DK4015003T3 - Forbedret antistof-oligonukleotid-konjugat - Google Patents
Forbedret antistof-oligonukleotid-konjugat Download PDFInfo
- Publication number
- DK4015003T3 DK4015003T3 DK21212184.2T DK21212184T DK4015003T3 DK 4015003 T3 DK4015003 T3 DK 4015003T3 DK 21212184 T DK21212184 T DK 21212184T DK 4015003 T3 DK4015003 T3 DK 4015003T3
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- DK
- Denmark
- Prior art keywords
- oligonucleotide conjugate
- improved antibody
- antibody
- improved
- oligonucleotide
- Prior art date
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- A61K47/6883—Polymer-drug antibody conjugates, e.g. mitomycin-dextran-Ab; DNA-polylysine-antibody complex or conjugate used for therapy
- A61K47/6885—Polymer-drug antibody conjugates, e.g. mitomycin-dextran-Ab; DNA-polylysine-antibody complex or conjugate used for therapy the conjugate or the polymer being a starburst, a dendrimer, a cascade
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EP3618867A4 (en) | 2017-05-02 | 2021-01-20 | Cornell University | METHODS AND REAGENTS FOR AGAINST TUMOR WITH HIGHER EFFICIENCY AND LOWER TOXICITY |
KR20210117274A (ko) * | 2018-12-21 | 2021-09-28 | 사프렘 테크놀로지스 비.브이. | 에피토프-결합 단백질에 접합된 사포닌 |
US20230357310A1 (en) * | 2019-06-24 | 2023-11-09 | Sapreme Technologies B.V. | Saponin derivatives with improved therapeutic window |
CN113527498B (zh) * | 2020-04-16 | 2022-03-04 | 上海洛启生物医药技术有限公司 | 抗Trop2纳米抗体及其应用 |
US20230293562A1 (en) * | 2020-06-24 | 2023-09-21 | Sapreme Technologies B.V. | Therapeutic combination of galnac-oligonucleotide conjugate and saponin, and uses thereof |
US20230277612A1 (en) * | 2020-06-24 | 2023-09-07 | Sapreme Technologies B.V. | Saponin derivatives for use in medicine |
KR20230043110A (ko) * | 2020-06-24 | 2023-03-30 | 사프렘 테크놀로지스 비.브이. | Vhh를 포함하는 adc 또는 aoc, 및 사포닌 또는 리간드-사포닌 접합체를 포함하는 조합물 |
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WO2021261992A1 (en) * | 2020-06-24 | 2021-12-30 | Sapreme Technologies B.V. | Conjugate of galnac and saponin, therapeutic composition comprising said conjugate and a galnac-oligonucleotide conjugate |
US20240115726A1 (en) * | 2020-06-24 | 2024-04-11 | Sapreme Technologies B.V. | Hydrazone-based saponin derivatives |
WO2022055351A1 (en) * | 2020-09-10 | 2022-03-17 | Sapreme Technologies B.V. | Conjugate of saponin, oligonucleotide and galnac |
WO2022055352A1 (en) * | 2020-09-10 | 2022-03-17 | Sapreme Technologies B.V. | Semicarbazone-based saponin conjugate |
US10947552B1 (en) | 2020-09-30 | 2021-03-16 | Alpine Roads, Inc. | Recombinant fusion proteins for producing milk proteins in plants |
US10894812B1 (en) | 2020-09-30 | 2021-01-19 | Alpine Roads, Inc. | Recombinant milk proteins |
AU2021353004A1 (en) | 2020-09-30 | 2023-04-13 | Nobell Foods, Inc. | Recombinant milk proteins and food compositions comprising the same |
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EP4355369A1 (en) * | 2021-06-18 | 2024-04-24 | Sapreme Technologies B.V. | Conjugate of saponin, oligonucleotide and galnac |
WO2023038517A1 (en) | 2021-09-09 | 2023-03-16 | Sapreme Technologies B.V. | Semicarbazone-based saponin conjugate |
KR20240125934A (ko) | 2021-12-22 | 2024-08-20 | 사프렘 테크놀로지스 비.브이. | 근육 소모 장애를 치료하기 위한 치료적 핵산 및 표적화된 사포닌을 포함하는 조성물 |
WO2023121447A1 (en) * | 2021-12-22 | 2023-06-29 | Sapreme Technologies B.V. | Conjugate of a single domain antibody, a saponin and an effector molecule, pharmaceutical composition comprising the same, therapeutic use of said pharmaceutical composition |
IL313728A (en) | 2021-12-22 | 2024-08-01 | Sapreme Tech Bv | Targeted saponin and nucleic acid conjugates for the treatment of muscle wasting diseases |
WO2023121445A1 (en) | 2021-12-22 | 2023-06-29 | Sapreme Technologies B.V. | Compositions comprising therapeutic nucleic acid and saponin for the treatment of muscle-wasting disorders |
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WO2024013360A1 (en) | 2022-07-15 | 2024-01-18 | Proqr Therapeutics Ii B.V. | Chemically modified oligonucleotides for adar-mediated rna editing |
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WO2024046622A1 (en) | 2022-09-01 | 2024-03-07 | Sapreme Technologies B.V. | Compositions of polyplexes and saponins |
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