DK2932265T3 - Probiotiske stammer til behandlingen og/eller forebyggelsen af diarré - Google Patents
Probiotiske stammer til behandlingen og/eller forebyggelsen af diarré Download PDFInfo
- Publication number
- DK2932265T3 DK2932265T3 DK13820807.9T DK13820807T DK2932265T3 DK 2932265 T3 DK2932265 T3 DK 2932265T3 DK 13820807 T DK13820807 T DK 13820807T DK 2932265 T3 DK2932265 T3 DK 2932265T3
- Authority
- DK
- Denmark
- Prior art keywords
- strain
- diarrhea
- protein
- expression
- probiotic
- Prior art date
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Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/20—Bacteria; Culture media therefor
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/12—Antidiarrhoeals
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/20—Bacteria; Culture media therefor
- C12N1/205—Bacterial isolates
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
- G01N33/5044—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics involving specific cell types
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
- G01N33/56911—Bacteria
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/135—Bacteria or derivatives thereof, e.g. probiotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K2035/11—Medicinal preparations comprising living procariotic cells
- A61K2035/115—Probiotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/66—Microorganisms or materials therefrom
- A61K35/74—Bacteria
- A61K35/741—Probiotics
- A61K35/742—Spore-forming bacteria, e.g. Bacillus coagulans, Bacillus subtilis, clostridium or Lactobacillus sporogenes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
- C12R2001/00—Microorganisms ; Processes using microorganisms
- C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
- C12R2001/07—Bacillus
- C12R2001/125—Bacillus subtilis ; Hay bacillus; Grass bacillus
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2500/00—Screening for compounds of potential therapeutic value
- G01N2500/10—Screening for compounds of potential therapeutic value involving cells
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Urology & Nephrology (AREA)
- Hematology (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Cell Biology (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Tropical Medicine & Parasitology (AREA)
- Analytical Chemistry (AREA)
- Physics & Mathematics (AREA)
- Food Science & Technology (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Zoology (AREA)
- Organic Chemistry (AREA)
- Virology (AREA)
- Wood Science & Technology (AREA)
- Genetics & Genomics (AREA)
- Toxicology (AREA)
- General Engineering & Computer Science (AREA)
- Mycology (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Claims (8)
1. Fremgangsmåde til at vælge en probiotisk stamme til behandling og/eller forebyggelse af diarré, hvor nævnte fremgangsmåde omfatter trinnene: - at måle effekten af mindst én teststamme ved udtryk af CFTR-protein et i en biologisk prøve, og - at vælge mindst én stamme der inducerer en reduktion i udtryk af CFTR-proteinet, hvor den biologiske prøve er en proksimal tarm- eller colonocytprøve.
2. Fremgangsmåde til at vælge ifølge krav 1, hvor nævnte fremgangsmåde omfatter trinnene: - at måle effekten af mindst én teststamme ved udtryk af NHE3-proteinet i en biologisk prøve, og - at vælge mindst én stamme der inducerer en stigning i udtryk af NHE3-proteinet, hvor den biologiske prøve er en proksimal tarm- eller colonocytprøve.
3. Fremgangsmåde til at vælge ifølge krav 1 eller krav 2, kendetegnet ved, at teststammen er en gærstamme eller en bakteriestamme.
4. Fremgangsmåde til at vælge ifølge krav 3, kendetegnet ved, at bakteriestammen er en stamme af Bacillus, fortrinsvis en stamme af Bacillus subtilis.
5. Fremgangsmåde til at vælge ifølge et hvilket som helst af kravene 1 til 4, kendetegnet ved, at udtrykket af CFTR-proteinet og/eller af NHE3-proteinet er målt ved elektroforese, Western-blot, immunoassay, immunohistokemi, immunocytokemi, massespektrometri, RT-PCR eller Northern-blot.
6. Probiotisk stamme, eller sammensætning omfattende nævnte probiotiske stamme til anvendelse i behandlingen og/eller forebyggelse af diarré, kendetegnet ved, at den probiotiske stamme er stammen af Bacillus subtilis CU1 deponeret hos CNCM den 25. oktober 2001 under nummer 1-2745.
7. Probiotisk stamme, eller sammensætning til anvendelse ifølge krav 6, kendetegnet ved, at diarréen er akut diarré eller kronisk diarré.
8. Probiotisk stamme, eller sammensætning til anvendelse ifølge krav 6 eller krav 7, kendetegnet ved, at diarréen er diarré af infektiøs oprindelse eller diarré af ikke-infektiøs oprindelse.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR1261916A FR2999191B1 (fr) | 2012-12-12 | 2012-12-12 | Souches probiotiques pour le traitement et/ou la prevention de la diarrhee |
| PCT/FR2013/053044 WO2014091160A1 (fr) | 2012-12-12 | 2013-12-12 | Souches probiotiques pour le traitement et/ou la prévention de la diarrhée |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK2932265T3 true DK2932265T3 (da) | 2018-11-26 |
Family
ID=48128446
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK13820807.9T DK2932265T3 (da) | 2012-12-12 | 2013-12-12 | Probiotiske stammer til behandlingen og/eller forebyggelsen af diarré |
Country Status (14)
| Country | Link |
|---|---|
| US (2) | US20160000840A1 (da) |
| EP (1) | EP2932265B1 (da) |
| JP (1) | JP6401180B2 (da) |
| KR (1) | KR102181606B1 (da) |
| CN (1) | CN105008924B9 (da) |
| CA (1) | CA2893990C (da) |
| DK (1) | DK2932265T3 (da) |
| ES (1) | ES2692660T3 (da) |
| FR (1) | FR2999191B1 (da) |
| PH (1) | PH12015501273A1 (da) |
| RU (1) | RU2642320C2 (da) |
| SG (1) | SG11201504542PA (da) |
| TW (1) | TWI602921B (da) |
| WO (1) | WO2014091160A1 (da) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR3007655B1 (fr) * | 2013-06-28 | 2016-12-23 | Lesaffre & Cie | Souche bacillus subtilis pour le traitement et/ou la prevention de maladies inflammatoires chroniques |
| US11173184B2 (en) | 2016-05-31 | 2021-11-16 | Evonik Operations Gmbh | Bacillus subtilis strain with probiotic activity |
| JP6991162B2 (ja) * | 2016-05-31 | 2022-02-04 | エボニック オペレーションズ ゲーエムベーハー | プロバイオティック活性を示すバチルス・サブティリス（Ｂａｃｉｌｌｕｓ ｓｕｂｔｉｌｉｓ）菌株 |
| BE1027162B1 (nl) * | 2019-03-29 | 2020-11-05 | My Res Comm V | Bacillus coagulans en Bacillus subtilis voor de preventie en behandeling van functionele gastro-intestinale stoornissen |
| CN113462597A (zh) * | 2021-06-29 | 2021-10-01 | 广西壮族自治区兽医研究所 | 一种产木质素过氧化物酶的枯草芽孢杆菌和含有该枯草芽孢杆菌的菌剂及其应用 |
| CN114947134B (zh) * | 2022-05-06 | 2024-01-26 | 河北一然生物科技股份有限公司 | 嗜热链球菌s131在改善肠道健康及调节肠道菌群中的应用 |
| CN116463258B (zh) * | 2023-04-12 | 2024-01-09 | 山东威曼宠物食品有限公司 | 一种用于预防宠物腹泻的凝结芽孢杆菌King27及菌剂、制备方法和应用 |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2528055B2 (ja) * | 1991-10-04 | 1996-08-28 | カルピス食品工業株式会社 | 鳥類飼料添加用腸内サルモネラ属細菌減少剤及びその使用法 |
| JP2837835B2 (ja) * | 1996-05-15 | 1998-12-16 | オリンパス光学工業株式会社 | 射出成形機における金型要素自動交換方法 |
| FR2837835B1 (fr) | 2002-03-29 | 2007-06-22 | Maria Urdaci | Souche bacillus subtilis cu1, son utilisation comme agent immunomodulateur du systeme immunitaire et vaccin recombinant vivant contre h. pylori la contenant |
| PL376147A1 (en) | 2002-09-30 | 2005-12-27 | The Regents Of The University Of California | Cystic fibrosis transmembrane conductance regulator protein inhibitors and uses thereof |
| RU2246537C2 (ru) * | 2002-11-11 | 2005-02-20 | Закрытое акционерное общество "КУЛ" | Штамм бактерий bacillus subtilis, используемый для получения пробиотического препарата, предназначенного для профилактики и лечения желудочно-кишечных заболеваний сельскохозяйственных животных, птицы и рыбы |
| US20080057047A1 (en) * | 2005-11-29 | 2008-03-06 | Benedikt Sas | Use of bacillus amyloliquefaciens PB6 for the prophylaxis or treatment of gastrointestinal and immuno-related diseases |
| JP4805859B2 (ja) * | 2007-02-02 | 2011-11-02 | 全国農業協同組合連合会 | 飼料添加剤 |
| JP2009044971A (ja) * | 2007-08-15 | 2009-03-05 | National Agriculture & Food Research Organization | 反芻家畜に対するプロバイオティック効果をサイレージ調製用乳酸菌に付加する新規酵母菌およびその利用 |
| AU2009228307A1 (en) * | 2008-03-25 | 2009-10-01 | The Regents Of The University Of California | Water soluble small molecule inhibitors of the cystic fibrosis transmembrane conductance regulator |
| EP2341776A4 (en) * | 2008-09-19 | 2012-05-30 | Inst Oneworld Health | COMPOUNDS, COMPOSITIONS AND METHODS COMPRISING IMIDAZOL AND TRIAZOL DERIVATIVES |
| CA2751215A1 (en) * | 2009-02-02 | 2010-08-05 | Chromocell Corporation | Cell lines expressing cftr and methods of using them |
| JP5769333B2 (ja) * | 2010-07-09 | 2015-08-26 | 雪印種苗株式会社 | セロトニン代謝性バチルス属菌 |
| CN102732464A (zh) * | 2012-06-29 | 2012-10-17 | 扬州大学 | 一种用于快速初步筛选具有免疫调节功能益生菌的方法 |
-
2012
- 2012-12-12 FR FR1261916A patent/FR2999191B1/fr active Active
-
2013
- 2013-12-12 KR KR1020157015784A patent/KR102181606B1/ko active IP Right Grant
- 2013-12-12 US US14/649,763 patent/US20160000840A1/en not_active Abandoned
- 2013-12-12 ES ES13820807.9T patent/ES2692660T3/es active Active
- 2013-12-12 JP JP2015547122A patent/JP6401180B2/ja active Active
- 2013-12-12 CN CN201380064960.8A patent/CN105008924B9/zh active Active
- 2013-12-12 DK DK13820807.9T patent/DK2932265T3/da active
- 2013-12-12 CA CA2893990A patent/CA2893990C/fr active Active
- 2013-12-12 EP EP13820807.9A patent/EP2932265B1/fr active Active
- 2013-12-12 TW TW102145855A patent/TWI602921B/zh active
- 2013-12-12 RU RU2015128101A patent/RU2642320C2/ru active
- 2013-12-12 SG SG11201504542PA patent/SG11201504542PA/en unknown
- 2013-12-12 WO PCT/FR2013/053044 patent/WO2014091160A1/fr active Application Filing
-
2015
- 2015-06-04 PH PH12015501273A patent/PH12015501273A1/en unknown
-
2018
- 2018-10-10 US US16/156,576 patent/US10736925B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| US20190038681A1 (en) | 2019-02-07 |
| CA2893990A1 (fr) | 2014-06-19 |
| US10736925B2 (en) | 2020-08-11 |
| SG11201504542PA (en) | 2015-07-30 |
| CA2893990C (fr) | 2021-05-11 |
| KR20150093172A (ko) | 2015-08-17 |
| CN105008924A (zh) | 2015-10-28 |
| KR102181606B1 (ko) | 2020-11-23 |
| CN105008924B (zh) | 2017-03-08 |
| RU2642320C2 (ru) | 2018-01-24 |
| RU2015128101A (ru) | 2017-01-19 |
| EP2932265B1 (fr) | 2018-08-15 |
| EP2932265A1 (fr) | 2015-10-21 |
| JP2016505254A (ja) | 2016-02-25 |
| FR2999191B1 (fr) | 2016-02-05 |
| ES2692660T3 (es) | 2018-12-04 |
| PH12015501273B1 (en) | 2015-08-24 |
| PH12015501273A1 (en) | 2015-08-24 |
| TWI602921B (zh) | 2017-10-21 |
| FR2999191A1 (fr) | 2014-06-13 |
| WO2014091160A1 (fr) | 2014-06-19 |
| CN105008924B9 (zh) | 2017-04-19 |
| JP6401180B2 (ja) | 2018-10-03 |
| TW201437373A (zh) | 2014-10-01 |
| US20160000840A1 (en) | 2016-01-07 |
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