SG11202106575YA - Antibody-drug conjugate with improved therapeutic window - Google Patents

Antibody-drug conjugate with improved therapeutic window

Info

Publication number
SG11202106575YA
SG11202106575YA SG11202106575YA SG11202106575YA SG11202106575YA SG 11202106575Y A SG11202106575Y A SG 11202106575YA SG 11202106575Y A SG11202106575Y A SG 11202106575YA SG 11202106575Y A SG11202106575Y A SG 11202106575YA SG 11202106575Y A SG11202106575Y A SG 11202106575YA
Authority
SG
Singapore
Prior art keywords
antibody
drug conjugate
therapeutic window
improved therapeutic
window
Prior art date
Application number
SG11202106575YA
Inventor
Ruben Postel
Hendrik Fuchs
Original Assignee
Sapreme Tech Bv
Univ Berlin Charite
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sapreme Tech Bv, Univ Berlin Charite filed Critical Sapreme Tech Bv
Publication of SG11202106575YA publication Critical patent/SG11202106575YA/en

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    • A61K47/68Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6835Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
    • A61K47/6883Polymer-drug antibody conjugates, e.g. mitomycin-dextran-Ab; DNA-polylysine-antibody complex or conjugate used for therapy
    • A61K47/6885Polymer-drug antibody conjugates, e.g. mitomycin-dextran-Ab; DNA-polylysine-antibody complex or conjugate used for therapy the conjugate or the polymer being a starburst, a dendrimer, a cascade
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