparing medicines for treating diseases related to the dysfunction of peripheral benzodiazepin receptors |
| FR2829939A1 (fr) * | 2001-09-21 | 2003-03-28 | Sanofi Synthelabo | Utilisation du 7-chloro-n,n,5-trimethyl-4-oxo-3-phenyl-3,5- dihydro-4h-pyridazino(4,5-b)indole-1-acetamide pour la preparation de medicaments destines au traitement de la polyarthrite rhumatoide |
| WO2005034999A2 (en) * | 2003-10-10 | 2005-04-21 | Bvm Holding Co. | Composition comprising association complex of a pharmaceutical and a poloxamer |
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| Title |
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| FERZAZ BADIA ET AL.: "SSR180575 (7-chloro-N,N,5-trimethyl-4-oxo-3-phenyl-3,5-dihydro-4H-pyridazino(4,5-b)indole-1-acetamide), a peripheral benzodiazepine receptor ligand, promotes neuronal survival and repair'' JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, vol. 301, no. 3, June 2002 (2002-06), pages 1067-1078, XP002432965 ISSN: 0022-3565 the whole document esp. abstract esp. page 1074, left column, 1st paragraph * |
| GAL1EGUE S. ET AL.: "THE PERIPHERAL BENZODIAZEPINE RECEPTOR: A PROMISING THERAPEUTIC DRUG TARGET" CURRENT MEDICINAL CHEMISTRY, BENTHAM SCIENCE PUBLISHERS BV, BE, vol. 10, no. 16, 2003, pages 1563-1572, XP009027200 ISSN: 0929-8673 the whole document esp. paragraph "2-2 Inflammation, Auto-immune Diseases" on page 1566-1567 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2767872C2 (ru) * | 2017-07-04 | 2022-03-22 | Цзянсу Хэнжуй Медсин Ко., Лтд. | Фармацевтическая композиция и способ ее получения |
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