KR102712584B1 - 종양 치료에 사용하기 위한 코르텍솔론의 17ａ,21-디에스테르 - Google Patents
종양 치료에 사용하기 위한 코르텍솔론의 17ａ,21-디에스테르 Download PDFInfo
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- KR102712584B1 KR102712584B1 KR1020237011743A KR20237011743A KR102712584B1 KR 102712584 B1 KR102712584 B1 KR 102712584B1 KR 1020237011743 A KR1020237011743 A KR 1020237011743A KR 20237011743 A KR20237011743 A KR 20237011743A KR 102712584 B1 KR102712584 B1 KR 102712584B1
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/38—Drugs for disorders of the endocrine system of the suprarenal hormones
- A61P5/46—Drugs for disorders of the endocrine system of the suprarenal hormones for decreasing, blocking or antagonising the activity of glucocorticosteroids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J5/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond
- C07J5/0046—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa
- C07J5/0053—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa not substituted in position 16
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Organic Chemistry (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Physiology (AREA)
- Dermatology (AREA)
- Nutrition Science (AREA)
- Oncology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Diabetes (AREA)
- Endocrinology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Steroid Compounds (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| KR1020247032041A KR20240149968A (ko) | 2014-10-08 | 2015-10-07 | 종양 치료에 사용하기 위한 코르텍솔론의 17ａ,21-디에스테르 |
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP14188063.3A EP3006453A1 (en) | 2014-10-08 | 2014-10-08 | 17alpha-monoesters and 17alpha,21-diesters of cortexolone for use in the treatment of tumors |
| EP14188063.3 | 2014-10-08 | ||
| PCT/EP2015/073172 WO2016055533A1 (en) | 2014-10-08 | 2015-10-07 | 17a,21-diesters of cortexolone for use in the treatment of tumors |
| KR1020217002286A KR102520411B1 (ko) | 2014-10-08 | 2015-10-07 | 종양 치료에 사용하기 위한 코르텍솔론의 17ａ,21-디에스테르 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020217002286A Division KR102520411B1 (ko) | 2014-10-08 | 2015-10-07 | 종양 치료에 사용하기 위한 코르텍솔론의 17ａ,21-디에스테르 |
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| KR1020247032041A Division KR20240149968A (ko) | 2014-10-08 | 2015-10-07 | 종양 치료에 사용하기 위한 코르텍솔론의 17ａ,21-디에스테르 |
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| KR20230052990A KR20230052990A (ko) | 2023-04-20 |
| KR102712584B1 true KR102712584B1 (ko) | 2024-10-04 |
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| Application Number | Title | Priority Date | Filing Date |
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| KR1020237011743A Active KR102712584B1 (ko) | 2014-10-08 | 2015-10-07 | 종양 치료에 사용하기 위한 코르텍솔론의 17ａ,21-디에스테르 |
| KR1020247032041A Pending KR20240149968A (ko) | 2014-10-08 | 2015-10-07 | 종양 치료에 사용하기 위한 코르텍솔론의 17ａ,21-디에스테르 |
| KR1020177011114A Active KR102248983B1 (ko) | 2014-10-08 | 2015-10-07 | 종양 치료에 사용하기 위한 코르텍솔론의 17ａ,21-디에스테르 |
| KR1020217002286A Active KR102520411B1 (ko) | 2014-10-08 | 2015-10-07 | 종양 치료에 사용하기 위한 코르텍솔론의 17ａ,21-디에스테르 |
| KR1020177011239A Withdrawn KR20170063821A (ko) | 2014-10-08 | 2015-10-07 | 종양 치료에 사용하기 위한 코르텍솔론 17α-벤조에이트 |
Family Applications After (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020247032041A Pending KR20240149968A (ko) | 2014-10-08 | 2015-10-07 | 종양 치료에 사용하기 위한 코르텍솔론의 17ａ,21-디에스테르 |
| KR1020177011114A Active KR102248983B1 (ko) | 2014-10-08 | 2015-10-07 | 종양 치료에 사용하기 위한 코르텍솔론의 17ａ,21-디에스테르 |
| KR1020217002286A Active KR102520411B1 (ko) | 2014-10-08 | 2015-10-07 | 종양 치료에 사용하기 위한 코르텍솔론의 17ａ,21-디에스테르 |
| KR1020177011239A Withdrawn KR20170063821A (ko) | 2014-10-08 | 2015-10-07 | 종양 치료에 사용하기 위한 코르텍솔론 17α-벤조에이트 |
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| JP (5) | JP6735739B2 (enExample) |
| KR (5) | KR102712584B1 (enExample) |
| CN (5) | CN115671114A (enExample) |
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| BR (2) | BR112017007076B1 (enExample) |
| CA (3) | CA2960928C (enExample) |
| DK (2) | DK3456330T3 (enExample) |
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| HU (2) | HUE055143T2 (enExample) |
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| MX (3) | MX385557B (enExample) |
| PL (2) | PL3204400T3 (enExample) |
| PT (2) | PT3456330T (enExample) |
| RS (2) | RS58607B1 (enExample) |
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| SI (2) | SI3204400T1 (enExample) |
| TR (1) | TR201901422T4 (enExample) |
| WO (2) | WO2016055533A1 (enExample) |
| ZA (2) | ZA201702209B (enExample) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8859774B2 (en) | 2012-05-25 | 2014-10-14 | Corcept Therapeutics, Inc. | Heteroaryl-ketone fused azadecalin glucocorticoid receptor modulators |
| US12226412B2 (en) | 2012-05-25 | 2025-02-18 | Corcept Therapeutics, Inc. | Heteroaryl-ketone fused azadecalin glucocorticoid receptor modulators |
| EP3006453A1 (en) | 2014-10-08 | 2016-04-13 | Cosmo Technologies Ltd. | 17alpha-monoesters and 17alpha,21-diesters of cortexolone for use in the treatment of tumors |
| US9943505B2 (en) | 2016-09-09 | 2018-04-17 | Corcept Therapeutics, Inc. | Glucocorticoid receptor modulators to treat pancreatic cancer |
| MX2019011543A (es) | 2017-03-31 | 2019-12-16 | Corcept Therapeutics Inc | Moduladores del receptor de glucocorticoides para el tratamiento de cancer cervical. |
| US11234971B2 (en) | 2018-12-19 | 2022-02-01 | Corcept Therapeutics Incorporated | Methods of treating cancer comprising administration of a glucocorticoid receptor modulator and a cancer chemotherapy agent |
| IL284061B2 (en) | 2018-12-19 | 2025-02-01 | Corcept Therapeutics Inc | A preparation containing a relaxant |
| WO2020132046A1 (en) | 2018-12-19 | 2020-06-25 | Corcept Therapeutics Incorporated | Methods of treating cancer comprising administration of a glucocorticoid receptor modulator and a cancer chemotherapy agent |
| CN110698527B (zh) * | 2019-11-19 | 2022-08-26 | 湖南新合新生物医药有限公司 | 一种高纯度氢化可的松-17-戊酸酯的制备方法 |
| CN112028956A (zh) * | 2020-09-10 | 2020-12-04 | 那路新 | 合成21-羟基-17-(1-氧代丙氧基)孕甾-4-烯-3,20-二酮的方法 |
| WO2022134033A1 (en) | 2020-12-25 | 2022-06-30 | Corcept Therapeutics Incorporated | Methods of preparing heteroaryl-ketone fused azadecalin glucocorticoid receptor modulators |
| CN114113603B (zh) * | 2021-06-30 | 2023-11-17 | 四川大学华西医院 | Cytl1作为胃癌预后标志物的应用 |
| WO2023088308A1 (zh) * | 2021-11-16 | 2023-05-25 | 石家庄迪斯凯威医药科技有限公司 | 一种具有抗耐药性的抗菌化合物 |
| EP4598513A1 (en) | 2022-10-06 | 2025-08-13 | Corcept Therapeutics Incorporated | Formulations of glucocorticoid receptor modulators |
| IL320512A (en) | 2022-10-28 | 2025-06-01 | Corcept Therapeutics Inc | Amyotrophic lateral sclerosis treatments using desocorilant |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR102520411B1 (ko) * | 2014-10-08 | 2023-04-11 | 코스모 테크놀러지스 리미티드 | 종양 치료에 사용하기 위한 코르텍솔론의 17ａ,21-디에스테르 |
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| DE1195748B (de) * | 1961-06-24 | 1965-07-01 | Vismara Francesco Spa | Verfahren zur Herstellung von 1'-substituierten 17alpha, 21-(1'-Alkoxy)-methylendioxysterioden |
| BE619180A (fr) * | 1961-06-24 | 1962-12-20 | Vismara Francesco Spa | 17-monoesters de 17 alpha, 21-dihydroxy stéroïdes et leur procédé de préparation |
| NL6605514A (enExample) | 1966-04-25 | 1967-10-26 | ||
| EP0001737B1 (de) * | 1977-10-26 | 1981-01-07 | Schering Aktiengesellschaft | 17-Alpha-(3-Jodbenzoyloxy)-9-Alpha-chlor-4-pregnen-3.20-dione, deren D-Homo-analoga und Verfahren zu ihrer Herstellung |
| DE2748442C3 (de) | 1977-10-26 | 1981-08-27 | Schering Ag Berlin Und Bergkamen, 1000 Berlin | 17α-(3-Jodbenzoyloxy)-9α -chlor4-pregnen-3.20-dione, Zwischenprodukte und Verfahren zu ihrer Herstellung, 9α -chlor-17α, 21-dihydroxy-1,4-pregnadien-3,20-dion und dieses enthaltende Arzneimittel |
| DE3169460D1 (en) * | 1980-12-23 | 1985-04-25 | Schering Ag | 6-alpha-methyl hydrocortisone derivatives, their preparation and their utilization |
| ATE8790T1 (de) | 1981-02-02 | 1984-08-15 | Schering Corporation | Aromatische heterocyclische steroidester, verfahren zu ihrer herstellung und pharmazeutische zusammensetzungen, die sie enthalten. |
| US4920216A (en) * | 1987-05-28 | 1990-04-24 | The Trustees Of Columbia In The City Of New York | Selective chlorination of steroids and other substrates directed by covalently linked pyridine derivatives acting as templates |
| US5990099A (en) | 1988-10-31 | 1999-11-23 | Alcon Laboratories, Inc. | Angiostatic agents and methods and compositions for controlling ocular hypertension |
| ES2062528T3 (es) | 1989-02-07 | 1994-12-16 | Upjohn Co | Deshalogenacion de compuestos organicos usando estaño o plomo. |
| DE4121484A1 (de) | 1991-06-26 | 1993-01-07 | Schering Ag | Verfahren zur herstellung von 6-methylensteroiden |
| US6172054B1 (en) | 1995-06-15 | 2001-01-09 | Alcon Laboratories, Inc. | Combination therapy for lowering and controlling intraocular pressure |
| WO2000049993A2 (en) | 1999-02-24 | 2000-08-31 | Nitromed, Inc. | Nitrosated and nitrosylated steroids for the treatment of cardiovascular diseases and disorders |
| CN1173695C (zh) * | 1999-06-14 | 2004-11-03 | 科斯默股份公司 | 控制释放与掩蔽味道的口服药物组合物 |
| IT1314184B1 (it) | 1999-08-12 | 2002-12-06 | Nicox Sa | Composizioni farmaceutiche per la terapia di condizioni di stressossidativo |
| EP1341541A4 (en) | 2000-11-16 | 2004-11-17 | Alcon Mfg Ltd | COMBINATION THERAPY FOR LOWERING AND CONTROLLING THE EYE PRESSURE |
| ITMI20011762A1 (it) | 2001-08-10 | 2003-02-10 | Cosmo Spa | Esteri di 17alfa,21-diidrossipregnene, loro uso come agenti anti-androgenetici e procedimenti per la loro preparazione |
| ITMI20051695A1 (it) | 2005-09-14 | 2007-03-15 | Cosmo Spa | Uso di 17a-esteri c3-c10 del 9,11-deidrocortexolone cme agenti anti-gonadotropinici |
| DE102006059063A1 (de) | 2005-12-24 | 2007-06-28 | Bayer Healthcare Ag | Verwendung von BAY 59-3074 zur Herstellung von Medikamenten zur Therapie von Hirntumoren sowie Kombinationen von BAY 59-3074 |
| US7687484B2 (en) | 2006-05-25 | 2010-03-30 | Bodor Nicholas S | Transporter enhanced corticosteroid activity |
| ITMI20071616A1 (it) * | 2007-08-03 | 2009-02-04 | Cosmo Spa | Processo enzimatico per l'ottenimento di 17-alfa monoesteri del cortexolone e/o suoi 9,11-deidroderivati. |
| CN101397317A (zh) | 2007-09-27 | 2009-04-01 | 天津药业研究院有限公司 | 一种新型硝酸酯类甾体化合物 |
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| RU2506974C1 (ru) | 2012-11-06 | 2014-02-20 | Федеральное государственное бюджетное учреждение "Ростовский научно-исследовательский онкологический институт" Министерства здравоохранения Российской Федерации | Способ лечения первично нерезектабельного рака легкого |
| JOP20200097A1 (ar) * | 2013-01-15 | 2017-06-16 | Aragon Pharmaceuticals Inc | معدل مستقبل أندروجين واستخداماته |
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2014
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Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR102520411B1 (ko) * | 2014-10-08 | 2023-04-11 | 코스모 테크놀러지스 리미티드 | 종양 치료에 사용하기 위한 코르텍솔론의 17ａ,21-디에스테르 |
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