SG11202106603UA - Biologically active cluster of molecules - Google Patents

Biologically active cluster of molecules

Info

Publication number
SG11202106603UA
SG11202106603UA SG11202106603UA SG11202106603UA SG11202106603UA SG 11202106603U A SG11202106603U A SG 11202106603UA SG 11202106603U A SG11202106603U A SG 11202106603UA SG 11202106603U A SG11202106603U A SG 11202106603UA SG 11202106603U A SG11202106603U A SG 11202106603UA
Authority
SG
Singapore
Prior art keywords
molecules
biologically active
active cluster
cluster
biologically
Prior art date
Application number
SG11202106603UA
Inventor
Ruben Postel
Hendrik Fuchs
Original Assignee
Sapreme Tech Bv
Univ Berlin Charite
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sapreme Tech Bv, Univ Berlin Charite filed Critical Sapreme Tech Bv
Publication of SG11202106603UA publication Critical patent/SG11202106603UA/en

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    • A61K47/6835Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
    • A61K47/6883Polymer-drug antibody conjugates, e.g. mitomycin-dextran-Ab; DNA-polylysine-antibody complex or conjugate used for therapy
    • A61K47/6885Polymer-drug antibody conjugates, e.g. mitomycin-dextran-Ab; DNA-polylysine-antibody complex or conjugate used for therapy the conjugate or the polymer being a starburst, a dendrimer, a cascade
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    • A61K47/549Sugars, nucleosides, nucleotides or nucleic acids
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    • A61K47/6889Conjugates wherein the antibody being the modifying agent and wherein the linker, binder or spacer confers particular properties to the conjugates, e.g. peptidic enzyme-labile linkers or acid-labile linkers, providing for an acid-labile immuno conjugate wherein the drug may be released from its antibody conjugated part in an acidic, e.g. tumoural or environment
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