EA004180B1 - Гетероарильные производные аминогуанидинов и алкоксигуанидинов (варианты), способ их получения и их применение в качестве ингибиторов протеаз - Google Patents
Гетероарильные производные аминогуанидинов и алкоксигуанидинов (варианты), способ их получения и их применение в качестве ингибиторов протеаз Download PDFInfo
- Publication number
- EA004180B1 EA004180B1 EA200000578A EA200000578A EA004180B1 EA 004180 B1 EA004180 B1 EA 004180B1 EA 200000578 A EA200000578 A EA 200000578A EA 200000578 A EA200000578 A EA 200000578A EA 004180 B1 EA004180 B1 EA 004180B1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- methyl
- amino
- aminocarbonylmethyl
- pyridinone
- guanidinooxyethyl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/74—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/75—Amino or imino radicals, acylated by carboxylic or carbonic acids, or by sulfur or nitrogen analogues thereof, e.g. carbamates
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06139—Dipeptides with the first amino acid being heterocyclic
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US6647597P | 1997-11-26 | 1997-11-26 | |
US6732497P | 1997-12-05 | 1997-12-05 | |
US7910798P | 1998-03-23 | 1998-03-23 | |
PCT/US1998/025185 WO1999026926A1 (en) | 1997-11-26 | 1998-11-25 | Heteroaryl aminoguanidines and alkoxyguanidines and their use as protease inhibitors |
Publications (2)
Publication Number | Publication Date |
---|---|
EA200000578A1 EA200000578A1 (ru) | 2001-02-26 |
EA004180B1 true EA004180B1 (ru) | 2004-02-26 |
Family
ID=27370979
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EA200000578A EA004180B1 (ru) | 1997-11-26 | 1998-11-25 | Гетероарильные производные аминогуанидинов и алкоксигуанидинов (варианты), способ их получения и их применение в качестве ингибиторов протеаз |
Country Status (14)
Families Citing this family (64)
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JP2001524467A (ja) * | 1997-11-26 | 2001-12-04 | 3−ディメンショナル ファーマシューティカルズ, インコーポレイテッド | ヘテロアリールアミノグアニジンおよびアルコキシグアニジンおよびプロテアーゼインヒビターとしてのこれらの使用 |
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KR20010113970A (ko) * | 1999-05-19 | 2001-12-28 | 추후보정 | 응고 캐스케이드의 선택적 억제에 유용한 치환 폴리시클릭아릴 및 헤테로아릴 피리돈 |
US6867217B1 (en) | 1999-05-19 | 2005-03-15 | Pharmacia Corporation | Substituted polycyclic aryl and heteroaryl pyridones useful for selective inhibition of the coagulation cascade |
US6458952B1 (en) * | 1999-05-19 | 2002-10-01 | Pharmacia Corporation | Substituted polycyclic aryl and heteroaryl uracils useful for selective inhibition of the coagulation cascade |
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US6716838B1 (en) | 1999-05-19 | 2004-04-06 | Pharmacia Corporation | Substituted polycyclic aryl and heteroaryl uracils as anticoagulative agents |
US6750342B1 (en) | 1999-05-19 | 2004-06-15 | Pharmacia Corporation | Substituted polycyclic aryl and heteroaryl pyrimidinones useful for selective inhibition of the coagulation cascade |
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US6908919B2 (en) * | 1999-05-19 | 2005-06-21 | Pharmacia Corporation | Substituted polycyclic aryl and heteroaryl pyrazinones useful for selective inhibition of the coagulation cascade |
US7015230B1 (en) | 1999-05-19 | 2006-03-21 | Pharmacia Corporation | Substituted polycyclic aryl and heteroaryl uracils useful for selective inhibition of the coagulation cascade |
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1998
- 1998-11-25 JP JP2000522084A patent/JP2001524467A/ja active Pending
- 1998-11-25 ES ES98962838T patent/ES2274587T3/es not_active Expired - Lifetime
- 1998-11-25 EP EP98962838A patent/EP1036063B1/en not_active Expired - Lifetime
- 1998-11-25 AU AU17991/99A patent/AU751412B2/en not_active Ceased
- 1998-11-25 AT AT98962838T patent/ATE344246T1/de not_active IP Right Cessation
- 1998-11-25 TW TW087119488A patent/TWI222441B/zh not_active IP Right Cessation
- 1998-11-25 DE DE69836346T patent/DE69836346T2/de not_active Expired - Fee Related
- 1998-11-25 CA CA002311969A patent/CA2311969A1/en not_active Abandoned
- 1998-11-25 BR BR9815325-0A patent/BR9815325A/pt not_active Application Discontinuation
- 1998-11-25 US US09/199,167 patent/US6037356A/en not_active Expired - Lifetime
- 1998-11-25 PL PL98340560A patent/PL340560A1/xx not_active Application Discontinuation
- 1998-11-25 WO PCT/US1998/025185 patent/WO1999026926A1/en active IP Right Grant
- 1998-11-25 EA EA200000578A patent/EA004180B1/ru not_active IP Right Cessation
- 1998-11-26 AR ARP980106006A patent/AR016702A1/es unknown
-
2000
- 2000-01-14 US US09/482,540 patent/US6245763B1/en not_active Expired - Lifetime
-
2001
- 2001-04-06 US US09/827,292 patent/US6350764B2/en not_active Expired - Lifetime
- 2001-12-12 US US10/012,445 patent/US6472399B2/en not_active Expired - Lifetime
-
2002
- 2002-09-12 US US10/241,513 patent/US6566379B1/en not_active Expired - Lifetime
-
2003
- 2003-03-27 US US10/400,073 patent/US6706021B2/en not_active Expired - Lifetime
- 2003-11-17 US US10/714,988 patent/US7029654B2/en not_active Expired - Lifetime
-
2005
- 2005-10-19 US US11/254,086 patent/US7402586B2/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
WO1999026926A1 (en) | 1999-06-03 |
DE69836346T2 (de) | 2007-05-24 |
US20040106633A1 (en) | 2004-06-03 |
US7029654B2 (en) | 2006-04-18 |
AU751412B2 (en) | 2002-08-15 |
EP1036063A1 (en) | 2000-09-20 |
US6706021B2 (en) | 2004-03-16 |
US20030087921A1 (en) | 2003-05-08 |
US6245763B1 (en) | 2001-06-12 |
ES2274587T3 (es) | 2007-05-16 |
BR9815325A (pt) | 2001-12-26 |
DE69836346D1 (de) | 2006-12-14 |
CA2311969A1 (en) | 1999-06-03 |
TWI222441B (en) | 2004-10-21 |
US7402586B2 (en) | 2008-07-22 |
PL340560A1 (en) | 2001-02-12 |
US6472399B2 (en) | 2002-10-29 |
ATE344246T1 (de) | 2006-11-15 |
JP2001524467A (ja) | 2001-12-04 |
US20030225115A1 (en) | 2003-12-04 |
US20020007070A1 (en) | 2002-01-17 |
US6037356A (en) | 2000-03-14 |
US20060211719A1 (en) | 2006-09-21 |
US20020086872A1 (en) | 2002-07-04 |
EA200000578A1 (ru) | 2001-02-26 |
AU1799199A (en) | 1999-06-15 |
EP1036063B1 (en) | 2006-11-02 |
US6350764B2 (en) | 2002-02-26 |
AR016702A1 (es) | 2001-07-25 |
US6566379B1 (en) | 2003-05-20 |
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