EA014904B1 - Новые гетероциклические соединения в качестве положительных аллостерических модуляторов метаботропных глутаматных рецепторов - Google Patents
Новые гетероциклические соединения в качестве положительных аллостерических модуляторов метаботропных глутаматных рецепторов Download PDFInfo
- Publication number
- EA014904B1 EA014904B1 EA200702471A EA200702471A EA014904B1 EA 014904 B1 EA014904 B1 EA 014904B1 EA 200702471 A EA200702471 A EA 200702471A EA 200702471 A EA200702471 A EA 200702471A EA 014904 B1 EA014904 B1 EA 014904B1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- alkyl
- piperidin
- oxadiazol
- methanone
- disorder
- Prior art date
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- 102000016193 Metabotropic glutamate receptors Human genes 0.000 title claims description 3
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- -1 methoxyphenyl Chemical group 0.000 claims description 225
- RWTNPBWLLIMQHL-UHFFFAOYSA-N fexofenadine Chemical compound C1=CC(C(C)(C(O)=O)C)=CC=C1C(O)CCCN1CCC(C(O)(C=2C=CC=CC=2)C=2C=CC=CC=2)CC1 RWTNPBWLLIMQHL-UHFFFAOYSA-N 0.000 claims description 190
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 claims description 141
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- WSFSSNUMVMOOMR-BJUDXGSMSA-N methanone Chemical compound O=[11CH2] WSFSSNUMVMOOMR-BJUDXGSMSA-N 0.000 claims description 69
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- MUMITROLTOTPRS-UHFFFAOYSA-N [3-[3-(3-fluorophenoxy)-1,2,4-oxadiazol-5-yl]piperidin-1-yl]-(4-fluorophenyl)methanone Chemical compound C1=CC(F)=CC=C1C(=O)N1CC(C=2ON=C(OC=3C=C(F)C=CC=3)N=2)CCC1 MUMITROLTOTPRS-UHFFFAOYSA-N 0.000 claims description 4
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- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 2
- WCPAKWJPBJAGKN-UHFFFAOYSA-N oxadiazole Chemical compound C1=CON=N1 WCPAKWJPBJAGKN-UHFFFAOYSA-N 0.000 claims description 2
- 125000001037 p-tolyl group Chemical group [H]C1=C([H])C(=C([H])C([H])=C1*)C([H])([H])[H] 0.000 claims description 2
- GQTQLSCRSBJTTO-UHFFFAOYSA-N pyridin-4-ylmethanone Chemical compound [C+](C1=CC=NC=C1)=O GQTQLSCRSBJTTO-UHFFFAOYSA-N 0.000 claims description 2
- QJZUKDFHGGYHMC-UHFFFAOYSA-N pyridine-3-carbaldehyde Chemical compound O=CC1=CC=CN=C1 QJZUKDFHGGYHMC-UHFFFAOYSA-N 0.000 claims description 2
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Classifications
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- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
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- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
Landscapes
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- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
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| GBGB0510139.9A GB0510139D0 (en) | 2005-05-18 | 2005-05-18 | Novel compounds B1 |
| PCT/IB2006/001882 WO2006129199A1 (en) | 2005-05-18 | 2006-05-17 | Novel heterocyclic compounds as positive allosteric modulators of metabotropic glutamate receptors |
Publications (2)
| Publication Number | Publication Date |
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| EA200702471A1 EA200702471A1 (ru) | 2008-06-30 |
| EA014904B1 true EA014904B1 (ru) | 2011-02-28 |
Family
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| EA200702471A EA014904B1 (ru) | 2005-05-18 | 2006-05-17 | Новые гетероциклические соединения в качестве положительных аллостерических модуляторов метаботропных глутаматных рецепторов |
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| EP (1) | EP1896464A1 (enExample) |
| JP (1) | JP2008540636A (enExample) |
| KR (1) | KR20080017040A (enExample) |
| CN (1) | CN101218231B (enExample) |
| AU (1) | AU2006253863A1 (enExample) |
| BR (1) | BRPI0610067A2 (enExample) |
| CA (1) | CA2609513A1 (enExample) |
| EA (1) | EA014904B1 (enExample) |
| GB (1) | GB0510139D0 (enExample) |
| IL (1) | IL187189A0 (enExample) |
| MX (1) | MX2007014400A (enExample) |
| NO (1) | NO20076477L (enExample) |
| NZ (1) | NZ564255A (enExample) |
| UA (1) | UA92914C2 (enExample) |
| WO (1) | WO2006129199A1 (enExample) |
| ZA (1) | ZA200710280B (enExample) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2561920C2 (ru) * | 2009-10-27 | 2015-09-10 | Ф. Хоффманн-Ля Рош Аг | Позитивные аллостерические модуляторы (рам) |
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| GB0510141D0 (en) * | 2005-05-18 | 2005-06-22 | Addex Pharmaceuticals Sa | Novel compounds B3 |
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| WO2006123255A2 (en) * | 2005-05-18 | 2006-11-23 | Addex Pharma Sa | Substituted oxadiazole derivatives as positive allosteric modulators of metabotropic glutamate receptors |
| GB0510140D0 (en) * | 2005-05-18 | 2005-06-22 | Addex Pharmaceuticals Sa | Novel compounds B2 |
| IL169855A (en) * | 2005-07-25 | 2014-05-28 | Elta Systems Ltd | A system and method for locating a receiver location |
| WO2007013830A1 (en) | 2005-07-26 | 2007-02-01 | Portela & Ca. S.A. | Nitrocatechol derivatives as comt inhibitors |
| PT2404919E (pt) | 2005-11-08 | 2013-10-22 | Vertex Pharma | Composto heterocíclico útil como um modulador de transportadores de cassete de ligação a atp |
| HUE028588T2 (hu) | 2005-12-13 | 2016-12-28 | Incyte Holdings Corp | Heteroaril-szubsztituált pirrolo[2,3-b]piridinek és pirrolo[2,3-b]pirimidinek mint Janus-kináz inhibitorok |
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| DK2481410T3 (en) | 2007-01-31 | 2016-10-24 | Bial - Portela & Ca S A | Nitrocatecholderivater as COMT inhibitors administered in a specific dosage regimen |
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| CA2989620C (en) | 2007-12-07 | 2022-05-03 | Vertex Pharmaceuticals Incorporated | Processes for producing cycloalkylcarboxamido-pyridine benzoic acids |
| HUE049642T2 (hu) | 2007-12-07 | 2020-09-28 | Vertex Pharma | 3-(6-(1-(2,2-Difluorbenzo[d][1,3]dioxol-5-il)-ciklopropánkarboxamido)-3-metilpiridin-2-il)-benzoesav szilárd formái |
| EP2259777A2 (en) * | 2008-02-28 | 2010-12-15 | BIAL - Portela & Ca., S.A. | Pharmaceutical composition for poorly soluble drugs |
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| MY165582A (en) | 2008-03-11 | 2018-04-05 | Incyte Holdings Corp | Azetidine and cyclobutane derivatives as jak inhibitors |
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| UA103319C2 (en) | 2008-05-06 | 2013-10-10 | Глаксосмитклайн Ллк | Thiazole- and oxazole-benzene sulfonamide compounds |
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| CA2609513A1 (en) | 2006-12-07 |
| GB0510139D0 (en) | 2005-06-22 |
| NO20076477L (no) | 2008-01-23 |
| MX2007014400A (es) | 2008-04-11 |
| CN101218231B (zh) | 2011-12-21 |
| KR20080017040A (ko) | 2008-02-25 |
| JP2008540636A (ja) | 2008-11-20 |
| WO2006129199A1 (en) | 2006-12-07 |
| NZ564255A (en) | 2011-04-29 |
| AU2006253863A8 (en) | 2006-12-07 |
| AU2006253863A1 (en) | 2006-12-07 |
| ZA200710280B (en) | 2009-03-25 |
| UA92914C2 (ru) | 2010-12-27 |
| EP1896464A1 (en) | 2008-03-12 |
| EA200702471A1 (ru) | 2008-06-30 |
| CN101218231A (zh) | 2008-07-09 |
| BRPI0610067A2 (pt) | 2010-05-25 |
| US20100004284A1 (en) | 2010-01-07 |
| IL187189A0 (en) | 2008-02-09 |
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