DK2644591T3 - Optisk aktivt 2-arylcyclopropancarboxamid-mellemprodukt - Google Patents

Optisk aktivt 2-arylcyclopropancarboxamid-mellemprodukt Download PDF

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Publication number
DK2644591T3
DK2644591T3 DK13171373.7T DK13171373T DK2644591T3 DK 2644591 T3 DK2644591 T3 DK 2644591T3 DK 13171373 T DK13171373 T DK 13171373T DK 2644591 T3 DK2644591 T3 DK 2644591T3
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DK
Denmark
Prior art keywords
optically active
derivative
difluorophenyl
aryl
production
Prior art date
Application number
DK13171373.7T
Other languages
English (en)
Inventor
Masaru Mitsuda
Tadashi Moroshima
Kentaro Tsukuya
Kazuhiko Watabe
Masahiko Yamada
Original Assignee
Astrazeneca Ab
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Publication date
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=37027328&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK2644591(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab
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Publication of DK2644591T3 publication Critical patent/DK2644591T3/da

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/09—Preparation of carboxylic acids or their salts, halides or anhydrides from carboxylic acid esters or lactones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C209/00—Preparation of compounds containing amino groups bound to a carbon skeleton
    • C07C209/44—Preparation of compounds containing amino groups bound to a carbon skeleton by reduction of carboxylic acids or esters thereof in presence of ammonia or amines, or by reduction of nitriles, carboxylic acid amides, imines or imino-ethers
    • C07C209/50—Preparation of compounds containing amino groups bound to a carbon skeleton by reduction of carboxylic acids or esters thereof in presence of ammonia or amines, or by reduction of nitriles, carboxylic acid amides, imines or imino-ethers by reduction of carboxylic acid amides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C209/00—Preparation of compounds containing amino groups bound to a carbon skeleton
    • C07C209/54—Preparation of compounds containing amino groups bound to a carbon skeleton by rearrangement reactions
    • C07C209/56—Preparation of compounds containing amino groups bound to a carbon skeleton by rearrangement reactions from carboxylic acids involving a Hofmann, Curtius, Schmidt, or Lossen-type rearrangement
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C209/00—Preparation of compounds containing amino groups bound to a carbon skeleton
    • C07C209/54—Preparation of compounds containing amino groups bound to a carbon skeleton by rearrangement reactions
    • C07C209/58—Preparation of compounds containing amino groups bound to a carbon skeleton by rearrangement reactions from or via amides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C211/00—Compounds containing amino groups bound to a carbon skeleton
    • C07C211/33—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of rings other than six-membered aromatic rings
    • C07C211/34—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of rings other than six-membered aromatic rings of a saturated carbon skeleton
    • C07C211/35—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of rings other than six-membered aromatic rings of a saturated carbon skeleton containing only non-condensed rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/57—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of rings other than six-membered aromatic rings
    • C07C233/58—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of rings other than six-membered aromatic rings having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C67/00—Preparation of carboxylic acid esters
    • C07C67/30—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group
    • C07C67/333—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group by isomerisation; by change of size of the carbon skeleton
    • C07C67/343—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/02—Systems containing only non-condensed rings with a three-membered ring

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Claims (2)

1. Forbindelsen (IF,
2.R)-2-(3,4-difluorphenyl)-1- cyclopropancarboxamid.
DK13171373.7T 2006-08-05 2007-08-02 Optisk aktivt 2-arylcyclopropancarboxamid-mellemprodukt DK2644591T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB0615620.2A GB0615620D0 (en) 2006-08-05 2006-08-05 A process for the preparation of optically active intermediates
EP07794103A EP2049463A4 (en) 2006-08-05 2007-08-02 PROCESS FOR THE PREPARATION OF OPTICALLY ACTIVE CYCLOPROPYLAMINES

Publications (1)

Publication Number Publication Date
DK2644591T3 true DK2644591T3 (da) 2018-02-26

Family

ID=37027328

Family Applications (1)

Application Number Title Priority Date Filing Date
DK13171373.7T DK2644591T3 (da) 2006-08-05 2007-08-02 Optisk aktivt 2-arylcyclopropancarboxamid-mellemprodukt

Country Status (21)

Country Link
US (3) US7790927B2 (da)
EP (2) EP2644591B1 (da)
JP (2) JP2010500344A (da)
KR (2) KR20150006076A (da)
CN (1) CN101495444B (da)
AR (1) AR062149A1 (da)
AU (1) AU2007282182B2 (da)
BR (1) BRPI0714571B1 (da)
CA (1) CA2659091C (da)
CL (1) CL2007002268A1 (da)
DK (1) DK2644591T3 (da)
ES (1) ES2659722T3 (da)
GB (1) GB0615620D0 (da)
HR (1) HRP20180213T1 (da)
IL (1) IL196234A (da)
MX (2) MX343702B (da)
MY (1) MY148095A (da)
SG (1) SG174825A1 (da)
SI (1) SI2644591T1 (da)
TW (1) TWI385141B (da)
WO (1) WO2008018823A1 (da)

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CN104603098B (zh) 2012-03-30 2016-06-29 桑多斯股份公司 2-(3,4-二氟苯基)环丙胺衍生物和盐的合成
EP2644590A1 (en) 2012-03-30 2013-10-02 LEK Pharmaceuticals d.d. Synthesis of 2-(3,4-difluorophenyl)cyclopropanamine derivatives and salts
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CN102796007B (zh) * 2012-08-14 2014-03-26 济南瑞丰医药科技有限公司 一种替卡格雷中间体的制备方法
CN103664697B (zh) * 2012-09-07 2016-12-21 博瑞生物医药（苏州）股份有限公司 用于制备芳香族环丙腈及环丙胺的化学方法
WO2014083139A1 (en) 2012-11-29 2014-06-05 Actavis Group Ptc Ehf Novel amorphous form of ticagrelor
EP2740474A1 (en) * 2012-12-05 2014-06-11 Instituto Europeo di Oncologia S.r.l. Cyclopropylamine derivatives useful as inhibitors of histone demethylases kdm1a
US10159296B2 (en) 2013-01-18 2018-12-25 Riddell, Inc. System and method for custom forming a protective helmet for a customer's head
CN103073525B (zh) * 2013-02-04 2015-01-28 北京科技大学 一种合成制备(s)-(3,4-二氟苯基)环氧己烷的方法
WO2014206187A1 (zh) 2013-06-24 2014-12-31 苏州明锐医药科技有限公司 替卡格雷及其中间体的制备方法
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US10011605B2 (en) 2014-06-18 2018-07-03 Flamma Spa Process for the preparation of triazolo[4,5-D] pyrimidine cyclopentane compounds
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CN106854158B (zh) * 2016-12-08 2019-06-14 淮阴工学院 一种替格瑞洛中间体的合成方法及其中间体
JP7021503B2 (ja) * 2017-11-02 2022-02-17 三菱瓦斯化学株式会社 脂肪族ジアミンの製造方法
CN108083997A (zh) * 2017-11-14 2018-05-29 南通常佑药业科技有限公司 一种手性芳基环丙胺衍生物的制备方法
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Also Published As

Publication number Publication date
EP2644591A1 (en) 2013-10-02
AR062149A1 (es) 2008-10-15
HRP20180213T1 (hr) 2018-03-09
US7790927B2 (en) 2010-09-07
SI2644591T1 (en) 2018-03-30
TW200817308A (en) 2008-04-16
JP2010500344A (ja) 2010-01-07
CN101495444B (zh) 2015-02-04
CN101495444A (zh) 2009-07-29
BRPI0714571A2 (pt) 2013-06-11
KR20150006076A (ko) 2015-01-15
US20100331575A1 (en) 2010-12-30
MY148095A (en) 2013-02-28
JP5624645B2 (ja) 2014-11-12
US8026396B2 (en) 2011-09-27
US20120136167A1 (en) 2012-05-31
KR20090035694A (ko) 2009-04-10
MX2009001019A (es) 2009-02-05
GB0615620D0 (en) 2006-09-13
CA2659091C (en) 2014-11-04
EP2644591B1 (en) 2017-12-13
IL196234A (en) 2014-04-30
AU2007282182B2 (en) 2011-09-29
BRPI0714571B1 (pt) 2020-08-11
IL196234A0 (en) 2009-09-22
SG174825A1 (da) 2011-10-28
MX343702B (es) 2016-11-18
JP2013177417A (ja) 2013-09-09
AU2007282182A1 (en) 2008-02-14
WO2008018823A1 (en) 2008-02-14
EP2049463A1 (en) 2009-04-22
US8278475B2 (en) 2012-10-02
EP2049463A4 (en) 2012-06-06
ES2659722T3 (es) 2018-03-19
CA2659091A1 (en) 2008-02-14
CL2007002268A1 (es) 2008-04-04
TWI385141B (zh) 2013-02-11
US20080071114A1 (en) 2008-03-20

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