DK3443096T5 - Sammensætninger og fremgangsmåder til selektiv ekspression af kimære antigenreceptorer - Google Patents

Sammensætninger og fremgangsmåder til selektiv ekspression af kimære antigenreceptorer Download PDF

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DK3443096T5
DK3443096T5 DK17737079.8T DK17737079T DK3443096T5 DK 3443096 T5 DK3443096 T5 DK 3443096T5 DK 17737079 T DK17737079 T DK 17737079T DK 3443096 T5 DK3443096 T5 DK 3443096T5
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compositions
methods
chimeric antigen
antigen receptors
selective expression
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DK17737079.8T
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English (en)
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DK3443096T3 (da
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Andrei Golosov
Carla Guimaraes
Gregory Motz
Michael Milone
Christoph T Ellebrecht
Aimee S Payne
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Novartis Ag
Univ Pennsylvania
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    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/7051—T-cell receptor (TcR)-CD3 complex
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A—HUMAN NECESSITIES
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    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
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    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/70517—CD8
    • C—CHEMISTRY; METALLURGY
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    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70575—NGF/TNF-superfamily, e.g. CD70, CD95L, CD153, CD154
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    • C07—ORGANIC CHEMISTRY
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    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622—Single chain antibody (scFv)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/03—Fusion polypeptide containing a localisation/targetting motif containing a transmembrane segment
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/50—Fusion polypeptide containing protease site
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/95—Fusion polypeptide containing a motif/fusion for degradation (ubiquitin fusions, PEST sequence)

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DK17737079.8T 2016-04-15 2017-04-14 Sammensætninger og fremgangsmåder til selektiv ekspression af kimære antigenreceptorer DK3443096T5 (da)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201662322931P 2016-04-15 2016-04-15
US201762481094P 2017-04-03 2017-04-03
PCT/US2017/027778 WO2017181119A2 (en) 2016-04-15 2017-04-14 Compositions and methods for selective protein expression

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DK3443096T3 DK3443096T3 (da) 2023-05-22
DK3443096T5 true DK3443096T5 (da) 2024-09-09

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US (1) US20230071283A1 (enExample)
EP (2) EP4219721A3 (enExample)
JP (3) JP7497955B6 (enExample)
KR (2) KR102821235B1 (enExample)
CN (1) CN109715808A (enExample)
AU (1) AU2017250304B2 (enExample)
BR (1) BR112018071096A2 (enExample)
CA (1) CA3021027A1 (enExample)
DK (1) DK3443096T5 (enExample)
ES (1) ES2944607T3 (enExample)
HR (1) HRP20230457T1 (enExample)
IL (2) IL312206A (enExample)
MX (3) MX2018012615A (enExample)
MY (1) MY209117A (enExample)
PH (1) PH12018502191A1 (enExample)
PL (1) PL3443096T3 (enExample)
PT (1) PT3443096T (enExample)
SG (1) SG11201809041TA (enExample)
SI (1) SI3443096T1 (enExample)
WO (1) WO2017181119A2 (enExample)

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