ATE163547T1 - Stabilisierte impfstoffzusammensetzungen - Google Patents

Stabilisierte impfstoffzusammensetzungen

Info

Publication number
ATE163547T1
ATE163547T1 AT90913372T AT90913372T ATE163547T1 AT E163547 T1 ATE163547 T1 AT E163547T1 AT 90913372 T AT90913372 T AT 90913372T AT 90913372 T AT90913372 T AT 90913372T AT E163547 T1 ATE163547 T1 AT E163547T1
Authority
AT
Austria
Prior art keywords
vaccine compositions
stabilized vaccine
polyimines
stabilized
amino
Prior art date
Application number
AT90913372T
Other languages
English (en)
Inventor
Brent Dorval
Marie Chow
Alexander Klibanov
Original Assignee
Massachusetts Inst Technology
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Massachusetts Inst Technology filed Critical Massachusetts Inst Technology
Application granted granted Critical
Publication of ATE163547T1 publication Critical patent/ATE163547T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A61K39/125—Picornaviridae, e.g. calicivirus
    • A61K39/13—Poliovirus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
    • C12N2770/00011—Details
    • C12N2770/32011—Picornaviridae
    • C12N2770/32611—Poliovirus
    • C12N2770/32634—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Virology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
AT90913372T 1989-08-15 1990-08-14 Stabilisierte impfstoffzusammensetzungen ATE163547T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US39399689A 1989-08-15 1989-08-15

Publications (1)

Publication Number Publication Date
ATE163547T1 true ATE163547T1 (de) 1998-03-15

Family

ID=23557105

Family Applications (1)

Application Number Title Priority Date Filing Date
AT90913372T ATE163547T1 (de) 1989-08-15 1990-08-14 Stabilisierte impfstoffzusammensetzungen

Country Status (9)

Country Link
US (1) US5618539A (de)
EP (1) EP0487632B1 (de)
JP (1) JP3064413B2 (de)
AT (1) ATE163547T1 (de)
CA (1) CA2065023A1 (de)
DE (1) DE69032102T2 (de)
DK (1) DK0487632T3 (de)
ES (1) ES2113348T3 (de)
WO (1) WO1991002543A1 (de)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4370451B2 (ja) * 2001-09-28 2009-11-25 大塚製薬株式会社 医薬組成物
WO2003088946A1 (en) * 2002-04-19 2003-10-30 The Regents Of The University Of Michigan Polymer compositions that stabilize and control the release of formaldehyde-treated vaccine antigens
CA2517181C (en) * 2003-02-25 2013-07-16 Medimmune Vaccines, Inc. Methods of producing influenza vaccine compositions
US20060110406A1 (en) * 2003-02-25 2006-05-25 Medimmune Vaccines, Inc. Refrigerator-temperature stable influenza vaccine compositions
US20060141483A1 (en) * 2004-12-23 2006-06-29 Calton Gary J Stabilization of viral compositions
TWI398272B (zh) * 2005-03-08 2013-06-11 Intervet Int Bv 化學定義的安定劑
BRPI0800357A2 (pt) * 2008-03-10 2009-10-27 Fundacao Oswaldo Cruz método para produção de uma vacina estabilizada
US20110212127A1 (en) * 2008-09-24 2011-09-01 Stabilitech Ltd. Method for Preserving Polypeptides Using a Sugar and Polyethyleneimine
GB2479069B (en) * 2008-09-24 2012-07-25 Stabilitech Ltd Method for preserving polypeptides using a sugar and polyethyleneimine
AU2011234264B2 (en) 2010-03-31 2016-02-04 Stabilitech Ltd Excipients for stabilising viral particles, polypeptides or biological material
ES2708989T3 (es) 2010-03-31 2019-04-12 Stabilitech Biopharma Ltd Método de conservación de adyuvantes de alumbre y vacunas potenciadas con alumbre
DK2898890T3 (da) 2010-03-31 2019-11-25 Stabilitech Biopharma Ltd Stabilisering af viruspartikler
JP6417217B2 (ja) * 2011-06-28 2018-10-31 ロイコケア・アクチェンゲゼルシャフト ウイルスまたは細菌の新規な安定化方法
GB201117233D0 (en) 2011-10-05 2011-11-16 Stabilitech Ltd Stabilisation of polypeptides
US9283270B2 (en) 2012-01-20 2016-03-15 Serum Institute Of India Ltd. Method for stabilization of biological molecules
TWI690322B (zh) * 2012-10-02 2020-04-11 法商傳斯堅公司 含病毒的調配物及其使用
WO2014204303A2 (en) * 2013-06-17 2014-12-24 De Staat Der Nederlanden, Vert. Door De Minister Van Vws, Ministerie Van Volksgezondheid, Welzijn En Sport Methods for the prevention of aggregation of viral components
GB201406569D0 (en) 2014-04-11 2014-05-28 Stabilitech Ltd Vaccine compositions
GB2562241B (en) 2017-05-08 2022-04-06 Stabilitech Biopharma Ltd Vaccine compositions

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3097142A (en) * 1960-03-30 1963-07-09 Merck & Co Inc Benzyl alcohol stabilized polio vaccines and production thereof
US3097143A (en) * 1960-03-30 1963-07-09 Merck & Co Inc Myristyl-gamma-picolinium chloride preserved polio vaccine and its production
US3128229A (en) * 1961-10-05 1964-04-07 Baylor Medical Foundation Stabilization of viral vaccine and inactivation of adventitious tissue culture contaminants therein
GB1564998A (en) * 1975-03-21 1980-04-16 Connaught Lab Vaccine and stabilizing solution therefor
US4338335A (en) * 1980-02-05 1982-07-06 Merck & Co., Inc. Vaccine stabilizer containing L-glutamic acid and L-arginine
US4337242A (en) * 1980-02-05 1982-06-29 Merck & Co., Inc. Vaccine stabilizer containing L-glutamic acid and L-arginine
FR2505657A1 (fr) * 1981-05-13 1982-11-19 Pasteur Institut Perfectionnements apportes aux agents de stabilisation de virus vivants pour la preparation de vaccins, et vaccins stabilises contenant lesdits agents de stabilisation

Also Published As

Publication number Publication date
EP0487632A1 (de) 1992-06-03
EP0487632B1 (de) 1998-03-04
ES2113348T3 (es) 1998-05-01
DE69032102D1 (de) 1998-04-09
WO1991002543A1 (en) 1991-03-07
JP3064413B2 (ja) 2000-07-12
JPH04506973A (ja) 1992-12-03
US5618539A (en) 1997-04-08
DE69032102T2 (de) 1998-06-25
DK0487632T3 (da) 1998-05-25
CA2065023A1 (en) 1991-02-16

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Legal Events

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UEP Publication of translation of european patent specification
REN Ceased due to non-payment of the annual fee