DK3416962T3 - 6,7-dihydro-5h-benzo[7]annulenderivater som modulatorer af østrogenreceptorer - Google Patents

6,7-dihydro-5h-benzo[7]annulenderivater som modulatorer af østrogenreceptorer Download PDF

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DK3416962T3
DK3416962T3 DK17705842.7T DK17705842T DK3416962T3 DK 3416962 T3 DK3416962 T3 DK 3416962T3 DK 17705842 T DK17705842 T DK 17705842T DK 3416962 T3 DK3416962 T3 DK 3416962T3
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benzo
dihydro
estrogen receptor
receptor modulators
annulene derivatives
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DK17705842.7T
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English (en)
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Maurice Brollo
Victor Certal
Youssef El-Ahmad
Bruno Filoche-Rommé
Frank Halley
Gary Mccort
Laurent Schio
Michel Tabart
Corinne Terrier
Fabienne Thompson
Monsif Bouaboula
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Sanofi Sa
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/4025—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil not condensed and containing further heterocyclic rings, e.g. cromakalim
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    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • A61K31/4015—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil having oxo groups directly attached to the heterocyclic ring, e.g. piracetam, ethosuximide
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    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
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    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
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    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic System
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    • C07F7/081—Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te
    • C07F7/0812—Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te comprising a heterocyclic ring
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    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
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    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
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    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers
DK17705842.7T 2016-02-15 2017-02-14 6,7-dihydro-5h-benzo[7]annulenderivater som modulatorer af østrogenreceptorer DK3416962T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP16305174 2016-02-15
PCT/EP2017/053282 WO2017140669A1 (en) 2016-02-15 2017-02-14 6,7-dihydro-5h-benzo[7]annulene derivatives as estrogen receptor modulators

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DK3416962T3 true DK3416962T3 (da) 2021-07-26

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DK19164243.8T DK3524600T3 (da) 2016-02-15 2017-02-14 Fremgangsmåder og mellemprodukter til fremstilling af hidtil ukendte substituerede 6,7-dihydro-5h-benzo[7]annulenforbindelser
DK17705842.7T DK3416962T3 (da) 2016-02-15 2017-02-14 6,7-dihydro-5h-benzo[7]annulenderivater som modulatorer af østrogenreceptorer

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DK19164243.8T DK3524600T3 (da) 2016-02-15 2017-02-14 Fremgangsmåder og mellemprodukter til fremstilling af hidtil ukendte substituerede 6,7-dihydro-5h-benzo[7]annulenforbindelser

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US (5) US9714221B1 (da)
EP (2) EP3416962B1 (da)
JP (4) JP6425852B1 (da)
KR (2) KR20180105759A (da)
CN (2) CN108884079B (da)
AR (1) AR107616A1 (da)
AU (2) AU2017221083B2 (da)
BR (1) BR112018016490A2 (da)
CA (1) CA3014424A1 (da)
CL (1) CL2018002290A1 (da)
CO (1) CO2018009534A2 (da)
CR (1) CR20180442A (da)
CY (1) CY1125165T1 (da)
DK (2) DK3524600T3 (da)
DO (1) DOP2018000184A (da)
EA (2) EA034994B1 (da)
EC (1) ECSP18069466A (da)
ES (2) ES2906208T3 (da)
HR (1) HRP20211043T1 (da)
HU (2) HUE055107T2 (da)
IL (2) IL261099B (da)
LT (1) LT3416962T (da)
MA (2) MA46479A (da)
MX (2) MX2020011469A (da)
MY (1) MY196486A (da)
PE (1) PE20181893A1 (da)
PH (1) PH12018501679A1 (da)
PL (1) PL3416962T3 (da)
PT (1) PT3416962T (da)
RS (1) RS62132B1 (da)
SG (2) SG10202106024XA (da)
SI (1) SI3416962T1 (da)
TN (1) TN2018000285A1 (da)
TW (3) TWI779620B (da)
UY (1) UY37124A (da)
WO (1) WO2017140669A1 (da)
ZA (1) ZA201805137B (da)

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WO2022001971A1 (zh) * 2020-06-28 2022-01-06 南京明德新药研发有限公司 并环吲唑类化合物
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TW202304424A (zh) 2021-04-12 2023-02-01 法商賽諾菲公司 包含依維莫司和安森司群的組合
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