EA014097B1 - ОЛИГОНУКЛЕОТИДЫ ЗАМКНУТОЙ НУКЛЕИНОВОЙ КИСЛОТЫ (LNA) ДЛЯ МОДУЛИРОВАНИЯ ЭКСПРЕССИИ HIF-1a И ИХ ПРИМЕНЕНИЕ - Google Patents
ОЛИГОНУКЛЕОТИДЫ ЗАМКНУТОЙ НУКЛЕИНОВОЙ КИСЛОТЫ (LNA) ДЛЯ МОДУЛИРОВАНИЯ ЭКСПРЕССИИ HIF-1a И ИХ ПРИМЕНЕНИЕ Download PDFInfo
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- EA014097B1 EA014097B1 EA200701033A EA200701033A EA014097B1 EA 014097 B1 EA014097 B1 EA 014097B1 EA 200701033 A EA200701033 A EA 200701033A EA 200701033 A EA200701033 A EA 200701033A EA 014097 B1 EA014097 B1 EA 014097B1
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- oligonucleotide
- ενα
- sequence
- cancer
- nucleotide
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Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
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| US62656304P | 2004-11-09 | 2004-11-09 | |
| US64718605P | 2005-01-25 | 2005-01-25 | |
| US69972105P | 2005-07-15 | 2005-07-15 | |
| US72462105P | 2005-10-07 | 2005-10-07 | |
| PCT/DK2005/000721 WO2006050734A2 (en) | 2004-11-09 | 2005-11-09 | Potent lna oligonucleotides for the inhibition of hif-1a expression |
Publications (2)
| Publication Number | Publication Date |
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| EA200701033A1 EA200701033A1 (ru) | 2007-12-28 |
| EA014097B1 true EA014097B1 (ru) | 2010-08-30 |
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| EA200701033A EA014097B1 (ru) | 2004-11-09 | 2005-11-09 | ОЛИГОНУКЛЕОТИДЫ ЗАМКНУТОЙ НУКЛЕИНОВОЙ КИСЛОТЫ (LNA) ДЛЯ МОДУЛИРОВАНИЯ ЭКСПРЕССИИ HIF-1a И ИХ ПРИМЕНЕНИЕ |
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| EP (1) | EP1833840B9 (OSRAM) |
| JP (3) | JP4825807B2 (OSRAM) |
| KR (1) | KR101176245B1 (OSRAM) |
| AT (1) | ATE476441T1 (OSRAM) |
| AU (1) | AU2005304112B2 (OSRAM) |
| BR (1) | BRPI0515726A8 (OSRAM) |
| CA (1) | CA2587173C (OSRAM) |
| DE (1) | DE602005022768D1 (OSRAM) |
| DK (1) | DK1833840T3 (OSRAM) |
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| IL (1) | IL183054A0 (OSRAM) |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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| RU2756865C2 (ru) * | 2013-06-04 | 2021-10-06 | Президент Энд Фэллоуз Оф Харвард Коллидж | Направляемая рнк регуляция транскрипции |
Families Citing this family (73)
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| DK2284269T3 (en) | 2002-11-18 | 2017-10-23 | Roche Innovation Ct Copenhagen As | Antisense design |
| US7144999B2 (en) * | 2002-11-23 | 2006-12-05 | Isis Pharmaceuticals, Inc. | Modulation of hypoxia-inducible factor 1 alpha expression |
| DK1606406T4 (da) | 2003-03-21 | 2013-12-16 | Santaris Pharma As | Short Interfering RNA (siRNA) Analogues |
| EP1713912B1 (en) * | 2004-01-30 | 2013-09-18 | Santaris Pharma A/S | Modified short interfering rna (modified sirna) |
| US9447138B2 (en) | 2004-11-09 | 2016-09-20 | Roche Innovation Center Copenhagen A/S | Potent LNA oligonucleotides for the inhibition of HIF-1a expression |
| MX2007005558A (es) * | 2004-11-09 | 2008-01-31 | Santaris Pharma As | Oligonucleotidos de lna potentes para la inhibicion dela expresion de hif-1a. |
| JP5713377B2 (ja) | 2005-12-28 | 2015-05-07 | ザ スクリプス リサーチ インスティテュート | 薬物標的としての天然アンチセンスおよび非コードrna転写物 |
| WO2007085485A2 (en) * | 2006-01-27 | 2007-08-02 | Santaris Pharma A/S | Lna modified phosphorothiolated oligonucleotides |
| WO2007107162A2 (en) | 2006-03-23 | 2007-09-27 | Santaris Pharma A/S | Small internally segmented interfering rna |
| WO2007131237A2 (en) | 2006-05-05 | 2007-11-15 | Isis Pharmaceuticals, Inc. | Compounds and methods for modulating expression of ptp1b |
| BRPI0716823A2 (pt) * | 2006-09-15 | 2015-05-26 | Enzon Pharmaceuticals Inc | Conjunto poliméricos contendo porções positivamente carregadas |
| WO2008113832A2 (en) * | 2007-03-22 | 2008-09-25 | Santaris Pharma A/S | SHORT RNA ANTAGONIST COMPOUNDS FOR THE MODULATION OF TARGET mRNA |
| EP2149605B1 (en) | 2007-03-22 | 2013-07-03 | Santaris Pharma A/S | Short RNA antagonist compounds for the modulation of target mRNA |
| ES2462416T3 (es) * | 2007-08-06 | 2014-05-22 | Senju Pharmaceutical Co., Ltd. | Producto farmacéutico que contiene un inhibidor de la expresión de HIF-1 alfa y HIF-2 alfa |
| JP5723154B2 (ja) * | 2007-09-19 | 2015-05-27 | アプライド バイオシステムズ リミテッド ライアビリティー カンパニー | RNAiにおけるオフターゲット表現型の影響を減少させるためのSiRNA配列非依存性修飾フォーマットおよびその安定化型 |
| JP2010539961A (ja) * | 2007-10-04 | 2010-12-24 | サンタリス ファーマ アー/エス | HIF1αの調節のための短いRNAアンタゴニスト化合物 |
| CN102239260B (zh) | 2008-10-03 | 2017-04-12 | 库尔纳公司 | 通过抑制针对载脂蛋白‑a1的天然反义转录物治疗载脂蛋白‑a1相关疾病 |
| CA2746003C (en) | 2008-12-04 | 2020-03-31 | Opko Curna, Llc | Treatment of vascular endothelial growth factor (vegf) related diseases by inhibition of natural antisense transcript to vegf |
| ES2629630T3 (es) | 2008-12-04 | 2017-08-11 | Curna, Inc. | Tratamiento de enfermedades relacionadas con eritropoyetina (EPO) mediante inhibición del transcrito antisentido natural a EPO |
| KR101840618B1 (ko) | 2008-12-04 | 2018-03-20 | 큐알엔에이, 인크. | 종양 억제 유전자에 대한 천연 안티센스 전사체의 억제에 의해 종양 억제 유전자 관련된 질환의 치료 |
| ES2560107T3 (es) | 2009-02-12 | 2016-02-17 | Curna, Inc. | Tratamiento de enfermedades relacionadas con el factor neurotrófico derivado de cerebro (BDNF) por inhibición de transcrito antisentido natural para BDNF |
| CN102482677B (zh) | 2009-03-16 | 2017-10-17 | 库尔纳公司 | 通过抑制nrf2的天然反义转录物治疗核因子(红细胞衍生2)‑样2(nrf2)相关疾病 |
| CA2755404C (en) | 2009-03-17 | 2020-03-24 | Joseph Collard | Treatment of delta-like 1 homolog (dlk1) related diseases by inhibition of natural antisense transcript to dlk1 |
| ES2609655T3 (es) | 2009-05-06 | 2017-04-21 | Curna, Inc. | Tratamiento de enfermedades relacionadas con tristetraprolina (TTP) mediante inhibición de transcrito antisentido natural para TTP |
| EP2427553A4 (en) | 2009-05-06 | 2012-11-07 | Opko Curna Llc | TREATMENT OF LIPID TRANSPORT AND METABOLISM-RELATED DISEASES BY INHIBITING THE NATURAL ANTISENSE TRANSCRIPT AGAINST A LIPID TRANSPORT AND METABOLIC TREATMENT |
| WO2010129861A2 (en) | 2009-05-08 | 2010-11-11 | Curna, Inc. | Treatment of dystrophin family related diseases by inhibition of natural antisense transcript to dmd family |
| US8957037B2 (en) | 2009-05-18 | 2015-02-17 | Curna, Inc. | Treatment of reprogramming factor related diseases by inhibition of natural antisense transcript to a reprogramming factor |
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| JP4825807B2 (ja) | 2011-11-30 |
| KR101176245B1 (ko) | 2012-08-22 |
| EA200701033A1 (ru) | 2007-12-28 |
| NO341878B1 (no) | 2018-02-12 |
| EP1833840B9 (en) | 2010-11-10 |
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