DK2989975T3 - Optiske systemer og fremgangsmåder til ratiometrisk måling af blodglucosekoncentration - Google Patents

Optiske systemer og fremgangsmåder til ratiometrisk måling af blodglucosekoncentration Download PDF

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Publication number
DK2989975T3
DK2989975T3 DK15183137.7T DK15183137T DK2989975T3 DK 2989975 T3 DK2989975 T3 DK 2989975T3 DK 15183137 T DK15183137 T DK 15183137T DK 2989975 T3 DK2989975 T3 DK 2989975T3
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Prior art keywords
light
glucose
emission
certain embodiments
excitation
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DK15183137.7T
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English (en)
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David R Markle
Ritchie A Wessling
Donald J Kolehmainen
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Medtronic Minimed Inc
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
    • A61B5/14532—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue for measuring glucose, e.g. by tissue impedance measurement
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
    • A61B5/0071—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence by measuring fluorescence emission
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
    • A61B5/1455—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using optical sensors, e.g. spectral photometrical oximeters
    • A61B5/14551—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using optical sensors, e.g. spectral photometrical oximeters for measuring blood gases
    • A61B5/14552—Details of sensors specially adapted therefor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
    • A61B5/1455—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using optical sensors, e.g. spectral photometrical oximeters
    • A61B5/1459—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using optical sensors, e.g. spectral photometrical oximeters invasive, e.g. introduced into the body by a catheter
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/72—Signal processing specially adapted for physiological signals or for diagnostic purposes
    • A61B5/7203—Signal processing specially adapted for physiological signals or for diagnostic purposes for noise prevention, reduction or removal
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/6428—Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes"
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/645—Specially adapted constructive features of fluorimeters

Claims (4)

1. Optisk indretning til bestemmelse af blodglucosekoncentration, hvilken indretning omfatter: en excitationslyskilde (401), der udsender et excitationslyssignal; en fiberoptisk sensor (407), som er dimensioneret til at blive anbragt i et blodkar, idet sensoren er optisk koblet til excitationslyskilden (401) og omfatter et indikatorsystem, der omfatter en fluorofor, som er operabelt koblet til en glucosebindende gruppe, hvor indikatorsystemet efter absorption af mindst en del af excitationslyssignalet udsender et første emissionslyssignal med en første emissionsbølgelængde og et andet emissionslyssignal med en anden emissionsbølgelængde; og et mikrospektrometer (411), som er operabelt koblet til mindst den fiberoptiske sensor (407); kendetegnet ved, at: mikrospektrometret (411) er konfigureret til samtidigt at måle excitationslysintensiteten samt begge emissionslysintensiteter; hvor forholdet mellem den målte intensitet for det første emissionslyssignal og den målte excitationslysintensitet er forbundet med glucosekoncentration; forholdet mellem den målte intensitet for det andet emissionslyssignal og den målte excitationslysintensitet er forbundet med glucosekoncentration; og hvor forholdet mellem de målte intensiteter for det første og det andet emissionslyssignal ikke er følsomt over for glucose og følsomt over for pH.
2. Optisk indretning ifølge krav 1, hvor data fra mikrospektrometret (411) sendes til en computer (412) med henblik på bearbejdning.
3. Optisk indretning ifølge krav 1, hvor fluoroforen er et fluorescerende organisk farvestof.
4. Optisk indretning ifølge krav 3, hvor: den glucosebindende gruppe er et funktionaliseret borsyreviologen; og indikatorsystemet omfatter en hydrogelmatrix.
DK15183137.7T 2007-02-06 2008-02-06 Optiske systemer og fremgangsmåder til ratiometrisk måling af blodglucosekoncentration DK2989975T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US88847707P 2007-02-06 2007-02-06
EP08729209A EP2120680A2 (en) 2007-02-06 2008-02-06 Optical systems and methods for rationmetric measurement of blood glucose concentration

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DK2989975T3 true DK2989975T3 (da) 2018-09-24

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US (2) US8838195B2 (da)
EP (2) EP2120680A2 (da)
JP (1) JP2010517693A (da)
AU (1) AU2008213677A1 (da)
CA (1) CA2677009A1 (da)
DK (1) DK2989975T3 (da)
WO (1) WO2008098087A2 (da)

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