DK4219508T3 - Substitueret polycyklisk pyridonderivat og prodrug deraf - Google Patents

Substitueret polycyklisk pyridonderivat og prodrug deraf Download PDF

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Publication number
DK4219508T3
DK4219508T3 DK23150186.7T DK23150186T DK4219508T3 DK 4219508 T3 DK4219508 T3 DK 4219508T3 DK 23150186 T DK23150186 T DK 23150186T DK 4219508 T3 DK4219508 T3 DK 4219508T3
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Prior art keywords
prodrug
substituted polycyclic
pyridone derivative
polycyclic pyridone
derivative
Prior art date
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DK23150186.7T
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Danish (da)
English (en)
Inventor
Makoto Kawai
Kenji Tomita
Masayoshi Miyagawa
Toshiyuki Akiyama
Azusa Okano
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Shionogi & Co
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Application filed by Shionogi & Co filed Critical Shionogi & Co
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Publication of DK4219508T3 publication Critical patent/DK4219508T3/da

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5383—1,4-Oxazines, e.g. morpholine ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • A61K31/542—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/553—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having at least one nitrogen and one oxygen as ring hetero atoms, e.g. loxapine, staurosporine
    • A—HUMAN NECESSITIES
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    • A61K31/66—Phosphorus compounds
    • A61K31/675—Phosphorus compounds having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
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    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
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    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
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    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1617—Organic compounds, e.g. phospholipids, fats
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    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
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    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
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    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/14—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
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    • C07D491/22—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains four or more hetero rings
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    • C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
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    • C07D513/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains three hetero rings
    • C07D513/14—Ortho-condensed systems
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    • C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
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    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
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    • C07C2601/16—Systems containing only non-condensed rings with a six-membered ring the ring being unsaturated

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Virology (AREA)
  • Molecular Biology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Pulmonology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biophysics (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Dermatology (AREA)
  • Otolaryngology (AREA)
  • Zoology (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Plural Heterocyclic Compounds (AREA)
DK23150186.7T 2015-04-28 2016-04-27 Substitueret polycyklisk pyridonderivat og prodrug deraf DK4219508T3 (da)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2015090909 2015-04-28
JP2015236844 2015-12-03
EP16786500.5A EP3290424B1 (en) 2015-04-28 2016-04-27 Substituted polycyclic pyridone derivatives and prodrug thereof

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DK4219508T3 true DK4219508T3 (da) 2024-08-05

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DK23150186.7T DK4219508T3 (da) 2015-04-28 2016-04-27 Substitueret polycyklisk pyridonderivat og prodrug deraf
DK18189193.8T DK3428170T3 (da) 2015-04-28 2016-04-27 Anti-influenza polycyklisk pyridonderivat og prodrug deraf
DK16786500.5T DK3290424T3 (da) 2015-04-28 2016-04-27 Substituerede polycykliske pyridonderivater og prodrug deraf

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DK18189193.8T DK3428170T3 (da) 2015-04-28 2016-04-27 Anti-influenza polycyklisk pyridonderivat og prodrug deraf
DK16786500.5T DK3290424T3 (da) 2015-04-28 2016-04-27 Substituerede polycykliske pyridonderivater og prodrug deraf

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US (5) US10392406B2 (enExample)
EP (4) EP3428170B1 (enExample)
JP (3) JP5971830B1 (enExample)
KR (3) KR101981912B1 (enExample)
CN (4) CN107709321A (enExample)
AU (1) AU2016256125B9 (enExample)
BR (1) BR112017022550B1 (enExample)
CA (1) CA2984130C (enExample)
CL (1) CL2017002711A1 (enExample)
CO (1) CO2017010384A2 (enExample)
CR (1) CR20170530A (enExample)
CY (2) CY2021006I2 (enExample)
DK (3) DK4219508T3 (enExample)
ES (3) ES2986814T3 (enExample)
FI (3) FI4219508T3 (enExample)
HK (1) HK1248673A1 (enExample)
HR (3) HRP20230215T1 (enExample)
HU (3) HUE061440T2 (enExample)
IL (1) IL255295B (enExample)
LT (3) LT3290424T (enExample)
LU (1) LUC00198I2 (enExample)
MD (1) MD3428170T2 (enExample)
MX (2) MX385402B (enExample)
MY (1) MY189144A (enExample)
NZ (1) NZ736259A (enExample)
PE (1) PE20180194A1 (enExample)
PH (1) PH12017501909B1 (enExample)
PL (3) PL4219508T3 (enExample)
PT (3) PT4219508T (enExample)
RS (3) RS64012B1 (enExample)
RU (1) RU2712275C9 (enExample)
SG (1) SG11201708721XA (enExample)
SI (3) SI4219508T1 (enExample)
SM (1) SMT202100102T1 (enExample)
TW (3) TW201825492A (enExample)
UA (1) UA123725C2 (enExample)
WO (1) WO2016175224A1 (enExample)
ZA (1) ZA201707111B (enExample)

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