DK3490986T3 - Piperidin-cxcr7-receptormodulatorer - Google Patents

Piperidin-cxcr7-receptormodulatorer Download PDF

Info

Publication number
DK3490986T3
DK3490986T3 DK17754283.4T DK17754283T DK3490986T3 DK 3490986 T3 DK3490986 T3 DK 3490986T3 DK 17754283 T DK17754283 T DK 17754283T DK 3490986 T3 DK3490986 T3 DK 3490986T3
Authority
DK
Denmark
Prior art keywords
piperidine
receptor modulators
cxcr7 receptor
cxcr7
modulators
Prior art date
Application number
DK17754283.4T
Other languages
English (en)
Inventor
Hamed Aissaoui
Philippe Guerry
Francois Lehembre
Julien Pothier
Laetitia Pouzol
Sylvia Richard-Bildstein
Shuguang Yuan
Original Assignee
Idorsia Pharmaceuticals Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Idorsia Pharmaceuticals Ltd filed Critical Idorsia Pharmaceuticals Ltd
Application granted granted Critical
Publication of DK3490986T3 publication Critical patent/DK3490986T3/da

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445Non condensed piperidines, e.g. piperocaine
    • A61K31/4523Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/4545Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • A61P13/12Drugs for disorders of the urinary system of the kidneys
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • A61P17/06Antipsoriatics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/02Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/08Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/08Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • A61P37/06Immunosuppressants, e.g. drugs for graft rejection
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/08Antiallergic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00Drugs for disorders of the endocrine system
    • A61P5/14Drugs for disorders of the endocrine system of the thyroid hormones, e.g. T3, T4
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D413/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D413/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D417/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07BGENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07Optical isomers
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07BGENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00Indexing scheme relating to specific properties of organic compounds
    • C07B2200/09Geometrical isomers
DK17754283.4T 2016-07-28 2017-07-27 Piperidin-cxcr7-receptormodulatorer DK3490986T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP2016068052 2016-07-28
PCT/EP2017/068990 WO2018019929A1 (en) 2016-07-28 2017-07-27 Piperidine cxcr7 receptor modulators

Publications (1)

Publication Number Publication Date
DK3490986T3 true DK3490986T3 (da) 2022-03-07

Family

ID=59656027

Family Applications (2)

Application Number Title Priority Date Filing Date
DK17754283.4T DK3490986T3 (da) 2016-07-28 2017-07-27 Piperidin-cxcr7-receptormodulatorer
DK20201796.8T DK3798217T3 (da) 2016-07-28 2017-07-27 Piperidin-cxcr7-receptormodulatorer

Family Applications After (1)

Application Number Title Priority Date Filing Date
DK20201796.8T DK3798217T3 (da) 2016-07-28 2017-07-27 Piperidin-cxcr7-receptormodulatorer

Country Status (32)

Country Link
US (2) US10752620B2 (da)
EP (2) EP3798217B1 (da)
JP (2) JP6655754B2 (da)
KR (2) KR102497095B1 (da)
CN (2) CN109563085B (da)
AR (2) AR109180A1 (da)
AU (2) AU2017302079B2 (da)
BR (1) BR112019001551A2 (da)
CA (1) CA3032017C (da)
CL (2) CL2019000169A1 (da)
CY (1) CY1125016T1 (da)
DK (2) DK3490986T3 (da)
EA (2) EA037507B1 (da)
ES (2) ES2954152T3 (da)
FI (1) FI3798217T3 (da)
HR (2) HRP20211988T1 (da)
HU (2) HUE057315T2 (da)
IL (2) IL264424B (da)
LT (2) LT3798217T (da)
MA (2) MA54653B1 (da)
MX (2) MX2019001042A (da)
MY (1) MY198113A (da)
NZ (1) NZ751006A (da)
PH (1) PH12019500188A1 (da)
PL (2) PL3490986T3 (da)
PT (2) PT3490986T (da)
RS (2) RS64130B1 (da)
SG (2) SG10201906942PA (da)
SI (2) SI3798217T1 (da)
TW (3) TWI683812B (da)
WO (1) WO2018019929A1 (da)
ZA (1) ZA201901256B (da)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR102502046B1 (ko) * 2018-01-26 2023-02-20 이도르시아 파마슈티컬스 리미티드 Cxcr7 수용체 작동제 (3s,4s)-1-시클로프로필메틸-4-{[5-(2,4-디플루오로-페닐)-이속사졸-3-카르보닐]-아미노}-피페리딘-3-카르복실산 (1-피리미딘-2-일-시클로프로필)-아미드의 결정질 형태
KR20220093330A (ko) 2019-10-31 2022-07-05 이도르시아 파마슈티컬스 리미티드 Cxcr7 안타고니스트와 s1p1 수용체 조절인자의 조합
WO2023012044A1 (en) 2021-08-02 2023-02-09 Syngenta Crop Protection Ag Microbiocidal pyrazole derivatives
CN117396471A (zh) * 2021-10-01 2024-01-12 株式会社次代生物科学 新的哌啶衍生物和包含其的用于抑制自分泌运动因子的药物组合物
WO2023110871A1 (en) 2021-12-17 2023-06-22 Syngenta Crop Protection Ag Microbiocidal pyrazole derivatives
EP4238970A1 (en) 2022-03-03 2023-09-06 InterAx Biotech AG Modulators of ackr3 and uses thereof
CN115403510B (zh) * 2022-08-11 2023-04-25 南方医科大学 一种pd-l1/cxcl12双靶点抑制剂、制备方法和用途

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040102324A1 (en) * 2002-02-28 2004-05-27 Annis Gary David Heterocyclic diamide invertebrate pest control agents
EP2431357A3 (en) 2002-11-27 2012-08-22 Incyte Corporation 3-Aminopyrrolidine Derivatives as Modulators of Chemokine Receptors
TW200526626A (en) * 2003-09-13 2005-08-16 Astrazeneca Ab Chemical compounds
WO2005032490A2 (en) 2003-10-08 2005-04-14 Bristol-Myers Squibb Company Cyclic diamines and derivatives as factor xa inhibitors
AU2006215399B2 (en) 2005-02-18 2010-12-09 Astrazeneca Ab Antibacterial piperidine derivatives
CA2742515C (en) * 2008-11-04 2017-07-11 Chemocentryx, Inc. 1,4-diazepane modulators of cxcr7
JP6094578B2 (ja) 2011-06-09 2017-03-15 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング 代謝性障害の治療のためのgpr119モジュレーターとしての置換ピペリジン
WO2013084241A1 (en) * 2011-12-09 2013-06-13 Cadila Healthcare Limited Compounds as inhibitors of renin
AR091516A1 (es) * 2012-06-22 2015-02-11 Actelion Pharmaceuticals Ltd Derivados de 1-[m-carboxamido(hetero)aril-metil]-heterociclil-carboxamida
RU2649004C2 (ru) * 2012-11-29 2018-03-29 Кемосентрикс, Инк. Антагонисты cxcr7
CA2912133C (en) 2013-05-30 2021-06-22 Actelion Pharmaceuticals Ltd Cxcr7 receptor modulators
AU2014315457B2 (en) 2013-09-04 2018-05-10 Bristol-Myers Squibb Company Compounds useful as immunomodulators
PT3363790T (pt) 2013-09-06 2020-05-06 Aurigene Discovery Tech Ltd Derivados 1,2,4-oxadiazoles como imunomoduladores
WO2015044900A1 (en) 2013-09-27 2015-04-02 Aurigene Discovery Technologies Limited Therapeutic immunomodulating compounds
MX2017002986A (es) * 2014-09-10 2017-10-24 Epizyme Inc Compuestos de piperidina sustituidos.
EP3227263B1 (en) 2014-12-01 2019-04-10 Idorsia Pharmaceuticals Ltd Cxcr7 receptor modulators
KR102502046B1 (ko) 2018-01-26 2023-02-20 이도르시아 파마슈티컬스 리미티드 Cxcr7 수용체 작동제 (3s,4s)-1-시클로프로필메틸-4-{[5-(2,4-디플루오로-페닐)-이속사졸-3-카르보닐]-아미노}-피페리딘-3-카르복실산 (1-피리미딘-2-일-시클로프로필)-아미드의 결정질 형태

Also Published As

Publication number Publication date
PL3490986T3 (pl) 2022-04-04
CY1125016T1 (el) 2023-03-24
IL264424A (en) 2019-02-28
CA3032017A1 (en) 2018-02-01
KR20200092420A (ko) 2020-08-03
TWI691497B (zh) 2020-04-21
MX2021004000A (es) 2021-06-23
KR102497091B1 (ko) 2023-02-06
EP3798217A1 (en) 2021-03-31
US20200385373A1 (en) 2020-12-10
ES2954152T3 (es) 2023-11-20
CA3032017C (en) 2023-04-18
SI3490986T1 (sl) 2022-02-28
JP6655742B2 (ja) 2020-02-26
JP6655754B2 (ja) 2020-02-26
EP3798217B1 (en) 2023-02-22
KR102497095B1 (ko) 2023-02-06
MA45782B1 (fr) 2021-12-31
US10752620B2 (en) 2020-08-25
CL2019003281A1 (es) 2020-05-04
AU2017302079A1 (en) 2019-03-21
RS62855B1 (sr) 2022-02-28
TWI683812B (zh) 2020-02-01
SG11201900633XA (en) 2019-02-27
MX2019001042A (es) 2019-06-10
MA45782A (fr) 2019-06-05
NZ751006A (en) 2021-07-30
US11306078B2 (en) 2022-04-19
TWI691494B (zh) 2020-04-21
TW201932454A (zh) 2019-08-16
AU2020204578A1 (en) 2020-07-30
DK3798217T3 (da) 2023-05-22
MA54653B1 (fr) 2023-04-28
EP3490986B1 (en) 2021-11-24
AR115662A2 (es) 2021-02-10
SI3798217T1 (sl) 2023-05-31
CN109563085A (zh) 2019-04-02
RS64130B1 (sr) 2023-05-31
CN110563717B (zh) 2022-08-09
EA202091262A1 (ru) 2020-08-13
HUE062019T2 (hu) 2023-09-28
ES2905755T3 (es) 2022-04-12
PH12019500188A1 (en) 2019-10-21
CN110563717A (zh) 2019-12-13
PT3490986T (pt) 2022-02-01
LT3490986T (lt) 2022-02-10
PL3798217T3 (pl) 2023-06-12
IL282942A (en) 2021-06-30
US20190169180A1 (en) 2019-06-06
IL264424B (en) 2021-08-31
FI3798217T3 (fi) 2023-05-03
IL282942B (en) 2022-01-01
HUE057315T2 (hu) 2022-04-28
SG10201906942PA (en) 2019-09-27
CL2019000169A1 (es) 2019-06-21
HRP20230313T1 (hr) 2023-05-12
TW201806940A (zh) 2018-03-01
KR20190034620A (ko) 2019-04-02
WO2018019929A1 (en) 2018-02-01
CN109563085B (zh) 2022-08-09
PT3798217T (pt) 2023-05-23
BR112019001551A2 (pt) 2019-05-14
EA201990388A1 (ru) 2019-08-30
HRP20211988T1 (hr) 2022-03-18
MY198113A (en) 2023-08-03
JP2019142874A (ja) 2019-08-29
MA54653A (fr) 2021-12-29
AR109180A1 (es) 2018-11-07
EP3490986A1 (en) 2019-06-05
AU2020204578B2 (en) 2022-03-10
LT3798217T (lt) 2023-05-25
ZA201901256B (en) 2021-08-25
EA037507B1 (ru) 2021-04-06
TW201922738A (zh) 2019-06-16
JP2019525927A (ja) 2019-09-12
AU2017302079B2 (en) 2021-07-22

Similar Documents

Publication Publication Date Title
MA43382A (fr) Modulateurs des récepteurs des chimiokines
MA55328A (fr) Modulateurs de ror-gamma
MA53943A (fr) Modulateurs de ror-gamma
DK3305266T3 (da) Stiftformig stimulationsindretning
DK3359160T3 (da) Farnesoid x receptor modulatorer
DK3405050T3 (da) Børnesikret snusbeholder
DK3404169T3 (da) Gondolanordning
DK3331876T3 (da) Modulators of ror-gamma
DK3368060T3 (da) Glugacon-receptor-agonister
DK3131902T3 (da) Forbindelser som ROR-gamma-modulatorer
DK3297438T3 (da) Ccr2-modulatorer
DK3848027T3 (da) Octahydro-kondenserede azadecalinglucocorticoidreceptormodulatorer
DK3743406T3 (da) Tmem16a modulatorer
DK3436823T3 (da) Antigen-array
DK3458111T3 (da) Immunomodulatorer til pet-billeddannelse
DK3490986T3 (da) Piperidin-cxcr7-receptormodulatorer
DK3445708T3 (da) Stigbøjle
BR112016022040A2 (pt) aparelho de fixação.
DK3335532T3 (da) Tandharve
DK3402792T3 (da) Quinolin-2-on-derivater
DK3426850T3 (da) Kabellægnings-indretning
MA52555A (fr) Modulateurs du récepteur des oestrogènes
DK3145916T3 (da) Imidazolderivater som formylpeptidreceptormodulatorer
DK3548016T3 (da) Ror-gamma (rory)-modulatorer
DE112017006386A5 (de) Schraubarbeitszylinder