ES2539603T3 - Agente inductor de inmunidad - Google Patents
Agente inductor de inmunidad Download PDFInfo
- Publication number
- ES2539603T3 ES2539603T3 ES09805008.1T ES09805008T ES2539603T3 ES 2539603 T3 ES2539603 T3 ES 2539603T3 ES 09805008 T ES09805008 T ES 09805008T ES 2539603 T3 ES2539603 T3 ES 2539603T3
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- Prior art keywords
- polypeptide
- agent
- immunity inducing
- cancer
- inducing agent
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- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 230000036039 immunity Effects 0.000 title abstract description 15
- 230000001939 inductive effect Effects 0.000 title abstract description 14
- 239000003795 chemical substances by application Substances 0.000 abstract description 26
- 229920001184 polypeptide Polymers 0.000 abstract description 12
- 108090000765 processed proteins & peptides Proteins 0.000 abstract description 12
- 102000004196 processed proteins & peptides Human genes 0.000 abstract description 12
- 238000000034 method Methods 0.000 abstract description 4
- 150000001413 amino acids Chemical class 0.000 abstract description 3
- 238000001727 in vivo Methods 0.000 abstract description 2
- 239000004480 active ingredient Substances 0.000 abstract 1
- 125000003275 alpha amino acid group Chemical group 0.000 abstract 1
- 102000040430 polynucleotide Human genes 0.000 abstract 1
- 108091033319 polynucleotide Proteins 0.000 abstract 1
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- 208000031422 Lymphocytic Chronic B-Cell Leukemia Diseases 0.000 description 2
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 2
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- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 description 2
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- IISBACLAFKSPIT-UHFFFAOYSA-N bisphenol A Chemical compound C=1C=C(O)C=CC=1C(C)(C)C1=CC=C(O)C=C1 IISBACLAFKSPIT-UHFFFAOYSA-N 0.000 description 1
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- 239000003814 drug Substances 0.000 description 1
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- 230000002708 enhancing effect Effects 0.000 description 1
- 201000004101 esophageal cancer Diseases 0.000 description 1
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- 239000008273 gelatin Substances 0.000 description 1
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- 235000019322 gelatine Nutrition 0.000 description 1
- 235000011852 gelatine desserts Nutrition 0.000 description 1
- 239000008187 granular material Substances 0.000 description 1
- 230000028993 immune response Effects 0.000 description 1
- 230000006698 induction Effects 0.000 description 1
- -1 inhalers Substances 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
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- 238000001361 intraarterial administration Methods 0.000 description 1
- 238000007918 intramuscular administration Methods 0.000 description 1
- 238000001990 intravenous administration Methods 0.000 description 1
- 239000008101 lactose Substances 0.000 description 1
- 208000032839 leukemia Diseases 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 239000000314 lubricant Substances 0.000 description 1
- 201000005202 lung cancer Diseases 0.000 description 1
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- 210000001165 lymph node Anatomy 0.000 description 1
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- 235000019359 magnesium stearate Nutrition 0.000 description 1
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- 208000004019 papillary adenocarcinoma Diseases 0.000 description 1
- 238000007911 parenteral administration Methods 0.000 description 1
- 229920001223 polyethylene glycol Polymers 0.000 description 1
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- 230000003449 preventive effect Effects 0.000 description 1
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- 239000000243 solution Substances 0.000 description 1
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- 239000000829 suppository Substances 0.000 description 1
- 239000003826 tablet Substances 0.000 description 1
- 239000000454 talc Substances 0.000 description 1
- 229910052623 talc Inorganic materials 0.000 description 1
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- 210000001519 tissue Anatomy 0.000 description 1
- 235000010487 tragacanth Nutrition 0.000 description 1
- 239000000196 tragacanth Substances 0.000 description 1
- 229940116362 tragacanth Drugs 0.000 description 1
- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/08—Peptides having 5 to 11 amino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/10—Peptides having 12 to 20 amino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- A61K38/1709—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/19—Cytokines; Lymphokines; Interferons
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/0005—Vertebrate antigens
- A61K39/0011—Cancer antigens
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/46—Cellular immunotherapy
- A61K39/463—Cellular immunotherapy characterised by recombinant expression
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
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- A—HUMAN NECESSITIES
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- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4748—Tumour specific antigens; Tumour rejection antigen precursors [TRAP], e.g. MAGE
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0634—Cells from the blood or the immune system
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
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- A—HUMAN NECESSITIES
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- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/53—DNA (RNA) vaccination
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- A61K38/00—Medicinal preparations containing peptides
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Zoology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- Biomedical Technology (AREA)
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- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Wood Science & Technology (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Microbiology (AREA)
- Epidemiology (AREA)
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- Toxicology (AREA)
- Oncology (AREA)
- Mycology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Marine Sciences & Fisheries (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Abstract
Un agente para su uso como agente inductor de inmunidad en un método de tratamiento médico o veterinario, comprendiendo el agente, como principio activo, al menos un polipéptido que tiene actividad inductora de inmunidad y seleccionado de los siguientes polipéptidos (a), (b) y (c), o un vector recombinante que comprende un polinucleótido que codifica dicho polipéptido y capaz de expresar dicho polipéptido in vivo: (a) un polipéptido que tiene la secuencia de aminoácidos mostrada por cualquiera de las SEC ID Nº: 43 a 76 en el listado de secuencias; (b) un polipéptido que tiene el 85 % o más de identidad de secuencia con el polipéptido (a); y (c) un polipéptido de hasta 12 aminoácidos que comprende el polipéptido (a) como secuencia parcial del mismo.
Description
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E09805008
15-06-2015
<Agente inductor de inmunidad>
Como se describe específicamente en los ejemplos siguientes, la administración del polipéptido mencionado anteriormente que tiene actividad inductora de inmunidad a un cuerpo vivo portador de cáncer permite la regresión de un tumor existente. Por lo tanto, el agente inductor de la inmunidad puede usarse como agente terapéutico y / o preventivo para el cáncer.
Los términos "tumor" y "cáncer" utilizados en el presente documento se refieren a neoplasias malignos, y estos términos se utilizan indistintamente entre sí.
En este caso, los tipos de cáncer DIAN son aquellos que expresan un gen que codifica un polipéptido que comprende una secuencia de aminoácidos mostrada por cualquier SEC ID de número de entre las SEC ID N1 2 a 30
o una secuencia parcial de la misma que consiste en al menos 7 aminoácidos contiguos. Preferentemente, tales tipos de cáncer son cáncer de mama, tumor cerebral, leucemia, cáncer de pulmón, linfoma, tumor de mastocitos, cáncer de esófago y cáncer colorrectal. Ejemplos de tales cánceres especificados incluyen, entre otros, cáncer de la glándula mamaria, cáncer de la glándula mamaria combinado, tumor mixto maligno de la glándula mamaria, adenocarcinoma papilar intraductal, leucemia linfocítica crónica, linfoma gastrointestinal, linfoma digestivo, y linfoma de células pequeñas a medianas.
Los animales destinatarios son mamíferos y ejemplos de los mismos incluyen animales mamíferos, incluidos los primates, mascotas, animales de granja y animales competitivos, siendo particularmente preferibles los seres humanos, perros, y gatos.
El agente inductor de la inmunidad para uso en la presente invención se puede administrar por vía oral o parenteral a un organismo. La administración parenteral, tal como administración intramuscular, subcutánea, intravenosa, o intraarterial es preferible. Cuando se utiliza dicho agente inductor de inmunidad para el propósito del tratamiento del cáncer, el agente puede administrarse a los ganglios linfáticos regionales en la proximidad del tumor a tratar, a fin de mejorar los efectos antitumorales como se describe en los ejemplos siguientes. La dosis puede ser cualquier cantidad siempre que sea eficaz para la inducción de inmunidad. Cuando se utiliza el agente para el tratamiento y / o prevención del cáncer, por ejemplo, una cantidad eficaz para el tratamiento y / o prevención del cáncer es suficiente, y tal cantidad puede alterarse dependiendo de, por ejemplo, el peso corporal, el sexo (es decir, hombre o mujer), o síntoma de un animal. La cantidad eficaz para el tratamiento y / o prevención del cáncer se determina adecuadamente de acuerdo con el tamaño del tumor, los síntomas, u otras afecciones. En general, una cantidad eficaz para un animal diana por día es de 0,0001 µg a 1.000 µg, y preferentemente de 0,001 µg a 1.000 µg, y el agente puede administrarse a través de una sola dosis o una pluralidad de dosis. Preferentemente, el agente se administra a través de varias dosis separadas cada varios días o meses. Como se describe específicamente en los ejemplos siguientes, el agente inductor de inmunidad para su uso en la presente invención permite la regresión de un tumor existente. Por lo tanto, el agente puede ejercer los efectos antitumorales en un pequeño número de células de cáncer en una etapa temprana de desarrollo. El uso del mismo antes de la aparición de cáncer o después del tratamiento conduce a la prevención del desarrollo o recurrencia de cáncer. Específicamente, el agente inductor de inmunidad para su uso en la presente invención es útil para el tratamiento y prevención del cáncer.
El agente inductor de la inmunidad para su uso en la presente invención puede consistir en un polipéptido, o puede mezclarse adecuadamente con un aditivo que es adecuado para una forma de dosificación relevante, tal como un vehículo, un diluyente, un excipiente farmacéuticamente aceptable o similares. Los métodos de preparación de un agente y los aditivos que se pueden utilizar son bien conocidos en el campo de preparación médica y se pueden emplear cualquier método y aditivo. Ejemplos específicos de aditivos incluyen, entre otros: diluyentes, tales como soluciones fisiológica tampón; excipientes, tales como azúcar, lactosa, almidón de maíz, fosfato de calcio, sorbitol y glicina; aglutinantes, tales como jarabe, gelatina, goma arábiga, sorbitol, cloruro de polivinilo, y tragacanto; y lubricantes, tales como estearato de magnesio, polietilenglicol, talco, y sílice. Ejemplos de formas de preparaciones incluyen agentes orales, tales como comprimidos, cápsulas, gránulos, polvos, y soluciones de jarabe, y agentes parenterales, tales como inhaladores, preparaciones para inyección, supositorios, y medicamentos líquidos. Tales agentes se pueden preparar por métodos comunes.
El agente inductor de la inmunidad para su uso en la presente invención se puede utilizar en combinación con un agente inmunopotenciador capaz de potenciar una respuesta inmunológica in vivo.
El agente inmunopotenciador puede incorporarse en el agente inductor de inmunidad para su uso en la presente invención, o puede administrarse a un paciente como otra composición en combinación con el agente de inducción de inmunidad para su uso en la presente invención.
El término "paciente" utilizado en el presente documento se refiere a un animal, un animal mamífero, en particular, y es preferentemente un ser humano, perro, o gato.
Un ejemplo del agente inmunopotenciador es un adyuvante. Un adyuvante proporciona un depósito de antígeno (fuera de la célula o en el macrófago), activa los macrófagos, y estimula los linfocitos en un tejido dado. Por lo tanto,
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Claims (1)
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imagen1 imagen2
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2008202065 | 2008-08-05 | ||
| JP2008202065 | 2008-08-05 | ||
| PCT/JP2009/063881 WO2010016525A1 (ja) | 2008-08-05 | 2009-08-05 | 免疫誘導剤 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2539603T3 true ES2539603T3 (es) | 2015-07-02 |
Family
ID=41663742
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES14185710.2T Active ES2619322T3 (es) | 2008-08-05 | 2009-08-05 | Agente inductor de inmunidad |
| ES09805008.1T Active ES2539603T3 (es) | 2008-08-05 | 2009-08-05 | Agente inductor de inmunidad |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
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| CN106039307A (zh) | 2008-08-05 | 2016-10-26 | 东丽株式会社 | 用于治疗和预防癌症的药物组合物 |
| KR101606779B1 (ko) | 2008-08-05 | 2016-03-28 | 도레이 카부시키가이샤 | 암의 검출 방법 |
| CN102821788B (zh) * | 2010-02-04 | 2016-11-16 | 东丽株式会社 | 癌的治疗和/或预防用药物组合物 |
| KR101843807B1 (ko) * | 2010-02-04 | 2018-03-30 | 도레이 카부시키가이샤 | 암의 치료 및/또는 예방을 위한 의약품 |
| CN102822335B (zh) | 2010-02-04 | 2015-09-30 | 东丽株式会社 | 癌的治疗和/或预防用药物组合物 |
| HUE030102T2 (en) * | 2010-02-04 | 2017-04-28 | Toray Industries | A pharmaceutical composition comprising anti-caprin-1 antibodies for the treatment and / or prevention of cancer |
| BR112012018951C8 (pt) * | 2010-02-04 | 2020-06-23 | Toray Industries | anticorpo monoclonal, composição farmacêutica, combinação farmacêutica, uso de um anticorpo, uso de uma composição farmacêutica e uso de uma combinação farmacêutica |
| KR101758117B1 (ko) | 2010-02-04 | 2017-07-14 | 도레이 카부시키가이샤 | 암의 치료 및/또는 예방용 의약 조성물 |
| CA2836568C (en) * | 2011-05-19 | 2020-07-21 | Toray Industries, Inc. | Immunity induction agent |
| MX351414B (es) | 2011-08-04 | 2017-10-13 | Toray Industries | Composicion farmaceutica para el tratamiento y/o prevencion de cancer pancreatico. |
| EP2740793B1 (en) * | 2011-08-04 | 2017-11-29 | Toray Industries, Inc. | Drug composition for cancer treatment and/or prevention |
| HUE033628T2 (en) | 2011-08-04 | 2017-12-28 | Toray Industries | Method for detecting pancreatic cancer |
| WO2013018894A1 (ja) * | 2011-08-04 | 2013-02-07 | 東レ株式会社 | 癌の治療及び／又は予防用医薬組成物 |
| DK2740794T3 (en) * | 2011-08-04 | 2018-06-14 | Toray Industries | PHARMACEUTICAL COMPOSITION FOR TREATMENT AND / OR CANCER PREVENTION |
| JP6065592B2 (ja) * | 2011-08-04 | 2017-01-25 | 東レ株式会社 | 癌の治療及び／又は予防用医薬組成物 |
| KR101980554B1 (ko) * | 2011-08-04 | 2019-05-21 | 도레이 카부시키가이샤 | 암의 치료 및/또는 예방용 의약 조성물 |
| EP2818482B1 (en) | 2012-02-21 | 2019-05-22 | Toray Industries, Inc. | Pharmaceutical composition for treatment of cancer |
| MX363136B (es) | 2012-02-21 | 2019-03-12 | Toray Industries | Composicion farmaceutica para el tratamiento y/o prevencion del cancer. |
| BR112014021103A2 (pt) | 2012-02-21 | 2019-10-15 | Toray Industries, Inc | Anticorpo, composição farmacêutica, droga de combinação, dna, método de tratamento e uso de anticorpo |
| PL2818483T3 (pl) | 2012-02-21 | 2018-01-31 | Toray Industries | Kompozycja lecznicza do leczenia i/lub zapobiegania nowotworowi |
| HUE036424T2 (hu) * | 2012-03-30 | 2018-07-30 | Toray Industries | Gyógyászati készítmény májrák kezelésére és/vagy megelõzésére |
| KR102052400B1 (ko) * | 2012-03-30 | 2019-12-06 | 도레이 카부시키가이샤 | 담낭암의 치료 및/또는 예방용 의약 조성물 |
| WO2014014082A1 (ja) | 2012-07-19 | 2014-01-23 | 東レ株式会社 | 癌の検出方法 |
| CA2879185C (en) | 2012-07-19 | 2021-08-24 | Toray Industries, Inc. | Method for detecting cancer |
| CN105452294B (zh) | 2013-08-09 | 2019-08-02 | 东丽株式会社 | 癌的治疗和/或预防用药物组合物 |
| HUE052947T2 (hu) * | 2015-04-30 | 2021-05-28 | Toray Industries | Immunitásindukáló ágens |
| BR112019008335A2 (pt) * | 2016-10-28 | 2020-01-28 | Toray Industries | conjugado de um anticorpo, composição farmacêutica e método para o tratamento e/ou a prevenção de um câncer |
| AU2019242520A1 (en) * | 2018-03-30 | 2020-10-29 | Toray Industries, Inc. | Pharmaceutical composition for treatment and/or prevention of cancer |
| CN109206501B (zh) * | 2018-09-26 | 2022-03-04 | 东北农业大学 | 猫干扰素ω、其编码基因及其在抗病毒方面的应用 |
| CN109206502B (zh) * | 2018-09-26 | 2022-03-04 | 东北农业大学 | 一种猫干扰素ω及其制备方法和在抗病毒中的应用 |
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| UA56132C2 (uk) | 1995-04-25 | 2003-05-15 | Смітклайн Бічем Байолоджікалс С.А. | Композиція вакцини (варіанти), спосіб стабілізації qs21 відносно гідролізу (варіанти), спосіб приготування композиції вакцини |
| US5698396A (en) | 1995-06-07 | 1997-12-16 | Ludwig Institute For Cancer Research | Method for identifying auto-immunoreactive substances from a subject |
| CA2334038A1 (en) * | 1998-07-14 | 2000-01-27 | Corixa Corporation | Compositions and methods for therapy and diagnosis of prostate cancer |
| WO2002083070A2 (en) * | 2001-04-10 | 2002-10-24 | Corixa Corporation | Compounds for immunotherapy and diagnosis of colon cancer and methods for their use |
| US20030190640A1 (en) * | 2001-05-31 | 2003-10-09 | Mary Faris | Genes expressed in prostate cancer |
| MXPA04003901A (es) * | 2001-11-07 | 2004-07-08 | Cytos Biotechnology Ag | Disposiciones de antigenos para el tratamiento de enfermedades eosinofilicas alergicas. |
| US20050003390A1 (en) * | 2002-05-17 | 2005-01-06 | Axenovich Sergey A. | Targets for controlling cellular growth and for diagnostic methods |
| US20060121029A1 (en) | 2002-08-30 | 2006-06-08 | Hiroshi Shiku | Method and composition for regulating the activity of regulatory t cells |
| WO2005100998A2 (en) | 2004-04-16 | 2005-10-27 | Europroteome Ag | Membrane markers for use in cancer diagnosis and therapy |
| DE102004026135A1 (de) * | 2004-05-25 | 2006-01-05 | Immatics Biotechnologies Gmbh | An MHC-Moleküle bindende Tumor-assoziierte Peptide |
| CA2642342A1 (en) | 2006-02-14 | 2007-08-23 | Dana-Farber Cancer Institute, Inc. | Compositions, kits, and methods for identification, assessment, prevention, and therapy of cancer |
| US20080107668A1 (en) * | 2006-08-30 | 2008-05-08 | Immunotope, Inc. | Cytotoxic t-lymphocyte-inducing immunogens for prevention, treatment, and diagnosis of cancer |
| KR20080075722A (ko) | 2007-02-13 | 2008-08-19 | 엘지이노텍 주식회사 | 튜너 |
| JP4826496B2 (ja) | 2007-02-16 | 2011-11-30 | 三菱マテリアル株式会社 | 電解メッキ用アノード電極取付構造 |
| WO2013143026A1 (en) * | 2012-03-31 | 2013-10-03 | Abmart (Shanghai) Co., Ltd | Peptide and antibody libraries and uses thereof |
| WO2014197471A1 (en) * | 2013-06-03 | 2014-12-11 | Acetylon Pharmaceuticals, Inc. | Histone deacetylase ( hdac) biomarkers in multiple myeloma |
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