DK3456330T3 - Cortexolon-17alpha-valerat til anvendelse ved behandling af tumorer - Google Patents
Cortexolon-17alpha-valerat til anvendelse ved behandling af tumorer Download PDFInfo
- Publication number
- DK3456330T3 DK3456330T3 DK18198653.0T DK18198653T DK3456330T3 DK 3456330 T3 DK3456330 T3 DK 3456330T3 DK 18198653 T DK18198653 T DK 18198653T DK 3456330 T3 DK3456330 T3 DK 3456330T3
- Authority
- DK
- Denmark
- Prior art keywords
- cortexolon
- valerat
- 17alpha
- tumor treatment
- tumor
- Prior art date
Links
- 206010028980 Neoplasm Diseases 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J5/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond
- C07J5/0046—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa
- C07J5/0053—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa not substituted in position 16
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
- A61K31/573—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/38—Drugs for disorders of the endocrine system of the suprarenal hormones
- A61P5/46—Drugs for disorders of the endocrine system of the suprarenal hormones for decreasing, blocking or antagonising the activity of glucocorticosteroids
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Organic Chemistry (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Dermatology (AREA)
- Physiology (AREA)
- Nutrition Science (AREA)
- Oncology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Diabetes (AREA)
- Endocrinology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Steroid Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP14188063.3A EP3006453A1 (en) | 2014-10-08 | 2014-10-08 | 17alpha-monoesters and 17alpha,21-diesters of cortexolone for use in the treatment of tumors |
| EP15778634.4A EP3204400B1 (en) | 2014-10-08 | 2015-10-07 | 17a,21-diesters of cortexolone for use in the treatment of tumors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK3456330T3 true DK3456330T3 (da) | 2021-07-26 |
Family
ID=51687868
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK18198653.0T DK3456330T3 (da) | 2014-10-08 | 2015-10-07 | Cortexolon-17alpha-valerat til anvendelse ved behandling af tumorer |
| DK15778634.4T DK3204400T3 (en) | 2014-10-08 | 2015-10-07 | 17ALFA, 21-DIESTERS OF CORTEXOLON FOR USE IN TUMOR TREATMENT |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK15778634.4T DK3204400T3 (en) | 2014-10-08 | 2015-10-07 | 17ALFA, 21-DIESTERS OF CORTEXOLON FOR USE IN TUMOR TREATMENT |
Country Status (23)
| Country | Link |
|---|---|
| US (8) | US10183030B2 (enExample) |
| EP (4) | EP3006453A1 (enExample) |
| JP (5) | JP6735739B2 (enExample) |
| KR (5) | KR102712584B1 (enExample) |
| CN (5) | CN116102604A (enExample) |
| AU (3) | AU2015330003A1 (enExample) |
| BR (2) | BR112017007076B1 (enExample) |
| CA (3) | CA2960928C (enExample) |
| DK (2) | DK3456330T3 (enExample) |
| ES (3) | ES2806094T3 (enExample) |
| HR (2) | HRP20190194T1 (enExample) |
| HU (2) | HUE055143T2 (enExample) |
| IL (3) | IL272095B2 (enExample) |
| LT (2) | LT3204400T (enExample) |
| MX (3) | MX385557B (enExample) |
| PL (2) | PL3204400T3 (enExample) |
| PT (2) | PT3456330T (enExample) |
| RS (2) | RS58607B1 (enExample) |
| RU (2) | RU2712752C2 (enExample) |
| SI (2) | SI3456330T1 (enExample) |
| TR (1) | TR201901422T4 (enExample) |
| WO (2) | WO2016055537A1 (enExample) |
| ZA (2) | ZA201702209B (enExample) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8859774B2 (en) | 2012-05-25 | 2014-10-14 | Corcept Therapeutics, Inc. | Heteroaryl-ketone fused azadecalin glucocorticoid receptor modulators |
| US12226412B2 (en) | 2012-05-25 | 2025-02-18 | Corcept Therapeutics, Inc. | Heteroaryl-ketone fused azadecalin glucocorticoid receptor modulators |
| EP3006453A1 (en) | 2014-10-08 | 2016-04-13 | Cosmo Technologies Ltd. | 17alpha-monoesters and 17alpha,21-diesters of cortexolone for use in the treatment of tumors |
| EP3108879A1 (en) | 2015-06-25 | 2016-12-28 | Cassiopea S.p.A. | High concentration formulation |
| US9943505B2 (en) * | 2016-09-09 | 2018-04-17 | Corcept Therapeutics, Inc. | Glucocorticoid receptor modulators to treat pancreatic cancer |
| AU2018244928B2 (en) | 2017-03-31 | 2023-10-19 | Corcept Therapeutics, Inc. | Glucocorticoid receptor modulators to treat cervical cancer |
| US11389432B2 (en) | 2018-12-19 | 2022-07-19 | Corcept Therapeutics Incorporated | Methods of treating cancer comprising administration of a glucocorticoid receptor modulator and a cancer chemotherapy agent |
| CN113194931B (zh) | 2018-12-19 | 2023-11-10 | 科塞普特治疗公司 | 含有瑞拉可兰、杂芳基-酮稠合的氮杂十氢化萘化合物的药物制剂 |
| US11234971B2 (en) | 2018-12-19 | 2022-02-01 | Corcept Therapeutics Incorporated | Methods of treating cancer comprising administration of a glucocorticoid receptor modulator and a cancer chemotherapy agent |
| CN110698527B (zh) * | 2019-11-19 | 2022-08-26 | 湖南新合新生物医药有限公司 | 一种高纯度氢化可的松-17-戊酸酯的制备方法 |
| EP4157276A4 (en) | 2020-05-27 | 2024-06-12 | Corcept Therapeutics Incorporated | Concomitant administration of glucocorticoid receptor modulator relacorilant and paclitaxel, a dual substrate of cyp2c8 and cyp3a4 |
| CN112028956A (zh) * | 2020-09-10 | 2020-12-04 | 那路新 | 合成21-羟基-17-(1-氧代丙氧基)孕甾-4-烯-3,20-二酮的方法 |
| WO2022134033A1 (en) | 2020-12-25 | 2022-06-30 | Corcept Therapeutics Incorporated | Methods of preparing heteroaryl-ketone fused azadecalin glucocorticoid receptor modulators |
| CN114113603B (zh) * | 2021-06-30 | 2023-11-17 | 四川大学华西医院 | Cytl1作为胃癌预后标志物的应用 |
| WO2023088308A1 (zh) * | 2021-11-16 | 2023-05-25 | 石家庄迪斯凯威医药科技有限公司 | 一种具有抗耐药性的抗菌化合物 |
| WO2024077169A1 (en) | 2022-10-06 | 2024-04-11 | Corcept Therapeutics Incorporated | Formulations of glucocorticoid receptor modulators |
| US12433882B2 (en) | 2022-10-28 | 2025-10-07 | Corcept Therapeutics Incorporated | Treatments for amyotrophic lateral sclerosis using dazucorilant |
Family Cites Families (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CH429716A (de) * | 1961-06-24 | 1967-02-15 | Vismara Francesco Spa | Verfahren zur Herstellung von 17a-Acyloxy-21-hydroxy-Steroiden |
| BE619180A (fr) * | 1961-06-24 | 1962-12-20 | Vismara Francesco Spa | 17-monoesters de 17 alpha, 21-dihydroxy stéroïdes et leur procédé de préparation |
| NL6605514A (enExample) * | 1966-04-25 | 1967-10-26 | ||
| DE2748442C3 (de) | 1977-10-26 | 1981-08-27 | Schering Ag Berlin Und Bergkamen, 1000 Berlin | 17α-(3-Jodbenzoyloxy)-9α -chlor4-pregnen-3.20-dione, Zwischenprodukte und Verfahren zu ihrer Herstellung, 9α -chlor-17α, 21-dihydroxy-1,4-pregnadien-3,20-dion und dieses enthaltende Arzneimittel |
| EP0001737B1 (de) * | 1977-10-26 | 1981-01-07 | Schering Aktiengesellschaft | 17-Alpha-(3-Jodbenzoyloxy)-9-Alpha-chlor-4-pregnen-3.20-dione, deren D-Homo-analoga und Verfahren zu ihrer Herstellung |
| ATE12237T1 (de) * | 1980-12-23 | 1985-04-15 | Schering Ag | Neue 6-alpha-methylhydrocortison-derivate, ihre herstellung und verwendung. |
| CY1359A (en) | 1981-02-02 | 1987-08-07 | Schering Corp | Aromatic heterocyclic esters of steroids, their preparation and pharmaceutical compositions containing them |
| US4920216A (en) * | 1987-05-28 | 1990-04-24 | The Trustees Of Columbia In The City Of New York | Selective chlorination of steroids and other substrates directed by covalently linked pyridine derivatives acting as templates |
| US5990099A (en) | 1988-10-31 | 1999-11-23 | Alcon Laboratories, Inc. | Angiostatic agents and methods and compositions for controlling ocular hypertension |
| ES2062528T3 (es) | 1989-02-07 | 1994-12-16 | Upjohn Co | Deshalogenacion de compuestos organicos usando estaño o plomo. |
| DE4121484A1 (de) | 1991-06-26 | 1993-01-07 | Schering Ag | Verfahren zur herstellung von 6-methylensteroiden |
| US6172054B1 (en) | 1995-06-15 | 2001-01-09 | Alcon Laboratories, Inc. | Combination therapy for lowering and controlling intraocular pressure |
| AU3703900A (en) | 1999-02-24 | 2000-09-14 | Nitromed, Inc. | Nitrosated and nitrosylated steroids for the treatment of cardiovascular diseases and disorders |
| WO2000076478A1 (en) | 1999-06-14 | 2000-12-21 | Cosmo S.P.A. | Controlled release and taste masking oral pharmaceutical compositions |
| IT1314184B1 (it) | 1999-08-12 | 2002-12-06 | Nicox Sa | Composizioni farmaceutiche per la terapia di condizioni di stressossidativo |
| EP1341541A4 (en) | 2000-11-16 | 2004-11-17 | Alcon Mfg Ltd | COMBINATION THERAPY FOR LOWERING AND CONTROLLING THE EYE PRESSURE |
| ITMI20011762A1 (it) * | 2001-08-10 | 2003-02-10 | Cosmo Spa | Esteri di 17alfa,21-diidrossipregnene, loro uso come agenti anti-androgenetici e procedimenti per la loro preparazione |
| ITMI20051695A1 (it) | 2005-09-14 | 2007-03-15 | Cosmo Spa | Uso di 17a-esteri c3-c10 del 9,11-deidrocortexolone cme agenti anti-gonadotropinici |
| DE102006059063A1 (de) | 2005-12-24 | 2007-06-28 | Bayer Healthcare Ag | Verwendung von BAY 59-3074 zur Herstellung von Medikamenten zur Therapie von Hirntumoren sowie Kombinationen von BAY 59-3074 |
| US7687484B2 (en) | 2006-05-25 | 2010-03-30 | Bodor Nicholas S | Transporter enhanced corticosteroid activity |
| ITMI20071616A1 (it) * | 2007-08-03 | 2009-02-04 | Cosmo Spa | Processo enzimatico per l'ottenimento di 17-alfa monoesteri del cortexolone e/o suoi 9,11-deidroderivati. |
| CN101397317A (zh) | 2007-09-27 | 2009-04-01 | 天津药业研究院有限公司 | 一种新型硝酸酯类甾体化合物 |
| AU2008335469A1 (en) * | 2007-12-13 | 2009-06-18 | Novartis Ag | Combinations of therapeutic agents for treating cancer |
| EP2265628A1 (en) | 2008-03-18 | 2010-12-29 | Sicor, Inc. | Purification of air sensitive steroids |
| CN108872579A (zh) * | 2010-06-01 | 2018-11-23 | 梅坦诺米克斯保健有限公司 | 用于在受试者中诊断胰腺癌的工具和方法 |
| WO2012129305A1 (en) | 2011-03-23 | 2012-09-27 | Pop Test Cortisol Llc | Combination therapy |
| RU2506974C1 (ru) | 2012-11-06 | 2014-02-20 | Федеральное государственное бюджетное учреждение "Ростовский научно-исследовательский онкологический институт" Министерства здравоохранения Российской Федерации | Способ лечения первично нерезектабельного рака легкого |
| EP2945628B1 (en) | 2013-01-15 | 2020-04-15 | Aragon Pharmaceuticals, Inc. | Androgen receptor modulator in combination with abiraterone acetate and prednisone for treating prostate cancer |
| EP3006453A1 (en) * | 2014-10-08 | 2016-04-13 | Cosmo Technologies Ltd. | 17alpha-monoesters and 17alpha,21-diesters of cortexolone for use in the treatment of tumors |
-
2014
- 2014-10-08 EP EP14188063.3A patent/EP3006453A1/en not_active Withdrawn
-
2015
- 2015-10-07 CA CA2960928A patent/CA2960928C/en active Active
- 2015-10-07 KR KR1020237011743A patent/KR102712584B1/ko active Active
- 2015-10-07 KR KR1020217002286A patent/KR102520411B1/ko active Active
- 2015-10-07 RS RS20190207A patent/RS58607B1/sr unknown
- 2015-10-07 SI SI201531666T patent/SI3456330T1/sl unknown
- 2015-10-07 IL IL272095A patent/IL272095B2/en unknown
- 2015-10-07 PL PL15778634T patent/PL3204400T3/pl unknown
- 2015-10-07 RU RU2017115773A patent/RU2712752C2/ru active
- 2015-10-07 CA CA3160391A patent/CA3160391C/en active Active
- 2015-10-07 CN CN202211571443.7A patent/CN116102604A/zh active Pending
- 2015-10-07 MX MX2019008063A patent/MX385557B/es unknown
- 2015-10-07 EP EP15775455.7A patent/EP3204012B1/en active Active
- 2015-10-07 MX MX2017004661A patent/MX2017004661A/es unknown
- 2015-10-07 KR KR1020177011114A patent/KR102248983B1/ko active Active
- 2015-10-07 KR KR1020177011239A patent/KR20170063821A/ko not_active Withdrawn
- 2015-10-07 AU AU2015330003A patent/AU2015330003A1/en not_active Abandoned
- 2015-10-07 LT LTEP15778634.4T patent/LT3204400T/lt unknown
- 2015-10-07 US US15/517,653 patent/US10183030B2/en active Active
- 2015-10-07 RS RS20210928A patent/RS62147B1/sr unknown
- 2015-10-07 HR HRP20190194TT patent/HRP20190194T1/hr unknown
- 2015-10-07 LT LTEP18198653.0T patent/LT3456330T/lt unknown
- 2015-10-07 WO PCT/EP2015/073176 patent/WO2016055537A1/en not_active Ceased
- 2015-10-07 CN CN202211425819.3A patent/CN115671114A/zh active Pending
- 2015-10-07 HU HUE18198653A patent/HUE055143T2/hu unknown
- 2015-10-07 ES ES15775455T patent/ES2806094T3/es active Active
- 2015-10-07 BR BR112017007076-6A patent/BR112017007076B1/pt active IP Right Grant
- 2015-10-07 PT PT181986530T patent/PT3456330T/pt unknown
- 2015-10-07 EP EP18198653.0A patent/EP3456330B1/en active Active
- 2015-10-07 US US15/517,659 patent/US10231980B2/en active Active
- 2015-10-07 CN CN201580060690.2A patent/CN107001406B/zh active Active
- 2015-10-07 PT PT15778634T patent/PT3204400T/pt unknown
- 2015-10-07 CA CA2962746A patent/CA2962746A1/en not_active Abandoned
- 2015-10-07 EP EP15778634.4A patent/EP3204400B1/en active Active
- 2015-10-07 DK DK18198653.0T patent/DK3456330T3/da active
- 2015-10-07 ES ES15778634T patent/ES2713699T3/es active Active
- 2015-10-07 JP JP2017518978A patent/JP6735739B2/ja active Active
- 2015-10-07 TR TR2019/01422T patent/TR201901422T4/tr unknown
- 2015-10-07 CN CN201580060711.0A patent/CN107074905B/zh not_active Expired - Fee Related
- 2015-10-07 JP JP2017518340A patent/JP6503057B2/ja active Active
- 2015-10-07 WO PCT/EP2015/073172 patent/WO2016055533A1/en not_active Ceased
- 2015-10-07 DK DK15778634.4T patent/DK3204400T3/en active
- 2015-10-07 RU RU2017115771A patent/RU2712950C2/ru active
- 2015-10-07 MX MX2017004660A patent/MX366294B/es active IP Right Grant
- 2015-10-07 ES ES18198653T patent/ES2882223T3/es active Active
- 2015-10-07 HU HUE15778634A patent/HUE041503T2/hu unknown
- 2015-10-07 BR BR112017007078A patent/BR112017007078A2/pt not_active Application Discontinuation
- 2015-10-07 KR KR1020247032041A patent/KR20240149968A/ko active Pending
- 2015-10-07 SI SI201530614T patent/SI3204400T1/sl unknown
- 2015-10-07 AU AU2015329999A patent/AU2015329999B2/en active Active
- 2015-10-07 PL PL18198653T patent/PL3456330T3/pl unknown
- 2015-10-07 CN CN202010134553.1A patent/CN111285913B/zh active Active
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2017
- 2017-03-08 IL IL251028A patent/IL251028B/en active IP Right Grant
- 2017-03-23 IL IL251371A patent/IL251371A0/en unknown
- 2017-03-29 ZA ZA2017/02209A patent/ZA201702209B/en unknown
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2018
- 2018-11-23 US US16/199,015 patent/US10646497B2/en active Active
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2019
- 2019-01-17 JP JP2019006199A patent/JP7028809B2/ja active Active
- 2019-02-12 US US16/273,575 patent/US20190175618A1/en not_active Abandoned
- 2019-04-12 ZA ZA2019/02320A patent/ZA201902320B/en unknown
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2020
- 2020-02-27 AU AU2020201446A patent/AU2020201446B2/en active Active
- 2020-03-16 US US16/820,407 patent/US10993949B2/en active Active
- 2020-05-27 JP JP2020092411A patent/JP2020143140A/ja active Pending
- 2020-12-01 JP JP2020199555A patent/JP2021046418A/ja active Pending
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2021
- 2021-04-06 US US17/223,776 patent/US11712443B2/en active Active
- 2021-07-22 HR HRP20211177TT patent/HRP20211177T1/hr unknown
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2022
- 2022-12-19 US US18/068,346 patent/US11986484B2/en active Active
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2024
- 2024-03-01 US US18/592,730 patent/US20240277731A1/en not_active Abandoned
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