CA2587173C - Potent lna oligonucleotides for the inhibition of hif-1a expression - Google Patents
Potent lna oligonucleotides for the inhibition of hif-1a expression Download PDFInfo
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- CA2587173C CA2587173C CA2587173A CA2587173A CA2587173C CA 2587173 C CA2587173 C CA 2587173C CA 2587173 A CA2587173 A CA 2587173A CA 2587173 A CA2587173 A CA 2587173A CA 2587173 C CA2587173 C CA 2587173C
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Applications Claiming Priority (9)
| Application Number | Priority Date | Filing Date | Title |
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| US62656304P | 2004-11-09 | 2004-11-09 | |
| US60/626,563 | 2004-11-09 | ||
| US64718605P | 2005-01-25 | 2005-01-25 | |
| US60/647,186 | 2005-01-25 | ||
| US69972105P | 2005-07-15 | 2005-07-15 | |
| US60/699,721 | 2005-07-15 | ||
| US72462105P | 2005-10-07 | 2005-10-07 | |
| US60/724,621 | 2005-10-07 | ||
| PCT/DK2005/000721 WO2006050734A2 (en) | 2004-11-09 | 2005-11-09 | Potent lna oligonucleotides for the inhibition of hif-1a expression |
Publications (2)
| Publication Number | Publication Date |
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| CA2587173A1 CA2587173A1 (en) | 2006-05-18 |
| CA2587173C true CA2587173C (en) | 2016-09-06 |
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| Application Number | Title | Priority Date | Filing Date |
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| CA2587173A Expired - Fee Related CA2587173C (en) | 2004-11-09 | 2005-11-09 | Potent lna oligonucleotides for the inhibition of hif-1a expression |
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| Country | Link |
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| US (3) | US7589190B2 (OSRAM) |
| EP (1) | EP1833840B9 (OSRAM) |
| JP (3) | JP4825807B2 (OSRAM) |
| KR (1) | KR101176245B1 (OSRAM) |
| AT (1) | ATE476441T1 (OSRAM) |
| AU (1) | AU2005304112B2 (OSRAM) |
| BR (1) | BRPI0515726A8 (OSRAM) |
| CA (1) | CA2587173C (OSRAM) |
| DE (1) | DE602005022768D1 (OSRAM) |
| DK (1) | DK1833840T3 (OSRAM) |
| EA (1) | EA014097B1 (OSRAM) |
| IL (1) | IL183054A0 (OSRAM) |
| MX (1) | MX2007005558A (OSRAM) |
| NO (1) | NO341878B1 (OSRAM) |
| NZ (1) | NZ555644A (OSRAM) |
| WO (1) | WO2006050734A2 (OSRAM) |
Families Citing this family (74)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CA2506576C (en) | 2002-11-18 | 2018-03-06 | Santaris Pharma A/S | Antisense gapmer oligonucleotides |
| US7144999B2 (en) * | 2002-11-23 | 2006-12-05 | Isis Pharmaceuticals, Inc. | Modulation of hypoxia-inducible factor 1 alpha expression |
| EP1606406B2 (en) | 2003-03-21 | 2013-11-27 | Santaris Pharma A/S | SHORT INTERFERING RNA (siRNA) ANALOGUES |
| DK1713912T3 (da) * | 2004-01-30 | 2013-12-16 | Santaris Pharma As | Modificerede Korte Interfererende RNA (Modificerede siRNA) |
| US9447138B2 (en) | 2004-11-09 | 2016-09-20 | Roche Innovation Center Copenhagen A/S | Potent LNA oligonucleotides for the inhibition of HIF-1a expression |
| NZ555644A (en) * | 2004-11-09 | 2009-04-30 | Santaris Pharma As | Potent LNA oligonucleotides for the inhibition of HIF-1A expression |
| EP1976567B1 (en) | 2005-12-28 | 2020-05-13 | The Scripps Research Institute | Natural antisense and non-coding rna transcripts as drug targets |
| CA2638837A1 (en) * | 2006-01-27 | 2007-08-02 | Santaris Pharma A/S | Lna modified phosphorothiolated oligonucleotides |
| DK2002004T3 (en) * | 2006-03-23 | 2015-11-30 | Roche Innovation Ct Copenhagen As | LITTLE INTERNAL SEGMENTED INTERFERENCE RNA |
| EP2505646A1 (en) | 2006-05-05 | 2012-10-03 | Isis Pharmaceuticals, Inc. | Compounds and methods for modulating expression of CRP |
| AU2007296055A1 (en) * | 2006-09-15 | 2008-03-20 | Enzon Pharmaceuticals, Inc. | Polymeric conjugates containing positively-charged moieties |
| DK2149605T3 (da) | 2007-03-22 | 2013-09-30 | Santaris Pharma As | Korte RNA antagonist forbindelser til modulering af det ønskede mRNA |
| EP2149605B1 (en) | 2007-03-22 | 2013-07-03 | Santaris Pharma A/S | Short RNA antagonist compounds for the modulation of target mRNA |
| EP2186528B1 (en) | 2007-08-06 | 2014-03-19 | Senju Pharmaceutical Co., Ltd. | Pharmaceutical containing hif-1 alpha and hif-2 alpha expression inhibitor |
| DK2195428T3 (en) | 2007-09-19 | 2014-03-03 | Applied Biosystems Llc | SIRNA SEQUENCE-INDEPENDENT MODIFICATION FORMS TO REDUCE TARGET-FAILING PHENOTYPIC EFFECTS OF RNAI, AND STABILIZED FORMS THEREOF |
| JP2010539961A (ja) * | 2007-10-04 | 2010-12-24 | サンタリス ファーマ アー／エス | ＨＩＦ１αの調節のための短いＲＮＡアンタゴニスト化合物 |
| EP2352830B1 (en) | 2008-10-03 | 2019-01-16 | CuRNA, Inc. | Treatment of apolipoprotein-a1 related diseases by inhibition of natural antisense transcript to apolipoprotein-a1 |
| KR20110091796A (ko) | 2008-12-04 | 2011-08-12 | 오피케이오 큐알엔에이, 엘엘씨 | 종양 억제 유전자에 대한 천연 안티센스 전사체의 억제에 의해 종양 억제 유전자 관련된 질환의 치료 |
| CN102341498B (zh) | 2008-12-04 | 2017-12-19 | 库尔纳公司 | 通过抑制血管内皮生长因子(vegf)的天然反义转录子治疗vegf相关的疾病 |
| WO2010065792A2 (en) | 2008-12-04 | 2010-06-10 | Curna, Inc. | Treatment of erythropoietin (epo) related diseases by inhibition of natural antisense transcript to epo |
| EP2396038B1 (en) | 2009-02-12 | 2015-10-21 | CuRNA, Inc. | Treatment of brain derived neurotrophic factor (bdnf) related diseases by inhibition of natural antisense transcript to bdnf |
| CN102482677B (zh) | 2009-03-16 | 2017-10-17 | 库尔纳公司 | 通过抑制nrf2的天然反义转录物治疗核因子(红细胞衍生2)‑样2(nrf2)相关疾病 |
| EP2408920B1 (en) | 2009-03-17 | 2017-03-08 | CuRNA, Inc. | Treatment of delta-like 1 homolog (dlk1) related diseases by inhibition of natural antisense transcript to dlk1 |
| CA2761152A1 (en) | 2009-05-06 | 2010-11-11 | Opko Curna, Llc | Treatment of lipid transport and metabolism gene related diseases by inhibition of natural antisense transcript to a lipid transport and metabolism gene |
| US20120046236A1 (en) | 2009-05-06 | 2012-02-23 | Opko Curna Llc | Treatment of tristetraproline (ttp) related diseases by inhibition of natural antisense transcript to ttp |
| KR101742334B1 (ko) | 2009-05-08 | 2017-06-01 | 큐알엔에이, 인크. | Ｄｍｄ 패밀리에 대한 천연 안티센스 전사체의 억제에 의한 디스트로핀 패밀리 관련된 질환의 치료 |
| CA2762369C (en) | 2009-05-18 | 2021-12-28 | Joseph Collard | Treatment of reprogramming factor related diseases by inhibition of natural antisense transcript to a reprogramming factor |
| KR101703695B1 (ko) | 2009-05-22 | 2017-02-08 | 큐알엔에이, 인크. | 전사 인자 ｅ3(ｔｆｅ3)에 대한 천연 안티센스 전사체의 억제에 의해 ｔｆｅ3 및 인슐린 수용체 기질 2(ｉｒｓ2)의 치료 |
| WO2010138806A2 (en) | 2009-05-28 | 2010-12-02 | Curna, Inc. | Treatment of antiviral gene related diseases by inhibition of natural antisense transcript to an antiviral gene |
| EP2443237B1 (en) | 2009-06-16 | 2017-02-22 | CuRNA, Inc. | Treatment of collagen gene related diseases by inhibition of natural antisense transcript to a collagen gene |
| KR101702689B1 (ko) | 2009-06-16 | 2017-02-06 | 큐알엔에이, 인크. | Ｐｏｎ1에 대한 천연 안티센스 전사체의 억제에 의한 파라옥소나제 1(ｐｏｎ1) 관련된 질환의 치료 |
| CA2765889A1 (en) | 2009-06-24 | 2010-12-29 | Opko Curna, Llc | Treatment of tumor necrosis factor receptor 2 (tnfr2) related diseases by inhibition of natural antisense transcript to tnfr2 |
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| JP4825807B2 (ja) | 2011-11-30 |
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| EA014097B1 (ru) | 2010-08-30 |
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| IL183054A0 (en) | 2007-09-20 |
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| EP1833840B1 (en) | 2010-08-04 |
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| CA2587173A1 (en) | 2006-05-18 |
| US7589190B2 (en) | 2009-09-15 |
| AU2005304112B2 (en) | 2009-06-04 |
| NO20072933L (no) | 2007-06-08 |
| AU2005304112A1 (en) | 2006-05-18 |
| DE602005022768D1 (de) | 2010-09-16 |
| JP2011229540A (ja) | 2011-11-17 |
| US20060252721A1 (en) | 2006-11-09 |
| KR101176245B1 (ko) | 2012-08-22 |
| JP2014098027A (ja) | 2014-05-29 |
| US20090286859A1 (en) | 2009-11-19 |
| EP1833840B9 (en) | 2010-11-10 |
| EP1833840A2 (en) | 2007-09-19 |
| ATE476441T1 (de) | 2010-08-15 |
| BRPI0515726A8 (pt) | 2017-09-12 |
| NO341878B1 (no) | 2018-02-12 |
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