DK2552478T3 - Excipienser til stabilisering af viruspartikler - Google Patents
Excipienser til stabilisering af viruspartikler Download PDFInfo
- Publication number
- DK2552478T3 DK2552478T3 DK11714594.6T DK11714594T DK2552478T3 DK 2552478 T3 DK2552478 T3 DK 2552478T3 DK 11714594 T DK11714594 T DK 11714594T DK 2552478 T3 DK2552478 T3 DK 2552478T3
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- DK
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- Prior art keywords
- virus
- solution
- viral
- sugars
- concentration
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/20—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing sulfur, e.g. dimethyl sulfoxide [DMSO], docusate, sodium lauryl sulfate or aminosulfonic acids
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
- A61J1/05—Containers specially adapted for medical or pharmaceutical purposes for collecting, storing or administering blood, plasma or medical fluids ; Infusion or perfusion containers
- A61J1/06—Ampoules or carpules
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
- A61J1/05—Containers specially adapted for medical or pharmaceutical purposes for collecting, storing or administering blood, plasma or medical fluids ; Infusion or perfusion containers
- A61J1/10—Bag-type containers
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
- A61K39/145—Orthomyxoviridae, e.g. influenza virus
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
- A61K39/235—Adenoviridae
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
- A61K39/275—Poxviridae, e.g. avipoxvirus
- A61K39/285—Vaccinia virus or variola virus
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
- A61K41/10—Inactivation or decontamination of a medicinal preparation prior to administration to an animal or a person
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
- A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
- A61K47/183—Amino acids, e.g. glycine, EDTA or aspartame
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
- A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
- A61K47/186—Quaternary ammonium compounds, e.g. benzalkonium chloride or cetrimide
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/08—Solutions
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
- C07K16/241—Tumor Necrosis Factors
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/525—Virus
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/525—Virus
- A61K2039/5254—Virus avirulent or attenuated
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/55—Fab or Fab'
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/10011—Adenoviridae
- C12N2710/10311—Mastadenovirus, e.g. human or simian adenoviruses
- C12N2710/10334—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/10011—Adenoviridae
- C12N2710/10311—Mastadenovirus, e.g. human or simian adenoviruses
- C12N2710/10351—Methods of production or purification of viral material
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/24011—Poxviridae
- C12N2710/24111—Orthopoxvirus, e.g. vaccinia virus, variola
- C12N2710/24134—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/24011—Poxviridae
- C12N2710/24111—Orthopoxvirus, e.g. vaccinia virus, variola
- C12N2710/24151—Methods of production or purification of viral material
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/16011—Orthomyxoviridae
- C12N2760/16111—Influenzavirus A, i.e. influenza A virus
- C12N2760/16134—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/16011—Orthomyxoviridae
- C12N2760/16111—Influenzavirus A, i.e. influenza A virus
- C12N2760/16151—Methods of production or purification of viral material
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- Animal Behavior & Ethology (AREA)
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- Oil, Petroleum & Natural Gas (AREA)
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- Chemical Kinetics & Catalysis (AREA)
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- Proteomics, Peptides & Aminoacids (AREA)
- Genetics & Genomics (AREA)
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- Bioinformatics & Cheminformatics (AREA)
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- Wood Science & Technology (AREA)
- Molecular Biology (AREA)
- Pulmonology (AREA)
- Biotechnology (AREA)
- Biomedical Technology (AREA)
- General Engineering & Computer Science (AREA)
- Hematology (AREA)
- Inorganic Chemistry (AREA)
- Dermatology (AREA)
- Biophysics (AREA)
- Medicinal Preparation (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Treatments For Attaching Organic Compounds To Fibrous Goods (AREA)
- Peptides Or Proteins (AREA)
Claims (13)
1. Fremgangsmåde til fremstilling af en klar til brug, opbevaringsstabil, vandig opløsning, der tilvejebringes i en forseglet beholder, og som indeholder levende viruspartikler, hvilken fremgangsmåde omfatter: (a) tilvejebringelse afen opløsning omfattende: - vand eller fysiologisk saltvandsopløsning, der eventuelt er bufferet med en fysiologisk acceptabel buffer; levende viruspartikler fra Adenoviridae, Orthomyxoviridae, Paramyxoviridae, Parvoviridae, Picornaviridae, Poxviridae, Flaviviridae eller Herpesviridae] - en excipiens, der er et NkN-dKC^e-alkylj-glycin eller N,N,N-tri(C1.6-alkyl)- giycin, eller et/en fysiologisk acceptabelt/acceptabel salt eller ester deraf; - eventuelt et eller flere sukkere og - eventuelt en sulfonforbindelse med formlen (NC):
hvor Ra og Rb uafhængigt repræsenterer Ci.6-alkyl; og (b) forsegling af opløsningen i en beholder.
2. Fremgangsmåde ifølge krav 1, hvor viruspartiklerne er fra et adenovirus, vaccinia-virus, influenzavirus eller mæslingevirus.
3. Fremgangsmåde ifølge krav 1 eller 2, hvor excipiensen er N,N-dimethylglycin eller Ν,Ν,Ν-trimethylglycin, eller et/én fysiologisk acceptabelt/acceptabel salt eller ester deraf.
4. Fremgangsmåde ifølge krav 3, hvor excipiensen er Ν,Ν-dimethylglycin eller et/en fysiologisk acceptabelt/acceptabel salt eller ester deraf.
5. Fremgangsmåde ifølge et hvilket som helst af de foregående krav, hvor det ene eller flere sukkere omfatter saccharose eller mannitol.
6. Fremgangsmåde ifølge krav 5, hvor det ene eller flere sukkere omfatter saccharose og raffinose.
7. Fremgangsmåde ifølge et hvilket som helst af de foregående krav, hvor sulfonforbindelsen med formlen (IIC) er methylsulfonylmethan.
8. Fremgangsmåde ifølge et hvilket som helst af de foregående krav, hvor opløsningen endvidere omfatter: (a) et adjuvans; (b) et tonicitetsjusteringsmiddel og/eller (c) et konserveringsmiddel.
9. Fremgangsmåde ifølge et hvilket som helst af de foregående krav, hvor opløsningen er isotonisk.
10. Fremgangsmåde ifølge et hvilket som helst af de foregående krav, hvor opløsningen tilvejebringes i en forseglet beholder under nitrogen.
11. Fremgangsmåde ifølge et hvilket som helst af de foregående krav, hvor den forseglede beholder er et forseglet hætteglad, en ampul, sprøjte, patron, fleksibel pose eller glasflaske.
12. Fremgangsmåde ifølge et hvilket som helst af de foregående krav, hvor opløsningen passerer gennem et steriliserende filter i trin (a).
13. Klar til brug, opbevaringsstabil vandig opløsning indeholdende levende viruspartikler fra Adenoviridae, Orthomyxoviridae, Paramyxoviridae, Parvoviridae, Picornaviridae, Poxviridae, Flaviviridae eller Herpesviridae, der er tilvejebragt i en forseglet beholder, hvilken levende viruspartikelholdig vandig opløsning kan opnås ved en fremgangsmåde defineret i et hvilket som helt af de foregående krav.
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB1005521.8A GB201005521D0 (en) | 2010-03-31 | 2010-03-31 | Stabilised liquid formulations of virus particles |
GBGB1005517.6A GB201005517D0 (en) | 2010-03-31 | 2010-03-31 | Stabilised liquid formulations of polypeptides |
GBGB1017648.5A GB201017648D0 (en) | 2010-10-19 | 2010-10-19 | Liquid preparation containing stabilised viruses |
PCT/GB2011/000493 WO2011121301A1 (en) | 2010-03-31 | 2011-03-31 | Excipients for stabilising viral particles, polypeptides or biological material |
Publications (1)
Publication Number | Publication Date |
---|---|
DK2552478T3 true DK2552478T3 (da) | 2017-03-27 |
Family
ID=43902836
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK11714594.6T DK2552478T3 (da) | 2010-03-31 | 2011-03-31 | Excipienser til stabilisering af viruspartikler |
Country Status (15)
Country | Link |
---|---|
US (2) | US20130164296A1 (da) |
EP (1) | EP2552478B1 (da) |
JP (2) | JP5869553B2 (da) |
KR (2) | KR101884953B1 (da) |
CN (1) | CN102892427A (da) |
AU (2) | AU2011234264B2 (da) |
BR (1) | BR112012025047A2 (da) |
CA (1) | CA2795047C (da) |
DK (1) | DK2552478T3 (da) |
ES (1) | ES2617921T3 (da) |
GB (1) | GB2490644A (da) |
HU (1) | HUE033656T2 (da) |
IL (1) | IL221857A (da) |
WO (1) | WO2011121301A1 (da) |
ZA (1) | ZA201206956B (da) |
Families Citing this family (18)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
BR112012025047A2 (pt) | 2010-03-31 | 2016-06-21 | Stabilitech Ltd | formulações líquidas estabilizadas |
ES2543795T3 (es) * | 2010-03-31 | 2015-08-21 | Stabilitech Ltd. | Estabilización de partículas virales |
GB201117233D0 (en) * | 2011-10-05 | 2011-11-16 | Stabilitech Ltd | Stabilisation of polypeptides |
GB201208293D0 (en) * | 2012-05-11 | 2012-06-20 | Circassia Ltd | Hydrochlorice salt of peptide |
US11039621B2 (en) | 2014-02-19 | 2021-06-22 | Corning Incorporated | Antimicrobial glass compositions, glasses and polymeric articles incorporating the same |
US9622483B2 (en) | 2014-02-19 | 2017-04-18 | Corning Incorporated | Antimicrobial glass compositions, glasses and polymeric articles incorporating the same |
US11039620B2 (en) | 2014-02-19 | 2021-06-22 | Corning Incorporated | Antimicrobial glass compositions, glasses and polymeric articles incorporating the same |
GB201406569D0 (en) | 2014-04-11 | 2014-05-28 | Stabilitech Ltd | Vaccine compositions |
GB201513010D0 (en) * | 2015-07-23 | 2015-09-09 | Glaxosmithkline Biolog Sa | Novel formulation |
WO2018115305A1 (en) | 2016-12-22 | 2018-06-28 | Leibniz-Institut für Pflanzengenetik Und Kulturpflanzenforschung (IPK) | Oligomeric vaccines from plants by s-tag-s-protein fusions |
MX2019008105A (es) | 2017-01-06 | 2020-07-22 | Stabilitech Biopharma Ltd | Virus. |
KR101878599B1 (ko) * | 2017-03-28 | 2018-07-13 | 전북대학교산학협력단 | 메틸설포닐메테인과 만니톨의 흡수촉진 및 고미감소를 위한 공침조성물과 이의 제조방법 |
GB2562241B (en) * | 2017-05-08 | 2022-04-06 | Stabilitech Biopharma Ltd | Vaccine compositions |
AR113996A1 (es) | 2017-12-22 | 2020-07-08 | Intervet Int Bv | Vacunas líquidas de virus envueltos vivos |
EP3847246A1 (en) | 2018-09-06 | 2021-07-14 | Bavarian Nordic A/S | Storage improved poxvirus compositions |
IL296250A (en) | 2020-03-12 | 2022-11-01 | Bavarian Nordic As | The compounds that improve the stability of the smallpox virus |
CN114649066A (zh) * | 2020-12-17 | 2022-06-21 | 南开大学 | 一种提升d-氨基酸减缓mbr膜污染效能的智能优化方法 |
CN114392237B (zh) * | 2021-12-28 | 2024-02-02 | 上海允英生物医药科技有限公司 | 一种冻干病毒制剂及其制备方法 |
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2011
- 2011-03-31 BR BR112012025047A patent/BR112012025047A2/pt not_active Application Discontinuation
- 2011-03-31 KR KR1020127028704A patent/KR101884953B1/ko active IP Right Grant
- 2011-03-31 KR KR1020177022631A patent/KR101943429B1/ko active IP Right Grant
- 2011-03-31 EP EP11714594.6A patent/EP2552478B1/en active Active
- 2011-03-31 CN CN2011800181285A patent/CN102892427A/zh active Pending
- 2011-03-31 GB GB1216473.7A patent/GB2490644A/en not_active Withdrawn
- 2011-03-31 AU AU2011234264A patent/AU2011234264B2/en active Active
- 2011-03-31 DK DK11714594.6T patent/DK2552478T3/da active
- 2011-03-31 ES ES11714594.6T patent/ES2617921T3/es active Active
- 2011-03-31 US US13/637,913 patent/US20130164296A1/en not_active Abandoned
- 2011-03-31 WO PCT/GB2011/000493 patent/WO2011121301A1/en active Application Filing
- 2011-03-31 CA CA2795047A patent/CA2795047C/en active Active
- 2011-03-31 HU HUE11714594A patent/HUE033656T2/en unknown
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- 2016-05-03 AU AU2016202839A patent/AU2016202839B2/en active Active
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EP2552478A1 (en) | 2013-02-06 |
GB2490644A (en) | 2012-11-07 |
JP5869553B2 (ja) | 2016-02-24 |
US20130164296A1 (en) | 2013-06-27 |
ZA201206956B (en) | 2016-01-27 |
JP2016121155A (ja) | 2016-07-07 |
CA2795047C (en) | 2019-04-09 |
KR101884953B1 (ko) | 2018-08-02 |
BR112012025047A2 (pt) | 2016-06-21 |
JP6053969B2 (ja) | 2016-12-27 |
JP2013523704A (ja) | 2013-06-17 |
US10716859B2 (en) | 2020-07-21 |
KR101943429B1 (ko) | 2019-01-29 |
CN102892427A (zh) | 2013-01-23 |
IL221857A (en) | 2017-05-29 |
KR20130094180A (ko) | 2013-08-23 |
AU2016202839A1 (en) | 2016-05-26 |
US20160317665A1 (en) | 2016-11-03 |
AU2011234264B2 (en) | 2016-02-04 |
HUE033656T2 (en) | 2017-12-28 |
AU2016202839B2 (en) | 2017-04-20 |
GB201216473D0 (en) | 2012-10-31 |
KR20170096233A (ko) | 2017-08-23 |
WO2011121301A1 (en) | 2011-10-06 |
EP2552478B1 (en) | 2016-12-21 |
CA2795047A1 (en) | 2011-10-06 |
AU2011234264A1 (en) | 2012-10-04 |
ES2617921T3 (es) | 2017-06-20 |
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