EA200701033A1 - Эффективные олигонуклеотиды lna для ингибирования экспрессии hif-1a - Google Patents

Эффективные олигонуклеотиды lna для ингибирования экспрессии hif-1a

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Publication number
EA200701033A1
EA200701033A1 EA200701033A EA200701033A EA200701033A1 EA 200701033 A1 EA200701033 A1 EA 200701033A1 EA 200701033 A EA200701033 A EA 200701033A EA 200701033 A EA200701033 A EA 200701033A EA 200701033 A1 EA200701033 A1 EA 200701033A1
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EA
Eurasian Patent Office
Prior art keywords
lna
deoxynucleotide
designates
lna nucleotide
hif
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EA200701033A
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English (en)
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EA014097B1 (ru
Inventor
Франк Винтер Расмуссен
Майкен Вестергор
Хенрик Фрюденлунд Хансен
Шарлот Альбэк Тру
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Сантарис Фарма А/С
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Application filed by Сантарис Фарма А/С filed Critical Сантарис Фарма А/С
Publication of EA200701033A1 publication Critical patent/EA200701033A1/ru
Publication of EA014097B1 publication Critical patent/EA014097B1/ru

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Abstract

Настоящее изобретение относится к олигонуклеотиду LNA, состоящему из последовательности, выбранной из группы, состоящей из 5'-()GGcaagcatccTG()-3' и 5'-()TTactgccttcTT()-3' , где заглавными буквами обозначен аналог нуклеотида бета-D-окси-LNA, строчными буквами обозначен 2-дезоксинуклеотид, подчеркиванием обозначен либо аналог нуклеотида бета-D-окси-LNA, либо 2-дезоксинуклеотид, подстрочным индексом «s» обозначена фосфоротиоатная связь между соседними нуклеотидами/аналогами нуклеотида LNA и подстрочным индексом «х» обозначена либо фосфоротиоатная связь, либо фосфодиэфирная связь между соседними нуклеотидами/аналогами нуклеотида LNA и где последовательность при желании увеличена посредством добавления до пяти 2-дезоксинуклеотидных единиц. Олигонуклеотиды LNA применимы для модулирования экспрессии индуцируемого гипоксией фактора-1a (HIF-1a), например, при лечении онкологических заболеваний, ингибировании ангиогенеза, индукции апоптоза, предотвращения клеточной пролиферации или лечении ангиогенного заболевания, например диабетической ретинопатии, дегенерации желтого пятна (ARMD), псориаза, ревматоидного артрита и других воспалительных заболеваний.
EA200701033A 2004-11-09 2005-11-09 ОЛИГОНУКЛЕОТИДЫ ЗАМКНУТОЙ НУКЛЕИНОВОЙ КИСЛОТЫ (LNA) ДЛЯ МОДУЛИРОВАНИЯ ЭКСПРЕССИИ HIF-1a И ИХ ПРИМЕНЕНИЕ EA014097B1 (ru)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US62656304P 2004-11-09 2004-11-09
US64718605P 2005-01-25 2005-01-25
US69972105P 2005-07-15 2005-07-15
US72462105P 2005-10-07 2005-10-07
PCT/DK2005/000721 WO2006050734A2 (en) 2004-11-09 2005-11-09 Potent lna oligonucleotides for the inhibition of hif-1a expression

Publications (2)

Publication Number Publication Date
EA200701033A1 true EA200701033A1 (ru) 2007-12-28
EA014097B1 EA014097B1 (ru) 2010-08-30

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EA200701033A EA014097B1 (ru) 2004-11-09 2005-11-09 ОЛИГОНУКЛЕОТИДЫ ЗАМКНУТОЙ НУКЛЕИНОВОЙ КИСЛОТЫ (LNA) ДЛЯ МОДУЛИРОВАНИЯ ЭКСПРЕССИИ HIF-1a И ИХ ПРИМЕНЕНИЕ

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US (3) US7589190B2 (ru)
EP (1) EP1833840B9 (ru)
JP (3) JP4825807B2 (ru)
KR (1) KR101176245B1 (ru)
AT (1) ATE476441T1 (ru)
AU (1) AU2005304112B2 (ru)
BR (1) BRPI0515726A8 (ru)
CA (1) CA2587173C (ru)
DE (1) DE602005022768D1 (ru)
DK (1) DK1833840T3 (ru)
EA (1) EA014097B1 (ru)
IL (1) IL183054A0 (ru)
MX (1) MX2007005558A (ru)
NO (1) NO341878B1 (ru)
NZ (1) NZ555644A (ru)
WO (1) WO2006050734A2 (ru)

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