MX343702B - Proceso para preparacion de ciclopropilaminas opticamente activas. - Google Patents

Proceso para preparacion de ciclopropilaminas opticamente activas.

Info

Publication number
MX343702B
MX343702B MX2011004608A MX2011004608A MX343702B MX 343702 B MX343702 B MX 343702B MX 2011004608 A MX2011004608 A MX 2011004608A MX 2011004608 A MX2011004608 A MX 2011004608A MX 343702 B MX343702 B MX 343702B
Authority
MX
Mexico
Prior art keywords
optically active
preparation
cyclopropylamines
disubstituted aryl
propylthio
Prior art date
Application number
MX2011004608A
Other languages
English (en)
Inventor
Mitsuda Masaru
Moroshima Tadashi
Tsukuya Kentaro
Watabe Kazuhiko
Yamada Masahiko
Original Assignee
Astrazeneca Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=37027328&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MX343702(B) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab
Publication of MX343702B publication Critical patent/MX343702B/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/09—Preparation of carboxylic acids or their salts, halides or anhydrides from carboxylic acid esters or lactones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C209/00—Preparation of compounds containing amino groups bound to a carbon skeleton
    • C07C209/44—Preparation of compounds containing amino groups bound to a carbon skeleton by reduction of carboxylic acids or esters thereof in presence of ammonia or amines, or by reduction of nitriles, carboxylic acid amides, imines or imino-ethers
    • C07C209/50—Preparation of compounds containing amino groups bound to a carbon skeleton by reduction of carboxylic acids or esters thereof in presence of ammonia or amines, or by reduction of nitriles, carboxylic acid amides, imines or imino-ethers by reduction of carboxylic acid amides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C209/00—Preparation of compounds containing amino groups bound to a carbon skeleton
    • C07C209/54—Preparation of compounds containing amino groups bound to a carbon skeleton by rearrangement reactions
    • C07C209/56—Preparation of compounds containing amino groups bound to a carbon skeleton by rearrangement reactions from carboxylic acids involving a Hofmann, Curtius, Schmidt, or Lossen-type rearrangement
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C209/00—Preparation of compounds containing amino groups bound to a carbon skeleton
    • C07C209/54—Preparation of compounds containing amino groups bound to a carbon skeleton by rearrangement reactions
    • C07C209/58—Preparation of compounds containing amino groups bound to a carbon skeleton by rearrangement reactions from or via amides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C211/00—Compounds containing amino groups bound to a carbon skeleton
    • C07C211/33—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of rings other than six-membered aromatic rings
    • C07C211/34—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of rings other than six-membered aromatic rings of a saturated carbon skeleton
    • C07C211/35—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of rings other than six-membered aromatic rings of a saturated carbon skeleton containing only non-condensed rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/57—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of rings other than six-membered aromatic rings
    • C07C233/58—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of rings other than six-membered aromatic rings having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C67/00—Preparation of carboxylic acid esters
    • C07C67/30—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group
    • C07C67/333—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group by isomerisation; by change of size of the carbon skeleton
    • C07C67/343—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/02—Systems containing only non-condensed rings with a three-membered ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Esta invención se refiere a un proceso para la producción de un derivado de 2-(arilo disustituido)ciclopropilamina ópticamente activo y un derivado de 2-(arilo disustituido)ciclopropancarboxami da ópticamente activo que son intermediarios útiles para la preparación de agentes farmacéuticos, y particularmente el compuesto [1S-(1a,2a,3ß(1S*,2R*),5ß)]-3-[7-2(3,4-difluorofenil)-ci clopropil]amino]-5-(propiltio)-3H-1,2,3-triazolo[4,5-d]pirimidin- 3-il)-5-(2-hidroxietoxi)-ciclopentan-1 ,2-diol.
MX2011004608A 2006-08-05 2007-08-02 Proceso para preparacion de ciclopropilaminas opticamente activas. MX343702B (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB0615620.2A GB0615620D0 (en) 2006-08-05 2006-08-05 A process for the preparation of optically active intermediates
PCT/SE2007/000707 WO2008018823A1 (en) 2006-08-05 2007-08-02 A process for the preparation of optically active cyclopropylamines

Publications (1)

Publication Number Publication Date
MX343702B true MX343702B (es) 2016-11-18

Family

ID=37027328

Family Applications (2)

Application Number Title Priority Date Filing Date
MX2011004608A MX343702B (es) 2006-08-05 2007-08-02 Proceso para preparacion de ciclopropilaminas opticamente activas.
MX2009001019A MX2009001019A (es) 2006-08-05 2007-08-02 Proceso para preparacion de ciclopropilaminas opticamente activas.

Family Applications After (1)

Application Number Title Priority Date Filing Date
MX2009001019A MX2009001019A (es) 2006-08-05 2007-08-02 Proceso para preparacion de ciclopropilaminas opticamente activas.

Country Status (21)

Country Link
US (3) US7790927B2 (es)
EP (2) EP2644591B1 (es)
JP (2) JP2010500344A (es)
KR (2) KR20150006076A (es)
CN (1) CN101495444B (es)
AR (1) AR062149A1 (es)
AU (1) AU2007282182B2 (es)
BR (1) BRPI0714571B1 (es)
CA (1) CA2659091C (es)
CL (1) CL2007002268A1 (es)
DK (1) DK2644591T3 (es)
ES (1) ES2659722T3 (es)
GB (1) GB0615620D0 (es)
HR (1) HRP20180213T1 (es)
IL (1) IL196234A (es)
MX (2) MX343702B (es)
MY (1) MY148095A (es)
SG (1) SG174825A1 (es)
SI (1) SI2644591T1 (es)
TW (1) TWI385141B (es)
WO (1) WO2008018823A1 (es)

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GB0615620D0 (en) 2006-08-05 2006-09-13 Astrazeneca Ab A process for the preparation of optically active intermediates
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US20130150577A1 (en) 2010-04-20 2013-06-13 Actavis Group Ptc Ehf Novel process for preparing phenylcyclopropylamine derivatives using novel intermediates
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EP2721018A1 (en) 2011-06-15 2014-04-23 Actavis Group Ptc Ehf Improved process for preparing cyclopentylamine derivatives and intermediates thereof
EP2589587A1 (en) 2011-11-04 2013-05-08 Chemo Ibérica, S.A. Synthesis of nitrogen substituted cyclopropanes
WO2013079589A1 (en) 2011-11-30 2013-06-06 Actavis Group Ptc Ehf Novel crystalline form of ticagrelor and process for the preparation thereof
EP2628721A1 (en) 2012-02-20 2013-08-21 LEK Pharmaceuticals d.d. Synthesis of 2-(3,4-difluorophenyl)cyclopropanecarboxylic acid
CN104603098B (zh) 2012-03-30 2016-06-29 桑多斯股份公司 2-(3,4-二氟苯基)环丙胺衍生物和盐的合成
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CN102796007B (zh) * 2012-08-14 2014-03-26 济南瑞丰医药科技有限公司 一种替卡格雷中间体的制备方法
CN103664697B (zh) * 2012-09-07 2016-12-21 博瑞生物医药（苏州）股份有限公司 用于制备芳香族环丙腈及环丙胺的化学方法
WO2014083139A1 (en) 2012-11-29 2014-06-05 Actavis Group Ptc Ehf Novel amorphous form of ticagrelor
EP2740474A1 (en) * 2012-12-05 2014-06-11 Instituto Europeo di Oncologia S.r.l. Cyclopropylamine derivatives useful as inhibitors of histone demethylases kdm1a
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CN103073525B (zh) * 2013-02-04 2015-01-28 北京科技大学 一种合成制备(s)-(3,4-二氟苯基)环氧己烷的方法
WO2014206187A1 (zh) 2013-06-24 2014-12-31 苏州明锐医药科技有限公司 替卡格雷及其中间体的制备方法
WO2015162630A1 (en) 2014-04-25 2015-10-29 Anlon Chemical Research Organization Novel processes for preparing triazolo [4,5-d]- pyrimidines, including ticagrelor, vianew intermediates and new route of synthesis.
US10011605B2 (en) 2014-06-18 2018-07-03 Flamma Spa Process for the preparation of triazolo[4,5-D] pyrimidine cyclopentane compounds
WO2016116942A1 (en) 2015-01-20 2016-07-28 Anlon Chemical Research Organization Novel pharmaceutical compounds comprising ticagrelor with salts of aspirin
CN106854158B (zh) * 2016-12-08 2019-06-14 淮阴工学院 一种替格瑞洛中间体的合成方法及其中间体
JP7021503B2 (ja) * 2017-11-02 2022-02-17 三菱瓦斯化学株式会社 脂肪族ジアミンの製造方法
CN108083997A (zh) * 2017-11-14 2018-05-29 南通常佑药业科技有限公司 一种手性芳基环丙胺衍生物的制备方法
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CN110935436B (zh) * 2019-12-04 2022-09-27 上海海益环保科技有限公司 一种催化剂及其制备方法和应用
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Also Published As

Publication number Publication date
EP2644591B1 (en) 2017-12-13
CA2659091C (en) 2014-11-04
US7790927B2 (en) 2010-09-07
MY148095A (en) 2013-02-28
ES2659722T3 (es) 2018-03-19
DK2644591T3 (en) 2018-02-26
CN101495444B (zh) 2015-02-04
AU2007282182B2 (en) 2011-09-29
IL196234A0 (en) 2009-09-22
KR20090035694A (ko) 2009-04-10
HRP20180213T1 (hr) 2018-03-09
US8026396B2 (en) 2011-09-27
EP2644591A1 (en) 2013-10-02
EP2049463A4 (en) 2012-06-06
KR20150006076A (ko) 2015-01-15
SI2644591T1 (en) 2018-03-30
CN101495444A (zh) 2009-07-29
SG174825A1 (es) 2011-10-28
TW200817308A (en) 2008-04-16
MX2009001019A (es) 2009-02-05
US20080071114A1 (en) 2008-03-20
WO2008018823A1 (en) 2008-02-14
US20100331575A1 (en) 2010-12-30
IL196234A (en) 2014-04-30
JP2010500344A (ja) 2010-01-07
BRPI0714571B1 (pt) 2020-08-11
JP5624645B2 (ja) 2014-11-12
AR062149A1 (es) 2008-10-15
US8278475B2 (en) 2012-10-02
CL2007002268A1 (es) 2008-04-04
AU2007282182A1 (en) 2008-02-14
GB0615620D0 (en) 2006-09-13
US20120136167A1 (en) 2012-05-31
TWI385141B (zh) 2013-02-11
CA2659091A1 (en) 2008-02-14
BRPI0714571A2 (pt) 2013-06-11
JP2013177417A (ja) 2013-09-09
EP2049463A1 (en) 2009-04-22

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