CR9750A - Dispersiones solidas amorfas de 7-cloro-n,n,5-trimetil-4-oxo-3-fenil-3,5-dihidro-4h-prirdazino[4,5-b]indol-1-acetamida - Google Patents
Dispersiones solidas amorfas de 7-cloro-n,n,5-trimetil-4-oxo-3-fenil-3,5-dihidro-4h-prirdazino[4,5-b]indol-1-acetamidaInfo
- Publication number
- CR9750A CR9750A CR9750A CR9750A CR9750A CR 9750 A CR9750 A CR 9750A CR 9750 A CR9750 A CR 9750A CR 9750 A CR9750 A CR 9750A CR 9750 A CR9750 A CR 9750A
- Authority
- CR
- Costa Rica
- Prior art keywords
- acetamide
- dihydro
- trimethyl
- oxo
- phenyl
- Prior art date
Links
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
- A61K9/146—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic macromolecular compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/50—Pyridazines; Hydrogenated pyridazines
- A61K31/5025—Pyridazines; Hydrogenated pyridazines ortho- or peri-condensed with heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
- A61K47/38—Cellulose; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2059—Starch, including chemically or physically modified derivatives; Amylose; Amylopectin; Dextrin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4841—Filling excipients; Inactive ingredients
- A61K9/4866—Organic macromolecular compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Rheumatology (AREA)
- Physical Education & Sports Medicine (AREA)
- Psychiatry (AREA)
- Immunology (AREA)
- Hospice & Palliative Care (AREA)
- Cardiology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Dermatology (AREA)
- Inorganic Chemistry (AREA)
- Pain & Pain Management (AREA)
- Heart & Thoracic Surgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Abstract
Se describen formulaciones de dispersiones solidas amorfas que comprenden 7-cloro-N,N,5-trimetil-4-oxo-3-fenil-3,5-dihidro-4h-piridazino[4,5-b] indol-1-acetamida.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US71215005P | 2005-08-29 | 2005-08-29 |
Publications (1)
Publication Number | Publication Date |
---|---|
CR9750A true CR9750A (es) | 2008-06-18 |
Family
ID=37499538
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CR9750A CR9750A (es) | 2005-08-29 | 2008-02-21 | Dispersiones solidas amorfas de 7-cloro-n,n,5-trimetil-4-oxo-3-fenil-3,5-dihidro-4h-prirdazino[4,5-b]indol-1-acetamida |
Country Status (31)
Country | Link |
---|---|
US (1) | US7713548B2 (es) |
EP (1) | EP1926476B1 (es) |
JP (1) | JP5026426B2 (es) |
KR (1) | KR20080061354A (es) |
CN (1) | CN101272767B (es) |
AR (1) | AR055615A1 (es) |
AU (1) | AU2006285111B8 (es) |
BR (1) | BRPI0615609A2 (es) |
CA (1) | CA2619438A1 (es) |
CR (1) | CR9750A (es) |
DK (1) | DK1926476T3 (es) |
EA (1) | EA015715B1 (es) |
EC (1) | ECSP088203A (es) |
ES (1) | ES2414434T3 (es) |
HK (1) | HK1124785A1 (es) |
HN (1) | HN2008000360A (es) |
HR (1) | HRP20130533T1 (es) |
IL (1) | IL189587A (es) |
MA (1) | MA29783B1 (es) |
ME (1) | ME01560B (es) |
NO (1) | NO20081364L (es) |
NZ (1) | NZ566313A (es) |
PL (1) | PL1926476T3 (es) |
PT (1) | PT1926476E (es) |
RS (1) | RS52914B (es) |
SI (1) | SI1926476T1 (es) |
TN (1) | TNSN08069A1 (es) |
TW (1) | TWI398250B (es) |
UA (1) | UA93517C2 (es) |
WO (1) | WO2007027494A2 (es) |
ZA (1) | ZA200801893B (es) |
Families Citing this family (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DK2007756T3 (en) | 2006-04-07 | 2015-10-05 | Vertex Pharma | MODULATORS OF ATP BINDING CASSETTE TRANSPORT |
EP2155166A2 (en) * | 2007-05-11 | 2010-02-24 | F. Hoffmann-Roche AG | Pharmaceutical compositions for poorly soluble drugs |
AU2009223014A1 (en) * | 2008-03-11 | 2009-09-17 | Dr. Reddy's Laboratories Ltd. | Preparation of lenalidomide |
JP2012500268A (ja) * | 2008-08-18 | 2012-01-05 | サノフィ−アベンティス・ユー・エス・エルエルシー | 7−クロロ−N,N,5−トリメチル−4−オキソ−3−フェニル−3,5−ジヒドロ−4H−ピリダジノ[4,5−b]インドール−1−アセトアミドの多形体を製造するための方法 |
US8802868B2 (en) | 2010-03-25 | 2014-08-12 | Vertex Pharmaceuticals Incorporated | Solid forms of (R)-1(2,2-difluorobenzo[D][1,3]dioxo1-5-yl)-N-(1-(2,3-dihydroxypropyl-6-fluoro-2-(1-hydroxy-2-methylpropan2-yl)-1H-Indol-5-yl)-Cyclopropanecarboxamide |
NZ602665A (en) * | 2010-03-25 | 2014-10-31 | Vertex Pharma | Solid forms of (r)-1-(2,2-difluorobenzo[d][1,3]dioxol-5-yl)-n-(1-(2,3-dihyderoxypropyl)-6-fluoro-2-(1-hydroxy-2-methylpropan-2-yl)-1h-indol-5-yl) cyclopropanecarboxamide |
WO2013132457A2 (en) | 2012-03-07 | 2013-09-12 | National Institute Of Pharmaceutical Education And Research (Niper) | Nanocrystalline solid dispersion compositions and process of preparation thereof |
KR101986683B1 (ko) * | 2012-12-13 | 2019-06-10 | 한미약품 주식회사 | 테트라졸 유도체를 활성 성분으로 포함하는 용해도가 개선된 고체 분산체 |
CN105493092A (zh) * | 2013-08-30 | 2016-04-13 | 慧与发展有限责任合伙企业 | 实时移动与模式分布的比较 |
EP3120871B1 (en) * | 2014-03-18 | 2023-06-28 | Takeda Pharmaceutical Company Limited | Solid dispersion |
RS64400B1 (sr) | 2014-04-15 | 2023-08-31 | Vertex Pharma | Farmaceutske kompozicije za lečenje bolesti posredovanih transmembranskim regulatorom provodljivosti cistične fibroze |
JP6577143B2 (ja) | 2016-02-29 | 2019-09-18 | エフ.ホフマン−ラ ロシュ アーゲーF. Hoffmann−La Roche Aktiengesellschaft | ブルトンチロシンキナーゼの阻害剤を含む剤形組成物 |
WO2019007317A1 (zh) * | 2017-07-04 | 2019-01-10 | 江苏恒瑞医药股份有限公司 | 一种药物组合物及其制备方法 |
Family Cites Families (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5091381A (en) * | 1991-04-12 | 1992-02-25 | Biomeasure, Inc. | 2H-1,3,4-benzotriazepin-2-ones |
TW487582B (en) * | 1995-08-11 | 2002-05-21 | Nissan Chemical Ind Ltd | Method for converting sparingly water-soluble medical substance to amorphous state |
FR2766823B1 (fr) * | 1997-07-30 | 1999-10-08 | Synthelabo | Derives de 4-oxo-3,5-dihydro-4h-pyridazino[4,5-b] indole-1-acetamide, leur preparation et leur application en therapeutique |
PT901786E (pt) * | 1997-08-11 | 2007-08-07 | Pfizer Prod Inc | Disperções farmacêuticas sólidas com biodisponibilidade melhorada |
AUPP278498A0 (en) * | 1998-04-03 | 1998-04-30 | Australian Nuclear Science & Technology Organisation | Peripheral benzodiazepine receptor binding agents |
FR2788696B1 (fr) * | 1999-01-26 | 2004-03-05 | Synthelabo | Utilisation de derives de pyridazino [4,5-b] indole-1-acetamide pour la preparation de medicaments destines aux maladies du systeme nerveux central |
EP1970052A2 (en) * | 1999-02-09 | 2008-09-17 | Pfizer Products Inc. | Basic drug compositions with enhanced bioavailability |
ATE404178T1 (de) * | 1999-02-10 | 2008-08-15 | Pfizer Prod Inc | Vorrichtung mit matrixgesteuerter wirkstofffreisetzung |
ATE400252T1 (de) * | 1999-02-10 | 2008-07-15 | Pfizer Prod Inc | Pharmazeutische feste dispersionen |
EP1120109A3 (en) * | 2000-01-24 | 2002-07-10 | Pfizer Products Inc. | Rapidly disintegrating and fast dissolving solid dosage form |
FR2829939B3 (fr) * | 2001-09-21 | 2003-11-28 | Sanofi Synthelabo | Utilisation du 7-chloro-n,n,5-trimethyl-4-oxo-3-phenyl-3,5- dihydro-4h-pyridazino(4,5-b)indole-1-acetamide pour la preparation de medicaments destines au traitement de la polyarthrite rhumatoide |
CL2004001884A1 (es) * | 2003-08-04 | 2005-06-03 | Pfizer Prod Inc | Procedimiento de secado por pulverizacion para la formacion de dispersiones solidas amorfas de un farmaco y polimeros. |
US20050220881A1 (en) * | 2003-10-10 | 2005-10-06 | Bvm Holding Co. | Pharmaceutical composition |
-
2006
- 2006-08-24 EP EP06802215.1A patent/EP1926476B1/en active Active
- 2006-08-24 CA CA002619438A patent/CA2619438A1/en not_active Abandoned
- 2006-08-24 ME MEP-2013-80A patent/ME01560B/me unknown
- 2006-08-24 ZA ZA200801893A patent/ZA200801893B/xx unknown
- 2006-08-24 PT PT68022151T patent/PT1926476E/pt unknown
- 2006-08-24 KR KR1020087004952A patent/KR20080061354A/ko active IP Right Grant
- 2006-08-24 AU AU2006285111A patent/AU2006285111B8/en not_active Ceased
- 2006-08-24 JP JP2008529117A patent/JP5026426B2/ja not_active Expired - Fee Related
- 2006-08-24 UA UAA200803944A patent/UA93517C2/ru unknown
- 2006-08-24 PL PL06802215T patent/PL1926476T3/pl unknown
- 2006-08-24 CN CN2006800317142A patent/CN101272767B/zh not_active Expired - Fee Related
- 2006-08-24 NZ NZ566313A patent/NZ566313A/en not_active IP Right Cessation
- 2006-08-24 SI SI200631605T patent/SI1926476T1/sl unknown
- 2006-08-24 WO PCT/US2006/033022 patent/WO2007027494A2/en active Application Filing
- 2006-08-24 DK DK06802215.1T patent/DK1926476T3/da active
- 2006-08-24 BR BRPI0615609-6A patent/BRPI0615609A2/pt not_active IP Right Cessation
- 2006-08-24 ES ES06802215T patent/ES2414434T3/es active Active
- 2006-08-24 RS RS20130288A patent/RS52914B/en unknown
- 2006-08-24 EA EA200800713A patent/EA015715B1/ru not_active IP Right Cessation
- 2006-08-28 AR ARP060103739A patent/AR055615A1/es not_active Application Discontinuation
- 2006-08-29 TW TW095131682A patent/TWI398250B/zh not_active IP Right Cessation
-
2008
- 2008-02-12 US US12/029,691 patent/US7713548B2/en not_active Expired - Fee Related
- 2008-02-13 TN TNP2008000069A patent/TNSN08069A1/en unknown
- 2008-02-18 IL IL189587A patent/IL189587A/en not_active IP Right Cessation
- 2008-02-19 EC EC2008008203A patent/ECSP088203A/es unknown
- 2008-02-21 CR CR9750A patent/CR9750A/es unknown
- 2008-02-28 HN HN2008000360A patent/HN2008000360A/es unknown
- 2008-03-14 NO NO20081364A patent/NO20081364L/no not_active Application Discontinuation
- 2008-03-17 MA MA30752A patent/MA29783B1/fr unknown
-
2009
- 2009-03-20 HK HK09102705.3A patent/HK1124785A1/xx not_active IP Right Cessation
-
2013
- 2013-06-12 HR HRP20130533TT patent/HRP20130533T1/hr unknown
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