EA002819B1 - Циклическое пептидное соединение и его применение, бициклопептидное соединение, пептидное соединение и его применение, фармацевтическая композиция - Google Patents
Циклическое пептидное соединение и его применение, бициклопептидное соединение, пептидное соединение и его применение, фармацевтическая композиция Download PDFInfo
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- EA002819B1 EA002819B1 EA199901025A EA199901025A EA002819B1 EA 002819 B1 EA002819 B1 EA 002819B1 EA 199901025 A EA199901025 A EA 199901025A EA 199901025 A EA199901025 A EA 199901025A EA 002819 B1 EA002819 B1 EA 002819B1
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- Eurasian Patent Office
- Prior art keywords
- amino acid
- cyclo
- acre
- peptide
- equivalent amino
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D211/34—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
- A61P3/14—Drugs for disorders of the metabolism for electrolyte homeostasis for calcium homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/18—Drugs for disorders of the endocrine system of the parathyroid hormones
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/635—Parathyroid hormone, i.e. parathormone; Parathyroid hormone-related peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Endocrinology (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Physical Education & Sports Medicine (AREA)
- Rheumatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Diabetes (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Toxicology (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Biochemistry (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Genetics & Genomics (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Immunology (AREA)
- Epidemiology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US4647297P | 1997-05-14 | 1997-05-14 | |
| PCT/US1998/009843 WO1998051324A1 (en) | 1997-05-14 | 1998-05-13 | Peptide parathyroid hormone analogs |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| EA199901025A1 EA199901025A1 (ru) | 2000-06-26 |
| EA002819B1 true EA002819B1 (ru) | 2002-10-31 |
Family
ID=21943653
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EA199901025A EA002819B1 (ru) | 1997-05-14 | 1998-05-13 | Циклическое пептидное соединение и его применение, бициклопептидное соединение, пептидное соединение и его применение, фармацевтическая композиция |
Country Status (20)
| Country | Link |
|---|---|
| US (2) | US6472505B1 (enExample) |
| EP (1) | EP0986395A4 (enExample) |
| JP (1) | JP2001517957A (enExample) |
| KR (1) | KR100351213B1 (enExample) |
| CN (1) | CN1261281A (enExample) |
| AP (1) | AP9901686A0 (enExample) |
| AU (1) | AU746461B2 (enExample) |
| BG (1) | BG103957A (enExample) |
| BR (1) | BR9808786A (enExample) |
| CA (1) | CA2290443A1 (enExample) |
| EA (1) | EA002819B1 (enExample) |
| HU (1) | HUP0003349A3 (enExample) |
| IL (1) | IL132901A0 (enExample) |
| NO (1) | NO995568L (enExample) |
| OA (1) | OA11216A (enExample) |
| PL (1) | PL336803A1 (enExample) |
| SK (1) | SK151599A3 (enExample) |
| UA (1) | UA62967C2 (enExample) |
| WO (1) | WO1998051324A1 (enExample) |
| ZA (1) | ZA984077B (enExample) |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1163504C (zh) * | 1998-04-15 | 2004-08-25 | 阿温蒂斯药物公司 | 制备与树脂结合的环状肽的方法 |
| US6316410B1 (en) * | 1999-09-22 | 2001-11-13 | National Research Council Of Canada | Parathyroid hormone analogues for the treatment of osteoporosis |
| AU2003233286A1 (en) * | 2002-05-16 | 2003-12-02 | Theratechnologies Inc. | Pth derivatives resistant to skin proteases |
| WO2004073587A2 (en) * | 2003-02-19 | 2004-09-02 | Bayer Healthcare Ag | Diagnostics and therapeutics for diseases associated with parathyroid hormone receptor 1 (pthr1) |
| EP1644017A2 (en) * | 2003-07-15 | 2006-04-12 | National Research Council Of Canada | Cyclic analogs of human parathyroid hormone for the treatment of conditions characterized by hyperproliferative skin cells |
| US7439226B2 (en) * | 2003-09-30 | 2008-10-21 | The United States Of America As Represented By The Department Of Health And Human Services | Serine protease inhibitors |
| US20060052306A1 (en) * | 2004-05-10 | 2006-03-09 | Nastech Pharmaceutical Company Inc. | GRAS composition for enhanced mucosal delivery of parathyroid hormone |
| CN101151048A (zh) * | 2004-05-10 | 2008-03-26 | 纳斯泰克制药公司 | 增强甲状旁腺激素粘膜递送的组合物和方法 |
| US20060127320A1 (en) * | 2004-05-10 | 2006-06-15 | Nastech Pharmaceutical Company Inc. | Method of delivering parathyroid hormone to a human |
| US20060052305A1 (en) * | 2004-05-10 | 2006-03-09 | Nastech Pharmaceutical Company Inc. | Method of treating osteoporosis using intranasal parathyroid hormone |
| US9051379B2 (en) | 2005-07-07 | 2015-06-09 | Fulcrum Sp Ltd. | Sp1 polypeptides, modified Sp1 polypeptides and uses thereof |
| US20070173447A1 (en) * | 2005-10-25 | 2007-07-26 | Nastech Pharmaceutical Company Inc. | Method for treating osteoporosis by intranasal delivery of teriparatide with an anti-resorptive agent |
| CN101355959B (zh) * | 2005-11-10 | 2013-02-27 | 密歇根理工大学管理委员会 | 黑熊甲状旁腺素和使用黑熊甲状旁腺素的方法 |
| US20080051332A1 (en) * | 2005-11-18 | 2008-02-28 | Nastech Pharmaceutical Company Inc. | Method of modulating hematopoietic stem cells and treating hematologic diseases using intranasal parathyroid hormone |
| CN101522709B (zh) * | 2006-10-13 | 2013-03-20 | 伊莱利利公司 | 作为pth受体调节剂的聚乙二醇化的pth及其用途 |
| US8691760B2 (en) | 2009-02-02 | 2014-04-08 | Ramot At Tel-Aviv University | Peptides, pharmaceutical compositions comprising same and uses thereof |
| CA2759201A1 (en) | 2009-04-01 | 2010-10-07 | The Medical Research, Infrastructure, And Health Services Fund Of The Te L Aviv Medical Center | A method of regulating proliferation and differentiation of keratinocyes |
| WO2010116375A1 (en) | 2009-04-08 | 2010-10-14 | Yeda Research And Development Co. Ltd. | Isolated peptides for regulating apoptosis |
| EP2435078A1 (en) | 2009-05-28 | 2012-04-04 | Yeda Research and Development Co. Ltd. | Methods of treating inflammation |
| PT2459208T (pt) | 2009-07-29 | 2017-01-03 | Kai Pharmaceuticals Inc | Agentes terapêuticos para redução dos niveis de hormona paratiroideia |
| WO2011071480A1 (en) | 2009-12-07 | 2011-06-16 | Michigan Technological University | Black bear parathyroid hormone and methods of using black bear parathyroid hormone |
| EP2566500B1 (en) | 2010-05-05 | 2017-04-12 | Rappaport Family Institute for Research in the Medical Sciences | Ccl1 for use in therapy |
| MX358161B (es) * | 2010-05-13 | 2018-08-06 | The General Hospital Corp Star | Analogos de hormona paratiroidea y usos para los mismos. |
| EP2600885A2 (en) | 2010-08-04 | 2013-06-12 | Ramot at Tel Aviv University, Ltd. | Methods of treating autoimmune diseases of the central nervous system (cns) and neurodegenerative diseases |
| WO2012131680A2 (en) | 2011-03-28 | 2012-10-04 | Yeda Research And Development Co. Ltd. | Compositions and methods for treating inflammation |
| US8741491B2 (en) * | 2011-06-17 | 2014-06-03 | Fluidic, Inc. | Ionic liquid containing sulfonate ions |
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| WO2017212476A1 (en) | 2016-06-05 | 2017-12-14 | Tel Hashomer Medical Research Infrastructure And Services Ltd. | Novel molecules for the treatment of inflammation |
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| MX2018016003A (es) | 2016-12-01 | 2019-05-16 | Univ Ramot | Tratamiento combinado para lesiones neurológicas. |
| CA3059022A1 (en) | 2017-04-07 | 2018-10-11 | Yissum Research Development Company Of The Hebrew University Of Jerusam Ltd. | Hair care compositions |
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| EP3655009B1 (en) | 2017-07-20 | 2023-10-11 | Yissum Research Development Company of the Hebrew University of Jerusalem Ltd. | Nanoparticle compositions |
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| KR20230104160A (ko) | 2020-10-07 | 2023-07-07 | 프로탈릭스 리미티드 | 장기-작용성 데옥시리보뉴클레아제(dnase) |
| JP2023548496A (ja) | 2020-11-03 | 2023-11-17 | プロタリクス リミテッド | 修飾ウリカーゼ及びその使用 |
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| IL283563A (en) | 2021-05-30 | 2022-12-01 | Yeda Res & Dev | Profiling of amps for the diagnosis, monitoring and treatment of microbiome-related diseases |
| WO2023031934A1 (en) | 2021-09-02 | 2023-03-09 | Yeda Research And Development Co. Ltd. | Agents that target the glycine arginine-rich domain of nucleolin and uses thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4086196A (en) * | 1975-03-28 | 1978-04-25 | Armour Pharmaceutical Company | Parathyroid hormone |
| US4423037A (en) | 1982-05-13 | 1983-12-27 | The General Hospital Corporation | Inhibitors of peptide hormone action |
| US4427827A (en) | 1982-10-20 | 1984-01-24 | Usv Pharmaceutical Corporation | Synthesis of hormone fragments |
| FR2550204B1 (fr) * | 1983-08-05 | 1987-11-13 | Toyo Jozo Kk | Derives peptidiques de (nle8,nle1b, tyr34)-h-pth |
| US4771124A (en) | 1987-05-26 | 1988-09-13 | Merck & Co., Inc. | Parathyroid hormone antagonists with simplified synthetic methodology |
| CA2040264A1 (en) | 1990-04-12 | 1991-10-13 | Tatsuhiko Kanmera | Parathyroid hormone antagonists |
| CA2087087C (en) | 1992-01-22 | 2000-07-18 | Burton H. Sage, Jr. | Molecules for iontophoretic delivery |
| US5434246A (en) | 1992-03-19 | 1995-07-18 | Takeda Chemical Industries, Ltd. | Parathyroid hormone derivatives |
| US5814603A (en) | 1992-06-12 | 1998-09-29 | Affymax Technologies N.V. | Compounds with PTH activity |
| CA2098639A1 (en) | 1992-06-19 | 1993-12-20 | K. Anne Kronis | Bone stimulating, non-vasoactive parathyroid hormone variants |
| US5589452A (en) * | 1992-07-14 | 1996-12-31 | Syntex (U.S.A.) Inc. | Analogs of parathyroid hormone and parathyroid hormone related peptide: synthesis and use for the treatment of osteoporosis |
| AU672790B2 (en) | 1992-07-15 | 1996-10-17 | Novartis Ag | Variants of parathyroid hormone and its fragments |
| ES2179831T3 (es) | 1992-09-29 | 2003-02-01 | Inhale Therapeutic Syst | Liberacion en los pulmones de fragmentos activos de hormona paratiroidiana. |
| CA2126299C (en) | 1994-06-20 | 2000-12-12 | Gordon E. Willick | Parathyroid hormone analogues for the treatment of osteoporosis |
| CO4410206A1 (es) | 1994-07-28 | 1997-01-09 | Sandoz Ag | DERIVADOS DE PTH o PTHrP, SU PREPARACION Y COMPOSICIONES FARMACEUTICAS QUE LAS COMPRENDEN |
| DE19508672A1 (de) * | 1995-03-10 | 1996-09-12 | Boehringer Mannheim Gmbh | Neue cyclische Parathormonfragmente, Verfahren zu deren Herstellung und diese enthaltende Arzneimittel |
| US5717062A (en) * | 1995-06-07 | 1998-02-10 | Beth Israel Hospital Association | Cyclic analogs of PTH and PTHrP |
| DE69629758T2 (de) | 1995-06-07 | 2004-06-03 | Compaq Computer Corp., Houston | Verfahren und Vorrichtung für die Überwachung des Datenflusses in einem fehlertoleranten Multiprozessorsystem |
| US5723577A (en) | 1995-07-13 | 1998-03-03 | Biomeasure Inc. | Analogs of parathyroid hormone |
| GEP20033095B (en) * | 1996-08-02 | 2003-10-27 | Nat Res Council Canada | Parathyroid Hormone Analogues for the Treatment of Osteoporosis |
-
1998
- 1998-05-13 CA CA002290443A patent/CA2290443A1/en not_active Abandoned
- 1998-05-13 PL PL98336803A patent/PL336803A1/xx unknown
- 1998-05-13 KR KR1019997010523A patent/KR100351213B1/ko not_active Expired - Fee Related
- 1998-05-13 AU AU73867/98A patent/AU746461B2/en not_active Ceased
- 1998-05-13 WO PCT/US1998/009843 patent/WO1998051324A1/en not_active Ceased
- 1998-05-13 CN CN98806651A patent/CN1261281A/zh active Pending
- 1998-05-13 JP JP54953698A patent/JP2001517957A/ja not_active Ceased
- 1998-05-13 BR BR9808786-0A patent/BR9808786A/pt not_active Application Discontinuation
- 1998-05-13 AP APAP/P/1999/001686A patent/AP9901686A0/en unknown
- 1998-05-13 SK SK1515-99A patent/SK151599A3/sk unknown
- 1998-05-13 UA UA99126574A patent/UA62967C2/uk unknown
- 1998-05-13 IL IL13290198A patent/IL132901A0/xx unknown
- 1998-05-13 HU HU0003349A patent/HUP0003349A3/hu unknown
- 1998-05-13 EA EA199901025A patent/EA002819B1/ru not_active IP Right Cessation
- 1998-05-13 EP EP98921200A patent/EP0986395A4/en not_active Withdrawn
- 1998-05-14 ZA ZA984077A patent/ZA984077B/xx unknown
-
1999
- 1999-01-12 US US09/228,990 patent/US6472505B1/en not_active Expired - Fee Related
- 1999-11-12 OA OA9900247A patent/OA11216A/en unknown
- 1999-11-12 NO NO995568A patent/NO995568L/no not_active Application Discontinuation
- 1999-12-06 BG BG103957A patent/BG103957A/bg unknown
-
2002
- 2002-03-13 US US10/097,079 patent/US20020132973A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| PL336803A1 (en) | 2000-07-17 |
| EP0986395A1 (en) | 2000-03-22 |
| SK151599A3 (en) | 2000-09-12 |
| AU746461B2 (en) | 2002-05-02 |
| OA11216A (en) | 2003-07-10 |
| AP9901686A0 (en) | 1999-12-31 |
| EP0986395A4 (en) | 2004-12-01 |
| JP2001517957A (ja) | 2001-10-09 |
| UA62967C2 (en) | 2004-01-15 |
| IL132901A0 (en) | 2001-03-19 |
| AU7386798A (en) | 1998-12-08 |
| HUP0003349A2 (hu) | 2001-01-29 |
| NO995568L (no) | 1999-12-29 |
| US20020132973A1 (en) | 2002-09-19 |
| WO1998051324A1 (en) | 1998-11-19 |
| HUP0003349A3 (en) | 2001-12-28 |
| NO995568D0 (no) | 1999-11-12 |
| CA2290443A1 (en) | 1998-11-19 |
| US6472505B1 (en) | 2002-10-29 |
| EA199901025A1 (ru) | 2000-06-26 |
| ZA984077B (en) | 1998-11-24 |
| KR20010012568A (ko) | 2001-02-15 |
| CN1261281A (zh) | 2000-07-26 |
| BG103957A (bg) | 2000-04-28 |
| BR9808786A (pt) | 2000-07-11 |
| KR100351213B1 (ko) | 2002-09-05 |
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| TC4A | Change in name of a patent proprietor in a eurasian patent |
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| MM4A | Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s) |
Designated state(s): RU |