HRP20180213T1 - Optički aktivni međuprodukt 2-aril ciklopropan karboksamida - Google Patents

Optički aktivni međuprodukt 2-aril ciklopropan karboksamida Download PDF

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Publication number
HRP20180213T1
HRP20180213T1 HRP20180213TT HRP20180213T HRP20180213T1 HR P20180213 T1 HRP20180213 T1 HR P20180213T1 HR P20180213T T HRP20180213T T HR P20180213TT HR P20180213 T HRP20180213 T HR P20180213T HR P20180213 T1 HRP20180213 T1 HR P20180213T1
Authority
HR
Croatia
Prior art keywords
optically active
cyclopropane carboxamide
carboxamide intermediate
aryl cyclopropane
aryl
Prior art date
Application number
HRP20180213TT
Other languages
English (en)
Inventor
Masaru Mitsuda
Tadashi Moroshima
Kentaro Tsukuya
Kazuhiko Watabe
Masahiko Yamada
Original Assignee
Astrazeneca Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=37027328&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=HRP20180213(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab
Publication of HRP20180213T1 publication Critical patent/HRP20180213T1/hr

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/09—Preparation of carboxylic acids or their salts, halides or anhydrides from carboxylic acid esters or lactones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C209/00—Preparation of compounds containing amino groups bound to a carbon skeleton
    • C07C209/44—Preparation of compounds containing amino groups bound to a carbon skeleton by reduction of carboxylic acids or esters thereof in presence of ammonia or amines, or by reduction of nitriles, carboxylic acid amides, imines or imino-ethers
    • C07C209/50—Preparation of compounds containing amino groups bound to a carbon skeleton by reduction of carboxylic acids or esters thereof in presence of ammonia or amines, or by reduction of nitriles, carboxylic acid amides, imines or imino-ethers by reduction of carboxylic acid amides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C209/00—Preparation of compounds containing amino groups bound to a carbon skeleton
    • C07C209/54—Preparation of compounds containing amino groups bound to a carbon skeleton by rearrangement reactions
    • C07C209/56—Preparation of compounds containing amino groups bound to a carbon skeleton by rearrangement reactions from carboxylic acids involving a Hofmann, Curtius, Schmidt, or Lossen-type rearrangement
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C209/00—Preparation of compounds containing amino groups bound to a carbon skeleton
    • C07C209/54—Preparation of compounds containing amino groups bound to a carbon skeleton by rearrangement reactions
    • C07C209/58—Preparation of compounds containing amino groups bound to a carbon skeleton by rearrangement reactions from or via amides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C211/00—Compounds containing amino groups bound to a carbon skeleton
    • C07C211/33—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of rings other than six-membered aromatic rings
    • C07C211/34—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of rings other than six-membered aromatic rings of a saturated carbon skeleton
    • C07C211/35—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of rings other than six-membered aromatic rings of a saturated carbon skeleton containing only non-condensed rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/57—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of rings other than six-membered aromatic rings
    • C07C233/58—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of rings other than six-membered aromatic rings having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C67/00—Preparation of carboxylic acid esters
    • C07C67/30—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group
    • C07C67/333—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group by isomerisation; by change of size of the carbon skeleton
    • C07C67/343—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/02—Systems containing only non-condensed rings with a three-membered ring

Claims (1)

1. Spoj (1R, 2R)-2-(3,4-difluorofenil)-1-ciklopropankarboksamid.
HRP20180213TT 2006-08-05 2018-02-05 Optički aktivni međuprodukt 2-aril ciklopropan karboksamida HRP20180213T1 (hr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB0615620.2A GB0615620D0 (en) 2006-08-05 2006-08-05 A process for the preparation of optically active intermediates
EP13171373.7A EP2644591B1 (en) 2006-08-05 2007-08-02 Optically active 2-aryl cyclopropane carboxamide intermediate

Publications (1)

Publication Number Publication Date
HRP20180213T1 true HRP20180213T1 (hr) 2018-03-09

Family

ID=37027328

Family Applications (1)

Application Number Title Priority Date Filing Date
HRP20180213TT HRP20180213T1 (hr) 2006-08-05 2018-02-05 Optički aktivni međuprodukt 2-aril ciklopropan karboksamida

Country Status (21)

Country Link
US (3) US7790927B2 (hr)
EP (2) EP2049463A4 (hr)
JP (2) JP2010500344A (hr)
KR (2) KR20150006076A (hr)
CN (1) CN101495444B (hr)
AR (1) AR062149A1 (hr)
AU (1) AU2007282182B2 (hr)
BR (1) BRPI0714571B1 (hr)
CA (1) CA2659091C (hr)
CL (1) CL2007002268A1 (hr)
DK (1) DK2644591T3 (hr)
ES (1) ES2659722T3 (hr)
GB (1) GB0615620D0 (hr)
HR (1) HRP20180213T1 (hr)
IL (1) IL196234A (hr)
MX (2) MX343702B (hr)
MY (1) MY148095A (hr)
SG (1) SG174825A1 (hr)
SI (1) SI2644591T1 (hr)
TW (1) TWI385141B (hr)
WO (1) WO2008018823A1 (hr)

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CN102796007B (zh) * 2012-08-14 2014-03-26 济南瑞丰医药科技有限公司 一种替卡格雷中间体的制备方法
CN103664697B (zh) * 2012-09-07 2016-12-21 博瑞生物医药（苏州）股份有限公司 用于制备芳香族环丙腈及环丙胺的化学方法
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EP2740474A1 (en) 2012-12-05 2014-06-11 Instituto Europeo di Oncologia S.r.l. Cyclopropylamine derivatives useful as inhibitors of histone demethylases kdm1a
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CN103073525B (zh) * 2013-02-04 2015-01-28 北京科技大学 一种合成制备(s)-(3,4-二氟苯基)环氧己烷的方法
WO2014206187A1 (zh) 2013-06-24 2014-12-31 苏州明锐医药科技有限公司 替卡格雷及其中间体的制备方法
WO2015162630A1 (en) 2014-04-25 2015-10-29 Anlon Chemical Research Organization Novel processes for preparing triazolo [4,5-d]- pyrimidines, including ticagrelor, vianew intermediates and new route of synthesis.
US10011605B2 (en) 2014-06-18 2018-07-03 Flamma Spa Process for the preparation of triazolo[4,5-D] pyrimidine cyclopentane compounds
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CN106854158B (zh) * 2016-12-08 2019-06-14 淮阴工学院 一种替格瑞洛中间体的合成方法及其中间体
JP7021503B2 (ja) * 2017-11-02 2022-02-17 三菱瓦斯化学株式会社 脂肪族ジアミンの製造方法
CN108083997A (zh) * 2017-11-14 2018-05-29 南通常佑药业科技有限公司 一种手性芳基环丙胺衍生物的制备方法
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Also Published As

Publication number Publication date
MY148095A (en) 2013-02-28
BRPI0714571B1 (pt) 2020-08-11
CA2659091C (en) 2014-11-04
KR20150006076A (ko) 2015-01-15
AR062149A1 (es) 2008-10-15
US20080071114A1 (en) 2008-03-20
JP5624645B2 (ja) 2014-11-12
EP2644591B1 (en) 2017-12-13
MX2009001019A (es) 2009-02-05
TW200817308A (en) 2008-04-16
JP2013177417A (ja) 2013-09-09
CL2007002268A1 (es) 2008-04-04
SI2644591T1 (en) 2018-03-30
IL196234A0 (en) 2009-09-22
CN101495444A (zh) 2009-07-29
US7790927B2 (en) 2010-09-07
US8278475B2 (en) 2012-10-02
US8026396B2 (en) 2011-09-27
EP2644591A1 (en) 2013-10-02
SG174825A1 (hr) 2011-10-28
BRPI0714571A2 (pt) 2013-06-11
MX343702B (es) 2016-11-18
IL196234A (en) 2014-04-30
US20120136167A1 (en) 2012-05-31
KR20090035694A (ko) 2009-04-10
AU2007282182A1 (en) 2008-02-14
WO2008018823A1 (en) 2008-02-14
DK2644591T3 (en) 2018-02-26
EP2049463A1 (en) 2009-04-22
JP2010500344A (ja) 2010-01-07
US20100331575A1 (en) 2010-12-30
CA2659091A1 (en) 2008-02-14
AU2007282182B2 (en) 2011-09-29
CN101495444B (zh) 2015-02-04
ES2659722T3 (es) 2018-03-19
GB0615620D0 (en) 2006-09-13
TWI385141B (zh) 2013-02-11
EP2049463A4 (en) 2012-06-06

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