DK2705057T3 - Terapeutiske immunoglobuliner til hunde og fremgangsmåder til anvendelse deraf - Google Patents
Terapeutiske immunoglobuliner til hunde og fremgangsmåder til anvendelse deraf Download PDFInfo
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- DK2705057T3 DK2705057T3 DK12723733.7T DK12723733T DK2705057T3 DK 2705057 T3 DK2705057 T3 DK 2705057T3 DK 12723733 T DK12723733 T DK 12723733T DK 2705057 T3 DK2705057 T3 DK 2705057T3
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Classifications
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Claims (13)
1. Antistof, fusionsprotein eller et bindende fragment deraf til anvendelse til terapeutisk behandling af en hund, hvor der 5 ønskes målneutralisering i fravær af en uønskelig effektorfunktion, hvor antistoffet, fusionsproteinet eller det bindende fragment har et konstant domæne af tung kæde, der omfatter aminosyresekvensen ifølge SEQ ID NO: 8, SEQ ID NO: 11 eller SEQ ID NO: 13, hvor aminosyresekvensen for den tunge 10 kæde minimerer aktiveringen af nedstrøms- immunsystemeffektorfunktioner, når antistoffet, fusionsproteinet eller det bindende fragment er bundet til dets målantigen.
2. Antistof, fusionsprotein eller bindende fragment til anvendelse ifølge krav 1, hvor den terapeutiske behandling af hunden vedrører behandling, forebyggelse eller lindring af smerter eller inflammation hos hunden.
3. Antistof, fusionsprotein eller bindende fragment til anvendelse ifølge krav 1 eller krav 2, hvor den terapeutiske behandling af hunden vedrører behandling af arthritis eller en arthritis-tilstand.
4. Antistof, fusionsprotein eller bindende fragment til anvendelse ifølge krav 2, hvor smerterne er udvalgt fra gruppen, der består af neuropatiske smerter, onkologiske smerter, smerter, der er forbundet med eller skyldes rheumatoid arthritis, smerter, der er forbundet med eller 30 skyldes osteoarthritis, smerter, der er forbundet med eller skyldes inflammation, og smerter, der er forbundet med eller skyldes pruritis.
5. Antistof, fusionsprotein eller bindende fragment til 35 anvendelse ifølge et hvilket som helst af kravene 1 til 4, hvor nedstrøms-immunsystemeffektorfunktionerne er udvalgt fra gruppen, der består af komplementafhængig cytotoksicitet, antistofafhængig cellemedieret cytotoksicitet og antistofafhængig cellulær patogenese.
6. Antistof, fusionsprotein eller bindende fragment til anvendelse ifølge krav 5, hvor antistoffet har en tung kæde, 5 der omfatter aminosyresekvensen ifølge SEQ ID NO: 6.
7. Antistof, fusionsprotein eller bindende fragment til anvendelse ifølge et hvilket som helst af kravene 1 til 6, hvor målantigenet er udvalgt fra gruppen, der består af et 10 cytokin, et kemokin, en vækstfaktor, en celleoverfladereceptor, et virus og en komponent af komplementkaskaden.
8. Antistof eller fusionsprotein eller bindende fragment 15 deraf til anvendelse til terapeutisk behandling af en hund, hvor der ønskes måldestruktion, hvor antistoffet, fusionsproteinet eller det bindende fragment har et konstant domæne af tung kæde, der omfatter aminosyresekvensen ifølge SEQ ID NO: 9, SEQ ID NO: 10 eller SEQ ID NO: 14, hvor 20 aminosyresekvensen for den tunge kæde medierer aktivering af nedstrøms-immunsystemeffektorfunktioner, når antistoffet, fusionsproteinet eller det bindende fragment er bundet til dets målantigen.
9. Antistof, fusionsprotein eller bindende fragment til anvendelse ifølge krav 8, hvor den terapeutiske behandling vedrører behandling af cancer eller en infektionssygdom hos hunden.
10. Antistof, fusionsprotein eller bindende fragment til anvendelse ifølge krav 9, hvor nedstrøms- immunsystemef fektorfunktionerne er udvalgt fra gruppen, der består af komplementafhængig cytotoksicitet, antistofafhængig cellemedieret cytotoksicitet og antistofafhængig cellulær 35 patogenese.
11. Antistof, fusionsprotein eller bindende fragment til anvendelse ifølge krav 9 eller krav 10, hvor målantigenet er et cancerspecifikt antigen.
12. Antistof, fusionsprotein eller bindende fragment til anvendelse ifølge krav 11, hvor det cancerspecifikke antigen 5 er udvalgt fra gruppen, der består af et cytokin, et kemokin, en vækstfaktor, en celleoverfladereceptor, et virus og en komponent af komplementkaskaden.
13. Antistof, fusionsprotein eller bindende fragment til 10 anvendelse ifølge krav 11, hvor det cancerspecifikke antigen er udvalgt fra gruppen, der består af proteinerne CD2, CD4, CD8, CD20, EGFR, VEGFR og HER2.
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PCT/GB2012/051008 WO2012153126A1 (en) | 2011-05-06 | 2012-05-08 | Therapeutic canine immunoglobulins and methods of using the same |
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WO (2) | WO2012153121A1 (da) |
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