DK3008168T3 - Sc-celler og sammensætninger og fremgangsmåde til dannelse deraf - Google Patents
Sc-celler og sammensætninger og fremgangsmåde til dannelse deraf Download PDFInfo
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- DK3008168T3 DK3008168T3 DK14819763.5T DK14819763T DK3008168T3 DK 3008168 T3 DK3008168 T3 DK 3008168T3 DK 14819763 T DK14819763 T DK 14819763T DK 3008168 T3 DK3008168 T3 DK 3008168T3
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- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0676—Pancreatic cells
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- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0676—Pancreatic cells
- C12N5/0678—Stem cells; Progenitor cells; Precursor cells
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/37—Digestive system
- A61K35/39—Pancreas; Islets of Langerhans
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
- A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
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- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0603—Embryonic cells ; Embryoid bodies
- C12N5/0606—Pluripotent embryonic cells, e.g. embryonic stem cells [ES]
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- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0696—Artificially induced pluripotent stem cells, e.g. iPS
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- C12N2500/00—Specific components of cell culture medium
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- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/10—Growth factors
- C12N2501/11—Epidermal growth factor [EGF]
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- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/10—Growth factors
- C12N2501/117—Keratinocyte growth factors (KGF-1, i.e. FGF-7; KGF-2, i.e. FGF-12)
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- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/10—Growth factors
- C12N2501/15—Transforming growth factor beta (TGF-β)
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- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
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- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/30—Hormones
- C12N2501/375—Thyroid stimulating hormone [TSH]
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- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/30—Hormones
- C12N2501/38—Hormones with nuclear receptors
- C12N2501/385—Hormones with nuclear receptors of the family of the retinoic acid recptor, e.g. RAR, RXR; Peroxisome proliferator-activated receptor [PPAR]
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- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
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- C12N2501/38—Hormones with nuclear receptors
- C12N2501/395—Thyroid hormones
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- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/40—Regulators of development
- C12N2501/41—Hedgehog proteins; Cyclopamine (inhibitor)
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- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/70—Enzymes
- C12N2501/72—Transferases [EC 2.]
- C12N2501/727—Kinases (EC 2.7.)
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
- C12N2506/02—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from embryonic cells
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- C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
- C12N2506/03—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from non-embryonic pluripotent stem cells
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- C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
- C12N2506/22—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from pancreatic cells
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- C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
- C12N2506/45—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from artificially induced pluripotent stem cells
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Zoology (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- Wood Science & Technology (AREA)
- General Health & Medical Sciences (AREA)
- Cell Biology (AREA)
- Diabetes (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Developmental Biology & Embryology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Gynecology & Obstetrics (AREA)
- Transplantation (AREA)
- Nutrition Science (AREA)
- Virology (AREA)
- Hematology (AREA)
- Gastroenterology & Hepatology (AREA)
- Obesity (AREA)
- Physiology (AREA)
- Immunology (AREA)
- Emergency Medicine (AREA)
- Epidemiology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361833898P | 2013-06-11 | 2013-06-11 | |
| US201461972212P | 2014-03-28 | 2014-03-28 | |
| PCT/US2014/041988 WO2015002724A2 (en) | 2013-06-11 | 2014-06-11 | SC-β CELLS AND COMPOSITIONS AND METHODS FOR GENERATING THE SAME |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK3008168T3 true DK3008168T3 (da) | 2020-05-04 |
Family
ID=52022750
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK14819763.5T DK3008168T3 (da) | 2013-06-11 | 2014-06-11 | Sc-celler og sammensætninger og fremgangsmåde til dannelse deraf |
Country Status (17)
| Country | Link |
|---|---|
| US (16) | US20170029778A1 (https=) |
| EP (4) | EP4461806A3 (https=) |
| JP (8) | JP6514689B2 (https=) |
| KR (12) | KR102631225B1 (https=) |
| CN (6) | CN120796168A (https=) |
| AU (7) | AU2014284677B2 (https=) |
| BR (2) | BR112015030946A8 (https=) |
| CA (2) | CA2915091A1 (https=) |
| DE (2) | DE202014011287U1 (https=) |
| DK (1) | DK3008168T3 (https=) |
| GB (3) | GB2531952C (https=) |
| HK (1) | HK1257187B (https=) |
| MX (2) | MX2015017103A (https=) |
| PH (1) | PH12015502767A1 (https=) |
| RU (2) | RU2016100219A (https=) |
| SG (3) | SG10201710218RA (https=) |
| WO (2) | WO2015002724A2 (https=) |
Families Citing this family (105)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK2185693T3 (da) | 2007-07-31 | 2019-09-23 | Lifescan Inc | Differentiering af humane embryoniske stamceller |
| CA2954431C (en) | 2007-11-27 | 2021-08-24 | Lifescan, Inc. | Differentiation of human embryonic stem cells to pancreatic cells |
| FI2794857T3 (fi) | 2011-12-22 | 2026-03-25 | Janssen Biotech Inc | Ihmisen alkion kantasolujen erilaistaminen yksittäisiksi hormonaalisiksi insuliinipositiivisiksi soluiksi |
| DK2938723T3 (da) | 2012-12-31 | 2023-02-20 | Janssen Biotech Inc | Differentiering af humane embryonale stamceller til pancreatiske endokrine celler under anvendelse af hb9-regulatorer |
| ES2924479T3 (es) | 2013-04-08 | 2022-10-07 | Harvard College | Composiciones para rejuvenecer las células madre del músculo esquelético |
| CN120796168A (zh) | 2013-06-11 | 2025-10-17 | 哈佛学院校长同事会 | SC-β细胞以及用于产生其的组合物和方法 |
| WO2015175307A1 (en) | 2014-05-16 | 2015-11-19 | Janssen Biotech, Inc. | Use of small molecules to enhance mafa expression in pancreatic endocrine cells |
| WO2016100921A1 (en) * | 2014-12-18 | 2016-06-23 | President And Fellows Of Harvard College | METHODS FOR GENERATING STEM CELL-DERIVED β CELLS AND USES THEREOF |
| WO2016100898A1 (en) | 2014-12-18 | 2016-06-23 | President And Fellows Of Harvard College | Serum-free in vitro directed differentiation protocol for generating stem cell-derived b cells and uses thereof |
| CN107614678B (zh) | 2014-12-18 | 2021-04-30 | 哈佛学院校长同事会 | 干细胞来源的β细胞的产生方法及其使用方法 |
| EP3234110B1 (en) | 2014-12-18 | 2024-02-28 | President and Fellows of Harvard College | METHODS FOR GENERATING STEM CELL-DERIVED ß CELLS AND USES THEREOF |
| US10196613B2 (en) | 2014-12-19 | 2019-02-05 | Regeneron Pharmaceuticals, Inc. | Stem cells for modeling type 2 diabetes |
| EP3286563B1 (en) * | 2015-04-23 | 2022-11-02 | The Regents of The University of California | Controlled induction of human pancreatic progenitors produces functional beta-like cells |
| EP3285572B1 (en) * | 2015-04-24 | 2020-12-02 | University of Copenhagen | Method for production of insulin-producing cells |
| EP3819372A3 (en) * | 2015-04-24 | 2021-10-06 | University of Copenhagen | Isolation of bona fide pancreatic progenitor cells |
| EP3328404A4 (en) * | 2015-07-27 | 2018-12-26 | The Regents of The University of California | Methods and compositions for producing pancreatic beta cells |
| EP3369811B1 (en) * | 2015-10-29 | 2025-09-03 | Juntendo Educational Foundation | Method for producing pancreatic endocrine cells, and transdifferentiation agent |
| US11116777B2 (en) | 2015-11-10 | 2021-09-14 | City Of Hope | Conditioning regimens and methods for inducing mixed chimerism |
| WO2017116569A1 (en) * | 2015-12-31 | 2017-07-06 | City Of Hope | Methods for treating diabetes |
| CA3010799A1 (en) | 2016-01-06 | 2017-07-13 | President And Fellows Of Harvard College | Treatment with gdf11 prevents weight gain, improves glucose tolerance and reduces hepatosteatosis |
| US20190018000A1 (en) | 2016-01-12 | 2019-01-17 | Cedars-Sinai Medical Center | A method of non destructive monitoring of biological processes in microfluidic tissue culture systems |
| EP3411470A4 (en) | 2016-02-01 | 2019-10-09 | Emulate, Inc. | SYSTEMS AND METHOD FOR BREEDING DARM CELLS IN MICROFLUIDIC DEVICES |
| CN108699515A (zh) * | 2016-02-24 | 2018-10-23 | 诺和诺德股份有限公司 | 由人多能干细胞衍生的内分泌祖细胞生成功能性β细胞 |
| US10213511B2 (en) | 2016-03-02 | 2019-02-26 | Frequency Therapeutics, Inc. | Thermoreversible compositions for administration of therapeutic agents |
| US20190060371A1 (en) * | 2016-03-02 | 2019-02-28 | Frequency Therapeutics, Inc. | Methods for controlled proliferation of vestibular stem cells / generating inner ear hair cells using wnt and tgfbeta-inhibition |
| US10201540B2 (en) | 2016-03-02 | 2019-02-12 | Frequency Therapeutics, Inc. | Solubilized compositions for controlled proliferation of stem cells / generating inner ear hair cells using GSK3 inhibitors: I |
| ES3002713T3 (en) | 2016-04-08 | 2025-03-07 | Univ California | Production of fully functional mature beta cells from human pancreatic progenitors |
| WO2017214465A1 (en) * | 2016-06-09 | 2017-12-14 | Georgetown University | Process for continuous cell culture of islet cells |
| MD4194548T2 (ro) | 2016-06-21 | 2026-02-28 | Janssen Biotech Inc | Generarea de celule beta funcționale derivate din celule stem pluripotente umane care posedă respirație mitocondrială dependentă - de glucoză și răspuns la secreția de insulină în două faze |
| US12338462B2 (en) | 2016-11-16 | 2025-06-24 | Allele Biotechnology And Pharmaceuticals, Inc. | Induction of pancreatic beta cells by stem cell differentiation with RNA |
| KR102586507B1 (ko) | 2016-11-16 | 2023-10-11 | 알렐 바이오테크놀로지 앤 파마슈티칼스, 인크. | Rna를 사용한 줄기 세포 분화에 의한 간세포의 유도 |
| US11913022B2 (en) | 2017-01-25 | 2024-02-27 | Cedars-Sinai Medical Center | In vitro induction of mammary-like differentiation from human pluripotent stem cells |
| KR101745297B1 (ko) | 2017-02-02 | 2017-06-09 | 경북대학교 산학협력단 | 비만 진단용 조성물 및 이의 용도 |
| US11767513B2 (en) | 2017-03-14 | 2023-09-26 | Cedars-Sinai Medical Center | Neuromuscular junction |
| WO2018176001A2 (en) | 2017-03-24 | 2018-09-27 | Cedars-Sinai Medical Center | Methods and compositions for production of fallopian tube epithelium |
| US10767164B2 (en) | 2017-03-30 | 2020-09-08 | The Research Foundation For The State University Of New York | Microenvironments for self-assembly of islet organoids from stem cells differentiation |
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