DK2733492T3 - Fremgangsmåde til detektering af cancer - Google Patents

Fremgangsmåde til detektering af cancer Download PDF

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DK2733492T3
DK2733492T3 DK14153299.4T DK14153299T DK2733492T3 DK 2733492 T3 DK2733492 T3 DK 2733492T3 DK 14153299 T DK14153299 T DK 14153299T DK 2733492 T3 DK2733492 T3 DK 2733492T3
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DK14153299.4T
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Fumiyoshi Okano
Kana Suzuki
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Toray Industries
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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57407—Specifically defined cancers
    • G01N33/57415—Specifically defined cancers of breast
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57407—Specifically defined cancers
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/112—Disease subtyping, staging or classification

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Analytical Chemistry (AREA)
  • Pathology (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Oncology (AREA)
  • Organic Chemistry (AREA)
  • Hospice & Palliative Care (AREA)
  • Cell Biology (AREA)
  • General Physics & Mathematics (AREA)
  • Medicinal Chemistry (AREA)
  • Food Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Biophysics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Investigating Or Analysing Biological Materials (AREA)

Claims (7)

1. Fremgangsmåde til detektering af en cancer, der omfatter måling af ekspression af et polypeptid, som har en reaktivitet med hensyn til binding via en antigen-antistof-reaktion til et antistof mod et CAPRIN-1-protein med enhver af aminosyresekvenserne, der er vist i SEQ ID NR.: 2-30 med lige nummer i sekvenslisten, på en cancercelleflade i en prøve, der er adskilt fra en levende organisme.
2. Fremgangsmåde ifølge krav 1, hvorved polypeptidet, der skal måles, er et CAPRIN-1-protein, der har enhver af aminosyresekvenserne, der er vist i SEQ ID NR.: 2-30 med lige nummer, eller et polypeptid med 85 % eller mere sekvensidentitet med CAPRIN-1-proteinet.
3. Fremgangsmåde ifølge krav 1 eller 2, hvorved den levende organisme er et menneske, en hund eller en kat.
4. Fremgangsmåde ifølge krav 3, hvorved den levende organisme er en hund, og polypeptidet, der skal måles, har en aminosyresekvens, som er vist i SEQ ID NR.: 6, 8, 10, 12 eller 14.
5. Fremgangsmåde ifølge krav 3, hvorved den levende organisme er et menneske, og polypeptidet, der skal måles, har den i SEQ ID NR.: 2 eller 4 viste aminosyresekvens.
6. Fremgangsmåde ifølge et hvilket som helst af kravene 1 til 5, der endvidere omfatter detektering af malignitet af en cancer baseret på det faktum, at malignitet af cancer er høj, når polypeptidets ekspressionsniveau er højere end en kontrols.
7. Fremgangsmåde ifølge et hvilket som helst af kravene 1 til 6, der endvidere omfatter detektering af progression af cancer på basis af den indikator, at omfanget af cancer er fremskredent, når polypeptidets ekspressionsniveau er højere end en kontrols.
DK14153299.4T 2008-08-05 2009-08-05 Fremgangsmåde til detektering af cancer DK2733492T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2008202320 2008-08-05
EP09805010.7A EP2325648B1 (en) 2008-08-05 2009-08-05 Method for detecting cancer

Publications (1)

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DK2733492T3 true DK2733492T3 (da) 2016-04-25

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DK14153299.4T DK2733492T3 (da) 2008-08-05 2009-08-05 Fremgangsmåde til detektering af cancer

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Country Status (16)

Country Link
US (1) US11137401B2 (da)
EP (2) EP2733492B1 (da)
JP (2) JP5644110B2 (da)
KR (2) KR101606779B1 (da)
CN (1) CN102171570B (da)
AU (2) AU2009278387B2 (da)
BR (1) BRPI0911925B8 (da)
CA (1) CA2732980C (da)
DK (2) DK2325648T3 (da)
ES (2) ES2570731T3 (da)
HU (1) HUE027332T2 (da)
MX (2) MX337991B (da)
PL (2) PL2733492T3 (da)
PT (1) PT2325648E (da)
RU (2) RU2519089C2 (da)
WO (1) WO2010016527A1 (da)

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