DZ3368A1 - Derives 3-azabicyclo[3.1.0] hexane ayant une affinite pour le recepteur opioide - Google Patents

Derives 3-azabicyclo[3.1.0] hexane ayant une affinite pour le recepteur opioide

Info

Publication number
DZ3368A1
DZ3368A1 DZ013368A DZ013368A DZ3368A1 DZ 3368 A1 DZ3368 A1 DZ 3368A1 DZ 013368 A DZ013368 A DZ 013368A DZ 013368 A DZ013368 A DZ 013368A DZ 3368 A1 DZ3368 A1 DZ 3368A1
Authority
DZ
Algeria
Prior art keywords
hexane
affinity
opioid receptor
azabicyclo derivatives
azabicyclo
Prior art date
Application number
DZ013368A
Other languages
English (en)
French (fr)
Inventor
Bernard Joseph Banks
Douglas James Critcher
Ashley Edward Fenwick
David Morris Gethin
Stephen Paul Gibson
Graham Lunn
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Application granted granted Critical
Publication of DZ3368A1 publication Critical patent/DZ3368A1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/04—Antipruritics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/32—Alcohol-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/34—Tobacco-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/36—Opioid-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/52—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring condensed with a ring other than six-membered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Neurosurgery (AREA)
  • Addiction (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Dermatology (AREA)
  • Hospice & Palliative Care (AREA)
  • Otolaryngology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Nutrition Science (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Indole Compounds (AREA)
DZ013368A 2000-06-23 2001-06-07 Derives 3-azabicyclo[3.1.0] hexane ayant une affinite pour le recepteur opioide DZ3368A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB0015562.2A GB0015562D0 (en) 2000-06-23 2000-06-23 Heterocycles
PCT/IB2001/001035 WO2001098267A1 (en) 2000-06-23 2001-06-07 3-azabicyclo (3.1.0) hexane derivatives having opioid receptor affinity

Publications (1)

Publication Number Publication Date
DZ3368A1 true DZ3368A1 (fr) 2001-12-27

Family

ID=9894368

Family Applications (1)

Application Number Title Priority Date Filing Date
DZ013368A DZ3368A1 (fr) 2000-06-23 2001-06-07 Derives 3-azabicyclo[3.1.0] hexane ayant une affinite pour le recepteur opioide

Country Status (34)

Country Link
EP (1) EP1292574A1 (hr)
JP (1) JP2004512263A (hr)
KR (1) KR20040002386A (hr)
CN (1) CN1639121A (hr)
AP (1) AP2002002698A0 (hr)
AR (1) AR028969A1 (hr)
AU (1) AU781837B2 (hr)
BG (1) BG107329A (hr)
BR (1) BR0111867A (hr)
CA (1) CA2412188A1 (hr)
CZ (1) CZ20023967A3 (hr)
DO (1) DOP2001000187A (hr)
DZ (1) DZ3368A1 (hr)
EA (1) EA005117B1 (hr)
GB (1) GB0015562D0 (hr)
HR (1) HRP20020998A2 (hr)
HU (1) HUP0301228A3 (hr)
IL (1) IL153427A0 (hr)
IS (1) IS6637A (hr)
MA (1) MA26915A1 (hr)
MX (1) MXPA02012878A (hr)
NO (1) NO20026168L (hr)
NZ (1) NZ523141A (hr)
OA (1) OA12293A (hr)
PA (1) PA8519401A1 (hr)
PE (1) PE20020253A1 (hr)
PL (1) PL365956A1 (hr)
SK (1) SK17172002A3 (hr)
TN (1) TNSN01094A1 (hr)
UA (1) UA73176C2 (hr)
UY (1) UY26787A1 (hr)
WO (1) WO2001098267A1 (hr)
YU (1) YU91802A (hr)
ZA (1) ZA200210278B (hr)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EA006708B1 (ru) * 2001-10-22 2006-02-24 Пфайзер Продактс Инк. Производные 3-азабицикло (3.1.0) гексана в качестве антагонистов опиоидного рецептора
CA2486000A1 (en) * 2002-05-17 2003-11-27 Merck Patent Gesellschaft Mit Beschraenkter Haftung Use of compounds that are effective as selective opiate receptor modulators
DE10259245A1 (de) 2002-12-17 2004-07-01 Merck Patent Gmbh Derivate des Asimadolins mit kovalent gebundenen Säuren
EP2070922B1 (en) * 2004-02-23 2011-08-17 Glaxo Group Limited Azabicyclo(3.1.0) hexane derivatives useful as modulators of dopamine D3 receptors
GB0507680D0 (en) 2005-04-15 2005-05-25 Glaxo Group Ltd Compounds
US7807698B2 (en) 2005-06-14 2010-10-05 Glaxo Group Limited Azabicyclo[3.1.0]hexane derivatives as modulators of the dopamine D3 receptor
DE602007012531D1 (de) * 2006-04-03 2011-03-31 Glaxo Group Ltd Azabicycloä3.1.0ühexanderivate als modulatoren von dopamin-d3-rezeptoren
WO2008121496A1 (en) 2007-03-30 2008-10-09 Tioga Pharmaceuticals Inc. Kappa-opiate agonists for the treatment of diarrhea-predominant and alternating irritable bowel syndrome
TWI423801B (zh) * 2007-08-27 2014-01-21 Theravance Inc 作為μ類鴉片受體拮抗劑之８－氮雜雙環〔３．２．１〕辛基－２－羥基苯甲醯胺化合物
AU2011263417B2 (en) * 2010-06-11 2014-03-27 Rhodes Technologies Transition metal-catalyzed processes for the preparation of N-allyl compounds and use thereof
WO2012042539A2 (en) 2010-09-28 2012-04-05 Panacea Biotec Ltd Novel bicyclic compounds
MX2016006482A (es) * 2013-11-20 2016-12-09 Sanwa Kagaku Kenkyusho Co Derivado novedoso de 3-azabiciclo[3.1.0]hexano y uso del mismo para proposito medico.
CN107428687B (zh) 2015-05-20 2021-06-11 宇部兴产株式会社 一种3-氮杂双环[3.1.0]己烷衍生物的盐的晶体以及其医药应用
CN110446495B (zh) 2017-02-17 2023-09-05 特维娜有限公司 含有7元氮杂杂环的δ阿片受体调节化合物及其使用和制备方法
BR112019016827A2 (pt) * 2017-02-17 2020-04-07 Trevena Inc compostos moduladores de receptor delta-opioide contendo aza-heterocíclico com 5 membros, métodos de uso e produção dos mesmos
WO2018159716A1 (ja) 2017-03-02 2018-09-07 株式会社 三和化学研究所 アルコール使用障害の治療薬
CN108250088B (zh) * 2018-01-04 2020-10-30 四川之江高新材料股份有限公司 N，n，n′-三甲基-n′-羟乙基双氨基乙基醚的制备方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3065230A (en) * 1959-03-16 1962-11-20 Burroughs Wellcome Co Azabicyclohexanes and method of preparing them
ES2058265T3 (es) * 1987-04-16 1994-11-01 Lilly Co Eli Piperidinas antagonistas de opiaceos.
US5159081A (en) * 1991-03-29 1992-10-27 Eli Lilly And Company Intermediates of peripherally selective n-carbonyl-3,4,4-trisubstituted piperidine opioid antagonists
DE4341403A1 (de) * 1993-12-04 1995-06-08 Basf Ag N-substituierte 3-Azabicycloalkan-Derivate, ihre Herstellung und Verwendung
TWI244481B (en) * 1998-12-23 2005-12-01 Pfizer 3-azabicyclo[3.1.0]hexane derivatives useful in therapy
PE20001420A1 (es) * 1998-12-23 2000-12-18 Pfizer Moduladores de ccr5

Also Published As

Publication number Publication date
NO20026168L (no) 2003-02-18
MA26915A1 (fr) 2004-12-20
PE20020253A1 (es) 2002-04-08
UA73176C2 (en) 2005-06-15
AP2002002698A0 (en) 2002-12-31
PL365956A1 (en) 2005-01-24
GB0015562D0 (en) 2000-08-16
CZ20023967A3 (cs) 2004-02-18
WO2001098267A8 (en) 2003-02-27
PA8519401A1 (es) 2002-12-30
MXPA02012878A (es) 2003-05-14
WO2001098267A1 (en) 2001-12-27
SK17172002A3 (sk) 2004-09-08
AU781837B2 (en) 2005-06-16
BR0111867A (pt) 2003-07-01
IS6637A (is) 2002-11-28
EP1292574A1 (en) 2003-03-19
IL153427A0 (en) 2003-07-06
CN1639121A (zh) 2005-07-13
ZA200210278B (en) 2003-12-19
AR028969A1 (es) 2003-05-28
CA2412188A1 (en) 2001-12-27
HUP0301228A2 (hu) 2003-08-28
DOP2001000187A (es) 2002-03-30
UY26787A1 (es) 2002-01-31
NO20026168D0 (no) 2002-12-20
NZ523141A (en) 2005-06-24
TNSN01094A1 (fr) 2005-11-10
EA005117B1 (ru) 2004-10-28
YU91802A (sh) 2006-05-25
KR20040002386A (ko) 2004-01-07
BG107329A (en) 2003-07-31
EA200201269A1 (ru) 2003-06-26
HRP20020998A2 (en) 2004-02-29
HUP0301228A3 (en) 2005-08-29
AU6259101A (en) 2002-01-02
JP2004512263A (ja) 2004-04-22
OA12293A (en) 2004-03-18

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