DK2604693T3 - Enkeltkædede TNFSF-molekyler - Google Patents

Enkeltkædede TNFSF-molekyler Download PDF

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DK2604693T3
DK2604693T3 DK13152482.9T DK13152482T DK2604693T3 DK 2604693 T3 DK2604693 T3 DK 2604693T3 DK 13152482 T DK13152482 T DK 13152482T DK 2604693 T3 DK2604693 T3 DK 2604693T3
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DK13152482.9T
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Christian Gieffers
Meinolf Thiemann
Oliver Hill
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Apogenix Gmbh
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/525—Tumour necrosis factor [TNF]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70575—NGF/TNF-superfamily, e.g. CD70, CD95L, CD153, CD154
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70578—NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/62—DNA sequences coding for fusion proteins
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/40—Immunoglobulins specific features characterized by post-translational modification
    • C07K2317/41—Glycosylation, sialylation, or fucosylation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/55—Fab or Fab'
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/20—Fusion polypeptide containing a tag with affinity for a non-protein ligand
    • C07K2319/22—Fusion polypeptide containing a tag with affinity for a non-protein ligand containing a Strep-tag
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/32—Fusion polypeptide fusions with soluble part of a cell surface receptor, "decoy receptors"
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/35—Fusion polypeptide containing a fusion for enhanced stability/folding during expression, e.g. fusions with chaperones or thioredoxin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
    • C07K2319/74—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor

Claims (12)

1. Enkeltkædet fusionspolypeptid, som omfatter: (i) et første opløseligt domæne fra et cytokin i TNF-familien, (ii) en første peptidli nker, (iii) et andet opløseligt domæne fra et cytokin i TNF-familien, (iv) en anden peptidlinker og (v) et tredje opløseligt domæne fra et cytokin i TNF-familien, hvor fusionspolypeptidet er i alt væsentligt ikke-aggregerende, og hvor domænerne (i), (iii) og (v) fra et cytokin i TNF-familien er opløselige humane LIGHT-domæner, som omfatter en aminosyresekvens, der begynder fra aminosyre 93, 94 eller 95 ifølge SEQ ID NO: 16.
2. Polypeptid ifølge krav 1, hvor det opløselige humane LIGHT-domæne omfatter aminosyrerne 93-240, 94-240 eller 95-240 ifølge SEQ ID NO: 16.
3. Polypeptid ifølge krav 1 eller 2, hvor de opløselige domæner omfatter mutationer, som ændrer de opløselige domæners bindingsegenskaber.
4. Polypeptid ifølge et hvilket som helst af kravene 1-3, hvor det andet og det tredje opløselige LIGFIT-domæne (iii) og (v) begynder mellem aminosyre Pro94 og Ala95 ifølge SEQ ID NO: 16.
5. Polypeptid ifølge et hvilket som helst af kravene 1 -4, hvor den første og den anden peptidlinker uafhængigt har en længde på fra 3 til 8 aminosyrer, navnlig en længde på 3, 4, 5, 6, 7 eller 8 aminosyrer, og fortrinsvis er glycin-/serinlinkere, eventuelt omfattende en asparaginrest, som kan være glycosyleret.
6. Polypeptid ifølge et hvilket som helst af kravene 1 -5, som endvidere omfatter et N-terminalt signalpeptiddomæne, som kan omfatte et proteasespaltningssted, og/eller som endvidere omfatter et C-terminalt element, som kan omfatte og/eller være forbundet til et genkendelses-/oprensningsdomæne.
7. Polypeptid ifølge et hvilket som helst af kravene 1 -6, som endvidere omfatter et yderligere domæne N-terminalt og/eller C-terminalt, f.eks. et enkeltkædet antistof eller antistoffragment, såsom et Fab- eller Fc-fragmentdomæne.
8. Nukleinsyremolekyle, som koder for et fusionspolypeptid ifølge et hvilket som helst af kravene 1-7, fortrinsvis operativt forbundet til en ekspressionskontrolsekvens.
9. Isoleret celle eller ikke-human organisme, som er transformeret eller transfi-ceret med et nukleinsyremolekyle ifølge krav 8, hvor cellen f.eks. er en prokaryot celle eller en eukaryot celle, fortrinsvis en pattedyrcelle eller, mere fortrinsvis, en human celle.
10. Farmaceutisk sammensætning, der som aktivt stof omfatter et fusionsprotein ifølge et hvilket som helst af kravene 1-7 eller et nukleinsyremolekyle ifølge krav 8.
11. Farmaceutisk sammensætning ifølge krav 10 til anvendelse til behandling.
12. Diagnostisk sammensætning, der som aktivt stof omfatter et fusionsprotein ifølge et hvilket som helst af kravene 1-7 eller et nukleinsyremolekyle ifølge krav 8.
DK13152482.9T 2008-07-21 2009-07-18 Enkeltkædede TNFSF-molekyler DK2604693T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP08013112 2008-07-21
EP09780803.4A EP2310509B1 (en) 2008-07-21 2009-07-18 Tnfsf single chain molecules

Publications (1)

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DK2604693T3 true DK2604693T3 (da) 2016-05-30

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ID=41165705

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DK13152482.9T DK2604693T3 (da) 2008-07-21 2009-07-18 Enkeltkædede TNFSF-molekyler

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US (10) US8450460B2 (da)
EP (4) EP3103875A1 (da)
JP (5) JP5674155B2 (da)
CA (3) CA2910512C (da)
CY (1) CY1116288T1 (da)
DK (2) DK2310509T3 (da)
ES (2) ES2538122T3 (da)
HR (1) HRP20150425T1 (da)
HU (1) HUE025236T2 (da)
PL (2) PL2604693T3 (da)
PT (1) PT2310509E (da)
SI (1) SI2310509T1 (da)
SM (1) SMT201500135B (da)
WO (1) WO2010010051A1 (da)

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