DK2433940T3 - Spiroimidazolonderivat - Google Patents

Spiroimidazolonderivat Download PDF

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DK2433940T3
DK2433940T3 DK10769728.6T DK10769728T DK2433940T3 DK 2433940 T3 DK2433940 T3 DK 2433940T3 DK 10769728 T DK10769728 T DK 10769728T DK 2433940 T3 DK2433940 T3 DK 2433940T3
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phenyl
spiro
dec
triaza
methyl
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Yoshikazu Nishimura
Yoshiaki Isshiki
Naoki Okamoto
Yoshiyuki Furuta
Akemi Mizutani
Masateru Ohta
Wayne Wen Lai
Tomoya Kotake
Toru Esaki
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Chugai Pharmaceutical Co Ltd
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    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
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    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
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    • C07D515/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains three hetero rings
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Claims (44)

1. Forbindelse som vist med følgende almene formel (1) eller (2):
eller et farmakologisk acceptabelt salt af en forbindelse som vist med formel (1) eller (2); [hvor i den almene formel (1) W er valgt fra: 1) en enkelt binding, 2) C1-C10 alkylen eventuelt indeholdende en carbonylgruppe, hvor alkylen eventuelt er substitueret med et halogenatom(er) og/eller en hydroxylgruppe(r), 3) C2-C10 alkenylen eventuelt substitueret med et halogenatom(er), 4) C2-C10 alkynylen, 5) arylen eventuelt substitueret med et halogenatom(er), 6) heteroarylen eventuelt substitueret med et halogenatom(er), 7) C1-C10 heteroalkylen eventuelt substitueret med et halogenatom(er),
8) -NH-, -NHCH2- eller -NHCH2CH2-, 9) cycloalkylen og 10) -(cycloalkylen)-CH2-; X er valgt fra følgende binding eller grupper: 1) en enkelt binding, 2) C1-C10 alkylen eventuelt substitueret med et halogenatom(er) eller cycloalkyl, 3) C2-C10 alkenylen eventuelt substitueret med et halogenatom(er), 4) C2-C10 alkynylen eventuelt substitueret med et halogenatom(er), 5) Cl-10 oxyalkylen eventuelt substitueret med et halogenatom(er) og
6) -NR47- hvor R47 er valgt fra: i) et hydrogen atom og ii) C1-C10 alkyl eventuelt substitueret med et halogenatom(er); Y er valgt fra: 1) et oxygenatom, 2) et svovlatom og 3) =NR37, eller 4) Y er -NR38R39 som vist i den følgende formel (A):
der kan være tautomer; R37 er valgt fra: 1) hydrogen, 2) hydroxy og 3) C1-C10 alkoxy; R38 og R39 er uafhængigt valgt fra hydrogen eller C1-C10 alkyl eventuelt substitueret med cycloalkyl, eller R3s og R39 kan bindes til hinanden til at danne en ring valgt fra gruppen bestående af azetidinyl, pyrrolidinyl, piperidinyl, piperazinyl og morpholinyl, og ringen er eventuelt substitueret med C1-C10 alkyl; m betegner et heltal fra 0 til 2; n betegner et heltal fra 0 til 2; Ri er valgt fra: 1) hydrogen, 2) cycloalkyl eventuelt substitueret med en gruppe(r) valgt fra R4, R5 og R6, 3) en heterocykel eventuelt substitueret med en gruppe(r) valgt fra R25, R4, Rs og R6, 4) aryl eventuelt substitueret med en gruppe(r) valgt fra R3, R4, Rs og R6 og 5) heteroaryl eventuelt substitueret med en gruppe(r) valgt fra R25, R4, Rs og R6; R3 er valgt fra: 1) -conr7r8,
2) -OR9,
3) -NR9R10, 4) -N(R9)CORu, 5) -N (R9)S02Ri2,
6) -SO2R15, 7) Cl-10 alkyl eventuelt substitueret med en gruppe(r) uafhængigt valgt fra et halogenatom, en hydroxylgruppe, -COR16 og -NR13R14, 8) heteroaryl eventuelt med Cl-10 alkyl og/eller Cl-10 alkoxy som en substituent(er) og 9) -N(R9)CSRn; R4 er valgt fra: 1) et halogenatom, 2) cyano, 3) nitro, 4) amino,
5) -NHCOR26, 6) C1-C10 alkyl eventuelt substitueret med en gruppe(r) uafhængigt valgt fra hydroxycarbonyl, C1-C10 alkoxycarbonyl og aminocarbonyl, 7) C1-C10 haloalkyl, 8) C1-C10 alkoxy, 9) C1-C10 haloalkylcarbonyl,
10) -CORie, 11) C1-C10 hydroxyalkyl og 12) C1-C10 heteroalkyl; R5 er valgt fra et halogenatom, C1-C10 alkyl, C1-C10 haloalkyl og C1-C10 alkoxy; Rs er valgt fra et halogenatom, C1-C10 alkyl og C1-C10 haloalkyl; R7 er valgt fra: 1) hydrogen, 2) C1-C10 alkyl eventuelt substitueret med en gruppe(r) uafhængigt valgt fra amino og C1-C10 alkylamino, 3) C1-C10 hydroxyalkyl, 4) C1-C10 haloalkyl, 5) C1-C10 heteroalkyl, 6) C1-C10 heteroalkyl eventuelt substitueret med en gruppe(r) valgt fra en hydroxylgruppe, C1-C10 alkylamino og C2-C10 alkenyl, 7) aryl, 8) heteroaryl, 9) aryl C1-C10 alkyl, 10) en heterocykel eventuelt substitueret med C1-C10 alkyl, 11) -(CH2)lCORi6 (hvor L betegner et heltal fra 1 til 4), 12) C1-C10 alkoxy, 13) C2-C10 alkenyl og
14) -NR40R41; R40 og R41 er uafhængigt valgt fra hydrogen, C1-C10 alkyl og C1-C10 alkylcarbonyl, eller R40 og R41 kan bindes til hinanden til at danne en ring valgt fra azetidinyl, pyrrolidinyl, piperidinyl, piperazinyl og morpholinyl, og heterocyklen er eventuelt substitueret med Cl-C 10 al kyl; Rs er valgt fra hydrogen og C1-C10 alkyl eventuelt substitueret med et halogenatom(er) og/eller en hydroxylgruppe(r); R7 og R8 kan bindes for at danne en 4- til 7-leddet heterocykel eventuelt indeholdende et yderligere element(er) eller gruppe(r) uafhængigt valgt fra O, N, S, SO og SO2 og heterocyklen eventuelt indeholder carbonyl, og heterocyklen er eventuelt substitueret med en substituent(er) uafhængigt valgt fra: 1) et halogenatom, 2) C1-C10 alkyl eventuelt med C1-C10 alkylamino som en substituent(er), 3) C1-C10 haloalkyl, 4) en hydroxylgruppe, 5) C1-C10 hydroxyalkyl, 6) C1-C10 alkoxy eventuelt substitueret med en gruppe(r) uafhængigt valgt fra et halogenatom, en hydroxylgruppe, amino og C1-C10 alkylamino, 7) aryl eventuelt substitueret med en gruppe(r) valgt fra et halogenatom, en hydroxylgruppe, amino og C1-C10 alkylamino, 8) C1-C10 heteroalkyl eventuelt substitueret med en gruppe(r) uafhængigt valgt fra et halogenatom, en hydroxylgruppe, amino og C1-C10 alkylamino, 9) en heterocykel eventuelt substitueret med C1-C10 alkyl, 10) heteroaryl eventuelt substitueret med C1-C10 alkyl, 11) heterocyclyl C1-C10 alkyl,
12) -CORie,
13) -NR19R20,
14) -SO2R21, 15) C1-C10 alkoxy-Cl-C10 alkyl eventuelt med en hydroxylgruppe(r) som en substituent(er) og 16) C1-C10 hydroxyalkyloxy, hvor hydrogenatomet af hydroxylgruppen er eventuelt erstattet med C1-C10 hydroxyalkyl, og heterocyklen kan yderligere danne en spiroring sammen med en 4- til 6-leddet heterocykel, og den bundne 4- til 6-leddede heterocykel eventuelt indeholder O og N som ring-dannende elementer udover carbonatomerne, og carbonatom(erne) kan oxideres for at danne carbonyl, og den 5- til 6-leddede heterocykel er eventuelt yderligere substitueret med C1-C10 alkyl; Ri6 er valgt fra: 1) en hydroxylgruppe, 2) C1-C10 alkoxy, 3) NR17R18 og 4) C1-C10 alkyl eventuelt substitueret med en substituent(er) valgt fra et halogenatom, en hydroxylgruppe, C1-C10 alkoxycarbonyl eller C1-C10 alkylamino; Ri? er valgt fra: 1) hydrogen, 2) C1-C10 alkyl eventuelt substitueret med en gruppe(r) valgt fra aryl, amino, Cl-C10 alkylamino, C1-C10 alkylcarbonylamino og en hydroxylgruppe, 3) heteroaryl og 4) C1-C10 alkoxy; Ris er valgt fra hydrogen, C1-C10 alkyl og C1-C10 hydroxyalkyl; R17 og Ris kan bindes til hinanden til at danne en ring valgt fra azetidinyl, pyrrolidinyl, piperidinyl, piperazinyl og morpholinyl, og ringen er eventuelt substitueret med en gruppe(r) valgt uafhængigt af hinanden fra C1-C10 alkyl, et halogenatom og C1-C10 alkoxycarbonyl; R19 er valgt fra hydrogen, C1-C10 alkyl, C1-C10 haloalkyl, C1-C10 alkylcarbonyl, C1-C10 hydroxyalkyl, C1-C10 aminoalkyl, C1-C10 alkoxycarbonyl og C1-C10 heteroalkyl; R20 er valgt fra hydrogen og C1-C10 alkyl; R19 og R20 kan bindes for at danne en ring valgt fra azetidinyl, pyrrolidinyl, piperidinyl, piperazinyl og morpholinyl, og ringen er eventuelt substitueret med en gruppe(r) valgt uafhængigt af hinanden fra C1-C10 alkyl og et halogenatom; R21 er valgt fra: 1) C1-C10 alkyl eventuelt substitueret med aryl, 2) amino, 3) C1-C10 alkylamino og 4) aryl eventuelt substitueret med C1-C10 alkyl; R9 er valgt fra: 1) hydrogen, 2) C1-C10 alkyl eventuelt substitueret med en gruppe(r) uafhængigt valgt fra R23, 3) aryl eventuelt substitueret med en gruppe(r) valgt fra et halogenatom, en hydroxylgruppe, amino og C1-C10 alkylamino, 4) cycloalkyl eventuelt substitueret med et halogenatom(er) eller en hydroxylgruppe(r), 5) en heterocykel eventuelt substitueret med en gruppe(r) uafhængigt valgt fra Cl-C10 alkyl, C1-C10 alkylcarbonyl, C1-C10 alkoxy, C1-C10 alkoxycarbonyl, amino og et halogenatom, 6) C1-C10 heteroalkyl eventuelt substitueret med en gruppe(r) uafhængigt valgt fra et halogenatom og en hydroxylgruppe, 7) heteroaryl eventuelt substitueret med en gruppe(r) valgt fra C1-C10 alkyl, Cl-C10 alkylcarbonyl, C1-C10 alkoxycarbonyl og et halogenatom og 8) cycloalkenyl eventuelt substitueret med en gruppe(r) valgt fra C1-C10 alkoxy, C1-C10 alkylamino, amino, en hydroxylgruppe og et halogenatom, hvor cycloalkenyl eventuelt indeholder en carbonylgruppe; R23 er uafhængigt valgt fra: 1) et halogenatom, 2) en hydroxylgruppe, 3) en C1-C10 alkylcarbonyloxygruppe,
4) -CORie, 5) amino, 6) C1-C10 alkylamino, 7) en heterocykel eventuelt substitueret med en gruppe(r) valgt fra C1-C10 alkyl, C1-C10 alkylcarbonyl, C1-C10 alkoxycarbonyl og et halogenatom og 8) cyano; Rio er valgt fra: 1) hydrogen og 2) C1-C10 alkyl eventuelt substitueret med en gruppe(r) valgt fra et halogenatom, en hydroxylgruppe og aryl; Rg og Ri o kan bindes for at danne en 4- til 7-leddet heterocykel eventuelt indeholdende et yderligere element(er) eller gruppe(r) uafhængigt valgt fra N, O, S, SO, SO2, carbonyl og thiocarbonyl, og heterocyklen er eventuelt substitueret med en substituent(er) uafhængigt valgt fra R24; R24 er uafhængigt valgt fra: 1) et halogenatom, 2) C1-C10 alkyl eventuelt substitueret med en gruppe(r) uafhængigt valgt fra Cl-C10 alkylamino og C1-C10 alkylcarbonylamino, 3) C1-C10 haloalkyl, 4) en hydroxylgruppe, 5) C1-C10 hydroxyalkyl, 6) C1-C10 alkoxy eventuelt substitueret med en gruppe(r) uafhængigt valgt fra et halogenatom, en hydroxylgruppe, amino og C1-C10 alkylamino, 7) aryl eventuelt substitueret med en gruppe(r) uafhængigt valgt fra et halogenatom, en hydroxylgruppe, amino og C1-C10 alkylamino, 8) C1-C10 heteroalkyl eventuelt substitueret med en gruppe(r) uafhængigt valgt fra et halogenatom, en hydroxylgruppe, amino og C1-C10 alkylamino, 9) en heterocykel eventuelt substitueret med C1-C10 alkyl, 10) heteroaryl, 11) heterocyclyl C1-C10 alkyl,
12) -CORie,
13) -NR19R20 og
14) -SO2R21; Ru er valgt fra: 1) C1-C10 alkyl eventuelt substitueret med en gruppe(r) uafhængigt valgt fra: 1) en hydroxylgruppe, ii) -NR17R18, iii) a C1-C10 alkoxygruppe, iv) et halogenatom, v) C1-C10 alkoxycarbonyl, vi) aminocarbonyl og vii) aryl eventuelt substitueret med en gruppe(r) uafhængigt valgt fra et halogenatom, en hydroxylgruppe, C1-C10 alkoxy, amino, C1-C10 alkylamino og - CO R22, 2) aryl eventuelt substitueret med en gruppe(r) uafhængigt valgt fra et halogenatom, en hydroxylgruppe, C1-C10 alkoxy, amino, C1-C10 alkylamino og - CO R22, 3) cycloalkyl eventuelt substitueret med et halogenatom(er), 4) en heterocykel eventuelt substitueret med en gruppe(r) valgt fra C1-C10 alkyl, C1-C10 alkylcarbonyl, C1-C10 alkoxycarbonyl og et halogenatom, 5) C1-C10 alkoxy, hvor alkylgruppen eventuelt er substitueret med en gruppe(r) uafhængigt valgt fra C1-C10 alkylcarbonylamino, amino, C1-C10 alkylamino og en hydroxylgruppe, 6) amino, 7) C1-C10 alkylamino, hvor alkylgruppen eventuelt er substitueret med en gruppe(r) uafhængigt valgt fra C1-C10 alkylcarbonylamino, amino, C1-C10 alkylamino, hydroxycarbonyl og en hydroxylgruppe og 8) C2-C10 alkenyl; R22 er valgt fra C1-C10 alkoxy, en hydroxylgruppe, amino og C1-C10 alkylamino; R12 er valgt fra: 1) C1-C10 alkyl, 2) amino og 3) C1-C10 alkylamino, hvor alkylgruppen eventuelt er substitueret med en gruppe(r) uafhængigt valgt fra amino, C1-C10 alkylamino og en hydroxygruppe; R13 er valgt fra: 1) hydrogen, 2) C1-C10 alkyl, 3) C1-C10 alkylcarbonyl, hvor alkyl eventuelt er substitueret med en hydroxylgruppe(r), 4) C1-C10 alkoxycarbonyl, 5) aminocarbonyl, 6) C1-C10 alkylaminocarbonyl og 7) heterocyklisk carbonyl eventuelt substitueret med C1-C10 alkyl; R14 er valgt fra: 1) hydrogen og 2) C1-C10 alkyl eventuelt substitueret med en gruppe(r) uafhængigt valgt fra et halogenatom, en hydroxylgruppe, amino og C1-C10 alkylamino; Ri3 og R14 kan bindes for at danne en 4- til 7-leddet heterocykel eventuelt indeholdende et yderligere element(er) eller gruppe(r) uafhængigt valgt fra O, N, S, SO og SO2, og heterocyklen eventuelt indeholder carbonyl, og heterocyklen er eventuelt substitueret med C1-C10 alkyl; Ris er valgt fra: 1) C1-C10 alkyl og
2) -NR35R36; R35 er valgt fra: 1) hydrogen, 2) C1-C10 alkyl eventuelt substitueret med en gruppe(r) uafhængigt valgt fra: i) et halogenatom, ii) en hydroxylgruppe, iii) C1-C10 alkylcarbonylamino, iv) -CORie, v) amino, vi) C1-C10 alkylamino, vii) C1-C10 alkoxy eventuelt substitueret med et halogenatom(er), viii) heteroaryl eventuelt substitueret med en C1-C10 alkyl gruppe(r) og ix) en heterocykel, 3) aryl eventuelt substitueret med en gruppe(r) uafhængigt valgt fra et halogenatom, en hydroxylgruppe, amino og C1-C10 alkylamino, 4) cycloalkyl eventuelt substitueret med en gruppe(r) uafhængigt valgt fra et halogenatom og en hydroxylgruppe, 5) en heterocykel eventuelt substitueret med en gruppe(r) uafhængigt valgt fra Cl-C10 alkyl, et halogenatom og aryl C1-C10 alkyl, 6) heteroaryl eventuelt substitueret med C1-C10 alkyl og 7) C1-C10 alkylcarbonyl; R36 er valgt fra: 1) hydrogen og 2) C1-C10 alkyl eventuelt substitueret med en gruppe(r) uafhængigt valgt fra et halogenatom, en hydroxylgruppe og aryl; R35 og R36 kan bindes til hinanden til at danne en ring valgt fra azetidinyl, pyrrolidinyl, piperidinyl, piperazinyl og morpholinyl, og ringen er eventuelt substitueret med en gruppe(r) valgt uafhængigt af hinanden fra C1-C10 alkyl og et halogenatom; R25 er valgt fra: 1) et halogenatom, 2) C1-C10 alkyl eventuelt substitueret med en gruppe(r) uafhængigt valgt fra: i) et halogenatom, ii) aryl, iii) heteroaryl, iv) en heterocykel eventuelt substitueret med en C1-C10 alkyl gruppe(r), V) -COR16, vi) -NR13R14 og vii) -SO2R21, 3) C1-C10 heteroalkyl eventuelt substitueret med en hydroxylgruppe(r), 4) C1-C10 hydroxyalkyl, hvor hver hydroxylgruppe uafhængigt kan være substitueret med en gruppe(r) valgt fra C1-C10 alkyl, aryl C1-C10 alkyl og C1-C10 alkylcarbonyl,
5) -COR16,
6) -SO2R21, 7) aryl og 8) cyano; R2 er valgt fra: 1) C1-C10 alkyl eventuelt substitueret med et halogenatom(er), hvor alkylgruppen er eventuelt yderligere substitueret med en substituent(er) uafhængigt valgt fra R42, 2) C2-C10 alkenyl eventuelt substitueret med et halogenatom(er), hvor alkynylgruppen er eventuelt yderligere substitueret med en substituent(er) uafhængigt valgt fra R42, 3) C2-C10 alkynyl eventuelt substitueret med et halogenatom(er), hvor alkynylgruppen eventuelt er yderligere substitueret med en substituent(er) uafhængigt valgt fra R42, 4) cycloalkyl eventuelt substitueret med en gruppe(r) uafhængigt valgt fra: i) et halogenatom, ii) C2-C10 alkenyl eller C1-C10 alkyl, iii) aryl eventuelt substitueret med 1 til 3 substituenter uafhængigt valgt fra Cl-C10 alkyl, et halogenatom, C1-C10 alkoxy, C1-C10 alkylamino og C1-C10 alkylcarbonyl, iv) cycloalkyl, v) C2-C10 alkenyl eventuelt substitueret med halogen, vi) C1-C10 alkyliden, hvor alkyliden er bundet til cycloalkyl med en dobbeltbinding og alkyliden eventuelt er substitueret med et halogenatom(er), vii) C1-C10 alkoxy eventuelt substitueret med et halogenatom(er), viii) C1-C10 alkyl eventuelt substitueret med en gruppe(r) uafhængigt valgt fra et halogenatom eller C1-C10 alkoxy eventuelt substitueret med et halogenatom(er), ix) C2-C10 alkynyl og x) -Si (1*43)3, 5) en heterocykel, hvor heterocyklen eventuelt er substitueret med en gruppe(r) uafhængigt valgt fra: i) en C1-C10 alkylgruppe, ii) C1-C10 alkylcarbonyl, hvor alkylgruppen eventuelt er substitueret med R27, iii) arylcarbonyl, hvor arylgruppen eventuelt er substitueret med en gruppe(r) uafhængigt valgt fra et halogenatom, C1-C10 alkyl og C1-C10 alkoxy, iv) heteroarylcarbonyl, v) C1-C10 alkoxycarbonyl, hvor alkylgruppen eventuelt er substitueret med en gruppe(r) uafhængigt valgt fra et halogenatom, aryl og C1-C10 alkoxy, vi) aryloxycarbonyl, hvor arylgruppen eventuelt er substitueret med et halogenatom(er) og/eller C1-C10 alkyl, vii) -CONR28R29, viii) -SO2R21, ix) et halogenatom, x) cycloalkylcarbonyl eventuelt kondenseret med an arylgruppe og xi) C2-C10 alkenylcarbonyl, hvor alkynylgruppen eventuelt er substitueret med aryl, hvor aryl eventuelt er substitueret med en gruppe(r) uafhængigt valgt fra et halogenatom, C1-C10 alkyl eller C1-C10 alkoxy, 6) aryl eventuelt substitueret med en gruppe(r) uafhængigt valgt fra R44, 7) heteroaryl eventuelt substitueret med en gruppe(r) uafhængigt valgt fra: i) et halogenatom, ii) C1-C10 alkyl og iii) C1-C10 alkoxy; 8) C1-C10 alkoxy eventuelt substitueret med et halogenatom(er), hvor alkoxygruppen er eventuelt yderligere substitueret med en substituent(er) uafhængigt valgt fra R42, 9) -S(0)qR43 (hvor q er et heltal på 0 til 2) og 10) cycloalkenyl eventuelt substitueret med C1-C10 alkyl; R44 er valgt fra: 1) et halogenatom, 2) cyano, 3) C1-C10 alkyl eventuelt substitueret med en gruppe(r) uafhængigt valgt fra: i) en hydroxylgruppe,
11) -OR26, iii) cyano, iv) aryloxy eventuelt substitueret med en gruppe(r) uafhængigt valgt fra et halogenatom, C1-C10 alkyl eventuelt substitueret med et halogenatom(er) eller C1-C10 alkoxy eventuelt substitueret med et halogenatom(er) og v) et halogenatom, 4) cycloalkyl eventuelt substitueret med en gruppe(r) uafhængigt valgt fra et halogenatom eller C1-C10 alkyl eventuelt substitueret med et halogenatom(er), 5) C1-C10 alkoxy eventuelt substitueret med et halogenatom(er) eller en C2-C6 alkenylgruppe(r),
6) -COR30, 7) C1-C10 alkylcarbonylamino, 8) C1-C10 alkoxycarbonylamino, hvor alkoxygruppen er eventuelt substitueret med aryl, 9) C1-C10 heteroalkyl eventuelt substitueret med et halogenatom(er), 10) aryl eventuelt substitueret med en substituent(er) uafhængigt valgt fra: i) et halogenatom, 11) C1-C10 alkyl, iii) C1-C10 alkoxy og iv) aryl eventuelt substitueret med aryl eventuelt substitueret med C1-C10 alkyl, 11) heteroaryl eventuelt substitueret med a C1-C10 alkyl gruppe(r),
12) -SO2R43,
13) -SOR43, 14) C1-C10 alkylthio eventuelt substitueret med et halogenatom(er),
15) -Si(R43)3 og
16) -SF5; R42 er valgt fra: 1) hydrogen, 2) aryl eventuelt substitueret med en gruppe(r) uafhængigt valgt fra C1-C10 alkyl eventuelt substitueret med halogen, et halogenatom og C1-C10 alkoxy, 3) hydroxycarbonyl, 4) C1-C10 alkoxycarbonyl, 5) aminocarbonyl, 6) C1-C10 alkylaminocarbonyl, 7) C1-C10 alkoxycarbonylamino, 8) amino, 9) en hydroxylgruppe og 10) oxetan, tetrahyd rof uran eller tetrahydropyran eventuelt substitueret med Cl-C10 alkyl; R43 betegner en C1-C10 alkylgruppe; R.26 er aryl, eller C1-C10 alkyl eventuelt substitueret med et halogenatom(er); R.27 er valgt fra: 1) aryl eventuelt substitueret med en gruppe uafhængigt valgt fra et halogenatom, C1-C10 alkyl og C1-C10 alkoxy, 2) C1-C10 alkoxy, hvor alkylgruppen eventuelt er substitueret med aryl, 3) en hydroxylgruppe, 4) amino, 5) C1-C10 alkylamino, 6) hydroxycarbonyl, 7) heteroaryl eventuelt substitueret med en gruppe(r) uafhængigt valgt fra C1-C10 alkyl og/eller aryl, og 8) heteroaryloxy; R.28 er valgt fra hydrogen eller C1-C10 alkyl eventuelt substitueret med aryl; R.29 er valgt fra hydrogen eller C1-C10 alkyl eventuelt substitueret med aryl; R28 og R29 kan bindes for at danne en ring valgt fra azetidinyl, pyrrolidinyl, piperidinyl, piperazinyl og morpholinyl, og ringen er eventuelt substitueret med en gruppe(r) valgt uafhængigt af hinanden fra C1-C10 alkyl og et halogenatom; R.30 er valgt fra en hydroxylgruppe, C1-C10 alkoxy og -NR31R32; R31 og R32 er uafhængigt valgt fra: 1) hydrogen, 2) C1-C10 alkyl eventuelt substitueret med aryl og 3) aryl; R31 og R32 kan bindes for at danne en ring valgt fra azetidinyl, pyrrolidinyl, piperidinyl, piperazinyl og morpholinyl, og ringen er eventuelt substitueret med en gruppe(r) valgt uafhængigt af hinanden fra C1-C10 alkyl, et halogenatom og Cl-C10 alkoxycarbonyl; og R33 og R34 er uafhængigt valgt fra: 1) hydrogen og 2) C1-C10 alkyl]; og [hvor i den almene formel (2) W, Y, m, n, R4, R5, R6, R7, R11, Ri6, R19, R20, R21, R33, R34 og R44 er som defineret for formlen (1) ; U betegner en binding, C1-C10 alkylen eller en hvilken som helst gruppe valgt grupperne betegnet med følgende formel:
(NB: "e" skal fjernes) A er valgt fra O, NH og Chh; R.46 er valgt fra hydrogen eller R44; T er valgt fra aryl og heteroaryl; V er valgt fra:
E er en 4- til 7-leddet heterocykel eventuelt indeholdende et yderligere element(er) eller gruppe(r) valgt fra O, N, S, SO og SO2, og heterocyklen er eventuelt substitueret med en gruppe(r) valgt fra: 1) hydrogen, 2) et halogenatom, 3) C1-C10 alkyl eventuelt med en hydroxylgruppe(r) uafhængigt valgt fra C1-C10 alkylamino, et halogenatom og en hydroxylgruppe, 4) en hydroxylgruppe, 5) C1-C10 alkoxy eventuelt substitueret med en gruppe(r) uafhængigt valgt fra et halogenatom, en hydroxylgruppe, amino og C1-C10 alkylamino, 6) aryl eventuelt substitueret med en gruppe(r) uafhængigt valgt fra et halogenatom, en hydroxylgruppe, amino og C1-C10 alkylamino, 7) C1-C10 heteroalkyl eventuelt substitueret med en gruppe(r) uafhængigt valgt fra et halogenatom, en hydroxylgruppe, amino og C1-C10 alkylamino, 8) en heterocykel eventuelt substitueret med C1-C10 alkyl, 9) heteroaryl eventuelt substitueret med C1-C10 alkyl, 10) heterocyclyl C1-C10 alkyl,
11) -CORie,
12) -NR19R20 og
13) -SO2R21; Z er en divalent gruppe valgt fra: 1) C1-C10 alkylen eller Cl-CIO heteroalkylen eventuelt substitueret med et halogenatom(er) og/eller en hydroxylgruppe(r), hvor og carbonatom(erne) kan oxideres for at danne carbonyl; 2) C2-C10 alkenylen eller C2-C10 heteroalkenylen eventuelt substitueret med et halogenatom(er) og/eller en hydroxylgruppe(r), hvor og carbonatom(erne) kan oxideres for at danne carbonyl; og 3) en gruppe valgt fra:
G er en divalent gruppe valgt fra: 1) Cl-CIO alkylen eller Cl-CIO heteroalkylen eventuelt substitueret med et halogenatom(er); og 2) C2-C10 alkenylen eller C2-C10 heteroalkenylen eventuelt substitueret med et halogenatom(er); J er en divalent gruppe valgt fra: 1) Cl-CIO alkylen eller Cl-CIO heteroalkylen eventuelt substitueret med et halogenatom(er); og 2) C2-C10 alkenylen eller C2-C10 heteroalkenylen - eventuelt substitueret med et halogenatom(er); B er valgt fra en heterocykel eller heteroaryl; og R45 er valgt fra hydrogen eller Cl-CIO alkyl]; og hvor i forbindelse vist med den almene formel (1) eller (2) udtrykket "heteroalkyl" betegner en gruppe indeholdende 1 til 5 heteroatomer i alkyl-skelettet, udtrykket "heteroalkylen" betegner en gruppe indeholdende 1 til 5 heteroatomer i alkylenskelettet, og udtrykket "heteroalkenylen" betegner en gruppe indeholdende 1 til 5 heteroatomer i alkenylenskelettet.
2. Forbindelsen eller et farmakologisk acceptabelt salt deraf ifølge krav 1, hvor W er valgt fra: 1) en enkelt binding, 2) C1-C10 alkylen eventuelt indeholdende en carbonylgruppe, hvor alkylen eventuelt er substitueret med et halogenatom(er) eller hydroxy, 3) C2-C10 alkenylen eventuelt substitueret med et halogenatom(er), 4) C2-C10 alkynylen, 5) arylen, 6) heteroarylen,
7) -NH-, -NHCH2- eller -NHCH2CH2-, 8) cycloalkylen og 9) -(cycloalkylen)-CH2-; X er valgt fra følgende binding eller grupper: 1) en enkelt binding, 2) C1-C10 alkylen eventuelt substitueret med cycloalkyl, 3) C2-C10 alkenylen, 4) C2-C10 alkynylen og 5) C1-C10 oxyalkylen; Ri er valgt fra: 1) hydrogen, 2) cycloalkyl eventuelt substitueret med en gruppe valgt fra R4, 3) en heterocykel eventuelt substitueret med en gruppe(r) valgt fra R25 og R4, 4) aryl eventuelt substitueret med en gruppe(r) valgt fra R3, R4, Rs og R6 og 5) heteroaryl eventuelt substitueret med en gruppe(r) valgt fra R25, R4 og Rs; Rg er valgt fra: 1) hydrogen, 2) C1-C10 alkyl eventuelt substitueret med en gruppe(r) uafhængigt valgt fra R23, 3) cycloalkyl eventuelt substitueret med et halogenatom(er) eller en hydroxylgruppe(r), 4) en heterocykel eventuelt substitueret med en gruppe(r) valgt fra C1-C10 alkyl, C1-C10 alkylcarbonyl, C1-C10 alkoxy, C1-C10 alkoxycarbonyl, amino og et halogenatom, 5) C1-C10 heteroalkyl eventuelt substitueret med en gruppe(r) valgt fra et halogenatom og en hydroxylgruppe, 6) heteroaryl eventuelt substitueret med en gruppe(r) uafhængigt valgt fra C1-C10 alkyl, C1-C10 alkylcarbonyl, C1-C10 alkoxycarbonyl og et halogenatom og 7) cycloalkenyl eventuelt substitueret med en gruppe(r) valgt fra C1-C10 alkoxy, C1-C10 alkylamino, amino, 1 til 3 hydroxylgrupper og 1 til 4 halogenatoms, hvor cycloalkenyl eventuelt indeholder en carbonylgruppe; Rio er valgt fra: - 1) hydrogen og 2) C1-C10 alkyl eventuelt substitueret med en gruppe(r) uafhængigt valgt fra et halogenatom, en hydroxylgruppe og aryl; R9 og Rio kan bindes for at danne en 4- til 7-leddet heterocykel eventuelt indeholdende et yderligere element(er) eller gruppe(r) uafhængigt valgt fra N, O, S, SO, SO2, carbonyl og thiocarbonyl, og heterocyklen er eventuelt substitueret med en substituent(er) uafhængigt valgt fra R24; R24 er valgt fra: 1) et halogenatom, 2) C1-C10 alkyl eventuelt substitueret med en gruppe(r) uafhængigt valgt fra Cl-C10 alkylamino og C1-C10 alkylcarbonylamino, 3) C1-C10 haloalkyl, 4) en hydroxylgruppe, 5) C1-C10 hydroxyalkyl, 6) C1-C10 alkoxy eventuelt substitueret med en gruppe(r) uafhængigt valgt fra et halogenatom, en hydroxylgruppe, amino og C1-C10 alkylamino, 7) aryl eventuelt substitueret med en gruppe(r) valgt fra et halogenatom, en hydroxylgruppe, amino og C1-C10 alkylamino, 8) C1-C10 heteroalkyl eventuelt substitueret med 1 til 2 grupper valgt fra et halogenatom, en hydroxylgruppe, amino og C1-C10 alkylamino,
9) -COR.16 og
10) -NR19R20; Ru er valgt fra: 1) C1-C10 alkyl eventuelt substitueret med 1 til 3 substituenter uafhængigt valgt fra: 1) en hydroxylgruppe,
11) -NR17R18, iii) a C1-C10 alkoxygruppe, iv) et halogenatom, v) C1-C10 alkoxycarbonyl og vi) aminocarbonyl, 2) aryl, 3) aryl C1-C10 alkyl, 4) cycloalkyl eventuelt substitueret med et halogenatom(er), 5) en heterocykel eventuelt substitueret med C1-C10 alkyl, 6) C1-C10 alkoxy, hvor alkylgruppen eventuelt er substitueret med en gruppe(r) uafhængigt valgt fra C1-C10 alkylcarbonylamino, amino, C1-C10 alkylamino og en hydroxylgruppe, 7) amino, 8) C1-C10 alkylamino, hvor alkylgruppen eventuelt er substitueret med en gruppe(r) uafhængigt valgt fra C1-C10 alkylcarbonylamino, amino, C1-C10 alkylamino, hydroxycarbonyl og en hydroxylgruppe og 9) C2-C10 alkenyl; og R33 og R34 er hydrogen, hvor R.3, R4, R.5, R.6, R16, R17, Ris, R19, R20, R23 og R25 er som defineret i krav 1, respektivt.
3. Forbindelsen eller et farmakologisk acceptabelt salt deraf ifølge krav 1 eller 2, hvor W er valgt fra: 1) en enkelt binding, 2) C1-C10 alkylen eventuelt substitueret med et halogenatom(er), 3) C2-C10 alkenylen, 4) C2-C10 alkynylen og 5) heteroarylen, X er valgt fra følgende binding eller grupper: 1) en enkelt binding, 2) C1-C10 alkylen, 3) C2-C10 alkenylen, 4) C2-C10 alkynylen og 5) C1-C10 oxyalkylen, hvor oxyalkylen er bundet til en l,3,8-triaza-spiro[4.5]dec- l-en-4-on ring eller en l,3,8-triaza-spiro[4.5]dec-l-en-4-thionring gennem et carbonatom i oxyalkylen; Ri er valgt fra: 1) aryl eventuelt substitueret med en gruppe(r) valgt fra R3, R4 og R5 og 2) heteroaryl eventuelt substitueret med en gruppe(r) valgt fra R25 og R4; R3 er valgt fra: 1) -conr7r8,
2) -OR9,
3) -NR9R10, 4) -N(R9)CORu, 5) -N(R9)S02Ri2,
6) -SO2R15, 7) C1-C10 alkyl eventuelt substitueret med en gruppe(r) valgt fra -COR16 og -NR13R14 og 8) -N(R9)CSNH2; R4 er valgt fra: 1) halogen, 2) cyano, 3) amino, 4) C1-C10 alkyl, 5) Cl-CIO haloalkyl, 6) Cl-CIO alkoxy, 7) Cl-CIO haloalkylcarbonyl,
8) -CORi6 og 9) Cl-CIO heteroalkyl; R2 er valgt fra: 1) Cl-CIO alkyl eventuelt substitueret med et halogenatom(er), hvor alkylgruppen er eventuelt yderligere substitueret med en gruppe valgt fra R42, 2) C2-C10 alkenyl eventuelt substitueret med et halogenatom(er), hvor alkynylgruppen er eventuelt yderligere substitueret med en gruppe valgt fra R42, 3) C2-C10 alkynyl eventuelt substitueret med et halogenatom(er), hvor alkynylgruppen eventuelt er yderligere substitueret med en gruppe valgt fra R42, 4) cycloalkyl eventuelt substitueret med en gruppe(r) uafhængigt valgt fra: i) et halogenatom, ii) C2-C10 alkenyl eller Cl-CIO alkyl, iii) aryl eventuelt substitueret med en gruppe(r) uafhængigt valgt fra Cl-CIO alkyl, et halogenatom og Cl-CIO alkoxy, iv) cycloalkyl, v) C2-C10 haloalkenyl eller Cl-CIO haloalkyl, vi) Cl-CIO alkyliden, hvor alkyliden er bundet til cycloalkyl med en dobbeltbinding og alkyliden er eventuelt substitueret med et halogenatom(er), vii) Cl-CIO alkoxy eventuelt substitueret med et halogenatom(er), viii) C1-C10 alkyl substitueret med Cl-CIO alkoxy, hvor alkyl og/eller alkyl i alkoxy eventuelt er substitueret med et halogenatom(er), ix) C2-C10 alkynyl og x) -Si (1*43)3, 5) en heterocykel, hvor heterocyklen er eventuelt substitueret med en gruppe(r) valgt fra: i) en Cl-CIO alkylgruppe, ii) Cl-CIO alkylcarbonyl, hvor alkylgruppen eventuelt er substitueret med R27, iii) arylcarbonyl, hvor arylgruppen eventuelt er substitueret med en gruppe(r) uafhængigt valgt fra et halogenatom, Cl-CIO alkyl og Cl-CIO alkoxy, iv) heteroarylcarbonyl, v) Cl-CIO alkoxycarbonyl, hvor alkylgruppen eventuelt er substitueret med en gruppe(r) uafhængigt valgt fra et halogenatom, aryl og Cl-CIO alkoxy, vi) aryloxycarbonyl, hvor arylgruppen eventuelt er substitueret med et halogenatom(er) og/eller Cl-CIO alkyl, vii) -CONR28R29 og viii) -SO2R21, 6) aryl eventuelt substitueret med en gruppe(r) uafhængigt valgt fra R44, 7) heteroaryl eventuelt substitueret med hvilke som helst af følgende grupper: i) Cl-CIO alkyl, 8) Cl-CIO alkoxy eventuelt substitueret med et halogenatom(er), hvor alkoxygruppen er eventuelt yderligere substitueret med en gruppe valgt fra R42, 9) -S(0)qR43 (hvor q er et heltal på 0 til 2) og 10) cycloalkenyl eventuelt substitueret med Cl-CIO alkyl, R.44 er valgt fra: 1) et halogenatom, 2) cyano, 3) C1-C10 alkyl eventuelt substitueret med hvilke som helst af følgende grupper: i) en hydroxylgruppe, ii) -OR.26, iii) cyano og iv) aryloxy eventuelt substitueret med en gruppe(r) valgt fra et halogenatom, Cl-C10 alkyl, C1-C10 haloalkyl eller C1-C10 haloalkoxy, 4) C1-C10 haloalkyl, 5) cycloalkyl eventuelt substitueret med en gruppe(r) valgt fra et halogenatom og C1-C10 haloalkyl, 6) C1-C10 alkoxy eventuelt substitueret med et halogenatom(er) eller en C2-C6 alkenyl gruppe(r),
7) -COR.30, 8) C1-C10 heteroalkyl eventuelt substitueret med et halogenatom(er), 9) aryl eventuelt substitueret med en gruppe(r) uafhængigt valgt fra: i) C1-C10 alkyl og ii) aryl, 10) heteroaryl eventuelt substitueret med en C1-C10 alkyl gruppe(r),
11) -SO2R43, 12) C1-C10 alkylthio eventuelt substitueret med et halogenatom(er),
13) -Si(R43) og
14) -SF5; og R27 er valgt fra: 1) aryl eventuelt substitueret med en gruppe(r) uafhængigt valgt fra et halogenatom, C1-C10 alkyl og C1-C10 alkoxy, 2) C1-C10 alkoxy, hvor alkylgruppen eventuelt er substitueret med aryl, 3) heteroaryl eventuelt substitueret med en gruppe(r) uafhængigt valgt fra C1-C10 alkyl og aryl og 4) heteroaryloxy, hvor Rs, R7, Rs, R9, Rio, Ru, R12, R13, R14, R15, Ri6, R21, R25, R26, R28, R29, R30, R42 og R43 er som defineret i krav 1 eller 2 fra hvilke krav 3 afhænger, respektivt.
4. Forbindelsen eller et farmakologisk acceptabelt salt deraf ifølge et hvilket som helst af kravene 1 til 3, hvor W er valgt fra: 1) C1-C6 alkylen eventuelt substitueret med et fluoratom(er), 2) C1-C6 alkenylen og 3) thiophen, X er valgt fra følgende binding eller grupper: 1) en enkelt binding, 2) C1-C6 alkylen og 3) C1-C6 oxyalkylen eventuelt substitueret med et halogenatom(er), hvor oxyalkylen er bundet til en l,3,8-triaza-spiro[4.5]dec-l-en-4-on-ring eller en l,3,8-triaza-spiro[4.5]dec-l-en-4-thion-ring gennem et carbonatom i oxyalkylen; Y betegner et oxygenatom; m betegner 1; og n betegner 1.
5. Forbindelsen eller et farmakologisk acceptabelt salt deraf ifølge et hvilket som helst af kravene 1 til 4, hvor W er valgt fra: 1) ethylen, 2) vinylen og 3) thiophen, X betegner en enkeltbinding; R.3 er valgt fra:
1) -CONR7R8,
2) -OR9,
3) -NRgRio, 4) -N(R9)CORii, 5) -N (R9)S02Ri2,
6) -SO2R15 og 7) C1-C6 alkyl eventuelt substitueret med en gruppe(r) valgt fra -COR16 og -NR13R14; R2 er valgt fra: 1) C1-C10 alkyl eventuelt substitueret med et halogenatom(er), hvor alkylgruppen er eventuelt yderligere substitueret med en gruppe valgt fra R42, 2) C2-C10 alkenyl eventuelt substitueret med et halogenatom(er), hvor alkynylgruppen er eventuelt yderligere substitueret med en gruppe valgt fra R42, 3) C2-C10 alkynyl eventuelt substitueret med et halogenatom(er), hvor alkynylgruppen eventuelt yderligere er substitueret med en gruppe valgt fra R42, 4) cycloalkyl eventuelt substitueret med en gruppe(r) uafhængigt valgt fra: i) et halogenatom, ii) C2-C6 alkenyl eller C1-C6 alkyl, iii) aryl eventuelt substitueret med en gruppe(r) uafhængigt valgt fra C1-C6 alkyl, et halogenatom, C1-C6 alkoxy, C1-C6 alkylamino og C1-C6 alkylcarbonyl, iv) cycloalkyl, v) C2-C6 haloalkenyl eller C1-C6 haloalkyl, vi) C1-C6 alkyliden, hvor alkyliden er bundet til cycloalkyl med en dobbeltbinding og alkyliden eventuelt er substitueret med et halogenatom(er), vii) C1-C6 alkoxy eventuelt substitueret med et halogenatom(er), viii) C1-C6 alkyl substitueret med C1-C6 alkoxy, hvor alkyl og/eller alkyl i alkoxy eventuelt er substitueret med halogen, ix) C2-C6 alkynyl og x) -Si (1^43)3, 5) en gruppe som vist med følgende almene formel (B):
(hvor Ra betegner en gruppe valgt fra: i) C1-C6 alkylcarbonyl, hvor alkylgruppen eventuelt er substitueret med R27, ii) arylcarbonyl, hvor arylgruppen eventuelt er substitueret med en gruppe(r) uafhængigt valgt fra et halogenatom, C1-C6 alkyl og C1-C6 alkoxy, iii) C1-C6 alkoxycarbonyl, hvor alkylgruppen eventuelt er substitueret med en gruppe(r) valgt fra et halogenatom, aryl og C1-C6 alkoxy, iv) aryloxycarbonyl, hvor arylgruppen eventuelt er substitueret med et halogenatom(er) eller C1-C6 alkyl, v) -CONR28R29 og vi) -SO2R21), 6) aryl eventuelt substitueret med en gruppe(r) uafhængigt valgt fra R44, 7) heteroaryl eventuelt substitueret med hvilke som helst af følgende grupper: i) et halogenatom, ii) C1-C6 alkyl og iii) C1-C6 alkoxy; 8) C1-C6 alkoxy eventuelt substitueret med et halogenatom(er), hvor alkoxygruppen eventuelt yderligere er substitueret med en gruppe valgt fra R42, 9) -S(0)qR43 (hvor q er et heltal på 0 til 2) og 10) cycloalkenyl eventuelt substitueret med C1-C6 alkyl; og R44 er valgt fra: 1) et halogenatom, 2) cyano, 3) C1-C6 alkyl eventuelt substitueret med hvilke som helst af følgende grupper: i) en hydroxylgruppe,
11) -OR26, iii) cyano og iv) aryloxy eventuelt substitueret med en gruppe(r) valgt fra et halogenatom, Cl-C6 alkyl, C1-C6 haloalkyl eller C1-C6 haloalkoxy, 4) C1-C6 haloalkyl, 5) cycloalkyl eventuelt substitueret med en gruppe(r) valgt fra et halogenatom og C1-C6 haloalkyl, 6) C1-C6 alkoxy eventuelt substitueret med et halogenatom(er),
7) -COR30, 8) C1-C6 heteroalkyl eventuelt substitueret med et halogenatom(er), 9) aryl eventuelt substitueret med en gruppe(r) uafhængigt valgt fra: i) C1-C6 alkyl og ii) aryl, 10) heteroaryl eventuelt substitueret med en C1-C6 alkyl gruppe(r),
11) -SO2R43, 12) C1-C6 alkylthio eventuelt substitueret med et halogenatom(er),
13) -Si(R43)3 og
14) -SF5, hvor R7, Re, R9, Rio, Ru, R12, R13, R14, Ris, Ri6, R21, R26, R27, R28, R29, R30, R42 og R43 er som defineret i kravene 1 til 4 fra hvilke krav 5 afhænger, respektivt.
6. Forbindelsen eller et farmakologisk acceptabelt salt deraf ifølge krav 3, hvor Ri er en gruppe som vist med følgende almene formel (3):
(3) hvor R3, R4 og R5 er som defineret for R3, R4 og R5 i krav 3.
7. Forbindelsen eller et farmakologisk acceptabelt salt deraf ifølge krav 3, hvor Ri er en gruppe som vist med følgende almene formel (4):
(4) hvor R.4 og R25 er som defineret for R4 og R25 i krav 3.
8. Forbindelsen eller et farmakologisk acceptabelt salt deraf ifølge krav 5, hvor Ri er en gruppe som vist med følgende almene formel (3):
(3) hvor R3, R4 og R5 er som defineret for R3, R4 og Rs i krav 5.
9. Forbindelsen eller et farmakologisk acceptabelt salt deraf ifølge krav 5, hvor Ri er en gruppe som vist med følgende almene formel (4):
(4) hvor R4 og R25 er som defineret for R4 og R25 i krav 5.
10. Forbindelse ifølge krav 1, hvor forbindelsen er: (1) 8-(3-chlor-benzensulfonyl)-2-cyclohexyl-l,3,8-triaza-spiro[4.5]dec-l-en-4-on; (2) 8-(3-chlor-benzensulfonyl)-2-pyridin-4-yl-l,3,8-triaza-spiro[4.5]dec-l-en-4-on; (3) 8-(3-chlor-benzensulfonyl)-2-propyl-l,3,8-triaza-spiro[4.5]dec-l-en-4-on; (4) 8-(3-chlor-benzensulfonyl)-2-isopropyl-l,3,8-triaza-spiro[4.5]dec-l-en-4-on; (5) 8-(3-chlor-benzensulfonyl)-2-(3-methoxy-phenyl)-l,3,8-triaza-spiro[4.5]dec-l-en-4-on; (6) 8-(3-chlor-benzensulfonyl)-2-(3-chlor-phenyl)-l,3,8-triaza-spiro[4.5]dec-l-en-4-on; (7) 2-benzyl-8-(3-chlor-benzensulfonyl)-l,3,8-triaza-spiro[4.5]dec-l-en-4-on; (8) 8-(3-chlor-benzensulfonyl)-2-methyl-l,3,8-triaza-spiro[4.5]dec-l-en-4-on; (10) 2-biphenyl-2-yl-8-(3-chlor-benzensulfonyl)-l,3,8-tnaza-spiro[4.5]dec-l-en-4-on (11) 8-(3-chlor-benzensulfonyl)-2-o-tolyl-l,3,8-triazaspiro[4.5]dec-l-en-4-on; (12) 8-(3-chlor-benzensulfonyl)-2-(4-trifluornnethylphenyl)-l,3,8-tnaza-spiro[4.5]dec-l-en-4-on; (13) 8-(3-chlor-benzensulfonyl)-2-(3-trifluornnethoxyphenyl)-l,3,8-tnaza-spiro[4.5]dec-l-en-4-on; (14) 8-(3-chlor-benzensulfonyl)-2-(l-methylcyclohexyl)-l,3,8-triaza-spiro[4.5]dec- l-en-4-on; (15) 2-(l-acetyl-piperidin-4-yl)-8-(3-chlorbenzensulfonyl)-l,3,8-triaza-spiro[4.5]dec-l-en-4-on; (16) 2-tert-butyl-8-(3-chlor-benzensulfonyl)-l,3,8-triaza-spiro[4.5]dec-l-en-4-on; (17) 8-(3-chlor-benzensulfonyl)-2-(4-trifluormethylcyclohexyl)-l,3,8-triaza-spiro[4.5]dec-l-en-4-on; (18) 3-[8-(3-chlor-benzensulfonyl)-4-oxo-l,3,8-triazaspiro[4.5]dec-l-en-2-yl]-piperidin-l-carboxylsyre-tert-butylester; (19) 8-(3-chlor-benzensulfonyl)-2-(3-methylcyclohexyl)-l,3,8-triaza-spiro[4.5]dec-l-en-4-on; (20) 8-(3-chlor-benzensulfonyl)-2-(2-methylcyclohexyl)-l,3,8-triaza-spiro[4.5]dec-l-en-4-on; (21) 8-(3-chlor-benzensulfonyl)-2-(4-propylcyclohexyl)-l,3,8-triaza-spiro[4.5]dec-l-en-4-on; (22) 2-(lR,2S,4S)-bicyclo[2.2.1]hept-2-yl-8-(3-chlorbenzensulfonyl)-l,3,8-triaza-spiro[4.5]dec-l-en-4-on; (23) 2-(lR,2R,4S)-bicyclo[2.2.1]hept-2-yl-8-(3-chlorbenzensulfonyl)-l,3,8-triaza-spiro[4.5]dec-l-en-4-on; (24) 8-(3-chlor-benzensulfonyl)-2-(4-methoxycyclohexyl)-l,3,8-triaza-spiro[4.5]dec-l-en-4-on; (25) 8-(3-chlor-benzensulfonyl)-2-(4-methoxycyclohexyl)-l,3,8-triaza-spiro[4.5]dec-l-en-4-on; (26) 2-(4-tert-butyl-cyclohexyl)-8-(3-chlorbenzensulfonyl)-l,3,8-tnaza-spiro[4.5]dec-l-en-4-on; (27) 8-(3-chlor-benzensulfonyl)-2-(4-fluormethylcyclohexyl)-l,3,8-tnaza-spiro[4.5]dec-l-en-4-on; (28) 8-(3-chlor-benzensulfonyl)-2-cyclohexylmethyl-l,3,8-triaza-spiro[4.5]dec-l-en-4-on; (29) 8-(3-chlor-benzensulfonyl)-2-phenethyl-l,3,8-tnaza-spiro[4.5]dec-l-en-4-on; (30) 8-(3-chlor-benzensulfonyl)-2-(2-cyclohexyl-ethyl)-l,3,8-triaza-spiro[4.5]dec-l-en-4-on; (31) 8-(3-chlor-benzensulfonyl)-2-(3-tnfluormethyl-phenyl)-l,3,8-tnaza-spiro[4.5]dec-l-en-4-on; (32) 8-(3-chlor-benzensulfonyl)-2-(3-methansulfonyl-phenyl)-l,3,8-tnaza-spiro[4.5]dec-l-en-4-on; (33) 8-(3-chlor-benzensulfonyl)-2-(l-phenylcyclohexyl)-l,3,8-triaza-spiro[4.5]dec-l-en-4-on; (34) 8-(3-chlor-benzensulfonyl)-2-(2-naphthalen-l-yl-ethyl)-l,3,8-tnaza-spiro[4.5]dec-l-en-4-on; (35) 8-(2-naphthalen-l-yl-ethansulfonyl)-2-(3-trifluormethyl-phenyl)-l,3,8-triaza-spiro[4.5]dec-l-en-4-on; (36) 2-tert-butyl-8-(2-naphthalen-l-yl-ethansulfonyl)-l,3,8-triaza-spiro[4.5]dec-l-en-4-on; (37) 8-(2-naphthalen-l-yl-ethansulfonyl)-2-(4-trifluormethyl-cyclohexyl)-l,3,8-triaza-spiro[4.5]dec-l-en-4-on; (38) 3-[8-(2-naphthalen-l-yl-ethansulfonyl)-4-oxo-l,3,8-triaza-spiro[4.5]dec-l-en-2-yl]-piperidin-l-carboxylsyre-tert-butylester; (39) 8-(2-naphthalen-l-yl-ethansulfonyl)-2-[l-(2-naphthalen-l-yl-ethansulfonyl)-piperidin-3-yl]-l,3,8-tnaza-spiro[4.5]dec-l-en-4-on; (40) 8-(3-chlor-benzensulfonyl)-2-[l-(propan-l-sulfonyl)-piperidin-3-yl]-l,3,8-triaza-spiro[4.5]dec-l-en-4-on; (41) 2-(l-benzensulfonyl-piperidin-3-yl)-8-(3-chlor-benzensulfonyl)-l,3,8-triaza-spiro[4.5]dec-l-en-4-on; (42) 8-(3-chlor-benzensulfonyl)-2-(l-phenylmethansulfonyl-piperidin-3-yl)-l,3,8-triaza-spiro[4.5]dec-l-en-4-on; (43) 8-(2-naphthalen-l-yl-ethansulfonyl)-2-(l-phenylmethansulfonyl-piperidin-3-yl)-l,3,8-triazaspiro[4.5]dec-l-en-4-on; (44) 8-(4-chlor-benzensulfonyl)-2-(2,4-dichlorphenyl)-l,3,8-triaza-spiro[4.5]dec-l-en-4-on; (45) 2-(2,4-dichlor-phenyl)-8-(2-trifluormethylbenzensulfonyl)-l,3,8-tnaza-spiro[4.5]dec-l-en-4-on; (46) 8-(butan-l-sulfonyl)-2-(2,4-dichlor-phenyl)-l,3,8-triaza-spiro[4.5]dec-l-en-4-on; (47) 2-(2,4-dichlor-phenyl)-8-(2-naphthalen-l-yl-ethansulfonyl)-l,3,8-triaza-spiro[4.5]dec-l-en-4-on; (48) 2-(2,4-dichlor-phenyl)-8-(quinolin-8-sulfonyl)-l,3,8-tnaza-spiro[4.5]dec-l-en-4-on; (49) 8-(3-chlor-4-fluor-benzensulfonyl)-2-(2,4-dichlor-phenyl)-l,3,8-triaza-spiro[4.5]dec-l-en-4-on; (50) 8-(3-chlor-benzensulfonyl)-2-(2,4-dichlorphenyl)-l,3,8-triaza-spiro[4.5]dec-l-en-4-on; (51) 2-(2-cyclohexyl-4-oxo-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl)-benzoesyre-methylester; (52) 2-cyclohexyl-8-(5-methyl-3-phenyl-isoxazol-4-sulfonyl)-1,3,8-triaza-spiro[4.5]dec-l-en-4-on; (53) 8-(benzo[b]thiophen-3-sulfonyl)-2-cyclohexyl-l,3,8-triaza-spiro[4.5]dec-l-en-4-on; (54) 8-(benzo[b]thiophen-2-sulfonyl)-2-cyclohexyl-l,3,8-triaza-spiro[4.5]dec-l-en-4-on; (55) 8-(5-chlor-thiophen-2-sulfonyl)-2-cyclohexyl-l,3,8-triaza-spiro[4.5]dec-l-en-4-on; (56) 2-cyclohexyl-8-(thiophen-2-sulfonyl)-l,3,8-triazaspiro[4.5]dec-l-en-4-on; (57) 2-cyclohexyl-8-(naphthalen-l-sulfonyl)-l,3,8-triaza-spiro[4.5]dec-l-en-4-on; (58) 2-cyclohexyl-8-(2,4-dimethyl-thiazol-5-sulfonyl)-l,3,8-triaza-spiro[4.5]dec-l-en-4-on; (59) 2-cyclohexyl-8-(3,5-dimethyl-isoxazol-4-sulfonyl)-l,3,8-triaza-spiro[4.5]dec-l-en-4-on; (60) 2-cyclohexyl-8-(2,3-dihydro-benzo[l,4]dioxin-6-sulfonyl)-l,3,8-triaza-spiro[4.5]dec-l-en-4-on; (61) 2-cyclohexyl-8-(2-naphthalen-l-yl-ethansulfonyl)-l,3,8-triaza-spiro[4.5]dec-l-en-4-on; (62) 3-(2-cyclohexyl-4-oxo-l,3,8-tnaza-spiro[4.5]dec-l-en-8-sulfonyl)-thiophen-2-carboxylsyre-methylester; (63) 5-(2-cyclohexyl-4-oxo-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl)-4-methyl-thiophen-2-carboxylsyre-methylester; (64) 2-cyclohexyl-8-(2,5-dimethyl-thiophen-3-sulfonyl)-l,3,8-triaza-spiro[4.5]dec-l-en-4-on; (65) 8-(5-bromo-thiophen-2-sulfonyl)-2-cyclohexyl-l,3,8-triaza-spiro[4.5]dec-l-en-4-on; (66) 8-(5-chlor-thiophen-2-sulfonyl)-2-(3-trifluormethyl-phenyl)-l,3,8-triaza-spiro[4.5]dec-l-en-4-on; (67) 8-(naphthalen-2-sulfonyl)-2-(3-trifluormethyl-phenyl)-l,3,8-triaza-spiro[4.5]dec-l-en-4-on; (68) 8-(benzo[b]thiophen-2-sulfonyl)-2-(3-trifluormethyl-phenyl)-l,3,8-triaza-spiro[4.5]dec-l-en-4-on; (69) 8-(5-bromo-thiophen-2-sulfonyl)-2-(3-trifluormethyl-phenyl)-l,3,8-triaza-spiro[4.5]dec-l-en-4-on; (70) 8-(3-chlor-benzensulfonyl)-2-cyclohexyl-l,3,8-triaza-spiro[4.6]undec-l-en-4-on; (71) 7-(3-chlor-benzensulfonyl)-2-cyclohexyl-l,3,7-triaza-spiro[4.5]dec-l-en-4-on; (72) 7-(3-chlor-benzensulfonyl)-2-cyclohexyl-l,3,7-triaza-spiro[4.4]non-l-en-4-on; (73) 4-{2-[2-(2,4-dichlor-phenyl)-4-oxo-l,3,8-triazaspiro[4.5]dec-l-en-8-sulfonyl]-ethyl>-3,N,N-trimethyl-benzamid; (74) 4-[2-(2-tert-butyl-4-oxo-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl)-ethyl]-3,N,N-trimethyl-benzamid; (75) 3,N,N,trimethyl-4-{2-[4-oxo-2-(4-trifluormethylphenyl)-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl]-ethyl}-benzamid; (76) 3,N,N-trimethyl-4-{2-[2-(4-methyl-cyclohexyl)-4-oxo-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl]-ethyl}-benzamid; (77) 4-[2-(2-cyclopentyl-4-oxo-l,3,8-triazaspiro[4.5]dec-l-en-8-sulfonyl)-ethyl]-3, Ν,Ν-tri methyl benzamid; (78) 4-{2-[2-(2,6-difluor-phenyl)-4-oxo-l,3,8-triazaspiro[4.5]dec-l-en-8-sulfonyl]-ethyl}-3,Ν,Ν-tri methyl benzamid; (79) 4-{2-[2-(2,6-dimethoxy-phenyl)-4-oxo-l,3,8-triazaspiro[4.5]dec-l-en-8-sulfonyl]-ethyl}-3, Ν,Ν-tri methyl benzamid; (80) 4-{2-[2-(3-methoxy-phenyl)-4-oxo-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl]-ethyl}-3,N,N-trimethyl-benzamid; (81) 4-{2-[2-(3-chlor-phenyl)-4-oxo-l,3,8-triazaspiro[4.5]dec-l-en-8-sulfonyl]-ethyl>-3,Ν,Ν-tri methyl-benzamid; (82) 4-{2-[2-(3,5-bis-trifluormethyl-phenyl)-4-oxo-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl]-ethyl}-3,N,N-trimethyl-benzamid; (83) 4-[2-(2-benzyl-4-oxo-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl)-ethyl]-3,Ν,Ν-tri methyl-benzamid; (84) 3,N,N-trimethyl-4-[2-(4-oxo-2-m-tolyl-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl)-ethyl]-benzamid; (85) 4-{2-[2-(2-chlor-5-t-rifluormethyl-phenyl)-4-oxo-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl]-ethyl>-3,N,N-trimethyl-benzamid; (86) 3, Ν,Ν-tri methyl-4-{2-[4-oxo-2-(3-trifluormethylphenyl)-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl]-ethyl>-benzamid; (87) 4-{2-[2-(4-chlor-phenyl)-4-oxo-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl]-ethyl}-3, Ν,Ν-tri methyl-benzamid; (88) 4-{2-[2-(2,3-dichlor-phenyl)-4-oxo-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl]-ethyl>-3,N,N-trimethylbenzamid; (89) 4-{2-[2-(3-chlor-4-fluor-phenyl)-4-oxo-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl]-ethyl>-3,N,N-trimethyl-benzamid; (90) 4-{2-[2-(2-chlor-4-fluor-phenyl)-4-oxo-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl]-ethyl>-3,N,N-trimethyl-benzamid; (91) 4-{2-[2-(3-bromo-phenyl)-4-oxo-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl]-ethyl}-3,N,N-trimethyl-benzamid; (92) 4-{2-[2-(2,2-difluor-benzo[l,3]dioxol-4-yl)-4-oxo-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl]-ethyl>-3,N,N-trimethyl-benzamid; (93) 4-{2-[2-(3-chlor-2-fluor-phenyl)-4-oxo-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl]-ethyl}-3,N,N-trimethyl-benzamid; (94) 3,N,N-trimethyl-4-(2-{4-oxo-2-[4-(l,l,2,2-tetrafluor-ethoxy)-phenyl]-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl>-ethyl)-benzamid; (95) 4-{2-[2-(4-chlor-3-methyl-phenyl)-4-oxo-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl]-ethyl>-3,N,N-trimethyl-benzamid; (96) 4-{2-[2-(3-fluor-4-trifluormethyl-phenyl)-4-oxo-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl]-ethyl>-3,N,N-trimethyl-benzamid; (97) 3,N,N-tnmethyl-4-(2-[2-(6-methyl-pyridin-2-yl)-4-oxo-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl]-ethyl}-benzamid; (98) 4-{2-[2-(3,4-dichlor-phenyl)-4-oxo-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl]-ethyl>-3,N,N-trimethyl-benzannid; (99) 3,N,N-trimethyl-4-{2-[4-oxo-2-(3-tnfluormethoxyphenyl)-l,3,8-tnaza-spiro[4.5]dec-l-en-8-sulfonyl]-ethyl>-benzamid; (100) 4-{2-[2-(2,4-bis-trifluormethyl-phenyl)-4-oxo-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl]-ethyl>-3,N,N-trimethyl-benzannid; (101) 3,N,N-trimethyl-4-[2-(4-oxo-2-phenethyl-l,3,8-tnaza-spiro[4.5]dec-l-en-8-sulfonyl)-ethyl]-benzamid; (102) 4-{2-[2-(2,4-dimethyl-thiazol-5-yl)-4-oxo-l,3,8-tnaza-spiro[4.5]dec-l-en-8-sulfonyl]-ethyl}-3,N,N-trimethyl-benzannid; (103) 4-[2-(2-cyclohexylmethyl-4-oxo-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl)-ethyl]-3,N,N-tnmethyl-benzamid; (104) 3,N,N-trimethyl-4-{2-[4-oxo-2-(4-tnfluormethyl-cyclohexyl)-l,3,8-tnaza-spiro[4.5]dec-l-en-8-sulfonyl]-ethyl>-benzamid; (105) 3,N,N-trimethyl-4-{2-[4-oxo-2-(2-tnfluormethoxy-phenyl)-l,3,8-tnaza-spiro[4.5]dec-l-en-8-sulfonyl]-ethyl>-benzamid; (106) 3,N,N-trimethyl-4-{2-[4-oxo-2-(4-tnfluormethoxy-phenyl)-l,3,8-tnaza-spiro[4.5]dec-l-en-8-sulfonyl]-ethyl>-benzamid; (107) 4-{2-[2-(4-fluor-3-trifluormethyl-phenyl)-4-oxo-l,3,8-tnaza-spiro[4.5]dec-l-en-8-sulfonyl]-ethyl>-3,N,N-tnmethyl-benzannid; (108) 4-{2-[2-(2-cyclohexyl-ethyl)-4-oxo-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl]-ethyl>-3,N,N-trimethyl-benzannid; (109) 4-{2-[2-(3-fluor-phenyl)-4-oxo-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl]-ethyl>-3,N,N-trimethyl-benzannid; (110) 4-{2-[2-(3-methansulfonyl-phenyl)-4-oxo-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl]-ethyl>-3,N,N-trimethyl-benzannid; (111) 3,N,N-tnmethyl-4-{2-[2-(2-methyl-3-trifluormethyl-phenyl)-4-oxo-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl]-ethyl>-benzamid; (112) 3,N,N-trimethyl-4-{2-[2-(2-methyl-5-trifluormethyl-phenyl)-4-oxo-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl]-ethyl>-benzamid; (113) 4-{2-[2-(2,3-dimethyl-phenyl)-4-oxo-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl]-ethyl>-3,N,N-trimethyl-benzamid; (114) 4-{2-[2-(3-fluor-2-methyl-phenyl)-4-oxo-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl]-ethyl>-3,N,N-trimethyl-benzamid; (115) 4-{2-[2-(3-fluor-5-trifluormethyl-phenyl)-4-oxo-l,3,8-triaza-spiro[4.5]dec-l-en-S-sulfony^-ethy^-SjNjN-trimethyl-benzamid; (116) 4-{2-[2-(2-fluor-3-trifluormethyl-phenyl)-4-oxo-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl]-ethyl>-3,N,N-trimethyl-benzamid; (117) 4-{2-[2-(4-fluor-3-methyl-phenyl)-4-oxo-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl]-ethyl>-3,N,N-trimethyl-benzannid; (118) 4-{2-[2-(4-difluormethoxy-phenyl)-4-oxo-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl]-ethyl>-3,N,N-trimethyl-benzannid; (119) 4-{2-[2-(2-methoxy-pyndin-4-yl)-4-oxo-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl]-ethyl}-3,N,N-trimethyl-benzannid; (120) 3,N,N-trimethyl-4-{2-[2-(5-methyl-pyrazin-2-yl)-4-oxo-l,3,8-tnaza-spiro[4.5]dec-l-en-8-sulfonyl]-ethyl>-benzamid; (121) 3,N,N-tnmethyl-4-[2-(4-oxo-2-thiazol-4-yl-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl)-ethyl]-benzamid; (122) 3,N,N-tnmethyl-4-{2-[2-(l-methyl-lH-imidazol-2-yl)-4-oxo-l,3,8-tnaza-spiro[4.5]dec-l-en-8-sulfonyl]-ethyl)--benzannid; (123) 3,N,N-trimethyl-4-{2-[4-oxo-2-(tetrahydro-pyran-4-yl)-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl]-ethyl}-benzamid; (124) 4-{2-[2-(4-chlor-phenoxymethyl)-4-oxo-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl]-ethyl}-3,N,N-trimethyl-benzamid; (125) 4-{2-[2-(4-fluor-phenoxymethyl)-4-oxo-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl]-ethyl}-3,N,N-trimethyl-benzamid; (126) 4-{2-[2-(4-chlor-3-trifluormethyl-phenyl)-4-oxo-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl]-ethyl}-3,N,N-trimethyl-benzamid; (127) 4-{2-[2-(3-chlor-5-trifluormethyl-phenyl)-4-oxo-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl]-ethyl>-3,N,N-trimethyl-benzamid; (128) 4-{2-[2-(4-chlor-2-methyl-phenyl)-4-oxo-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl]-ethyl>-3,N,N-trimethyl-benzamid; (129) 4-{2-[2-(4-chlor-2-fluor-phenyl)-4-oxo-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl]-ethyl>-3,N,N-trimethyl-benzamid; (130) 4-{2-[2-(3-isopropoxymethyl-phenyl)-4-oxo-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl]-ethyl}-3,N,N-trimethyl-benzamid; (131) 4-{2-[2-(2,4-dichlor-phenoxymethyl)-4-oxo-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl]-ethyl}-3,N,N-trimethyl-benzamid; (133) 4-{2-[2-(3-chlor-2-methyl-phenyl)-4-oxo-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl]-ethyl>-3,N,N-trimethyl-benzamid; (134) 4-{2-[2-(2,4-dichlor-benzyl)-4-oxo-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl]-ethyl}-3,N,N-trimethyl-benzamid; (135) 3,N,N-trimethyl-4-{2-[4-oxo-2-(3-trifluormethyl-benzyl)-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl]-ethyl>-benzamid; (136) 3,N,N-trimethyl-4-{2-[4-oxo-2-(l-trifluormethyl-cyclopropyl)-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl]-ethyl>-benzamid; (137) 3,N,N-tnmethyl-4-{2-[4-oxo-2-(l-trifluormethyl-cyclobutyl)-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl]-ethyl}-benzamid; (138) 3,N,N-tnmethyl-4-{2-[4-oxo-2-(l-trifluormethyl-cyclopentyl)-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl]-ethyl}-benzamid; (139) 4-{2-[2-(2-fluor-4-trifluormethyl-phenyl)-4-oxo-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl]-ethyl>-3,N,N-trimethyl-benzamid; (140) 3,N,N-trimethyl-4-(2-{4-oxo-2-[3-(l,l,2,2-tetrafluor-ethoxy)-phenyl]-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl>-ethyl)-benzamid; (141) 3,N,N-trimethyl-4-{2-[4-oxo-2-((E)-propenyl)-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl]-ethyl>-benzamid; (142) 3,N,N-trimethyl-4-{2-[4-oxo-2-((E)-styryl)-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl]-ethyl>-benzamid; (143) 4-[2-(2-benzothiazol-6-yl-4-oxo-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl)-ethyl]-3,N,N-trimethyl-benzannid; (144) 4-{2-[2-(4-methoxy-3-trifluormethyl-phenyl)-4-oxo-l,3,8-tnaza-spiro[4.5]dec-l-en-8-sulfonyl]-ethyl}-3,N,N-trimethyl-benzannid; (145) N-{3-methyl-4-[2-(4-oxo-2-m-tolyl-l,3,8-tnaza-spiro[4.5]dec-l-en-8-sulfonyl)-ethyl]-phenyl}-acetamid; (146) N-(4-{2-[2-(2,3-dimethyl-phenyl)-4-oxo-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl]-ethyl}-3-methylphenyl)-acetamid; (147) N-(4-{2-[2-(2,3-dichlor-phenyl)-4-oxo-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl]-ethyl>-3-methylphenyl)-acetamid; (148) N-(3-methyl-4-{2-[2-(4-nnethyl-cydohexyl)-4-oxo-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl]-ethyl>-phenyl)-acetamid; (149) N-(2-hydroxy-ethyl)-N-(3-methyl-4-{2-[4-oxo-2-(3-trifluormethoxy-phenyl)- l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl]-ethyl}-phenyl)-acetannid; (150) eddikesyre (S)-l-acetoxymethyl-2-[acetyl-(3-methyl-4-{2-[4-oxo-2-(3-trifluormethyl-phenyl)-1,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl]-ethyl }-phenyl)-aminoj-ethylester; (151) eddikesyre (S)-l-acetoxymethyl-2-[acetyl-(3-methyl-4-{2-[4-oxo-2-(4-trifluormethyl-phenyl)-1,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl]-ethyl>-phenyl)-amino]-ethylester; (152) eddikesyre (S)-l-acetoxymethyl-2-[acetyl-(3-methyl-4-{2-[4-oxo-2-(4-trifluornnethoxy-phenyl)-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl]-ethyl}-phenyl)-amino]-ethylester; (153) eddikesyre (S)-l-acetoxymethyl-2-[acetyl-(4-{2-[2-(4-fluor-3-trifluornnethyl-phenyl)-4-oxo-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl]-ethyl}-3-methyl-phenyl)-amino]-ethylester; (154) 8-{2-[4-((S)-2,3-dihydroxy-propylamino)-2-methyl-phenyl]-ethansulfonyl>- 2-(4-trifluornnethyl-phenyl)-l,3,8-triaza-spiro[4.5]dec-l-en-4-on; (155) 8-{2-[4-((S)-2,3-dihydroxy-propylamino)-2-methylphenyl]-ethansulfonyl>- 2-(3-trifluornnethyl-phenyl)-l,3,8-triaza-spiro[4.5]dec-l-en-4-on; (156) 8-{2-[4-((S)-2,3-dihydroxy-propylamino)-2-methyl-phenyl]-ethansulfonyl}-2-(4-trifluornnethoxy-phenyl)-l,3,8-triaza-spiro[4.5]dec-l-en-4-on; (157) 2-(3-chlor-phenyl)-8-{2-[4-((S)-2,3-dihydroxy-propylamino)-2-methyl-phenyl]-ethansulfonyl>-l,3,8-triaza-spiro[4.5]dec-l-en-4-on; (158) 2-(4-chlor-phenyl)-8-{2-[4-((S)-2,3-dihydroxy-propylamino)-2-methyl-phenyl]-ethansulfonyl>-l,3,8-triaza-spiro[4.5]dec-l-en-4-on; (159) 8-{2-[4-(2-hydroxy-ethylamino)-2-methyl-phenyl]-ethansulfonyl}-2-(3-trifluormethoxy-phenyl)-l,3,8-triaza-spiro[4.5]dec-l-en-4-on; (160) 8-{2-[4-(2-hydroxy-ethylamino)-2-methyl-phenyl]-ethansulfonyl}-2-(3-trifluormethyl-phenyl)-l,3,8-tnaza-spiro[4.5]dec-l-en-4-on; (161) 8-{2-[4-(2-hydroxy-ethylamino)-2-methyl-phenyl]-ethansulfonyl)--2-(4-trifluormethyl-phenyl)-l,3,8-tnaza-spiro[4.5]dec-l-en-4-on; (162) {4-[2-(2-tert-butyl-4-oxo-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl)-ethyl]- 3-methyl-benzyl>-carbaminsyre-tert-butylester; (163) (4-{2-[2-(4,4-difluor-cyclohexyl)-4-oxo-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl]-ethyl>-3-methyl-benzyl)-carbaminsyre-tert-butylester; (164) (4-{2-[2-(4-fluor-3-trifluormethyl-phenyl)-4-oxo-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl]-ethyl>-3-methyl-benzyl)-carbaminsyre-tert-butylester; (165) (3-methyl-4-{2-[4-oxo-2-(tetrahydro-pyran-4-yl)-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl]-ethyl>-benzyl)-carbaminsyre-tert-butylester; (166) 8-[2-(3-amino-phenyl)-ethansulfonyl]-2-cyclohexyl-l,3,8-triaza-spiro[4.5]dec-l-en-4-on; (167) N-{4-[2-(2-cyclohexyl-4-oxo-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl)-ethyl]-phenyl>-acetamid; (168) 3,N,N-trimethyl-4-(2-{4-oxo-2-[3-(2,2,2-tnfluorethoxymethyl)-phenyl]- l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl>-ethyl)-benzannid; (169) 4-(2-{2-[3-(2,2-difluor-ethoxymethyl)-phenyl]-4-oxo-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl>-ethyl)-3,N,N-trimethyl-benzannid; (170) 3,N,N-trimethyl-4-(2-{4-oxo-2-[3-(2,2,3,3-tetrafluor-propoxymethyl)-phenyl]-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl}-ethyl)-benzannid; (171) 4-(2-{2-[3-(3,5-dimethyl-isoxazol-4-yl)-phenyl]-4-oxo-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl>-ethyl)-3,N,N-trimethyl-benzannid; (172) 4-[2-(2-biphenyl-3-yl-4-oxo-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl)-ethyl]-3,N,N-trimethyl-benzannid; (173) 3,Ν,Ν-trimethyl-4-{2-[4-oxo-2-(3-pyridin-3-yl-phenyl)-1,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl]-ethyl>-benzamid; (174) 3-{8-[2-(4-dimethylcarbamoyl-2-methyl-phenyl)-ethansulfonyl]-4-oxo- l,3,8-triaza-spiro[4.5]dec-l-en-2-yl>-benzoesyre-methylester; (175) 4-(2-{2-[l-(2,4-dichlor-phenoxy)-l-methyl-ethyl]-4-oxo-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl}-ethyl)-3,N,N-trimethyl-benzamid; (176) 3,N,N-trimethyl-4-{2-[4-oxo-2-(2,3,4-trifluorphenoxymethyl)-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl]-ethyl>-benzamid; (177) 2-cyclohexyl-4-oxo-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonsyre (3-ethyl-phenyl)-amid; (178) 2-cyclohexyl-8-[(E)-2-(lH-indol-5-yl)-ethensulfonyl]-l,3,8-triaza-spiro[4.5]dec-l-en-4-on; (179) 2-cyclohexyl-8-[(E)-2-(2-tnfluormethyl-phenyl)-ethensulfonyl]-l,3,8-triaza-spiro[4.5]dec-l-en-4-on; (180) 2-cyclohexyl-8-[(E)-2-(3-methoxy-phenyl)-ethensulfonyl]-l,3,8-triaza-spiro[4.5]dec-l-en-4-on; (181) 2-cyclohexyl-8-[(E)-2-(2-methoxy-phenyl)-ethensulfonyl]-l,3,8-triaza-spiro[4.5]dec-l-en-4-on; (182) 2-cyclohexyl-8-[(E)-2-(lH-indol-4-yl)-ethensulfonyl]-l,3,8-triaza-spiro[4.5]dec-l-en-4-on; (183) 2-cyclohexyl-8-[(E)-2-(2-fluor-6-trifluormethylphenyl)-ethensulfonyl]-l,3,8-triaza-spiro[4.5]dec-l-en-4-on; (184) 2-cyclohexyl-8-[(E)-2-(2,3-difluor-phenyl)-ethensulfonyl]-l,3,8-triaza-spiro[4.5]dec-l-en-4-on; (185) 2-cyclohexyl-8-[(E)-2-(3-fluor-2-trifluormethylphenyl)-ethensulfonyl]-l,3,8-triaza-spiro[4.5]dec-l-en-4-on; (186) 2-cyclohexyl-8-((E)-2-o-tolyl-ethensulfonyl)-l,3,8-triaza-spiro[4.5]dec-l-en- 4-on; (187) 2-cyclohexyl-8-{(E)-2-[4-(2-hydroxy-ethyl)-phenyl]-ethensulfonyl}-l,3,8-triaza-spiro[4.5]dec-l-en-4-on; (188) 2-cyclohexyl-8-[(E)-2-(2-oxo-2,3-dihydrobenzoxazol-7-yl)-ethensulfonyl]- l,3,8-triaza-spiro[4.5]dec-l-en-4-on; (189) 4-[(E)-2-(2-cyclohexyl-4-oxo-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl)-vi nyl]-indole- 1-carboxylsyre-dimethylamid; (190) N-{2-[(E)-2-(2-cyclohexyl-4-oxo-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl)-vinyl]-3-methyl-phenyl>-acetamid; (191) 2-cyclohexyl-8-{(E)-2-[l-((S)-2,3-dihydroxypropyl)-lH-indol-4-yl]-ethensulfonyl}-l,3,8-triaza-spiro[4.5]dec-l-en-4-on; (192) 2-cyclohexyl-8-{(E)-2-[l-(2-morpholin-4-yl-ethyl)-lH-indol-4-yl]-ethensulfonyl>-l,3,8-triaza-spiro[4.5]dec-l-en-4-on; (193) 2-{4-[(E)-2-(2-cyclohexyl-4-oxo-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl)-vinyl]-indol-l-yl}-N,N-dimethyl-acetamid; (194) 3-{4-[(E)-2-(2-cyclohexyl-4-oxo-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl)-vinyl]-3-tnfluormethyl-phenyl}-l,l-dimethyl-urinstof; (195) cyclopropancarboxylsyre-{4-[(E)-2-(2-cyclohexyl-4-oxo-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl)-vinyl]-3-trifluormethyl-phenyl>-amid; (196) N-{4-[(E)-2-(2-cyclohexyl-4-oxo-l,3,8-triazaspiro[4.5]dec-l-en-8-sulfonyl)-vinyl]-3-trifluormethyl-phenyl>-2-hydroxy-acetamid; (197) {3-[(E)-2-(2-cyclohexyl-4-oxo-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl)-vi nyl] -4-methyl -phenyl }-carbaminsyre-methylester; (198) l-{4-[(E)-2-(2-cyclohexyl-4-oxo-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl)-vinyl]-3-trifluormethyl-phenyl>-3-(2-hydroxy-ethyl)-urinstof; (199) 2-cyclohexyl-8-{(E)-2-[5-(2-hydroxy-ethylamino)-2-methyl-phenyl]-ethensulfonyl>-l,3,8-triaza-spiro[4.5]dec-l-en-4-on; (200) 2-cyclohexyl-8-{(E)-2-[2-(2-hydroxy-ethylamino)-6-methyl-phenyl]-ethensulfonyl>-l,3,8-triaza-spiro[4.5]dec-l-en-4-on; (201) 2-{4-[(E)-2-(2-cyclohexyl-4-oxo-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl)-vinyl]-3-trifluormethyl-phenylamino}-N,N-dimethyl-acetamid; (202) 2-cyclohexyl-8-{(E)-2-[l-((S)-2,2-dimethyl-[l,3]dioxolan-4-ylmethyl)-3-fluor-lH-indol-4-yl]-ethensulfonyl>-l,3,8-triaza-spiro[4.5]dec-l-en-4-on; (203) 2-cyclohexyl-8-{(E)-2-[2-methyl-4-(3,3,4,4-tetrafluor-pyrrolidin-l-carbonyl)-phenyl]-ethensulfonyl>-l,3,8-triaza-spiro[4.5]dec-l-en-4-on; (204) N-{4-[(E)-2-(2-cyclohexyl-4-oxo-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl)-vinyl]-3,5-dimethylphenyl>-acetamid; (205) {4-[(E)-2-(2-cyclohexyl-4-oxo-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl)-vinyl]-3-trifluormethyl-benzyl}-carbaminsyre-tert-butylester; (206) 2-cyclohexyl-8-{(E)-2-[4-((R)-2,3-dihydroxypropoxy)-2,6-dimethyl-phenyl]-ethensulfonyl>-l,3,8-triaza-spiro[4.5]dec-l-en-4-on; (207) 2-cyclohexyl-8-((E)-2-{2-methyl-4-[(2-oxo-oxazolidin-5-ylmethyl)-amino]-phenyl>-ethensulfonyl)-l,3,8-triaza-spiro[4.5]dec-l-en-4-on; (208) 2-{4-[(E)-2-(2-cyclohexyl-4-oxo-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl)-vinyl]-phenyl}-N-(2-dimethylamino-ethyl)-acetamid; (209) 3-{(E)-2-[2-(4-methyl-cyclohexyl)-4-oxo-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl]-vinyl }-benzonitril; (210) 8-{(E)-2-[4-(3,4-dihydroxy-butoxy)-2-methyl-phenyl]-ethensulfonyl}-2-(3-trifluormethyl-phenyl)-1,3,8-triaza-spiro[4.5]dec-l-en-4-on; (211) 8-{(E)-2-[4-(2-hydroxy-ethylamino)-2-trifluormethyl-phenyl]-ethensulfonyl}-2-(3-trifluormethyl-phenyl)-l,3,8-triaza-spiro[4.5]dec-l-en-4-on; (212) 8-{(E)-2-[2-methyl-4-(pyrrolidin-l-carbonyl)-phenyl]-ethensulfonyl}-2-(3-trifluormethyl-phenyl)-l,3,8-triaza-spiro[4.5]dec-l-en-4-on; (213) 3-methyl-4-{(E)-2-[4-oxo-2-(3-trifluormethylphenyl)-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl]-vinyl}-benzensulfonamid; (214) N-(2-hydroxy-ethyl)-3,N-dimethyl-4-{(E)-2-[4-oxo-2-(3-trifluormethyl-phenyl)-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl]-vinyl}-benzamid; (215) N-(3-methyl-4-{(E)-2-[4-oxo-2-(3-trifluormethyl-phenyl)-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl]-vinyl}-phenyl)-acetamid; (216) 8-{(E)-2-[2-methyl-4-(4-methyl-piperazin-l-carbonyl)-phenyl]-ethensulfonyl>-2-(3-trifluormethylphenyl)-l,3,8-triaza-spiro[4.5]dec-l-en-4-on; (217) 3-methyl-4-{(E)-2-[4-oxo-2-(3-trifluormethyl-phenyl)-l,3,8-tnaza-spiro[4.5]dec-l-en-8-sulfonyl]-vinyl>-N-(2,2,2-trifluor-ethyl)-benzensulfonannid; (218) 3-methyl-N-(2-morpholin-4-yl-ethyl)-4-{(E)-2-[4-oxo-2-(3-trifluormethyl-phenyl)-l,3,8-triazaspiro[4.5]dec-l-en-8-sulfonyl]-vinyl}-benzensulfonannid; (219) 3-methyl-4-{(E)-2-[4-oxo-2-(3-trifluormethylphenyl)-l,3,8-tnaza-spiro[4.5]dec-l-en-8-sulfonyl]-vinyl}-N-pyridin-3-yl-benzensulfonannid; (220) 8-{(E)-2-[4-((R)-4-hydroxy-2-oxo-pyrrolidin-l-yl)-2-methyl-phenyl]-ethensulfonyl>-2-(3-trifluormethyl-phenyl)-l,3,8-tnaza-spiro[4.5]dec-l-en-4-on; (221) 8-{(E)-2-[4-((R)-2-hydroxymethyl-5-oxo-pyrrolidin-l-yl)-2-methyl-phenyl]-ethensulfonyl>-2-(3-tnfluormethyl-phenyl)-l,3,8-triaza-spiro[4.5]dec-l-en-4-on; (222) 8-{(E)-2-[4-((R)-5-hydroxymethyl-2-oxo-oxazolidin-3-yl)-2-methyl-phenyl]-ethensulfonyl}-2-(3-trifluormethyl-phenyl)-l,3,8-triaza-spiro[4.5]dec-l-en-4-on; (223) 8-((E)-2-{4-[3-(3-dimethylamino-propoxy)-azetidin-l-carbonyl]-2,6-dimethyl-phenyl}-ethensulfonyl)-2-(3-trifluormethyl-phenyl)-l,3,8-triaza-spiro[4.5]dec-l-en-4-on; (224) N-(4-hydroxy-butyl)-3-methyl-4-{(E)-2-[4-oxo-2-(3-trifluormethoxy-phenyl)-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl]-vinyl>-benzensulfonamid; (225) N-methyl-N-(4-methyl-3-{(E)-2-[4-oxo-2-(3-trifluormethoxy-phenyl)-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl]-vinyl>-phenyl)-acetamid; (226) 8-[(E)-2-(3-hydroxy-2-methyl-phenyl)-ethensulfonyl]-2-(3-trifluormethoxy-phenyl)-l,3,8-triaza-spiro[4.5]dec-l-en-4-on; (227) 8-[(E)-2-(5-hydroxy-2-methyl-phenyl)-ethensulfonyl]-2-(3-trifluormethoxy-phenyl)-l,3,8-triaza-spiro[4.5]dec-l-en-4-on; (228) N-(3-methyl-4-{(E)-2-[4-oxo-2-(3-trifluormethoxyphenyl)-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl]-vinyl}-phenyl)-N-(l-methyl-piperidin-4-yl)-acetamid; (229) N-(3,5-dimethyl-4-{(E)-2-[4-oxo-2-(3-trifluormethoxy-phenyl)-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl]-vinyl>-phenyl)-methansulfonamid; (230) 8-{(E)-2-[4-(4-hydroxy-piperidin-l-carbonyl)-2-methyl-phenyl]-ethensulfonyl>-2-(3-trifluormethoxy-phenyl)-l,3,8-triaza-spiro[4.5]dec-l-en-4-on; (231) 3,N,N-trimethyl-4-{(E)-2-[4-oxo-2-(3-tnfluormethoxy-phenyl)-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl]-vinyl>-benzamid; (232) N-(2-hydroxy-ethyl)-N-(3-methyl-4-{(E)-2-[4-oxo-2-(3-trifluormethoxy-phenyl)-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl]-vinyl>-phenyl)-acetamid; (233) 3-fluor-N,N-dimethyl-4-{(E)-2-[4-oxo-2-(3-trifluormethoxy-phenyl)-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl]-vinyl}-benzamid; (234) 8-{(E)-2-[2,5-dichlor-4-(3,4-dihydroxy-butoxy)-phenyl]-ethensulfonyl}-2-(3-trifluormethoxy-phenyl)-l,3,8-triaza-spiro[4.5]dec-l-en-4-on; (235) 8-{(E)-2-[4-(3-dimethylamino-propoxy)-2-methyl-phenyl]-ethensulfonyl>-2-(3-trifluormethoxy-phenyl)-l,3,8-triaza-spiro[4.5]dec-l-en-4-on; (236) N-methyl-N-(2-methyl-3-{(E)-2-[4-oxo-2-(3-trifluormethoxy-phenyl)-l,3,8-tnaza-spiro[4.5]dec-l-en-8-sulfonyl]-vinyl>-phenyl)-acetamid; (237) N-methyl-N-(3-methyl-4-{(E)-2-[4-oxo-2-(3-trifluormethoxy-phenyl)-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl]-vinyl>-phenyl)-acetannid; (238) N-(3,5-dimethyl-4-{(E)-2-[4-oxo-2-(3-trifluormethoxy-phenyl)-l,3,8-tnaza-spiro[4.5]dec-l-en-8-sulfonyl]-vinyl>-phenyl)-acetamid; (239) N-(3,5-dimethyl-4-{(E)-2-[4-oxo-2-(3-trifluormethoxy-phenyl)-l,3,8-tnaza-spiro[4.5]dec-l-en-8-sulfonyl]-vinyl}-phenyl)-N-methyl-acetamid; (240) 2-cycloheptyl-8-{(E)-2-[l-((S)-2,3-dihydroxypropyl)-lH-indol-4-yl]-ethensulfonyl>-l,3,8-triaza-spiro[4.5]dec-l-en-4-on; (241) 2-(4,4-difluor-cyclohexyl)-8-{(E)-2-[l-((S)-2,3-dihydroxy-propyl)-lH-indol-4-yl]-ethensulfonyl>-l,3,8-triaza-spiro[4.5]dec-l-en-4-on; (242) 8-{(E)-2-[4-((R)-2,3-dihydroxy-propoxy)-2,6-dimethyl-phenyl]-ethensulfonyl>-2-(4-fluor-3-trifluormethyl-phenyl)-l,3,8-triaza-spiro[4.5]dec-l-en-4-on; (243) 8-{(E)-2-[4-((R)-2,3-dihydroxy-propoxy)-2,6-dimethyl-phenyl]-ethensulfonyl>-2-(2-fluor-3-trifluormethyl-phenyl)-l,3,8-tnaza-spiro[4.5]dec-l-en-4-on; (244) 2-(2-fluor-3-trifluormethyl-phenyl)-8-{(E)-2-[4-(4-hydroxy-pipendin-l-carbonyl)-2,6-dimethyl-phenyl]-ethensulfonyl>-l,3,8-triaza-spiro[4.5]dec-l-en-4-on; (245) 8-{(E)-2-[l-((S)-2,2-dimethyl-[l,3]dioxolan-4-ylmethyl)-lH-indol-4-yl]-ethensulfonyl>-2-(4-tnfluormethyl-cyclohexyl)-l,3,8-triaza-spiro[4.5]dec-l-en-4-on; (246) 8-{(E)-2-[l-(2,2-dimethyl-[l,3]dioxolan-4-ylmethyl)-lH-indol-4-yl]-ethensulfonyl}-2-(tetrahydropyran-4-yl)-l,3,8-triaza-spiro[4.5]dec-l-en-4-on; (247) 8-{(E)-2-[4-(3,4-dihydroxy-butoxy)-2-methyl-phenyl]-ethensulfonyl>-2-(2-fluor-3-trifluormethyl-phenyl)-l,3,8-triaza-spiro[4.5]dec-l-en-4-on; (248) 2-(2-fluor-3-trifluormethyl-phenyl)-8-{(E)-2-[2-methyl-4-(pyrrolidin-l-carbonyl)-phenyl]-ethensulfonyl)-l,3,8-triaza-spiro[4.5]dec-l-en-4-on; (249) 2-(2,4-dichlor-phenyl)-8-{(E)-2-[l-((S)-2,3-dihydroxy-propyl)-lH-indol-4-yl]-ethensulfonyl>-l,3,8-triaza-spiro[4.5]dec-l-en-4-on; (250) 2-(4-chlor-phenyl)-8-{(E)-2-[l-((S)-2,3-dihydroxypropyl)-lH-indol-4-yl]-ethensulfonyl>-l,3,8-triaza-spiro[4.5]dec-l-en-4-on; (251) 2-cyclohexyl-8-[(E)-4-(lH-indol-4-yl)-but-3-en-l-sulfonyl]-l,3,8-triaza- spiro[4.5]dec-l-en-4-on; (252) 2-cyclohexyl-8-[(E)-5-(lH-indol-4-yl)-pent-4-en-l-sulfonyl]-l,3,8-triaza-spiro[4.5]dec-l-en-4-on; (253) 2-cyclohexyl-8-{(E)-3-[l-(2,3-dihydroxy-propyl)-lH-indol-4-yl]-prop-2-en-l-sulfonyl>-l,3,8-triaza-spiro[4.5]dec-l-en-4-on; (254) 8-{(E)-2-[3-(3,4-dihydroxy-butoxy)-2-methylphenyl]-ethensulfonyl>-2-(3-trifluormethoxy-phenyl)-l,3,8-triaza-spiro[4.5]dec-l-en-4-on; (255) 8-{(E)-2-[5-(3,4-dihydroxy-butoxy)-2-methyl-phenyl]-ethensulfonyl>-2-(3-trifluormethoxy-phenyl)-l,3,8-triaza-spiro[4.5]dec-l-en-4-on; (256) 8-{(E)-2-[3-(2-hydroxy-ethoxy)-2-methyl-phenyl]-ethensulfonyl>-2-(3-trifluormethoxy-phenyl)-l,3,8-triaza-spiro[4.5]dec-l-en-4-on; (257) N-(2-hydroxy-ethyl)-N-(4-methyl-3-{(E)-2-[4-oxo-2-(3-trifluormethoxy-phenyl)-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl]-vinyl}-phenyl)-acetamid; (258) 8-{(E)-2-[4-((R)-2-hydroxymethyl-5-oxo-pyrrolidin-l-yl)-2,6-dimethyl-phenyl]-ethensulfonyl>-2-(3-trifluormethoxy-phenyl)-l,3,8-triaza-spiro[4.5]dec-l-en-4-on; (259) N-(4-{(E)-2-[2-(2-fluor-3-trifluormethyl-phenyl)-4-oxo-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl]-vinyl>-3-methyl-phenyl)-N-(2-hydroxy-ethyl)-acetamid; (260) N-(3-methyl-4-{(E)-2-[4-oxo-2-(3-trifluormethoxyphenyl)-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl]-vinyl}-phenyl)-N-piperidin-4-yl-acetamid; (261) 2-cyclohexyl-8-[2-(2-oxo-2,3-dihydro-benzoxazol-7-yl)-ethansulfonyl]-l,3,8-triaza-spiro[4.5]dec-l-en-4-on; (262) 2-cyclohexyl-8-[5-(lH-indol-4-yl)-pentan-l-sulfonyl]-l,3,8-triaza-spiro[4.5]dec-l-en-4-on; (263) 2-cyclohexyl-8-[4-(lH-indol-4-yl)-butan-l-sulfonyl]-l,3,8-triaza-spiro[4.5]dec-l-en-4-on; (264) N-methyl-N-(2-methyl-3-{2-[4-oxo-2-(3-trifluormethoxy-phenyl)-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl]-ethyl>-phenyl)-acetamid; (265) N-methyl-N-(4-methyl-3-{2-[4-oxo-2-(3-trifluormethoxy-phenyl)-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl]-ethyl>-phenyl)-acetamid; (266) 8-{2-[3-(3,4-dihydroxy-butoxy)-2-methyl-phenyl]-ethansulfonyl}-2-(3-trifluormethoxy-phenyl)-l,3,8-triaza-spiro[4.5]dec-l-en-4-on; (267) 8-{2-[5-(3,4-dihydroxy-butoxy)-2-methyl-phenyl]-ethansulfonyl}-2-(3-trifluormethoxy-phenyl)-l,3,8-triaza-spiro[4.5]dec-l-en-4-on; (268) 8-{2-[4-((R)-2-hydroxymethyl-5-oxo-pyrrolidin-l-yl)-2-methyl-phenyl]-ethansulfonyl>-2-(3-trifluormethyl-phenyl)-l,3,8-triaza-spiro[4.5]dec-l-en-4-on; (269) 2-cyclohexyl-8-[2-(lH-indol-5-yl)-ethansulfonyl]-l,3,8-triaza-spiro[4.5]dec-l-en-4-on; (270) 2-{4-[2-(2-cyclohexyl-4-oxo-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl)-ethyl]-3-tnfluormethyl-phenylamino>-N,N-dimethyl-acetamid; (271) cyclopropancarboxylsyre-{4-[2-(2-cyclohexyl-4-oxo-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl)-ethyl]-3-trifluormethyl-phenyl>-amid; (272) {4-[2-(2-cyclohexyl-4-oxo-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl)-ethyl]-3-trifluormethyl-benzyl)--carbanninsyre-tert-butylester; (273) 3-{4-[2-(2-cyclohexyl-4-oxo-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl)-ethyl]-3-tnfluormethyl-phenyl}-l,l-dimethyl-urinstof; (274) {3-[2-(2-cyclohexyl-4-oxo-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl)-ethyl]-4-methyl-phenyl>-carbaminsyre-methylester; (275) 2-cyclohexyl-8-{2-[5-(2-hydroxy-ethylamino)-2-methyl-phenyl]-ethansulfonyl>-l,3,8-triaza-spiro[4.5]dec-l-en-4-on; (276) N-{2-[2-(2-cyclohexyl-4-oxo-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl)-ethyl]-3-methyl-phenyl>-acetamid; (277) 2-cyclohexyl-8-(2-o-tolyl-ethansulfonyl)-l,3,8-tnaza-spiro[4.5]dec-l-en-4-on; (278) l-{4-[2-(2-cyclohexyl-4-oxo-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl)-ethyl]-3-trifluormethyl-phenyl>-3-(2-hydroxy-ethyl)-urinstof; (279) 2-cyclohexyl-8-{2-[4-((R)-2,3-dihydroxy-propoxy)-2,6-dimethyl-phenyl]-ethansulfonyl>-l,3,8-triaza-spiro[4.5]dec-l-en-4-on; (280) 2-cyclohexyl-8-{2-[4-(2-hydroxy-ethyl)-phenyl]-ethansulfonyl>-l,3,8-triaza-spiro[4.5]dec-l-en-4-on; (281) 2-cyclohexyl-8-(2-{2-methyl-4-[(2-oxo-oxazolidin-5-ylmethyl)-amino]-phenyl }-ethansulfonyl)-1,3,8-triaza-spiro[4.5]dec-l-en-4-on; (282) 2-{4-[2-(2-cyclohexyl-4-oxo-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl)-ethyl]-phenyl>-N-(2-dimethylamino-ethyl)-acetannid; (283) 2-cyclohexyl-8-{2-[2-methyl-4-(3,3,4,4-tetrafluor-pyrrolidin-l-carbonyl)-phenyl]-ethansulfonyl>-l,3,8-triaza-spiro[4.5]dec-l-en-4-on; (284) 8-{2-[4-(3,4-dihydroxy-butoxy)-2-methyl-phenyl]-ethansulfonyl>-2-(3-trifluormethyl-phenyl)-1,3,8-triaza-spiro[4.5]dec-l-en-4-on; (285) 8-{2-[4-(4-hydroxy-pipendin-l-carbonyl)-2-methyl-phenyl]-ethansulfonyl>-2-(3-trifluornnethoxy-phenyl)-l,3,8-tnaza-spiro[4.5]dec-l-en-4-on; (286) 8-{2-[4-(2-hydroxy-ethylamino)-2-trifluormethylphenyl]-ethansulfonyl}-2-(3-trifluornnethyl-phenyl)-l,3,8-triaza-spiro[4.5]dec-l-en-4-on; (287) N-(4-hydroxy-butyl)-3-methyl-4-{2-[4-oxo-2-(3-trifluormethoxy-phenyl)- l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl]-ethyl}-benzensulfonamid; (288) 8-{2-[2-methyl-4-(pyrrolidin-l-carbonyl)-phenyl]-ethansulfonyl>-2-(3-trifluornnethyl-phenyl)-l,3,8-triaza-spiro[4.5]dec-l-en-4-on; (289) 8-{2-[2-methyl-4-(4-methyl-piperazin-l-carbonyl)-phenyl]-ethansulfonyl}-2-(3-trifluormethyl-phenyl)-l,3,8-triaza-spiro[4.5]dec-l-en-4-on; (290) 3-methyl-4-{2-[4-oxo-2-(3-trifluormethyl-phenyl)-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl]-ethyl}-N-(2,2,2-trifluor-ethyl)-benzensulfonamid; (291) 3-methyl-4-{2-[4-oxo-2-(3-trifluornnethyl-phenyl)-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl]-ethyl>-benzensulfonamid; (292) 3-methyl-N-(2-morpholin-4-yl-ethyl)-4-{2-[4-oxo-2-(3-tnfluornnethyl-phenyl)-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl]-ethyl>-benzensulfonannid; (293) 3-fluor-N,N-dimethyl-4-{2-[4-oxo-2-(3-trifluornnethoxy-phenyl)-l,3,8-tnaza-spiro[4.5]dec-l-en-8-sulfonyl]-ethyl>-benzamid; (294) 3-methyl-4-{2-[4-oxo-2-(3-trifluornnethyl-phenyl)-l,3,8-tnaza-spiro[4.5]dec-l-en-8-sulfonyl]-ethyl>-N-pyridin-3-yl-benzensulfonannid; (295) 8-{2-[4-(3-dimethylamino-propoxy)-2-methyl-phenyl]-ethansulfonyl>-2-(3-trifluormethoxy-phenyl)-l,3,8-triaza-spiro[4.5]dec-l-en-4-on; (296) 8-{2-[4-((R)-5-hydroxymethyl-2-oxo-oxazolidin-3-yl)-2-methyl-phenyl]-ethansulfonyl>-2-(3-trifluormethyl-phenyl)-l,3,8-triaza-spiro[4.5]dec-l-en-4-on; (297) 8-{2-[4-((R)-4-hydroxy-2-oxo-pyrrolidin-l-yl)-2-methyl-phenyl]-ethansulfonyl>-2-(3-trifluormethylphenyl)-l,3,8-triaza-spiro[4.5]dec-l-en-4-on; (298) N-(3-methyl-4-{2-[4-oxo-2-(3-trifluormethylphenyl)-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl]-ethyl}-phenyl)-acetamid; (299) N-methyl-N-(3-methyl-4-{2-[4-oxo-2-(3-trifluormethoxy-phenyl)-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl]-ethyl>-phenyl)-acetamid; (300) 2-hydroxy-N-methyl-N-(3-methyl-4-{2-[4-oxo-2-(3-trifluormethoxy-phenyl)- 1.3.8- tnaza-spiro[4.5]dec-l-en-8-sulfonyl]-ethyl>-phenyl)-acetamid; (301) l-methyl-l-(3-methyl-4-{2-[4-oxo-2-(3-trifluormethoxy-phenyl)-l,3,8-tnaza-spiro[4.5]dec-l-en-8-sulfonyl]-ethyl}-phenyl)-urinstof; (302) N-{4-[2-(2-cyclohexyl-4-oxo-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl)-ethyl]-3,5-dimethylphenyl}-acetamid; (303) 2-cyclohexyl-8-[2-(lH-indol-4-yl)-ethansulfonyl]-l,3,8-triaza-spiro[4.5]dec-l-en-4-on; (304) 2-(3-trifluormethoxy-phenyl)-8-[2-(2-trifluormethyl-phenyl)-ethansulfonyl]- 1.3.8- triaza-spiro[4.5]dec-l-en-4-on; (305) 8-[2-(lH-indol-4-yl)-ethansulfonyl]-2-(3-trifluormethoxy-phenyl)-l,3,8-triaza-spiro[4.5]dec-l-en-4-on; (306) 8-[2-(lH-indol-4-yl)-ethansulfonyl]-2-(4-methylcyclohexyl)-l,3,8-triaza-spiro[4.5]dec-l-en-4-on; (307) 8-[2-(2,2-difluor-benzo[l,3]dioxol-4-yl)-ethansulfonyl]-2-(3-trifluormethoxy-phenyl)-l,3,8-triaza-spiro[4.5]dec-l-en-4-on; (308) 8-[2-(l-methyl-lH-indol-7-yl)-ethansulfonyl]-2-(3-trifluormethoxy-phenyl)- 1.3.8- triaza-spiro[4.5]dec-l-en-4-on; (309) 2-cyclohexyl-8-{2-[l-((S)-2,3-dihydroxy-propyl)-lH-indol-4-yl]-ethansulfonyl>-l,3,8-triaza-spiro[4.5]dec-l-en-4-on; (310) 4-[2-(2-cyclohexyl-4-oxo-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl)-ethyl]-indole-l-carboxylsyre-dimethylamid; (311) 8-[3-(lH-indol-4-yl)-propan-l-sulfonyl]-2-(4-methyl-cyclohexyl)-l,3,8-triaza-spiro[4.5]dec-l-en-4-on; (312) 2-cyclohexyl-8-[2-(l-methansulfonyl-lH-indol-4-yl)-ethansulfonyl]-l,3,8-triaza-spiro[4.5]dec-l-en-4-on; (313) 2-cyclohexyl-8-{2-[l-(2-dimethylamino-ethyl)-lH-indol-4-yl]-ethansulfonyl>-l,3,8-triaza-spiro[4.5]dec-l-en-4-on; (314) 8-[2-(4-amino-2-trifluormethyl-phenyl)-ethansulfonyl]-2-cyclohexyl-l,3,8-triaza-spiro[4.5]dec-l-en-4-on; (315) 2-cyclohexyl-8-[3-(3-trifluormethyl-phenyl)-propan-l-sulfonyl]-l,3,8-triaza-spiro[4.5]dec-l-en-4-on; (316) 2-cyclohexyl-8-(3-m-tolyl-propan-l-sulfonyl)-l,3,8-triaza-spiro[4.5]dec-l-en-4-on; (317) 2-cyclohexyl-8-[3-(3-hydroxy-phenyl)-propan-l-sulfonyl]-l,3,8-triaza-spiro[4.5]dec-l-en-4-on; (318) 2-cyclohexyl-8-[3-(2-hydroxy-phenyl)-propan-l-sulfonyl]-l,3,8-triaza-spiro[4.5]dec-l-en-4-on; (319) 8-(2-benzo[b]thiophen-3-yl-ethansulfonyl)-2-cyclohexyl-l,3,8-triaza-spiro[4.5]dec-l-en-4-on; (320) 2-cyclohexyl-8-(2-isoquinolin-5-yl-ethansulfonyl)-l,3,8-triaza-spiro[4.5]dec-l-en-4-on; (321) 2-cyclohexyl-8-{2-[4-((S)-2,3-dihydroxy-propylamino)-2-methyl-phenyl]-ethansulfonyl>-l,3,8-triaza-spiro[4.5]dec-l-en-4-on; (322) 8-{2-[l-((S)-2,3-dihydroxy-propyl)-lH-indol-4-yl]-ethansulfonyl}-2-(4-trifluormethyl-cyclohexyl)-l,3,8-triaza-spiro[4.5]dec-l-en-4-on; (323) 2-cyclohexyl-8-[2-(2-tnfluornnethyl-phenyl)-ethansulfonyl]-1,3,8-triaza-spiro[4.5]dec-l-en-4-on; (324) 4-[3-(2-cydohexyl-4-oxo-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl)-propyl]-N,N-dimethyl-benzamid; (325) 8-{2-[4-((R)-2,3-dihydroxy-propoxy)-2-methyl-phenyl]-ethansulfonyl>-2-(3-trifluormethoxy-phenyl)-l,3,8-tnaza-spiro[4.5]dec-l-en-4-on; (326) N-(2-hydroxy-ethyl)-N-(4-methyl-3-{2-[4-oxo-2-(3-trifluormethoxy-phenyl)- 1.3.8- triaza-spiro[4.5]dec-l-en-8-sulfonyl]-ethyl}-phenyl)-acetannid; (327) N-(2-hydroxy-ethyl)-N-(2-methyl-3-{2-[4-oxo-2-(3-trifluormethoxy-phenyl)- 1.3.8- triaza-spiro[4.5]dec-l-en-8-sulfonyl]-ethyl>-phenyl)-acetannid; (328) 8-[3-(3-amino-phenyl)-propan-l-sulfonyl]-2-cyclohexyl-l,3,8-tnaza-spiro[4.5]dec-l-en-4-on; (329) N,N-dimethyl-4-{5-[4-oxo-2-(3-trifluormethyl-phenyl)-l,3,8-tnaza-spiro[4.5]dec-l-en-8-sulfonyl]-thiophen-2-yl>-benzamid; (330) N,N-dimethyl-3-{5-[4-oxo-2-(3-trifluormethyl-phenyl)-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl]-thiophen-2-yl}-benzamid; (331) 3,N,N-tnmethyl-4-{5-[4-oxo-2-(3-trifluormethyl-phenyl)-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl]-thiophen-2-yl}-benzamid; (332) N-{4-[5-(2-cyclohexyl-4-oxo-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl)-thiophen-2-yl]-3-methyl-phenyl>-acetamid; (333) 4-{5-[2-(4-fluor-3-trifluormethyl-phenyl)-4-oxo-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl]-thiophen-2-yl>-3,N,N-trimethyl-benzamid; (334) 3-{5-[2-(4-fluor-3-trifluormethyl-phenyl)-4-oxo-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl]-thiophen-2-yl}-4,N,N-trimethyl-benzamid; (335) 2-methyl-3'-[4-oxo-2-(3-trifluormethoxy-phenyl)-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl]-biphenyl-4-carboxylsyre-dimethylamid; (336) 2-methyl-4'-[4-oxo-2-(3-trifluormethoxy-phenyl)-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl]-biphenyl-4-carboxylsyre-dimethylamid; (337) 3,N,N-trimethyl-4-{6-[4-oxo-2-(3-trifluormethoxyphenyl)-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl]-pyridin-2-yl}-benzamid; (338) 2-cyclohexyl-8-{2-[2-(3,5-dimethyl-isoxazol-4-yl)-phenyl]-ethansulfonyl>- 1.3.8- triaza-spiro[4.5]dec-l-en-4-on; (339) 2-cyclohexyl-8-{2-[2-(6-methoxy-pyridin-3-yl)-phenyl]-ethansulfonyl>- 1.3.8- triaza-spiro[4.5]dec-l-en-4-on; (340) 2-cyclohexyl-8-{2-[2-(l-methyl-lH-pyrazol-4-yl)-phenyl]-ethansulfonyl>- 1.3.8- triaza-spiro[4.5]dec-l-en-4-on; (341) 8-{5-[4-(3,4-dihydroxy-butoxy)-2-methyl-phenyl]-thiophen-2-sulfonyl>-2-(4-fluor-3-trifluormethylphenyl)-l,3,8-triaza-spiro[4.5]dec-l-en-4-on; (342) N-(4-{5-[2-(4-fluor-3-trifluormethyl-phenyl)-4-oxo-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl]-thiophen-2-yl>-3-methyl-phenyl)-N-(2-hydroxy-ethyl)-acetamid; (343) 2-cyclohexyl-8-((E)-2-thiazol-2-yl-ethensulfonyl)-l,3,8-triaza-spiro[4.5]dec-l-en-4-on; (344) 2-cyclohexyl-8-((E)-2-cyclopentyl-ethensulfonyl)-l,3,8-triaza-spiro[4.5]dec-l-en-4-on; (345) 2-cyclohexyl-8-(2-thiazol-2-yl-ethansulfonyl)-l,3,8-triaza-spiro[4.5]dec-l-en-4-on; (346) 2-cyclohexyl-8-[3-(4-methoxy-phenyl)-propan-l-sulfonyl]-l,3,8-triaza-spiro[4.5]dec-l-en-4-on; (347) N-benzyl-2-(2-cyclohexyl-4-oxo-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl)-benzamid; (348) 8-(3-chlor-benzensulfonyl)-2-[3-(morpholin-4-carbonyl)-phenyl]-l,3,8-triaza-spiro[4.5]dec-l-en-4-on; (349) 3-[8-(3-chlor-benzensulfonyl)-4-oxo-l,3,8-triaza-spiro[4.5]dec-l-en-2-yl]-N-methyl-N-phenyl-benzamid; (350) N-benzyl-3-[8-(3-chlor-benzensulfonyl)-4-oxo-l,3,8-triaza-spiro[4.5]dec-l-en-2-yl]-benzamid; (351) 3-[8-(3-chlor-benzensulfonyl)-4-oxo-l,3,8-triaza-spiro[4.5]dec-l-en-2-yl]-N,N-dimethyl-benzamid; (352) 8-{2-[4-(4-methansulfonyl-piperazin-l-carbonyl)-2-methyl-phenyl]-ethansulfonyl>-2-(3-tnfluormethyl-phenyl)-l,3,8-triaza-spiro[4.5]dec-l-en-4-on; (353) N-[(R)-l-(3-methyl-4-{2-[4-oxo-2-(3-trifluormethyl-phenyl)-l,3,8-tnaza-spiro[4.5]dec-l-en-8-sulfonyl]-ethyl}-benzoyl)-pyrrolidin-3-yl]-acetamid; (354) 8-{2-[2-methyl-4-((S)-2-tnfluormethyl-pyrrolidin-l-carbonyl)-phenyl]-ethansulfonyl>-2-(3-tnfluormethyl-phenyl)-l,3,8-triaza-spiro[4.5]dec-l-en-4-on; (355) 8-{2-[4-((R)-3-hydroxy-pyrrolidin-l-carbonyl)-2-methyl-phenyl]-ethansulfonyl>-2-(3-trifluormethyl-phenyl)-l,3,8-triaza-spiro[4.5]dec-l-en-4-on; (356) 8-{2-[4-((S)-2-hydroxymethyl-pyrrolidin-l-carbonyl)-2-methyl-phenyl]-ethansulfonyl}-2-(3-trifluormethyl-phenyl)-l,3,8-triaza-spiro[4.5]dec-l-en-4-on; (357) 8-(2-{4-[4-(2-hydroxy-ethyl)-piperidin-l-carbonyl]-2-methyl-phenyl>-ethansulfonyl)-2-(3-trifluormethyl-phenyl)-l,3,8-triaza-spiro[4.5]dec-l-en-4-on; (358) 8-(2-{2-methyl-4-[4-(3-methyl-[l,2,4]oxadiazol-5-yl)-piperidin-l-carbonyl]-phenyl>-ethansulfonyl)-2-(3-trifluormethyl-phenyl)-l,3,8-triaza-spiro[4.5]dec-l-en-4-on; (359) 8-{2-[2-methyl-4-(4-pyrimidin-2-yl-piperazin-l-carbonyl)-phenyl]-ethansulfonyl>-2-(3-trifluormethyl-phenyl)-l,3,8-tnaza-spiro[4.5]dec-l-en-4-on; (360) 4-(3-methyl-4-{2-[4-oxo-2-(3-trifluormethylphenyl)-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl]-ethyl>-benzoyl)-piperazin-l-sulfonsyre-dimethylamid; (361) 8-{2-[2-methyl-4-(4-pyridin-2-yl-piperazin-l-carbonyl)-phenyl]-ethansulfonyl>-2-(3-trifluormethylphenyl)-l,3,8-triaza-spiro[4.5]dec-l-en-4-on; (362) 8-[2-(4-{4-[2-(2-hydroxy-ethoxy)-ethyl]-piperazin-l-carbonyl>-2-methyl-phenyl)-ethansulfonyl]-2-(3-trifluormethyl-phenyl)-l,3,8-triaza-spiro[4.5]dec-l-en-4-on; (363) 8-(2-{2-methyl-4-[4-(2-morpholin-4-yl-ethyl)-piperazin-l-carbonyl]-phenyl}-ethansulfonyl)-2-(3-trifluormethyl-phenyl)-l,3,8-triaza-spiro[4.5]dec-l-en-4-on; (364) 8-{2-[2-methyl-4-(4-thiazol-2-yl-piperazin-l-carbonyl)-phenyl]-ethansulfonyl}-2-(3-trifluormethyl-phenyl)-l,3,8-triaza-spiro[4.5]dec-l-en-4-on; (365) 8-{2-[4-(4,4-difluor-piperidin-l-carbonyl)-2-methyl-phenyl]-ethansulfonyl>-2-(3-trifluormethylphenyl)-l,3,8-triaza-spiro[4.5]dec-l-en-4-on; (366) 8-(2-{4-[4-(3-hydroxy-propyl)-piperazin-l-carbonyl]-2-methyl-phenyl}-ethansulfonyl)-2-(3-trifluormethyl-phenyl)-l,3,8-triaza-spiro[4.5]dec-l-en-4-on; (367) (S)-l-(3-methyl-4-{2-[4-oxo-2-(3-trifluormethyl-phenyl)-l,3,8-tnaza-spiro[4.5]dec-l-en-8-sulfonyl]-ethyl>-benzoyl)-pyrrolidin-2-carboxylsyre-amid; (368) 8-{2-[2-methyl-4-(3,3,4,4-tetrafluor-pyrrolidin-l-carbonyl)-phenyl]-ethansulfonyl>-2-(3-trifluormethyl-phenyl)-l,3,8-tnaza-spiro[4.5]dec-l-en-4-on; (369) (R)-l-(3-methyl-4-{2-[4-oxo-2-(3-trifluormethyl-phenyl)-l,3,8-tnaza-spiro[4.5]dec-l-en-8-sulfonyl]-ethyl>-benzoyl)-pyrrolidin-2-carboxylsyre-amid; (370) 8-{2-[4-((S)-3-hydroxy-pyrrolidin-l-carbonyl)-2-methyl-phenyl]-ethansulfonyl>-2-(3-trifluormethyl-phenyl)-l,3,8-triaza-spiro[4.5]dec-l-en-4-on; (371) 8-{2-[4-((R)-2-hydroxymethyl-pyrrolidin-l-carbonyl)-2-methyl-phenyl]-ethansulfonyl>-2-(3-trifluormethyl-phenyl)-l,3,8-triaza-spiro[4.5]dec-l-en-4-on; (372) 8-{2-[4-((S)-3-dimethylamino-pyrrolidin-l-carbonyl)-2-methyl-phenyl]-ethansulfonyl>-2-(3-trifluormethyl-phenyl)-l,3,8-triaza-spiro[4.5]dec-l-en-4-on; (373) 8-{2-[4-(4-tert-butyl-piperazin-l-carbonyl)-2-methyl-phenyl]-ethansulfonyl>-2-(3-trifluormethyl-phenyl)-l,3,8-triaza-spiro[4.5]dec-l-en-4-on; (374) 8-(2-{4-[4-(3-dimethylamino-propyl)-piperazin-l-carbonyl]-2-methyl-phenyl>-ethansulfonyl)-2-(3-trifluormethyl-phenyl)-l,3,8-triaza-spiro[4.5]dec-l-en-4-on; (375) 8-(2-{4-[4-(4-fluor-phenyl)-piperazin-l-carbonyl]-2-methyl-phenyl}-ethansulfonyl)-2-(3-trifluormethyl-phenyl)-l,3,8-triaza-spiro[4.5]dec-l-en-4-on; (376) 8-{2-[4-(4-isopropyl-piperazin-1-carbonyl)-2-methyl-phenyl] -ethansulfonyl>-2-(3-trifluormethylphenyl)-l,3,8-triaza-spiro[4.5]dec-l-en-4-on; (377) 8-{2-[4-(3-hydroxy-azetidin-l-carbonyl)-2-methyl-phenyl]-ethansulfonyl>-2-(3-trifluormethyl-phenyl)-l,3,8-triaza-spiro[4.5]dec-l-en-4-on; (378) 8-{2-[4-(3-fluor-pyrrolidin-l-carbonyl)-2-methyl-phenyl]-ethansulfonyl>-2-(3-trifluormethyl-phenyl)-l,3,8-triaza-spiro[4.5]dec-l-en-4-on; (379) 8-{2-[4-(3-fluor-azetidin-l-carbonyl)-2-methyl-phenyl]-ethansulfonyl}-2-(3-trifluormethyl-phenyl)-l,3,8-triaza-spiro[4.5]dec-l-en-4-on; (380) 8-{2-[2-methyl-4-(piperidin-l-carbonyl)-phenyl]-ethansulfonyl}-2-(3-trifluormethyl-phenyl)-l,3,8-triaza-spiro[4.5]dec-l-en-4-on; (381) 8-{2-[4-(azetidin-l-carbonyl)-2-methyl-phenyl]-ethansulfonyl}-2-(3-trifluormethyl-phenyl)-l,3,8-triaza-spiro[4.5]dec-l-en-4-on; (382) 4-(3-methyl-4-{2-[4-oxo-2-(3-trifluormethylphenyl)-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl]-ethyl}-benzoyl)-piperazin-l-carboxylsyre-dimethylamid; (383) 3,5,N,N-tetramethyl-4-{(E)-2-[4-oxo-2-(3-trifluormethyl-phenyl)-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl]-vinyl>-benzannid; (384) 8-{(E)-2-[4-(4-hydroxy-pipendin-l-carbonyl)-2,6-dimethyl-phenyl]-ethensulfonyl}-2-(3-trifluormethyl-phenyl)-l,3,8-triaza-spiro[4.5]dec-l-en-4-on; (385) 8-{(E)-2-[4-(3-hydroxy-azetidin-l-carbonyl)-2,6-dimethyl-phenyl]-ethensulfonyl>-2-(3-trifluormethyl-phenyl)-l,3,8-tnaza-spiro[4.5]dec-l-en-4-on; (386) 8-{(E)-2-[4-(4-hydroxy-4-hydroxymethyl-pipendin-l-carbonyl)-2,6-dimethyl-phenyl]-ethensulfonyl>-2-(3-trifluormethyl-phenyl)-l,3,8-tnaza-spiro[4.5]dec-l-en-4-on; (387) 8-{(E)-2-[4-((3R,4R)-3-dimethylamino-4-hydroxy-pyrrolidin-l-carbonyl)- 2,6-dimethyl-phenyl]-ethensulfonyl>-2-(3-trifluormethyl-phenyl)-1,3,8-triaza-spiro[4.5]dec-l-en-4-on; (388) 8-{(E)-2-[2,6-dimethyl-4-(pyrrolidin-l-carbonyl)-phenyl]-ethensulfonyl>-2-(3-trifluormethyl-phenyl)-l,3,8-tnaza-spiro[4.5]dec-l-en-4-on; (389) N-(3-hydroxy-propyl)-3,5,N-trimethyl-4-{(E)-2-[4-oxo-2-(3-trifluormethyl-phenyl)-1,3,8-triaza-spiro [4.5]dec-l-en-8-sulfonyl]-vinyl >-benzamid; (390) N-(2-dimethylamino-ethyl)-3,5,N-trimethyl-4-{(E)-2-[4-oxo-2-(3-trifluornnethyl-phenyl)-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl]-vinyl}-benzamid; (391) N-(3-dimethylamino-propyl)-3,5,N-trimethyl-4-{(E)-2-[4-oxo-2-(3-trifluormethyl-phenyl)-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl]-vinyl>-benzamid; (392) N-carbamoylmethyl-3,5,N-trimethyl-4-{(E)-2-[4-oxo-2-(3-trifluormethyl-phenyl)-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl]-vinyl}-benzamid; (393) 3,5,N-trimethyl-N-(l-methyl-piperidin-4-yl)-4-{(E)-2-[4-oxo-2-(3-trifluormethyl-phenyl)-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl]-vinyl>-benzamid; (394) 8-{(E)-2-[4-(4-acetyl-piperazin-l-carbonyl)-2,6-dimethyl-phenyl]-ethensulfonyl}-2-(3-trifluormethoxy-phenyl)-l,3,8-triaza-spiro[4.5]dec-l-en-4-on; (395) 4-(3,5-dimethyl-4-{(E)-2-[4-oxo-2-(3-tnfluornnethoxy-phenyl)-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl]-vinyl}-benzoyl)-piperazin-l-carboxylsyre-dimethylamid; (396) 4-(3,5-dimethyl-4-{(E)-2-[4-oxo-2-(3-tnfluornnethoxy-phenyl)-l,3,8-tnaza-spiro[4.5]dec-l-en-8-sulfonyl]-vinyl>-benzoyl)-piperazin-l-carboxylsyre-annid; (397) 8-((E)-2-{4-[4-(3-dimethylamino-propyl)-piperazin-l-carbonyl]-2,6-dimethyl-phenyl>-ethensulfonyl)-2-(3-tnfluormethoxy-phenyl)-l,3,8-tnaza-spiro[4.5]dec-l-en-4-on; (398) 8-{(E)-2-[2,6-dimethyl-4-((R)-3-methylamino-pyrrolidin-l-carbonyl)-phenyl]-ethensulfonyl}-2-(3-trifluormethoxy-phenyl)-l,3,8-triaza-spiro[4.5]dec-l-en-4-on; (399) 8-{(E)-2-[4-((R)-3-dimethylamino-pyrrolidin-l-carbonyl)-2,6-dimethyl-phenyl]-ethensulfonyl>-2-(3-trifluormethoxy-phenyl)-l,3,8-triaza-spiro[4.5]dec-l-en-4-on; (400) 8-{(E)-2-[4-(4-hydroxy-piperidin-l-carbonyl)-2,6-dimethyl-phenyl]-ethensulfonyl>-2-(3-trifluormethoxy-phenyl)-l,3,8-triaza-spiro[4.5]dec-l-en-4-on; (401) 8-{(E)-2-[4-((R)-3-hydroxy-pyrrolidin-l-carbonyl)-2,6-dimethyl-phenyl]-ethensulfonyl>-2-(3-trifluormethoxy-phenyl)-l,3,8-triaza-spiro[4.5]dec-l-en-4-on; (402) 8-{(E)-2-[4-((S)-3-hydroxy-pyrrolidin-l-carbonyl)-2,6-dimethyl-phenyl]-ethensulfonyl>-2-(3-trifluormethoxy-phenyl)-l,3,8-triaza-spiro[4.5]dec-l-en-4-on; (403) 8-{(E)-2-[4-(4-hydroxy-4-hydroxymethyl-piperidin-l-carbonyl)-2,6-dimethyl-phenyl]-ethensulfonyl}-2-(3-trifluormethoxy-phenyl)-l,3,8-triaza-spiro[4.5]dec-l-en-4-on; (404) 8-{(E)-2-[4-((R)-3-amino-pyrrolidin-l-carbonyl)-2,6-dimethyl-phenyl]-ethensulfonyl>-2-(3-trifluormethoxy-phenyl)-l,3,8-triaza-spiro[4.5]dec-l-en-4-on; (405) 8-{(E)-2-[4-(4-dimethylamino-piperidin-l-carbonyl)-2,6-dimethyl-phenyl]-ethensulfonyl>-2-(3-trifluormethoxy-phenyl)-l,3/8-triaza-spiro[4.5]dec-l-en-4-on; (406) 8-{(E)-2-[4-((3S,4S)-3-hydroxy-4-isopropylamino-pyrrolidin-l-carbonyl)- 2,6-dimethyl-phenyl]-ethensulfonyl>-2-(3-trifluormethoxy-phenyl)-l,3,8-triaza-spiro[4.5]dec-l-en-4-on; (407) 8-((E)-2-{4-[4-(2-dimethylamino-ethoxy)-piperidin-l-carbonyl]-2,6-dimethyl-phenyl>-ethensulfonyl)-2-(3-trifluormethoxy-phenyl)-l,3,8-tnaza-spiro[4.5]dec-l-en-4-on; (408) 8-{(E)-2-[4-(3-hydroxy-azetidin-l-carbonyl)-2,6-dimethyl-phenyl]-ethensulfonyl>-2-(3-trifluormethoxyphenyl)-l,3,8-tnaza-spiro[4.5]dec-l-en-4-on; (409) 2,N,N-trimethyl-3-{2-[4-oxo-2-(3-tnfluormethoxyphenyl)-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl]-ethyl>-benzamid; (410) 2-methyl-3-{2-[4-oxo-2-(3-trifluormethoxy-phenyl)-l,3,8-tnaza-spiro[4.5]dec-l-en-8-sulfonyl]-ethyl>-benzamid; (411) 8-{2-[2-methyl-3-(morpholin-4-carbonyl)-phenyl]-ethansulfonyl>-2-(3-trifluormethoxy-phenyl)-l,3,8-triaza-spiro[4.5]dec-l-en-4-on; (412) 4,N,N-trimethyl-3-{2-[4-oxo-2-(3-tnfluormethoxyphenyl)-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl]-ethyl>-benzamid; (413) N-(2-hydroxy-ethyl)-4,N-dimethyl-3-{2-[4-oxo-2-(3-trifluormethoxy-phenyl)-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl]-ethyl>-benzannid; (414) 8-{2-[2-methyl-5-(4-methyl-piperazin-l-carbonyl)-phenyl]-ethansulfonyl>-2-(3-trifluormethoxy-phenyl)-l,3,8-tnaza-spiro[4.5]dec-l-en-4-on; (415) 4,N-dimethyl-3-{2-[4-oxo-2-(3-trifluormethoxyphenyl)-l,3,8-tnaza-spiro[4.5]dec-l-en-8-sulfonyl]-ethyl}-benzamid; (416) 8-(2-{4-[4-(2-hydroxy-ethyl)-piperazin-l-carbonyl]-2-methyl-phenyl}-ethansulfonyl)-2-(3-trifluormethoxy-phenyl)-l,3,8-tnaza-spiro[4.5]dec-l-en-4-on; (417) 8-{2-[2-methyl-4-(thiazoliden-3-carbonyl)-phenyl]-ethansulfonyl>-2-(3-tnfluormethoxy-phenyl)-l,3,8-triaza-spiro[4.5]dec-l-en-4-on; (418) 2-fluor-5,N,N-trimethyl-4-{2-[4-oxo-2-(3-tnfluormethyl-phenyl)-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl]-ethyl>-benzannid; (419) 8-{2-[5-fluor-4-(4-hydroxy-piperidin-l-carbonyl)-2-methyl-phenyl]-ethansulfonyl>-2-(3-trifluormethyl-phenyl)-l,3,8-tnaza-spiro[4.5]dec-l-en-4-on; (420) N-benzyl-2-{4-[2-(2-cyclohexyl-4-oxo-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl)-ethyl]-lH-indol-3-yl}-acetamid; (421) 2-[2-(2-cyclohexyl-4-oxo-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl)-ethyl]-N-methyl-benzamid; (422) 3-[2-(2-cyclohexyl-4-oxo-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl)-ethyl]-N-pyridin-4-yl-benzamid; (423) 8-(3-chlor-benzensulfonyl)-2-[l-(3,3-dimethyl-butyryl)-piperidin-3-yl]-l,3,8-triaza-spiro[4.5]dec-l-en-4-on; (424) 8-(3-chlor-benzensulfonyl)-2-[l-(2-hydroxy-acetyl)-piperidin-3-yl]-l,3,8-triaza-spiro[4.5]dec-l-en-4-on; (425) 8-(3-chlor-benzensulfonyl)-2-[l-(4-chlorbenzoyl)-piperidin-3-yl]-l,3,8-triaza-spiro[4.5]dec-l-en-4-on; (426) 8-(3-chlor-benzensulfonyl)-2-[l-(3-methoxy-benzoyl)-piperidin-3-yl]-l,3,8-triaza-spiro[4.5]dec-l-en-4-on; (428) 2-[l-(lH-indole-5-carbonyl)-piperidin-3-yl]-8-(2-naphthalen-l-yl-ethansulfonyl)-l,3,8-triaza-spiro[4.5]dec-l-en-4-on; (429) 8-(2-naphthalen-l-yl-ethansulfonyl)-2-[l-(3-phenyl-propionyl)-piperidin-3-yl]-l,3,8-triaza-spiro[4.5]dec-l-en-4-on; (430) 8-(2-naphthalen-l-yl-ethansulfonyl)-2-[l-(l,2,3,4-tetrahydro-naphthalen-2-carbonyl)-piperidin-3-yl]-l,3,8-triaza-spiro[4.5]dec-l-en-4-on; (431) 8-(2-naphthalen-l-yl-ethansulfonyl)-2-[l-(quinolin-6-carbonyl)-piperidin-3-yl]-l,3,8-triaza-spiro[4.5]dec-l-en-4-on; (432) 2-[l-(2-3H-imidazol-4-yl-acetyl)-piperidin-3-yl]-8-(2-naphthalen-l-yl-ethansulfonyl)-l,3,8-triaza-spiro[4.5]dec-l-en-4-on; (433) 2-{l-[2-(2,5-dimethyl-thiazol-4-yl)-acetyl]-piperidin-3-yl}-8-(2-naphthalen-l-yl-ethansulfonyl)-l,3,8-triaza-spiro[4.5]dec-l-en-4-on; (434) 2-{l-[2-(5-methyl-2-phenyl-oxazol-4-yl)-acetyl]-piperidin-3-yl>-8-(2-naphthalen-l-yl-ethansulfonyl)-l,3,8-triaza-spiro[4.5]dec-l-en-4-on; (435) 8-(2-naphthalen-l-yl-ethansulfonyl)-2-[l-(2-pyridin-2-yl-acetyl)-piperidin-3-yl]-l,3,8-triaza-spiro[4.5]dec-l-en-4-on; (436) 2-[l-(4-benzyloxy-butyryl)-piperidin-3-yl]-8-(2-naphthalen-l-yl-ethansulfonyl)-l,3,8-triaza-spiro[4.5]dec-l-en-4-on; (437) 8-(2-naphthalen-l-yl-ethansulfonyl)-2-[l-(4-phenyl-butyryl)-piperidin-3-yl]- l,3,8-triaza-spiro[4.5]dec-l-en-4-on; (438) 8-(2-naphthalen-l-yl-ethansulfonyl)-2-[l-(2-pyridin-4-yl-acetyl)-pipendin-3-yl]-l,3,8-triaza-spiro[4.5]dec-l-en-4-on; (439) 2-[l-(2-tert-butoxy-acetyl)-piperidin-3-yl]-8-(2-naphthalen-l-yl-ethansulfonyl)-l,3,8-triaza-spiro[4.5]dec-l-en-4-on; (441) 8-(2-naphthalen-l-yl-ethansulfonyl)-2-{l-[(E)-(3-phenyl-acryloyl)]-piperidin-3-yl>-l,3,8-triaza-spiro[4.5]dec-l-en-4-on; (442) 2-[l-(2-amino-acetyl)-piperidin-3-yl]-8-(3-chlorbenzensulfonyl)-l,3,8-triaza-spiro[4.5]dec-l-en-4-on; (444) 8-{2-[2-methyl-4-(3-methylamino-pyrrolidin-l-carbonyl)-phenyl]-ethansulfonyl>-2-(3-trifluormethylphenyl)-l,3,8-triaza-spiro[4.5]dec-l-en-4-on; (445) 8-{2-[4-(3-amino-pyrrolidin-l-carbonyl)-2-methyl-phenyl]-ethansulfonyl>-2-(3-trifluormethyl-phenyl)-1,3,8-triaza-spiro[4.5]dec-l-en-4-on-hydrochlorid; (446) 8-{(E)-2-[2,6-dimethyl-4-(piperazin-l-carbonyl)-phenyl]-ethensulfonyl>-2-(3-trifluormethoxy-phenyl)-l,3,8-triaza-spiro[4.5]dec-l-en-4-on-hydrochlond; (447) 8-((E)-2-{4-[4-(2-hydroxy-acetyl)-piperazin-l-carbonyl]-2,6-dimethyl-phenyl}-ethensulfonyl)-2-(3-trifluormethoxy-phenyl)-l,3,8-triaza-spiro[4.5]dec-l-en-4-on; (448) 4-[4-(3,5-dimethyl-4-{(E)-2-[4-oxo-2-(3-trifluormethoxy-phenyl)-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl]-vinyl }-benzoyl)-piperazin-l-yl]-4-oxo-smørsyre-methylester; (449) 8-((E)-2-{4-[4-(4-dimethylamino-butyryl)-piperazin-l-carbonyl]-2,6-dimethyl-phenyl>-ethensulfonyl)-2-(3-trifluormethoxy-phenyl)-l,3,8-triaza-spiro[4.5]dec-l-en-4-on; (450) 2-methoxy-N-methyl-N-(3-methyl-4-{(E)-2-[4-oxo-2-(3-trifluormethoxy-phenyl)-l,3,8-tnaza-spiro[4.5]dec-l-en-8-sulfonyl]-vinyl>-phenyl)-acetamid; (451) 2-hydroxy-N-methyl-N-(3-methyl-4-{(E)-2-[4-oxo-2-(3-trifluormethoxy-phenyl)-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl]-vinyl}-phenyl)-acetamid; (452) [(3,5-dimethyl-4-{(E)-2-[4-oxo-2-(3-trifluormethyl-phenyl)-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl]-vinyl>-benzoyl)-methyl-amino]-eddikesyre; (453) 8-(3-chlor-benzensulfonyl)-2-[l-(3,3-dimethylbutyl)-piperidin-3-yl]-l,3,8-triaza-spiro[4.5]dec-l-en-4-on; (454) 3-[8-(3-chlor-benzensulfonyl)-4-oxo-l,3,8-triaza-spiro[4.5]dec-l-en-2-yl]-piperidin-1-carboxylsyre-tert-butylannid; (455) 3-[8-(2-naphthalen-l-yl-ethansulfonyl)-4-oxo-l,3,8-triaza-spiro[4.5]dec-l-en-2-yl]-piperidin-l-carboxylsyre-phenethyl-annid; (456) 8-(3-chlor-benzensulfonyl)-2-[l-(pipendin-l-carbonyl)-pipendin-3-yl]-l,3,8-triaza-spiro[4.5]dec-l-en-4-on; (457) 3-(2-dimethylamino-ethyl)-1-methyl-l-(3-methyl-4-{(E)-2-[4-oxo-2-(3-trifluormethoxy-phenyl)-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl]-vinyl}-phenyl)-urinstof; (458) l-methyl-l-(3-methyl-4-{(E)-2-[4-oxo-2-(3-trifluormethoxy-phenyl)-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl]-vinyl>-phenyl)-urinstof; (459) l-{3-[2-(2-cyclohexyl-4-oxo-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl)-ethyl]-2-methyl-phenyl>-3-methyl-urinstof; (460) 3-[8-(3-chlor-benzensulfonyl)-4-oxo-l,3,8-triaza-spiro[4.5]dec-l-en-2-yl]-piperidin-l-carboxylsyre-2-methoxy-ethylester; (461) 3-[8-(3-chlor-benzensulfonyl)-4-oxo-l,3,8-triaza-spiro[4.5]dec-l-en-2-yl]-piperidin-l-carboxylsyre-benzylester; (462) 3-[8-(3-chlor-benzensulfonyl)-4-oxo-l,3,8-triaza-spiro[4.5]dec-l-en-2-yl]-piperidin-l-carboxylsyre-isobutylester; (463) 3-[8-(3-chlor-benzensulfonyl)-4-oxo-l,3,8-triaza-spiro[4.5]dec-l-en-2-yl]-piperidin-l-carboxylsyre-methylester; (464) 3-[8-(2-naphthalen-l-yl-ethansulfonyl)-4-oxo-l,3,8-triaza-spiro[4.5]dec-l-en-2-yl]-piperidin-l-carboxylsyre-benzylester; (465) 3-[8-(2-naphthalen-l-yl-ethansulfonyl)-4-oxo-l,3,8-triaza-spiro[4.5]dec-l-en-2-yl]-piperidin-l-carboxylsyre-2,2-dimethyl-propylester; (466) methyl-(3-methyl-4-{(E)-2-[4-oxo-2-(3-trifluormethoxy-phenyl)-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl]-vinyl>-phenyl)-carbaminsyre-2-dimethylamino-ethylester; (467) methyl-(3-methyl-4-{(E)-2-[4-oxo-2-(3-trifluormethoxy-phenyl)-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl]-vinyl>-phenyl)-carbaminsyre-methylester; (468) methyl-(3-methyl-4-{2-[4-oxo-2-(3-trifluormethoxyphenyl)-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl]-ethyl}-phenyl)-carbaminsyre-methylester; (469) 2-cyclohexyl-8-(2-o-tolyl-ethansulfonyl)-l,3,8-triaza-spiro[4.5]dec-l-en-4-thion; (470) l-(3,5-dimethyl-4-{2-[2-(4-methyl-cyclohexyl)-4-oxo-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl]-ethyl}-phenyl)-l-methyl-urinstof; (471) l-(3,5-dimethyl-4-{(E)-2-[4-oxo-2-(4-trifluormethyl-cyclohexyl)-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl]-vinyl>-phenyl)-l-methyl-urinstof; (472) l-(3,5-dimethyl-4-12-[4-oxo-2-(4-trifluormethyl-cyclohexyl)-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl]-ethyl>-phenyl)-l-methyl-urinstof; (474) l-(3,5-dimethyl-4-{2-[2-(4-methyl-cyclohexyl)-4-oxo-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl]-ethyl>-phenyl)-l-methyl-thiourinstof; (475) 8-{2-[2,6-dimethyl-4-(methyl-thiazol-2-yl-amino)-phenyl]-ethansulfcmyl}-2-(4-methyl-cyclohexyl)-l,3,8-triaza-spiro[4.5]dec-l-en-4-on; (476) {4-[(E)-2-(2-cyclohexyl-4-oxo-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl)-vinyl]-indol-l-yl>-eddikesyre-methylester; (477) 2-cyclohexyl-8-{(E)-2-[l-(morpholin-4-carbonyl)-lH-indol-4-yl]-ethensulfonyl>-l,3,8-triaza-spiro[4.5]dec-l-en-4-on; (478) 2-cyclohexyl-8-{(E)-2-[l-(4-hydroxy-butyl)-lH-indol-4-yl]-ethensulfonyl>- 1.3.8- triaza-spiro[4.5]dec-l-en-4-on; (479) 2-cyclohexyl-8-[(E)-2-(lH-indol-7-yl)-ethensulfonyl]-l,3,8-triaza-spiro[4.5]dec-l-en-4-on; (480) 2-cyclohexyl-8-{(E)-2-[l-(3,4-dihydroxy-butyl)-lH-indol-4-yl]-ethensulfonyl>-l,3,8-triaza-spiro[4.5]dec-l-en-4-on; (481) N-(2-{4-[(E)-2-(2-cyclohexyl-4-oxo-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl)-vinyl]-phenyl>-ethyl)-acetamid; (482) N-(l-{4-[(E)-2-(2-cyclohexyl-4-oxo-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl)-vinyl]-phenyl}-ethyl)-acetamid; (483) 2-cyclohexyl-8-[(E)-2-(l-thiazol-2-ylmethyl-lH-indol-4-yl)-ethensulfonyl]- 1.3.8- triaza-spiro[4.5]dec-l-en-4-on; (484) 3-{4-[(E)-2-(2-cyclohexyl-4-oxo-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl)-vinyl]-indol-l-yl}-propan-l-sulfonsyreamid; (485) 4-methyl-piperazin-l-carboxylsyre-{4-[(E)-2-(2-cyclohexyl-4-oxo-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl)-vinyl]-3-trifluornnethyl-phenyl}-amid; (486) {4-[(E)-2-(2-cyclohexyl-4-oxo-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl)-vinyl]-benzyl}-carbaminsyre-isobutylester; (487) 2-cyclohexyl-8-((E)-2-{l-[2-(2-hydroxy-ethoxy)-ethyl]-lH-indol-5-yl>-ethensulfonyl)-l,3,8-triaza-spiro[4.5]dec-l-en-4-on; (488) 2-cyclohexyl-8-[(E)-2-(6-methyl-lH-indol-5-yl)-ethensulfonyl]-l,3,8-tnaza-spiro[4.5]dec-l-en-4-on; (489) N-{4-[(E)-2-(2-cyclohexyl-4-oxo-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl)-vinyl]-benzyl>-2-hydroxy-acetamid; (490) 3-(2-{4-[(E)-2-(2-cyclohexyl-4-oxo-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl)-vinyl]-phenyl>-ethyl)-l,l-dimethyl-urinstof; (491) 8-[(E)-2-(4-amino-2,6-bis-trifluornnethyl-phenyl)-ethensulfonyl]-2-cyclohexyl-l,3,8-triaza-spiro[4.5]dec-l-en-4-on; (492) 2-cyclohexyl-8-[(E)-2-(6-trifluornnethyl-lH-indol-5-yl)-ethensulfonyl]-l,3,8-triaza-spiro[4.5]dec-l-en-4-on; (493) {4-[(E)-2-(2-cyclohexyl-4-oxo-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl)-vinyl]-3-trifluormethyl-phenylannino>-eddikesyre-nnethylester; (494) 2-{4-[(E)-2-(2-cyclohexyl-4-oxo-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl)-vinyl]-3-trifluormethyl-phenylannino>-N-(2-hydroxy-ethyl)-acetamid; (495) 4-[(E)-2-(2-cyclohexyl-4-oxo-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl)-vinyl]-N-(2-hydroxyethyl)-N-methyl-3-trifluornnethyl-benzensulfonamid; (496) 4-[(E)-2-(2-cyclohexyl-4-oxo-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl)-vinyl]-N,N-bis-(2-hydroxy-ethyl)-3-trifluornnethyl-benzensulfonannid; (497) 2-cyclohexyl-8-{(E)-2-[4-(2-dimethylannino-ethylannino)-2-nnethyl-phenyl]-ethensulfonyl>-l,3,8-triaza-spiro[4.5]dec-l-en-4-on; (498) N-(2-acetylamino-ethyl)-2-{4-[(E)-2-(2-cyclohexyl-4-oxo-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl)-vinyl]-3-trifluormethyl-phenylannino>-aætannid; (499) 2-cyclohexyl-8-[(E)-2-(6-trifluormethyl-lH-benzimidazol-5-yl)-ethensulfonyl]-l,3,8-triaza-spiro[4.5]dec-l-en-4-on; (500) 2-cyclohexyl-8-{(E)-2-[l-((S)-2,2-dimethyl-[l,3]dioxolan-4-ylmethyl)-5-fluor-lH-indol-4-yl]-ethensulfonyl}-l,3,8-triaza-spiro[4.5]dec-l-en-4-on; (501) 2-cyclohexyl-8-((E)-2-{4-[(2-hydroxy-ethyl)-methyl-amino]-2-trifluormethyl-phenyl}-ethensulfonyl)-l,3,8-triaza-spiro[4.5]dec-l-en-4-on; (502) 2-cyclohexyl-8-{(E)-2-[4-(l,l-dioxo-lA6-thiomorpholin-4-carbonyl)-2-methyl-phenyl]-ethensulfonyl}-l,3,8-triaza-spiro[4.5]dec-l-en-4-on; (503) 4-[(E)-2-(2-cyclohexyl-4-oxo-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl)-vinyl]-N-(2-dimethylamino-ethyl)-3-methyl-benzensulfonamid; (504) 3-(3-methyl-4-{(E)-2-[2-(4-methyl-cyclohexyl)-4-oxo-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl]-vinyl}-phenyl)-imidazoliden-2,4-dion; (505) l-methyl-3-(3-methyl-4-{(E)-2-[2-(4-methyl-cyclohexyl)-4-oxo-li3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl]-vinyl>-phenyl)-imidazoliden-2,4-dion; (506) N-(3-isopropoxy-4-{(E)-2-[2-(4-methyl-cyclohexyl)-4-oxo-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl]-vinyl>-phenyl)-acetamid; (507) 3-(3,5-dimethyl-4-{(E)-2-[2-(4-methyl-cyclohexyl)-4-oxo-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl]-vinyl>-phenyl)-5,5-dimethyl-imidazoliden-2,4-dion; (508) 3-(3,5-dimethyl-4-{(E)-2-[2-(4-methyl-cyclohexyl)-4-oxo-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl]-vinyl>-phenyl)-l,5,5-trimethyl-innidazoliden-2,4-dion; (509) N-(3-ethoxy-4-{(E)-2-[2-(4-methyl-cyclohexyl)-4-oxo-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl]-vinyl>-phenyl)-acetamid; (510) N-(3-ethyl-4-{(E)-2-[2-(4-methyl-cyclohexyl)-4-oxo-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl]-vinyl>-phenyl)-acetamid; (511) 5,5-dimethyl-3-(3-methyl-4-{(E)-2-[2-(4-methyl-cyclohexyl)-4-oxo-l,3,8-tnaza-spiro[4.5]dec-l-en-8-sulfonyl]-vinyl>-phenyl)-imidazoliden-2,4-dion; (512) N-(3-methoxymethyl-4-{(E)-2-[2-(4-methyl-cyclohexyl)-4-oxo-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl]-vinyl>-phenyl)-acetamid; (513) 2-(4-methyl-cyclohexyl)-8-{(E)-2-[2-methyl-4-(2-oxo-oxazolidin-3-yl)-phenyl]-ethensulfonyl}-l,3,8-triaza-spiro[4.5]dec-l-en-4-on; (514) N-(3,5-dimethyl-4-{(E)-2-[2-(4-methyl-cyclohexyl)-4-oxo-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl]-vinyl>-phenyl)-N-(2-methoxy-ethyl)-acetamid; (515) 8-{(E)-2-[2,6-dimethyl-4-(3-oxo-morpholin-4-yl)-phenyl]-ethensulfonyl}-2-(4-methyl-cyclohexyl)-l,3,8-triaza-spiro[4.5]dec-l-en-4-on; (516) 8-{(E)-2-[2,6-dimethyl-4-(2-oxo-piperidin-l-yl)-phenyl]-ethensulfonyl}-2-(4-methyl-cyclohexyl)-l,3,8-triaza-spiro[4.5]dec-l-en-4-on; (517) N-(3,5-dimethyl-4-{(E)-2-[2-(4-methyl-cyclohexyl)-4-oxo-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl]-vinyl>-benzyl)-N-methyl-acetamid; (518) 3-(3,5-dimethyl-4-{(E)-2-[2-(4-methyl-cyclohexyl)-4-oxo-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl]-vinyl}-benzyl)-imidazoliden-2,4-dion; (519) 3-(3,5-dimethyl-4-{(E)-2-[2-(4-methyl-cyclohexyl)-4-oxo-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl]-vinyl>-benzyl)-5,5-dimethyl-imidazoliden-2,4-dion; (520) 8-{(E)-2-[2,6-dimethyl-4-(2-oxo-pyrrolidin-l-ylmethyl)-phenyl]-ethensulfonyl}-2-(4-methyl-cyclohexyl)-l,3,8-triaza-spiro[4.5]dec-l-en-4-on; (521) l-(3,5-dimethyl-4-{(E)-2-[2-(4-methyl-cyclohexyl)-4-oxo-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl]-vinyl>-benzyl)-pyrrolidin-2,5-dion; (522) N-(3,5-dimethyl-4-{(E)-2-[2-(4-methyl-cyclohexyl)-4-oxo-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl]-vinyl)--benzyl)-acetannid; (523) N-(3,5-difluor-4-{(E)-2-[2-(4-methyl-cyclohexyl)-4-oxo-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl]-vinyl}-phenyl)-N-methyl-acetamid; (524) 8-{(E)-2-[l-((S)-2,3-dihydroxy-propyl)-lH-indol-4-yl]-ethensulfonyl>-2-(3-trifluormethyl-phenyl)-l,3,8-triaza-spiro[4.5]dec-l-en-4-on; (525) [(S)-l-(3-methyl-4-{(E)-2-[4-oxo-2-(3-trifluormethyl-phenyl)-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl]-vinyl>-phenyl)-2,5-dioxo-pyrrolidin-3-yl]-carbaminsyre-tert-butylester; (526) 8-{(E)-2-[l-((S)-2,3-dihydroxy-propyl)-lH-indol-4-yl]-ethensulfonyl)-2-(3-trifluormethoxy-phenyl)-l,3,8-triaza-spiro[4.5]dec-l-en-4-on; (527) 8-{(E)-2-[2-methyl-4-(4-methyl-piperazin-l-carbonyl)-phenyl]-ethensulfonyl}-2-(3-trifluormethoxy-phenyl)-l,3,8-triaza-spiro[4.5]dec-l-en-4-on; (528) 8-((E)-2-{2-methyl-4-[2-(4-methyl-piperazin-l-yl)-2-oxo-ethylamino]-phenyl >-ethensulfonyl)-2-(3-tri fluormethoxy-phenyl)-l,3,8-triaza-spiro[4.5]dec-l-en-4-on; (529) 2-(3-methyl-4-{(E)-2-[4-oxo-2-(3-trifluormethoxy-phenyl)-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl]-vinyl>-phenylamino)-acetamid; (530) 3-methyl-4-{(E)-2-[4-oxo-2-(3-trifluormethoxy-phenyl)-l,3/8-triaza-spiro[4.5]dec-l-en-8-sulfonyl]-vinyl>-N-pyridin-4-yl-benzensulfonamid; (531) 8-{(E)-2-[4-(3,4-dihydroxy-butoxy)-2-methyl-phenyl]-ethensulfonyl}-2-(3-trifluornnethoxy-phenyl)-l,3,8-tnaza-spiro[4.5]dec-l-en-4-on; (532) l-(3,5-dimethyl-4-{(E)-2-[4-oxo-2-(3-tnfluornnethoxy-phenyl)-2,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl]-vinyl>-phenyl)-l,3-bis-(2-hydroxy-ethyl)-urinstof; (533) l-(3,5-dimethyl-4-{(E)-2-[4-oxo-2-(3-trifluornnethoxy-phenyl)-l,3,8-tnaza-spiro[4.5]dec-l-en-8-sulfonyl]-vinyl>-phenyl)-l,3-bis-(2-hydroxy-ethyl)-3-methyl-urinstof; (534) N-(3,5-dimethyl-4-{(E)-2-[4-oxo-2-(3-trifluornnethoxy-phenyl)-l,3,8-tnaza-spiro[4.5]dec-l-en-8-sulfonyl]-vinyl>-phenyl)-N-(tetrahydro-pyran-4-yl)-methansulfonamid; (535) 2-(4-fluor-3-trifluormethyl-phenyl)-8-{(E)-2-[4-(4-hydroxy-pipendin-l-carbonyl)-2,6-dimethyl-phenyl]-ethensulfonyl>-l,3,8-triaza-spiro[4.5]dec-l-en-4-on; (536) 3-{3-methyl-4-[(E)-2-(2-nonyl-4-oxo-l,3,8-tnaza-spiro[4.5]dec-l-en-8-sulfonyl)-vinyl]-phenyl>-imidazoliden-2,4-dion; (537) 3-{4-[(E)-2-(2-nonyl-4-oxo-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl)-vinyl]-3-trifluormethylphenyl}-imidazoliden-2,4-dion; (538) 4-{3-methyl-4-[(E)-2-(2-nonyl-4-oxo-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl)-vinyl]-phenyl}-morpholin-3,5-dion; (539) 3-{3,5-dimethyl-4-[(E)-2-(2-nonyl-4-oxo-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl)-vinyl]-phenyl>-imidazoliden-2,4-dion; (540) 5,5-dimethyl-3-[3-methyl-4-((E)-2-{4-oxo-2-[4-(3,3,3-trifluor-propyl)-cyclohexyl]-l,3/8-triaza-spiro[4.5]dec-l-en-8-sulfonyl}-vinyl)-phenyl]-imidazoliden-2,4-dion; (541) 8-{(E)-2-[l-((R)-2,3-dihydroxy-propyl)-lH-indol-4-yl]-ethensulfonyl>-2-[4-(3,3,3-trifluor-propyl)-cyclohexyl]-l,3,8-triaza-spiro[4.5]dec-l-en-4-on; (542) N-(2-methoxy-ethyl)-N-[3-methyl-4-((E)-2-{4-oxo-2-[4-(3,3,3-trifluor-propyl)-cyclohexyl]-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl>-vinyl)-phenyl]-acetamid; (543) N-[3,5-dimethyl-4-((E)-2-{4-oxo-2-[4-(3,3,3-trifluor-propyl)-cyclohexyl]- 1.3.8- triaza-spiro[4.5]dec-l-en-8-sulfonyl>-vinyl)-phenyl]-N-(2-methoxy-ethyl)-acetamid; (544) N-[2-(2-hydroxy-ethoxy)-ethyl]-N-[3-methyl-4-((E)-2-{4-oxo-2-[4-(3,3,3-tnfluor-propyl)-cyclohexyl]-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl>-vinyl)-phenylj-acetamid; (545) N-[2-(2-fluor-ethoxy)-ethyl]-N-[3-methyl-4-((E)-2-{4-oxo-2-[4-(3,3,3-tnfluor-propyl)-cyclohexyl]-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl>-vinyl)-phenylj-acetamid; (546) N-[3,5-dimethyl-4-((E)-2-{4-oxo-2-[4-(3,3,3-trifluor-propyl)-cyclohexyl]- 1.3.8- triaza-spiro[4.5]dec-l-en-8-sulfonyl}-vinyl)-phenyl]-N-methyl-acetamid; (547) 3,5-dimethyl-4-((E)-2-{4-oxo-2-[4-(3,3,3-trifluor-propyl)-cyclohexyl]-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl>-vinyl)-benzoesyre; (548) 3-[3,5-dimethyl-4-((E)-2-{4-oxo-2-[4-(3,3,3-trifluor-propyl)-cyclohexyl]- 1.3.8- triaza-spiro[4.5]dec-l-en-8-sulfonyl>-vinyl)-phenyl]-l-methyl-imidazoliden-2,4-dion; (549) 8-((E)-2-{4-[4-(2-fluor-ethyl)-piperazin-l-carbonyl]-2,6-dimethyl-phenyl}-ethensulfonyl)-2-[4-(3,3,3-trifluor-propyl)-cyclohexyl]-l,3,8-triaza-spiro[4.5]dec-l-en-4-on; (550) 8-{(E)-2-[2,6-dimethyl-4-(3-oxo-morpholin-4-yl)-phenyl]-ethensulfonyl}-2-[4-(3,3,3-trifluor-propyl)-cyclohexyl]-l,3,8-triaza-spiro[4.5]dec-l-en-4-on; (551) N-[3,5-dimethyl-4-((E)-2-{4-oxo-2-[4-(3,3,3-trifluor-propyl)-cyclohexyl]- 1.3.8- triaza-spiro[4.5]dec-l-en-8-sulfonyl}-vinyl)-phenyl]-N-[2-(2-fluor-ethoxy)-ethylj-acetamid; (552) 3,5-dimethyl-4-((E)-2-{4-oxo-2-[4-(3,3,3-trifluor-propyl)-cyclohexyl]-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl}-vinyl)-benzoesyre-N'-acetyl-hydrazid; (553) 8-[(E)-2-(4-hydroxymethyl-2,6-dimethyl-phenyl)-ethensulfonyl]-2-[4-(3,3,3-trifluor-propyl)-cyclohexyl]-l,3,8-triaza-spiro[4.5]dec-l-en-4-on; (554) 3-[3,5-dimethyl-4-((E)-2-{4-oxo-2-[4-(3,3,3-trifluor-propyl)-cyclohexyl]- 1.3.8- triaza-spiro[4.5]dec-l-en-8-sulfonyl}-vinyl)-benzyl]-imidazoliden-2,4-dion; (555) 3-[3,5-dimethyl-4-((E)-2-{4-oxo-2-[4-(3,3,3-trifluor-propyl)-cyclohexyl]- 1.3.8- triaza-spiro[4.5]dec-l-en-8-sulfonyl>-vinyl)-benzyl]-5,5-dimethyl-imidazoliden-2,4-dion (556) 8-{(E)-2-[2,6-dimethyl-4-(2-oxo-pyrrolidin-l-ylmethyl)-phenyl]-ethensulfonyl>-2-[4-(3,3,3-trifluorpropyl)-cyclohexyl]-l,3,8-triaza-spiro[4.5]dec-l-en-4-on; (557) l-[3,5-dimethyl-4-((E)-2-{4-oxo-2-[4-(3,3,3-trifluor-propyl)-cyclohexyl]- 1.3.8- triaza-spiro[4.5]dec-l-en-8-sulfonyl}-vinyl)-benzyl]-pyrrolidin-2,5-dion; (558) N-[3,5-dimethyl-4-((E)-2-{4-oxo-2-[4-(3,3,3-trifluor-propyl)-cyclohexyl]- 1.3.8- triaza-spiro[4.5]dec-l-en-8-sulfonyl}-vinyl)-benzyl]-acetamid; (559) N-[3,5-dimethyl-4-((E)-2-{4-oxo-2-[4-(3,3,3-trifluor-propyl)-cyclohexyl]- 1.3.8- triaza-spiro[4.5]dec-l-en-8-sulfonyl}-vinyl)-benzyl]-N-methyl-acetamid; (560) 3-(4-{(E)-2-[2-(4-butyl-cyclohexyl)-4-oxo-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl]-vinyl}-3-methyl-phenyl)-imidazoliden-2,4-dion; (561) N-(4-{(E)-2-[2-(4-butyl-cyclohexyl)-4-oxo-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl]-vinyl>-3,5-dimethyl-phenyl)-N-[2-(2-methoxy-ethoxy)-ethyl]-acetamid; (562) N-(4-{(E)-2-[2-(4-butyl-cyclohexyl)-4-oxo-l,3,8-tnaza-spiro[4.5]dec-l-en-8-sulfonyl]-vinyl>-3,5-dimethyl-phenyl)-N-[2-(2-fluor-ethoxy)-ethyl]-acetamid; (563) 3-(4-{(E)-2-[2-(4-isopropyl-cyclohexyl)-4-oxo-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl]-vinyl}-3-methyl-phenyl)-imidazoliden-2,4-dion; (564) 3-(4-{(E)-2-[2-(4-isopropyl-cydohexyl)-4-oxo-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl]-vinyl}-3,5-dimethyl-phenyl)-imidazoliden-2,4-dion; (565) 3-{4-[(E)-2-(2-cyclohexyl-4-oxo-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl)-vinyl]-benzyl}-l,l-dimethyl-urinstof; (566) (2-{4-[(E)-2-(2-cyclohexyl-4-oxo-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl)-vinyl]-phenyl}-ethyl)-carbaminsyre-methylester; (567) 4-methyl-piperazin-l-carboxylsyre-4-[(E)-2-(2-cyclohexyl-4-oxo-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl)-vinyl]-benzylamid; (568) N-{4-[(E)-2-(2-cyclohexyl-4-oxo-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyO-vinylJ-S-methyl-phenylJ-N^N'-dimethyl-sulfamid; (569) {4-[(E)-2-(2-cyclohexyl-4-oxo-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl)-vinyl]-3-methyl-benzyl>-(3-dimethylamino-propyl)-carbaminsyre-tert-butylester; (570) 2-{4-[(E)-2-(2-cyclohexyl-4-oxo-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl)-vinyl]-phenyl>-N-(2,2-dimethyl-propyl)-acetamid; (571) 2-{4-[(E)-2-(2-cyclohexyl-4-oxo-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl)-vinyl]-phenyl>-N-(2-diisopropylamino-ethyl)-acetamid; (572) 2-cyclohexyl-8-{(E)-2-[2-methyl-4-(2-oxo-azetidin-l-yl)-phenyl]-ethensulfonyl>-l,3,8-triaza-spiro[4.5]dec-l-en-4-on; (573) 2-cyclohexyl-8-{(E)-2-[2,6-dimethyl-4-(thiazol-2-ylannino)-phenyl]-ethensulfonyl)-l,3,8-triaza-spiro[4.5]dec-l-en-4-on; (574) N-{4-[(E)-2-(2-cyclohexyl-4-oxo-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl)-vinyl]-3,5-dimethylphenyl}-N-(3-methyl-oxetan-3-ylmethyl)-acetamid; (575) 3-(3,5-dimethyl-4-{(E)-2-[2-(4-methyl-cyclohexyl)-4-oxo-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl]-vinyl}-phenyl)-imidazoliden-2,4-dion; (576) N-(3-ethoxymethyl-4-{(E)-2-[2-(4-methylcyclohexyl)-4-oxo-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl]-vinyl}-phenyl)-acetamid; (577) 2-(4-methyl-cyclohexyl)-8-{(E)-2-[2-methyl-4-(4-oxo-oxazolidin-3-yl)-phenyl]-ethensulfonyl}-l,3,8-triaza-spiro[4.5]dec-l-en-4-on; (578) 4-(3-methyl-4-{(E)-2-[2-(4-methyl-cyclohexyl)-4-oxo-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl]-vinyl}-phenyl)-3-oxo-piperazin-l-carboxylsyre-tert-butylester; (579) 2-(4-methyl-cyclohexyl)-8-{(E)-2-[2-methyl-4-(4-methyl-2-oxo-oxazolidin- 3-yl)-phenyl]-ethensulfonyl>-l,3,8-triaza-spiro[4.5]dec-l-en-4-on; (580) 2-(4-methyl-cyclohexyl)-8-{(E)-2-[2-methyl-4-(3-oxo-isoxazolidin-2-yl)-phenyl]-ethensulfonyl>-l,3,8-triaza-spiro[4.5]dec-l-en-4-on; (581) 3-(2,5-dimethyl-4-{(E)-2-[2-(4-methyl-cyclohexyl)-4-oxo-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl]-vinyl}-phenyl)-imidazoliden-2,4-dion; (582) 3-(3,5-dimethyl-4-{(E)-2-[2-(4-methyl-cyclohexyl)-4-oxo-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl]-vinyl>-phenyl)-5-methyl-imidazoliden-2,4-dion; (583) 3-(2,6-dimethyl-4-{(E)-2-[2-(4-methyl-cyclohexyl)-4-oxo-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl]-vinyl>-phenyl)-imidazoliden-2,4-dion; (584) N-(2,6-dimethyl-4-{(E)-2-[2-(4-methyl-cydohexyl)-4-oxo-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl]-vinyl>-phenyl)-N-methyl-acetamid; (585) 8-[(E)-2-(3-methoxy-2-methyl-phenyl)-ethensulfonyl]-2-(4-methyl-cyclohexyl)-l,3,8-triaza-spiro[4.5]dec-l-en-4-on; (586) 8-((E)-2-{4-[(lH-imidazol-2-yl)-methyl-amino]-2,6-dimethyl-phenyl>-ethensulfonyl)-2-(4-methyl-cyclohexyl)-l,3,8-triaza-spiro[4.5]dec-l-en-4-on; (587) 1-(3,5-dimethyl-4-{(E)-2-[2-(4-methyl-cyclohexyl)-4-oxo-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl]-vinyl>-phenyl)-dihydro-pynmidin-2,4-dion; (588) 2-(4-methyl-cyclohexyl)-8-{(E)-2-[2-methyl-4-(5-oxo-pyrazolidin-l-yl)-phenyl]-ethensulfonyl}-l,3,8-tnaza-spiro[4.5]dec-l-en-4-on; (589) 5-tert-butoxymethyl-3-(3,5-dimethyl-4-{(E)-2-[2-(4-methyl-cyclohexyl)-4-oxo-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl]-vinyl>-phenyl)-imidazoliden-2,4-dion; (590) N,N-dimethyl-2-(3-methyl-4-{(E)-2-[4-oxo-2-(3-trifluormethyl-phenyl)- l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl]-vinyl>-benzensulfonylamino)-acetannid; (591) 3-methyl-4-{(E)-2-[4-oxo-2-(3-trifluormethyl-phenyl)-l,3,8-tnaza-spiro[4.5]dec-l-en-8-sulfonyl]-vinyl>-N-pyridin-3-ylmethyl-benzensulfonannid; (592) N-(4-hydroxy-cyclohexyl)-3-methyl-4-{(E)-2-[4-oxo-2-(3-trifluormethyl-phenyl)-l,3,8-tnaza-spiro[4.5]dec-l-en-8-sulfonyl]-vinyl>-benzensulfonamid; (593) 8-[(E)-2-(4-methansulfonyl-2-methyl-phenyl)-ethensulfonyl]-2-(3-trifluormethyl-phenyl)-l,3,8-triaza-spiro[4.5]dec-l-en-4-on; (594) N-acetyl-3-methyl-4-{(E)-2-[4-oxo-2-(3-trifluormethyl-phenyl)-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl]-vinyl}-benzensulfonamid; (595) N-(2-hydroxy-l,l-bis-hydroxymethyl-ethyl)-3-methyl-4-{(E)-2-[4-oxo-2-(3-trifluormethyl-phenyl)-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl]-vinyl}-benzensulfonamid; (596) N-(l-benzyl-piperidin-4-yl)-3-methyl-4-{(E)-2-[4-oxo-2-(3-trifluormethoxy-phenyl)-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl]-vinyl}-benzensulfonamid; (597) 8-{(E)-2-[l-((S)-2,3-dihydroxy-propyl)-lH-indol-5-yl]-ethensulfonyl}-2-(3-trifluormethoxy-phenyl)-l,3,8-triaza-spiro[4.5]dec-l-en-4-on; (598) 8-{(E)-2-[4-(4-isopropyl-piperazin-l-carbonyl)-2-methyl-phenyl]-ethensulfonyl>-2-(3-trifluormethoxyphenyl)-l,3,8-triaza-spiro[4.5]dec-l-en-4-on; (599) N-((R)-2,3-dihydroxy-propyl)-3-methyl-4-{(E)-2-[4-oxo-2-(3-trifluormethoxy-phenyl)-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl]-vinyl>-benzensulfonamid; (600) 8-{(E)-2-[4-(3,4-dihydroxy-butoxy)-3,5-difluor-phenyl]-ethensulfonyl)-2-(3-trifluormethoxy-phenyl)-l,3,8-triaza-spiro[4.5]dec-l-en-4-on; (601) 8-{(E)-2-[4-(3,4-dihydroxy-butoxy)-3,5-dimethylphenyl]-ethensulfonyl)-2-(3-trifluormethoxy-phenyl)-l,3,8-tnaza-spiro[4.5]dec-l-en-4-on; (602) 4-(3-methyl-4-{(E)-2-[4-oxo-2-(3-tnfluormethoxyphenyl)-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl]-vinyl)-phenoxy)-piperidin-l-carboxylsyre-tert-butylester; (603) N-isopropyl-N-(3-methyl-4-{(E)-2-[4-oxo-2-(3-trifluormethoxy-phenyl)- l,3,8-tnaza-spiro[4.5]dec-l-en-8-sulfonyl]-vinyl)-phenyl)-acetannid; (604) 4-[acetyl-(3-methyl-4-{(E)-2-[4-oxo-2-(3-trifluormethoxy-phenyl)-l,3,8-tnaza-spiro[4.5]dec-l-en-8-sulfonyl]-vinyl>-phenyl)-amino]-pipendin-l-carboxylsyre-tert-butylester; (605) l-(3,5-dimethyl-4-{(E)-2-[4-oxo-2-(3-tnfluormethoxy-phenyl)-l,3/8-triaza-spiro[4.5]dec-l-en-8-sulfonyl]-vinyl)-phenyl)-l-(2-hydroxy-ethyl)-urinstof; (606) 8-((E)-2-{4-[(R)-2-(isopropylamino-methyl)-5-oxo-pyrrolidin-l-yl]-2,6-dimethyl-phenyl)-ethensulfonyl)-2-(3-tnfluormethoxy-phenyl)-l,3,8-triaza-spiro[4.5]dec-l-en-4-on; (607) N-(2-dimethylamino-ethyl)-N-(3,5-dimethyl-4-{(E)-2-[4-oxo-2-(3-trifluormethoxy-phenyl)-l,3,8-tnaza-spiro[4.5]dec-l-en-8-sulfonyl]-vinyl>-phenyl)-acetamid; (608) 2-dimethylamino-N-(3,5-dimethyl-4-{(E)-2-[4-oxo-2-(3-trifluormethoxy-phenyl)-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl]-vinyl)-phenyl)-N-methyl-acetamid; (609) N-(2-dimethylamino-ethyl)-N-(3,5-dimethyl-4-{(E)-2-[4-oxo-2-(3-trifluormethoxy-phenyl)-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl]-vinyl}-phenyl)-methansulfonamid; (610) N-[(R)-l-(3,5-dimethyl-4-{(E)-2-[4-oxo-2-(3-trifluormethoxy-phenyl)-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl]-vinyl)-phenyl)-5-oxo-pyrrolidin-2-ylmethyl]-acetamid; (611) 8-{(E)-2-[4-((R)-2-dimethylaminomethyl-5-oxo-pyrrolidin-l-yl)-2,6-dimethyl-phenyl]-ethensulzonyl}-2-(3-trifluormethoxy-phenyl)-l,3,8-triaza-spiro[4.5]dec-l-en-4-on; (612) N-cyanomethyl-N-(3-methyl-4-{(E)-2-[4-oxo-2-(3-trifluormethoxy-phenyl)- l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl]-vinyl>-phenyl)-acetamid; (613) N-(3-methyl-4-{(E)-2-[4-oxo-2-(3-trifluormethoxyphenyl)-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl]-vinyl>-phenyl)-N-(2,2,2-trifluor-ethyl)-acetamid; (614) 3-(3,5-dimethyl-4-{(E)-2-[4-oxo-2-(3-trifluormethoxy-phenyl)-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl]-vinyl>-phenyl)-l,5,5-trimethyl-imidazoliden-2,4-dion; (615) 3-(3,5-dimethyl-4-{(E)-2-[4-oxo-2-(3-trifluormethoxy-phenyl)-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl]-vinyl>-phenyl)-5,5-dimethyl-imidazoliden-2,4-dion; (616) N-(3,5-dimethyl-4-{(E)-2-[4-oxo-2-(3-trifluormethoxy-phenyl)-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl]-vinyl>-phenyl)-N-(tetrahydro-pyran-4-yl)-acetamid; (617) 8-{(E)-2-[2-methyl-4-(3-oxo-morpholin-4-yl)-phenyl]-ethensulfonyl}-2-(3-trifluormethoxy-phenyl)-l,3,8-triaza-spiro[4.5]dec-l-en-4-on; (618) 3-(3-methyl-4-{(E)-2-[4-oxo-2-(3-trifluormethoxyphenyl)-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl]-vinyl>-phenyl)-imidazoliden-2,4-dion; (619) 2-(4-fluor-3-trifluormethyl-phenyl)-8-{(E)-2-[2-methyl-4-(pyrrolidin-l-carbonyl)-phenyl]-ethensulfonyl>-l,3,8-triaza-spiro[4.5]dec-l-en-4-on; (620) 2-(4-fluor-3-trifluormethyl-phenyl)-8-{(E)-2-[4-((R)-2-hydroxymethyl-5-oxo-pyrrolidin-l-yl)-2-methyl-phenyl]-ethensulfonyl>-l,3,8-triaza-spiro[4.5]dec-l-en-4-on; (621) 2-(4-fluor-3-trifluormethyl-phenyl)-8-{(E)-2-[4-((S)-2-hydroxymethyl-5-oxo-pyrrolidin-l-yl)-2-methyl-phenyl]-ethensulfonyl>-l,3,8-triaza-spiro[4.5]dec-l-en-4-on; (622) 8-{(E)-2-[l-((S)-2,3-dihydroxy-propyl)-lH-indol-4-yl]-ethensulfonyl}-2-(9,9,9-trifluor-nonyl)-l,3,8-triaza-spiro[4.5]dec-l-en-4-on; (623) 8-{(E)-2-[l-((S)-2,3-dihydroxy-propyl)-lH-indol-4-yl]-ethensulfonyl>-2-(8,8,9,9,9-pentafluor-nonyl)-l,3,8-triaza-spiro[4.5]dec-l-en-4-on; (624) l-(4-{(E)-2-[2-(4-ethyl-cyclohexyl)-4-oxo-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl]-vinyl}-3-methyl-phenyl)-imidazoliden-2,4-dion; (625) l-(4-{(E) -2- [2-(4-ethyl-cyclohexyl)-4-oxo-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl]-vinyl}-3-methyl-phenyl)-5-methyl-imidazoliden-2,4-dion; (626) l-(4-{(E)-2-[2-(4-ethyl-cyclohexyl)-4-oxo-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl]-vinyl}-3-methyl-phenyl)-5,5-dimethyl-imidazoliden-2,4-dion; (627) 8-{(E)-2-[4-(3,4-dihydroxy-butoxy)-2,6-dimethyl-phenyl]-ethensulfonyl}-2-nonyl-l,3,8-triaza-spiro[4.5]dec-l-en-4-on; (628) 3,5-dimethyl-4-[(E)-2-(2-nonyl-4-oxo-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl)-vinyl]-benzoesyre; (629) 3,5-dimethyl-4-((E)-2-{4-oxo-2-[4-(3,3,3-trifluor-propyl)-cyclohexyl]-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl>-vinyl)-benzoesyre-trimethylhydrazid; (630) 8-{(E)-2-[l-((R)-2,3-dihydroxy-propyl)-4,6-dimethyl-lH-indol-5-yl]-ethensulfonyl>-2-[4-(3/3,3-trifluor-propyl)-cyclohexyl]-l,3,8-triaza-spiro[4.5]dec-l-en-4-on; (631) 3-(4-{(E)-2-[2-(4-butyl-cyclohexyl)-4-oxo-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl]-vinyl>-3,5-dimethyl-phenyl)-imidazoliden-2,4-dion; (632) N-(4-{(E)-2-[2-(4-butyl-cyclohexyl)-4-oxo-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl]-vinyl>-3,5-dimethyl-phenyl)-N-(3-methyl-oxetan-3-ylmethyl)-acetamid; (633) 2-cyclohexyl-8-((E)-2-quinolin-8-yl-ethensulfonyl)-l,3,8-triaza-spiro[4.5]dec-l-en-4-on; (634) 2-cyclohexyl-8-[(E)-2-(2-oxo-2,3-dihydro-lH-indol-4-yl)-ethensulfonyl]- l,3,8-triaza-spiro[4.5]dec-l-en-4-on; (635) 3-(3,5-dimethyl-4-{(E)-2-[4-oxo-2-(3-trifluormethoxy-phenyl)-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl]-vinyl>-phenyl)-imidazoliden-2,4-dion; (636) 3-(4-{(E)-2-[2-(4-fluor-3-trifluormethyl-phenyl)-4-oxo-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl]-vinyl}-3,5-dimethyl-phenyl)-imidazoliden-2,4-dion; (637) 2-cyclohexyl-8-[(E)-2-(2-methyl-lH-indol-4-yl)-ethensulfonyl]-l,3,8-triaza-spiro[4.5]dec-l-en-4-on; (638) 2-cyclohexyl-8-[(E)-2-(l-methyl-l,2,3,4-tetrahydro-quinolin-5-yl)-ethensulfonyl]-l,3,8-triaza-spiro[4.5]dec-l-en-4-on; (639) 8-{(E)-2-[4-(3,4-dihydroxy-butoxy)-2,6-dimethyl-phenyl]-ethensulfonyl>-2-(4-fluor-3-trifluormethyl-phenyl)-l,3,8-triaza-spiro[4.5]dec-l-en-4-on; (640) (4-{(E)-2-[2-(4-fluor-3-trifluormethyl-phenyl)-4-oxo-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl]-vinyl>-3,5-dimethyl-phenyl)-[l,l,l-2H3]methyl-carbaminsyre-tert-butylester; (641) 8-{(E)-2-[4-(4-fluormethyl-4-hydroxy-piperidin-l-carbonyl)-2,6-dimethyl-phenyl]-ethensulfonyl>-2-(4-fluor-3-trifluormethyl-phenyl)-l,3/8-triaza-spiro[4.5]dec-l-en-4-on; (642) 2-(4-fluor-3-trifluormethyl-phenyl)-8-{(E)-2-[4-(4-hydroxy-4-methyl-piperidin-l-carbonyl)-2,6-dimethyl-phenyl]-ethensulfonyl>-l,3,8-triaza-spiro[4.5]dec-l-en-4-on; (643) 8-{(E)-2-[l-((S)-2,3-dihydroxy-propyl)-lH-indol-4-yl]-ethensulfonyl>-2-(4-fluor-3-trifluormethyl-phenyl)-l,3,8-triaza-spiro[4.5]dec-l-en-4-on; (644) 8-{(E)-2-[2,6-dimethyl-4-(2-oxa-7-aza-spiro[3.5]nonan-7-carbonyl)-phenyl]-ethensulfonyl}-2-(4-fluor-3-trifluormethyl-phenyl)-l,3,8-triaza-spiro[4.5]dec-l-en-4-on; (645) 2-cyclohexyl-8-[2-(l,2,3,4-tetrahydro-quinolin-5-yl)-ethansulfonyl]-l,3,8-triaza-spiro[4.5]dec-l-en-4-on; (646) 4-[2-(2-cyclohexyl-4-oxo-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl)-ethyl]-lH-indole-3-carbonitrile; (647) 7-[2-(2-cyclohexyl-4-oxo-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl)-ethyl]-indole-l-carboxylsyre-dimethylamid; (648) 2-cyclohexyl-8-(2-quinolin-5-yl-ethansulfonyl)-l,3,8-tnaza-spiro[4.5]dec-l-en-4-on; (649) 2-cyclohexyl-8-{2-[3-(2,2,2-trifluor-acetyl)-lH-indol-4-yl]-ethansulfonyl>- 1.3.8- triaza-spiro[4.5]dec-l-en-4-on; (650) 2-cyclohexyl-8-[2-(l-isopropyl-lH-indol-4-yl)-ethansulfonyl]-l,3,8-triaza-spiro[4.5]dec-l-en-4-on; (651) 2-cyclohexyl-8-{2-[l-(4-hydroxy-butyl)-lH-indol-4-yl]-ethansulfonyl}-l,3,8-triaza-spiro[4.5]dec-l-en-4-on; (652) N-{3-cyano-4-[2-(2-cyclohexyl-4-oxo-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl)-ethyl]-phenyl>-acetamid; (653) 8-(2-isoquinolin-5-yl-ethansulfonyl)-2-(3-trifluormethoxy-phenyl)-l,3,8-triaza-spiro[4.5]dec-l-en-4-on; (654) 8-(2-quinolin-5-yl-ethansulfonyl)-2-(3-trifluormethoxy-phenyl)-l,3,8-triaza-spiro[4.5]dec-l-en-4-on; (655) N-(3-methoxy-4-{2-[2-(4-methyl-cyclohexyl)-4-oxo-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl]-ethyl>-phenyl)-acetannid; (656) 8-{2-[4-(3,3-dimethyl-l,l,4-trioxo-lA5-[l,2,5]thiadiazolidin-2-yl)-2,6-dimethyl-phenyl]-ethansulfonyl>-2-(4-methyl-cyclohexyl)-l,3,8-triaza-spiro[4.5]dec-l-en-4-on; (657) 8-{2-[2-methyl-4-(3-oxo-morpholin-4-yl)-phenyl]-ethansulfonyl}-2-nonyl- 1.3.8- triaza-spiro[4.5]dec-l-en-4-on; (658) {4-[2-(2-cyclohexyl-4-oxo-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl)-ethyl]-benzyl>-carbaminsyre-isobutylester; (659) N-{4-[2-(2-cyclohexyl-4-oxo-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl)-ethyl]-benzyl>-2-hydroxy-acetamid; (660) 2-{4-[2-(2-cyclohexyl-4-oxo-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl)-ethyl]-3-trifluormethyl-phenylamino}-N-(4-hydroxy-butyl)-acetamid; (661) {4-[2-(2-cyclohexyl-4-oxo-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl)-ethyl J-3-trifluormethyl-phenyl }-carbaminsyre-isobutylester; (662) N-{4-[2-(2-cyclohexyl-4-oxo-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl)-ethyl]-3-trifluormethyl-phenyl >-benzamid; (663) 2-cyclohexyl-8-[2-(2-oxo-2,3-dihydro-benzothiazol-6-yl)-ethansulfonyl]- 1.3.8- triaza-spiro[4.5]dec-l-en-4-on; (664) N-(2-{4-[2-(2-cyclohexyl-4-oxo-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl)-ethyl]-3-methyl-benzensulfonylamino>-ethyl)-acetamid; (665) N-(2-dimethylamino-ethyl)-2-(3-methyl-4-{2-[4-oxo-2-(3-trifluormethoxy-phenyl)-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl]-ethyl}-phenylamino)-acetamid; (666) 8-{2-[4-((2R,6S)-2,6-dimethyl-morpholin-4-carbonyl)-2-methyl-phenyl]-ethansulfonyl>-2-(3-trifluormethoxy-phenyl)-li3/8-triaza-spiro[4.5]dec-l-en-4-on; (667) N-(2,2,3,3,4,4,4-heptafluor-butyl)-3-methyl-4-{2-[4-oxo-2-(3-tnfluormethyl-phenyl)-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl]-ethyl>-benzensulfonamid; (668) 8-[2-(3-methoxy-2-methyl-phenyl)-ethansulfonyl]-2-(4-methyl-cyclohexyl)- 1.3.8- triaza-spiro[4.5]dec-l-en-4-on; (669) (2-methoxy-3,5-dimethyl-4-{2-[2-(4-methyl-cyclohexyl)-4-oxo-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl]-ethyl>-phenyl)-methyl-carbaminsyre-tert-butylester; (670) 8-{2-[4-((S)-2-hydroxymethyl-5-oxo-pyrrolidin-l-yl)-2-methyl-phenyl]-ethansulfonyl}-2-nonyl-l,3,8-triaza-spiro[4.5]dec-l-en-4-on; (671) 8-[2-(5,7-dimethyl-2-oxo-2,3-dihydro-benzoxazol-6-yl)-ethansulfonyl]-2-(4-methyl-cyclohexyl)-l,3,8-triaza-spiro[4.5]dec-l-en-4-on; (672) (2-{4-[2-(2-cyclohexyl-4-oxo-l,3,8-tnaza-spiro[4.5]dec-l-en-8-sulfonyl)-ethyl]-phenyl>-ethyl)-carbaminsyre-methylester; (673) {4-[2-(2-cyclohexyl-4-oxo-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl)-ethyl]-3-methyl-benzyl}-methyl-carbaminsyre-tert-butylester; (674) 8-(2-{4-[3-(2-hydroxy-ethyl)-2-oxo-imidazolidin-l-yl]-2-methyl-phenyl}-ethansulfonyl)-2-(3-trifluormethyl-phenyl)-l,3,8-triaza-spiro[4.5]dec-l-en-4-on; (675) 2-(3-methyl-4-{2-[4-oxo-2-(3-trifluormethoxyphenyl)-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl]-ethyl>-benzensulfonylamino)-acetamid; (676) 8-{2-[4-(3,4-dihydroxy-butoxy)-2,6-dimethylphenyl]-ethansulfonyl>-2-(3-trifluormethoxy-phenyl)-l,3,8-triaza-spiro[4.5]dec-l-en-4-on; (677) 3-(4-{2-[2-(4-butyl-cyclohexyl)-4-oxo-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl]-ethyl}-3,5-dimethylphenyl)-imidazoliden-2,4-dion; (678) N-cyclopentyl-N-(3-methyl-4-{2-[4-oxo-2-(3-trifluormethoxy-phenyl)-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl]-ethyl>-phenyl)-acetamid; (679) l-(2,3-dimethyl-4-{2-[2-(4-methyl-cyclohexyl)-4-oxo-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl]-ethyl>-phenyl)-l-methyl-urinstof; (680) l-(2,5-dimethyl-4-{2-[2-(4-methyl-cyclohexyl)-4-oxo-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl]-ethyl}-phenyl)-l-methyl-urinstof; (681) {4-[2-(2-cyclohexyl-4-oxo-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl)-ethyl]-3-methyl-benzyl>-(2-hydroxy-ethyl)-carbaminsyre-tert-butylester; (682) l-(3-methoxy-5-methyl-4-{2-[2-(4-methylcyclohexyl)-4-oxo-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl]-ethyl>-phenyl)-l-methyl-urinstof; (683) l-(3-chlor-5-methyl-4-{2-[2-(4-methyl-cyclohexyl)-4-oxo-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl]-ethyl>-phenyl)-l-methyl-urinstof; (684) l-(2-methoxy-3,5-dimethyl-4-{2-[2-(4-methyl-cyclohexyl)-4-oxo-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl]-ethyl>-phenyl)-l-methyl-urinstof; (685) 5,7-dimethyl-6-{2-[2-(4-methyl-cyclohexyl)-4-oxo-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl]-ethyl}-lH-quinazolin-2,4-dion; (686) 8-{(E)-2-[l-(2-amino-ethyl)-lH-indol-4-yl]-ethensulfonyl>-2-cyclohexyl- l,3,8-triaza-spiro(4.5]dec-l-en-4-on; (687) 8-[(E)-2-(4-aminomethyl-phenyl)-ethensulfonyl]-2-cyclohexyl-l,3i8-triaza-spiro[4.5]dec-l-en-4-on; (688) (S)-2-amino-3-hydroxy-N-(3-methyl-4-{(E)-2-[4-oxo-2-(3-tnfluormethyl-phenyl)-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl]-vinyl>-phenyl)-propionamid; (689) N-(3,5-dimethyl-4-{(E)-2-[4-oxo-2-(3-trifluormethoxy-phenyl)-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl]-vinyl}-phenyl)-N-piperidin-4-yl-methansulfonamid; (690) 8-[(E)-2-(2,6-dimethyl-4-methylamino-phenyl)-ethensulfonyl]-2-(9,9,9-trifluor-nonyl)-l,3,8-triaza-spiro[4.5]dec-l-en-4-on; (691) 8-[(E)-2-(2,6-dimethyl-4-methylamino-phenyl)-ethensulfonyl]-2-(8,8,9,9,9-pentafluor-nonyl)-l,3,8-triaza-spiro[4.5]dec-l-en-4-on; (692) l-{3,5-dimethyl-4-[(E)-2-(2-nonyl-4-oxo-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl)-vinyl]-phenyl>-l-methyl-urinstof; (693) l-(2-methoxy-3,5-dimethyl-4-{(E)-2-[2-(4-methyl-cyclohexyl)-4-oxo-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl]-vinyl>-phenyl)-l-methyl-urinstof; (694) l-[3,5-dimethyl-4-((E)-2-{4-oxo-2-[4-(3,3,3-trifluor-propyl)-cyclohexyl]- 1.3.8- triaza-spiro[4.5]dec-l-en-8-sulfonyl>-vinyl)-phenyl]-l-(2-fluor-ethyl)-urinstof; (695) l-(3-chlor-5-methyl-4-{(E)-2-[2-(4-methylcyclohexyl)-4-oxo-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl]-vinyl>-phenyl)-l-methyl-urinstof; (696) l-[3,5-dimethyl-4-(2-{4-oxo-2-[4-(3,3,3-trifluor-propyl)-cyclohexyl]-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl>-ethyl)-phenyl]-l-methyl-urinstof; (697) 8-{(E)-2-[4-((R)-2,3-dihydroxy-propoxy)-2,6-dimethyl-phenyl]-ethensulfonyl>-2-[4-(3,3,3-trifluorpropyl)-cyclohexyl]-l,3,8-triaza-spiro[4.5]dec-l-en-4-on; (698) 8-((E)-2-{4-[2-((R)-2,3-dihydroxy-propoxy)-ethoxy]-2,6-dimethyl-phenyl>-ethensulfonyl)-2-[4-(3,3,3-trifluor-propyl)-cyclohexyl]-l,3,8-triaza-spiro[4.5]dec-l-en-4-on; (699) N-[3,5-dimethyl-4-((E)-2-{4-oxo-2-[4-(3,3,3-trifluor-propyl)-cyclohexyl]- 1.3.8- triaza-spiro[4.5]dec-l-en-B-sulfonyl}-vinyl)-phenyl]-N-[2-(2-hydroxy-ethoxy)-ethyl]-acetamid; (700) N-[2-(2-hydroxy-ethoxy)-ethyl]-N-{3-methyl-4-[(E)-2-(2-nonyl-4-oxo-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl)-vinyl]-phenyl>-acetamid (701) N-{3,5-dimethyl-4-[(E)-2-(2-nonyl-4-oxo-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl)-vinyl]-phenyl>-N-(2-hydroxy-ethyl)-acetamid; (702) 2-cyclohexyl-8-{(E)-2-[l-((S)-2,3-dihydroxy-propyl)-lH-indol-5-yl]-ethensulfonyl>-l,3,8-triaza-spiro[4.5]dec-l-en-4-on; (704) 8-((E)-2-{l-[2-((S)-2,3-dihydroxy-propoxy)-ethyl]-lH-indol-4-yl}-ethensulfonyl)-2-[4-(3,3/3-trifluorpropyl)-cyclohexyl]-l,3,8-triaza-spiro[4.5]dec-l-en-4-on; (705) 8-{(E)-2-[2,6-dimethyl-4-((2S,3S)-2,3,4-trihydroxy-butoxy)-phenyl]-ethensulfonyl>-2-[4-(3/3,3-trifluor-propyl)-cyclohexyl]-l,3,8-triaza-spiro[4.5]dec-l-en-4-on; (706) 2-[4-(3,3,3-trifluor-propyl)-cyclohexyl]-8-((E)-2-{l-[2-((2S/3S)-2,3/4-trihydroxy-butoxy)-ethyl]-lH-indol-4-yl>-ethensulfonyl)-l,3,8-triaza-spiro[4.5]dec-l-en-4-on; (707) N-((S)-2,3-dihydroxy-propyl)-N-(3,5-dimethyl-4-{(E)-2-[4-oxo-2-(9,9,9-trifluor-nonyl)-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl]-vinyl>-phenyl)-acetamid; (708) {4-[(E)-2-(2-cyclohexyl-4-oxo-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl)-vinyl]-3-methyl-benzyl>-(2-hydroxy-ethyl)-carbaminsyre-tert-butylester; (709) N-{4-[(E)-2-(2-cyclohexyl-4-oxo-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl)-vinyl]-3,5-dimethyl-phenyl}-N-(4-hydroxy-cyclohexyl)-acetamid; (710) 2-cyclohexyl-8-((E)-2-{4-[(R)-2-(2-hydroxy-ethoxymethyl)-5-oxo-pyrrolidin-l-yl]-2,6-dimethyl-phenyl>-ethensulfonyl)-l,3,8-triaza-spiro[4.5]dec-l-en-4-on; (711) N-(2-hydroxy-ethyl)-N-(3-methyl-4-{(E)-2-[4-oxo-2-(3-trifluormethoxy-phenyl)-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl]-vinyl}-phenyl)-isobutylamid; (712) 8-{(E)-2-[4-((R)-5-hydroxymethyl-3,3-dimethyl-2-oxo-pyrrolidin-l-yl)-2,6-dimethyl-phenyl]-ethensulfonyl}-2-(3-trifluormethoxy-phenyl)-l,3,8-triaza-spiro[4.5]dec-l-en-4-on; (713) 8-{(E)-2-[4-((R)-5-hydroxymethyl-3-methyl-2-oxo-pyrrolidin-l-yl)-2,6-dimethyl-phenyl]-ethensulfonyl>-2-(3-trifluormethoxy-phenyl)-l,3,8-triaza-spiro[4.5]dec-l-en-4-on; (714) 3-(3,5-dimethyl-4-{(E)-2-[4-oxo-2-(3-trifluormethoxy-phenyl)-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl]-vinyl>-phenyl)-l-(2-hydroxy-ethyl)-5,5-dimethyl-imidazoliden-2,4-dion; (715) N-(3,5-dimethyl-4-{(E)-2-[4-oxo-2-(3-trifluormethoxy-phenyl)-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl]-vinyl>-phenyl)-N-(4-hydroxy-cyclohexyl)-methansulfonamid; (716) N-(4-{(E)-2-[2-(4-butyl-cyclohexyl)-4-oxo-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl]-vinyl>-3,5-dimethyl-phenyl)-N-[2-(2-hydroxy-ethoxy)-ethyl]-acetamid; (717) N-(2-fluor-5-methyl-4-{(E)-2-[4-oxo-2-(3-trifluormethoxy-phenyl)-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl]-vinyl}-phenyl)-N-(2-hydroxy-ethyl)-acetamid; (718) N-(4-{(E)-2-[2-(4-fluor-3-trifluormethyl-phenyl)-4-oxo-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl] - vinyl}-3,5-dimethyl-phenyl)-N-(2-hydroxy-ethyl)-acetamid; (719) N-(2-hydroxy-ethyl)-N-(3-methyl-4-{(E)-2-[4-oxo-2-(3-trifluormethoxy-phenyl)-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl]-vinyl>-phenyl)-methansulfonamid; (720) N-(2-hydroxy-ethyl)-N-{3-methyl-4-[2-(2-nonyl-4-oxo-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl)-ethyl]-phenyl}-methansulfonamid; (721) N-(4-{2-[2-(4-fluor-3-trifluormethyl-phenyl)-4-oxo-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl]-ethyl}-3-methyl-phenyl)-N-(2-hydroxy-ethyl)-acetamid; (722) 2-hydroxy-N-(2-hydroxy-ethyl)-N-(3-methyl-4-{(E)-2-[4-oxo-2-(3-trifluormethoxy-phenyl)-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl]-vinyl>-phenyl)-acetamid; (723) l-[3,5-dimethyl-4-((E)-2-{4-oxo-2-[4-(3,3,3-trifluor-propyl)-cyclohexyl]- l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl}-vinyl)-phenyl]-l-methyl-urinstof; (724) l-[3,5-dimethyl-4-((E)-2-{4-oxo-2-[4-(3,3,3-trifluor-propyl)-cyclohexyl]- 1.3.8- triaza-spiro[4.5]dec-l-en-8-sulfonyl}-vinyl)-phenyl]-l-[2-(2-hydroxy-ethoxy)-ethyl]-urinstof; (725) l-[3,5-dimethyl-4-((E)-2-{4-oxo-2-[4-(3,3,3-trifluor-propyl)-cyclohexyl]- 1.3.8- triaza-spiro[4.5]dec-l-en-8-sulfonyl}-vinyl)-phenyl]-l-(2-methoxy-ethyl)-urinstof; (726) l-(3,5-dimethyl-4-{(E)-2-[2-(4-methyl-cyclohexyl)-4-oxo-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl]-vinyl}-phenyl)-l-isopropyl-uri nstof; (727) l-(3-ethyl-4-{(E)-2-[2-(4-methyl-cydohexyl)-4-oxo-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl]-vinyl}-phenyl)-l-methyl-urinstof; (728) l-(3-methoxy-5-methyl-4-{(E)-2-[2-(4-methyl-cyclohexyl)-4-oxo-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl]-vinyl>-phenyl)-l-methyl-unnstof; (729) l-cyanomethyl-l-(3-methyl-4-{(E)-2-[4-oxo-2-(3-trifluormethoxy-phenyl)- 1.3.8- triaza-spiro[4.5]dec-l-en-8-sulfonyl]-vinyl >-phenyl)-uri nstof; (730) l-cyclopentyl-l-(3-methyl-4-{(E)-2-[4-oxo-2-(3-trifluormethoxy-phenyl)- 1.3.8- triaza-spiro[4.5]dec-l-en-8-sulfonyl]-vinyl}-phenyl)-urinstof; (731) l-(3-methyl-4-{(E)-2-[4-oxo-2-(3-trifluormethoxy-phenyl)-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl]-vinyl}-phenyl)-l-(2,2,2-trifluor-ethyl)-urinstof; (732) l-(4-{2-[2-(4-ethyl-cyclohexyl)-4-oxo-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl]-ethyl}-3,5-dimethylphenyl)-l-methyl-urinstof; (733) l-((S)-2,3-dihydroxy-propyl)-l-(3,5-dimethyl-4-{(E)-2-[2-(4-methyl-cyclohexyl)-4-oxo-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl]-vinyl}-phenyl)-urinstof; (734) N-{4-[(E)-2-(2-cyclohexyl-4-oxo-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl)-vinyl]-3-methyl-phenyl}-N-cyclopentyl-acetamid; (735) (S)-2-amino-N-{4-[(E)-2-(2-cyclohexyl-4-oxo-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl)-vinyl]-3,5-dimethyl-phenyl}-3-methyl-butylamid; (736) 2-{4-[(E)-2-(2-cyclohexyl-4-oxo-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl)-vinyl]-indol-l-yl}-N-pyridin-4-yl-acetamid; (737) 2-(3-methyl-4-{(E)-2-[2-(4-methyl-cyclohexyl)-4-oxo-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl]-vinyl>-phenyl)-acetamid; (738) 2-cyclohexyl-8-{(E)-2-[4-(4,5-dihydro-thiazol-2-ylamino)-2,6-dimethyl-phenyl]-ethensulfonyl>-l,3,8-triaza-spiro[4.5]dec-l-en-4-on; (739) 2-cyclohexyl-8-{(E)-2-[2-methyl-4-(3-methyl-oxetan-3-ylmethoxy)-phenyl]-ethensulfonyl>-l,3,8-triaza-spiro[4.5]dec-l-en-4-on; (740) l-(3,5-dimethyl-4-{2-[2-(4-methyl-cyclohexyl)-4-oxo-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl]-cyclopropyl)--phenyl)-l-methyl-urinstof; (741) l-(3,5-dimethyl-4-{(E)-l-methyl-2-[2-(4-methyl-cyclohexyl)-4-oxo-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl]-vinyl>-phenyl)-l-methyl-urinstof; (742) N-(3-methyl-4-{(E)-2-[4-oxo-2-(3-trifluormethoxy-phenyl)-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl]-vinyl>-phenyl)-sulfamid; (743) N-(3-hydroxy-propyl)-N'-(3-methyl-4-{(E)-2-[4-oxo-2-(3-trifluormethoxy-phenyl)-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl]-vinyl}-phenyl)-sulfamid; (744) N-methyl-N-(3-methyl-4-{(E)-3-[2-(4-methylcyclohexyl)-4-oxo-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl]-propenyl}-phenyl)-acetamid; (745) 2-cyclohexyl-8-[2-(2-methyl-lH-indol-4-yl)-ethansulfonyl]-l,3,8-triaza-spiro[4.5]dec-l-en-4-on; (746) 8-{2-[l-((S)-2,3-dihydroxy-propyl)-lH-indol-4-yl]-ethansulfonyl}-2-(3-trifluormethoxy-phenyl)-l,3,8-triaza-spiro[4.5]dec-l-en-4-on; (747) 2-cyclohexyl-8-[2-(l-methyl-l,2,3,4-tetrahydro-quinolin-5-yl)-ethansulfonyl]-l,3,8-triaza-spiro[4.5]dec-l-en-4-on; (748) 2-cyclohexyl-8-{2-[l-(3,4-dihydroxy-butyl)-lH-indol-4-yl]-ethansulfonyl>- l,3,8-triaza-spiro[4.5]dec-l-en-4-on; (749) 3-(2,6-dimethyl-4-{2-[2-(4-methyl-cyclohexyl)-4-oxo-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl]-ethyl}-phenyl)-imidazoliden-2,4-dion; (750) 2-(3-methyl-4-{2-[2-(4-methyl-cyclohexyl)-4-oxo-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl]-ethyl}-phenyl)-acetamid; (751) N-(3-ethoxy-4-{2-[2-(4-methyl-cyclohexyl)-4-oxo-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl]-ethyl}-phenyl)-acetamid; (752) N-(3-ethyl-4-{2-(2-(4-methyl-cyclohexyl)-4-oxo-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl]-ethyl}-phenyl)-acetamid; (753) N-(3-ethoxymethyl-4-{2-[2-(4-methyl-cyclohexyl)-4-oxo-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl]-ethyl}-phenyl)-acetamid; (754) N-(3-methoxymethyl-4-{2-[2-(4-methyl-cyclohexyl)-4-oxo-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl]-ethyl>-phenyl)-acetamid; (755) N-(2-methoxy-ethyl)-N-[3-methyl-4-(2-{4-oxo-2-[4-(3,3,3-trifluor-propyl)-cyclohexyl]-l,3,8-tnaza-spiro[4.5]dec-l-en-8-sulfonyl>-ethyl)-phenyl]-acetamid; (756) N-[3,5-dimethyl-4-(2-{4-oxo-2-[4-(3,3,3-trifluorpropyl)-cyclohexyl]-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl>-ethyl)-phenyl]-N-(2-methoxy-ethyl)-acetamid; (757) N-[2-(2-fluor-ethoxy)-ethyl]-N-[3-methyl-4-(2-{4-oxo-2-[4-(3,3,3-trifluor-propyl)-cyclohexyl]-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl}-ethyl)-phenyl]- acetamid; (758) N-[2-(2-hydroxy-ethoxy)-ethyl]-N-[3-methyl-4-(2-{4-oxo-2-[4-(3,3,3-tnfluor-propyl)-cyclohexyl]-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl>-ethyl)-phenylj-acetamid; (759) N-[3,5-dimethyl-4-(2-{4-oxo-2-[4-(3,3,3-trifluor-propyl)-cyclohexyl]-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl>-ethyl)-phenyl]-N-methyl-acetannid; (760) 3-[3,5-dimethyl-4-(2-{4-oxo-2-[4-(3,3,3-trifluor-propyl)-cyclohexyl]-l,3,8-tnaza-spiro[4.5]dec-l-en-8-sulfonyl>-ethyl)-phenyl]-l-methyl-imidazoliden-2,4-dion; (761) 8-(2-{4-[4-(2-fluor-ethyl)-piperazin-l-carbonyl]-2,6-dimethyl-phenyl>-ethansulfonyl)-2-[4-(3,3,3-trifluor-propyl)-cy clohexyl]-1,3,8-triaza-spiro [4.5]dec-l-en-4-on; (764) 8-{2-[2,6-dimethyl-4-(3-oxo-morpholin-4-yl)-phenyl]-ethansulfonyl>-2-[4-(3,3,3-trifluor-propyl)-cy clohexyl]-!, 3,8-triaza-spiro[4.5]dec-l-en-4-on; (765) 8-{2-[2,6-dimethyl-4-(3-oxo-morpholin-4-yl)-phenyl]-ethansulfonyl)-2-(4-methyl-cyclohexyl)-1,3,8-triaza-spiro[4.5]dec-l-en-4-on; (766) N-[3,5-dimethyl-4-(2-{4-oxo-2-[4-(3,3,3-trifluor-propyl)-cyclohexyl]-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl)-ethyl)-phenyl]-N-[2-(2-fluor-ethoxy)-ethyl]-acetamid; (767) 3-{3,5-dimethyl-4-{2-[2-(4-methyl-cyclohexyl)-4-oxo-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl]-ethyl>-phenyl)-5-methyl-imidazoliden-2,4-dion; (768) 3,5-dimethyl-4-(2-{4-oxo-2-[4-(3,3,3-trifluor-propyl)-cyclohexyl]-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl}-ethyl)-benzoesyre; (769) 3,5-dimethyl-4-(2-{4-oxo-2-[4-(3,3,3-trifluor-propyl)-cyclohexyl]-1,3,8-tnaza-spiro[4.5]dec-l-en-8-sulfonyl]-ethyl)-benzoesyre-N'-acetyl-hydrazid; (770) 8-[2-(4-hydroxymethyl-2,6-dimethyl-phenyl)-ethansulfonyl]-2-[4-(3,3,3-trifluor-propyl)-cyclohexyl]-l,3,8-triaza-spiro[4.5]dec-l-en-4-on; (771) 8-{2-[2,6-dimethyl-4-(2-oxo-pipendin-l-yl)-phenyl]-ethansulfonyl}-2-(4-methyl-cyclohexyl )-1,3,8-triaza-spiro[4.5]dec-l-en-4-on; (772) N-[3,5-dimethyl-4-(2-{4-oxo-2-[4-(3,3,3-trifluor-propyl)-cyclohexyl]-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl}-ethyl)-benzyl]-acetamid; (773) N-(3,5-dimethyl-4-{2-[2-(4-methyl-cyclohexyl)-4-oxo-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl]-ethyl}-benzyl)-acetamid; (774) 3-[3,5-dimethyl-4-(2-{4-oxo-2-[4-(3,3,3-trifluorpropyl)-cyclohexyl]-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl}-ethyl)-benzyl]-imidazoliden-2,4-dion; (775) 3-[3,5-dimethyl-4-(2-{4-oxo-2-[4-(3/3/3-trifluorpropyl)-cyclohexyl]-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl}-ethyl)-benzyl]-5,5-dimethyl-imidazoliden-2,4-dion; (776) 8-{2-[2,6-dimethyl-4-(2-oxo-pyrrolidin-l-ylmethyl)-phenyl]-ethansulfonyl>-2-[4-(3,3,3-trifluor-propyl)-cyclohexyl]-l,3,8-triaza-spiro[4.5]dec-l-en-4-on; (777) l-[3,5-dimethyl-4-(2-{4-oxo-2-[4-(3,3,3-trifluor-propyl)-cyclohexyl]-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl)-ethyl)-benzyl]-pyrrolidin-2,5-dion; (778) 3-(2,5-dimethyl-4-{2-[2-(4-methyl-cyclohexyl)-4-oxo-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl]-ethyl}-phenyl)-imidazoliden-2,4-dion (779) 3-(3,5-dimethyl-4-{2-[2-(4-methyl-cyclohexyl)-4-oxo-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl]-ethyl}-benzyl)-imidazoliden-2,4-dion; (780) 3-(3,5-dimethyl-4-{2-[2-(4-methyl-cyclohexyl)-4-oxo-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl]-ethyl}-benzyl)-5,5-dimethyl-imidazoliden-2,4-dion; (781) 8-{2-[2,6-dimethyl-4-(2-oxo-pyrrolidin-l-ylmethyl)-phenyl]-ethansulfonyl>-2-(4-methyl-cyclohexyl)-l,3,8-triaza-spiro[4.5]dec-l-en-4-on; (782) l-(3,5-dimethyl-4-{2-[2-(4-methyl-cyclohexyl)-4-oxo-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl]-ethyl>-benzyl)-pyrrolidin-2,5-dion; (783) N-(2,6-dimethyl-4-{2-[2-(4-methyl-cyclohexyl)-4-oxo-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl]-ethyl>-phenyl)-N-methyl-acetamid; (784) N-[3,5-dimethyl-4-(2-{4-oxo-2-[4-(3,3,3-trifluor-propyl)-cyclohexyl]-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl>-ethyl)-benzyl]-N-methyl-acetamid; (785) N-(3,5-dimethyl-4-{2-[2-(4-methyl-cyclohexyl)-4-oxo-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl]-ethyl}-benzyl)-N-methyl-acetamid; (786) l-(3,5-dimethyl-4-{2-[2-(4-methyl-cyclohexyl)-4-oxo-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl]-ethyl}-phenyl)-dihydro-pyrimidin-2,4-dion; (787) 3,5-dimethyl-4-(2-{4-oxo-2-[4-(3,3,3-trifluor-propyl)-cyclohexyl]-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl}-ethyl)-benzoesyre-trimethylhydrazid; (788) 8-{2-[l-((S)-2,3-dihydroxy-propyl)-lH-indol-4-yl]-ethansulfonyl>-2-(8,8,9/9/9-pentafluor-nonyl)-l,3,8-tnaza-spiro[4.5]dec-l-en-4-on; (789) 8-{2-[l-((S)-2,3-dihydroxy-propyl)-lH-indol-4-yl]-ethansulfonyl>-2-(9,9,9-trifluor-nonyl)-l,3i8-triaza-spiro[4.5]dec-l-en-4-on; (790) 3-{3-methyl-4-[2-(2-nonyl-4-oxo-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl)-ethyl]-phenyl>-imidazoliden-2,4-dion; (791) 8-{2-[l-((R)-2,3-dihydroxy-propyl)-4,6-dimethyl-lH-indol-5-yl]-ethansulfonyl>-2-[4-(3,3,3-trifluorpropyl)-cyclohexyl]-l,3,8-triaza-spiro[4.5]dec-l-en-4-on; (792) 3-(3-methyl-4-{2-[4-oxo-2-(3-trifluormethoxyphenyl)-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl]-ethyl>-phenyl)-imidazoliden-2,4-dion; (793) 8-{2-[2-methyl-4-(3-oxo-morpholin-4-yl)-phenyl]-ethansulfonyl}-2-(3-trifluormethoxy-phenyl)-l,3,8-triaza-spiro[4.5]dec-l-en-4-on; (794) N-(4-{2-[2-(4-fluor-3-trifluormethyl-phenyl)-4-oxo-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl]-ethyl>-3,5-dimethyl-phenyl)-N-(2-hydroxy-ethyl)-acetamid; (795) 3-{4-[2-(2-nonyl-4-oxo-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl)-ethyl]-3-trifluormethyl-phenyl }-imidazoliden-2,4-dion; (796) 3,5-dimethyl-4-[2-(2-nonyl-4-oxo-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl)-ethyl]-benzoesyre; (797) 2-(4-fluor-3-trifluormethyl-phenyl)-8-{2-[4-(4-hydroxy-piperidin-l-carbonyl)-2,6-dimethyl-phenyl]-ethansulfonyl}-l,3,8-triaza-spiro[4.5]dec-l-en-4-on; (798) 8-{2-[4-(3,4-dihydroxy-butoxy)-2,6-dimethylphenyl]-ethansulfonyl>-2-nonyl-l,3,8-triaza-spiro[4.5]dec-l-en-4-on; (799) 3-(3,5-dimethyl-4-{2-[4-oxo-2-(3-trifluormethoxy-phenyl)-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl]-ethyl}-phenyl)-imidazoliden-2,4-dion; (800) 3-(4-{2-[2-(4-fluor-3-trifluormethyl-phenyl)-4-oxo-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl]-ethyl}-3,5-dimethyl-phenyl)-imidazoliden-2,4-dion; (801) 8-{2-[4-(3,4-dihydroxy-butoxy)-2,6-dimethylphenyl]-ethansulfonyl}-2-(4-fluor-3-trifluormethyl-phenyl)-l,3,8-triaza-spiro[4.5]dec-l-en-4-on; (802) 8-{2-[4-(4-fluormethyl-4-hydroxy-piperidin-l-carbonyl)-2,6-dimethyl-phenyl]-ethansulfonyl>-2-(4-fluor-3-trifluormethyl-phenyl)-l,3,8-triaza-spiro[4.5]dec-l-en-4-on; (803) 2-(4-fluor-3-trifluormethyl-phenyl)-8-{2-[4-(4-hydroxy-4-methyl-piperidin-l-carbonyl)-2,6-dimethyl-phenyl]-ethansulfonyl}-l,3,8-triaza-spiro[4.5]dec-l-en- 4-on; (804) 8-{2-[2,6-dimethyl-4-(2-oxa-7-aza-spiro[3.5]nonan-7-carbonyl)-phenyl]-ethansulfonyl}-2-(4-fluor-3-trifluormethyl-phenyl)-l,3,8-triaza-spiro[4.5]dec-l-en- 4-on; (812) N-(3-isopropoxy-4-{2-[2-(4-methyl-cyclohexyl)-4-oxo-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl]-ethyl}-phenyl)-acetamid; (817) l-{3,5-dimethyl-4-[2-(2-nonyl-4-oxo-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl)-ethyl]-phenyl>-l-methyl-urinstof; (818) l-[3,5-dimethyl-4-(2-{4-oxo-2-[4-(3,3,3-trifluorpropyl)-cyclohexyl]-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl>-ethyl)-phenyl]-l-(2-fluor-ethyl)-urinstof; (820) N-[3,5-dimethyl-4-(2-{4-oxo-2-[4-(3,3,3-trifluorpropyl)-cyclohexyl]-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl>-ethyl)-phenyl]-N-[2-(2-hydroxy-ethoxy)-ethyl]-acetamid; (821) 8-{2-[4-((R)-2,3-dihydroxy-propoxy)-2,6-dimethylphenyl]-ethansulfonyl}-2-[4-(3,3,3-trifluor-propyl)-cyclohexyl]-l,3,8-triaza-spiro[4.5]dec-l-en-4-on; (822) 8-(2-{l-[2-((S)-2,3-dihydroxy-propoxy)-ethyl]-lH-indol-4-yl>-ethansulfonyl)-2-[4-(3,3,3-trifluorpropyl)-cyclohexyl]-l,3,8-triaza-spiro[4.5]dec-l-en-4-on; (823) 2-[4-(3,3,3-trifluor-propyl)-cyclohexyl]-8-(2-{l-[2-((2S,3S)-2,3,4-trihydroxy-butoxy)-ethyl]-lH-indol-4-yl}-ethansulfonyl)-l,3,8-triaza-spiro[4.5]dec-l-en-4-on; (824) N-((S)-2,3-dihydroxy-propyl)-N-(3,5-dimethyl-4-{2-[4-oxo-2-(9,9,9-trifluor-nonyl)-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl]-ethyl>-phenyl)-acetamid; (825) N-[2-(2-hydroxy-ethoxy)-ethyl]-N-{3-methyl-4-[2-(2-nonyl-4-oxo-l,3,8-tnaza-spiro[4.5]dec-l-en-8-sulfonyl)-ethyl]-phenyl>-acetamid; (826) l-[3,5-dimethyl-4-(2-{4-oxo-2-[4-(3,3,3-trifluor-propyl)-cyclohexyl]-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl>-ethyl)-phenyl]-l-[2-(2-hydroxy-ethoxy)-ethyl]-urinstof; (827) l-[3,5-dimethyl-4-(2-{4-oxo-2-[4-(3,3,3-trifluor-propyl)-cyclohexyl]-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl>-ethyl)-phenyl]-l-(2-methoxy-ethyl)-urinstof; (828) l-(3,5-dimethyl-4-{2-[2-(4-methyl-cyclohexyl)-4-oxo-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl]-ethyl>-phenyl)-l-isopropyl-urinstof; (829) l-(3-ethyl-4-{2-[2-(4-methyl-cyclohexyl)-4-oxo-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl]-ethyl>-phenyl)-l-methyl-urinstof; (830) l-((S)-2,3-dihydroxy-propyl)-l-(3,5-dimethyl-4-{2-[2-(4-methyl-cydohexyl)-4-oxo-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl]-ethyl>-phenyl)-urinstof; (831) 8-{2-[4-(4-hydroxy-4-hydroxymethyl-piperidin-l-carbonyl)-2,6-dimethyl-phenyl]-ethansulfonyl}-2-(3-trifluormethoxy-phenyl)-l,3,8-triaza-spiro[4.5]dec-l-en-4-on; (832) 3-{3,5-dimethyl-4-[2-(2-nonyl-4-oxo-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl)-ethyl]-phenyl}-imidazoliden-2,4-dion; (833) 5-tert-butoxymethyl-3-(3,5-dimethyl-4-{2-[2-(4-methyl-cyclohexyl)-4-oxo- 1.3.8- triaza-spiro[4.5]dec-l-en-8-sulfonyl]-ethyl}-phenyl)-imidazoliden-2,4-dion; (834) 2-(4-methyl-cyclohexyl)-8-{2-[2-methyl-4-(5-oxo-pyrazolidin-l-yl)-phenyl]-ethansulfonyl}-l,3,8-triaza-spiro[4.5]dec-l-en-4-on; (835) 2-cyclohexyl-8-[2-(lH-indol-7-yl)-ethansulfonyl]-l,3,8-triaza-spiro[4.5]dec-l-en-4-on; (836) 2-cyclohexyl-8-[2-(6-trifluormethyl-lH-indol-5-yl)-ethansulfonyl]-l,3,8-triaza-spiro[4.5]dec-l-en-4-on; (837) 2-cyclohexyl-8-[2-(6-methyl-lH-indol-5-yl)-ethansulfonyl]-l,3,8-triaza-spiro[4.5]dec-l-en-4-on; (838) 2-cyclohexyl-8-(2-{l-[2-(2-hydroxy-ethoxy)-ethyl]-lH-indol-5-yl>-ethansulfonyl)-l,3,8-triaza-spiro[4.5]dec-l-en-4-on; (839) 2-cyclohexyl-8-[2-(6-tnfluormethyl-lH-benzinnidazol-5-yl)-ethansulfonyl]- 1.3.8- triaza-spiro[4.5]dec-l-en-4-on; (840) 8-{2-[l-((S)-2,3-dihydroxy-propyl)-lH-indol-4-yl]-ethansulfonyl}-2-(3-trifluormethyl-phenyl)-l,3,8-triaza-spiro[4.5]dec-l-en-4-on; (841) 2-cyclohexyl-8-{2-[4-(l,l-dioxo-lA6-thiomorpholin-4-carbonyl)-2-methyl-phenyl]-ethansulfonyl>-l,3,8-triaza-spiro[4.5]dec-l-en-4-on; (842) 2-cyclohexyl-8-{2-[4-(2-dimethylamino-ethylamino)-2-methyl-phenyl]-ethansulfonyl>-l,3,8-triaza-spiro[4.5]dec-l-en-4-on; (843) 8-{2-[2-methyl-4-(4-methyl-piperazin-l-carbonyl)-phenyl]-ethansulfonyl}-2-(3-trifluormethoxy-phenyl)-l,3,8-triaza-spiro[4.5]dec-l-en-4-on; (844) 4-[2-(2-cyclohexyl-4-oxo-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl)-ethyl]-N-(2-dimethylamino-ethyl)-3-methyl-benzensulfonamid; (845) 8-(2-{2-methyl-4-[2-(4-methyl-piperazin-l-yl)-2-oxo-ethylamino]-phenyl}-ethansulfonyl)-2-(3-trifluormethoxy-phenyl)-l,3,8-triaza-spiro[4.5]dec-l-en-4-on; (846) 3-methyl-4-{2-[4-oxo-2-(3-trifluormethoxy-phenyl)-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl]-ethyl}-N-pyridin-4-yl-benzensulfonamid; (847) 2-(3-methyl-4-{2-[4-oxo-2-(3-trifluormethoxy-phenyl)-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl]-ethyl}-phenylamino)-acetamid; (848) N-(l-benzyl-piperidin-4-yl)-3-methyl-4-{2-[4-oxo-2-(3-trifluormethoxy-phenyl)-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl]-ethyl}-benzensulfonamid; (849) 8-{2-[4-(4-isopropyl-piperazin-l-carbonyl)-2-methyl-phenyl]-ethansulfonyl}-2-(3-trifluormethoxyphenyl)-l,3,8-triaza-spiro[4.5]dec-l-en-4-on; (850) 8-{2-[l-((S)-2,3-dihydroxy-propyl)-lH-indol-5-yl]-ethansulfonyl}-2-(3-trifluornnethoxy-phenyl)-l,3,8-triaza-spiro[4.5]dec-l-en-4-on; (851) N-((R)-2,3-dihydroxy-propyl)-3-methyl-4-{2-[4-oxo-2-(3-trifluormethoxy-phenyl)-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl]-ethyl}-benzensulfonamid; (852) 3-methyl-4-{2-[4-oxo-2-(3-trifluormethyl-phenyl)-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl]-ethyl}-N-pyridin-3-ylmethyl-benzensulfonamid; (853) N-(4-hydroxy-cyclohexyl)-3-methyl-4-{2-[4-oxo-2-(3-trifluormethyl-phenyl)- l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl]-ethyl}-benzensulfonamid; (854) N-(2-hydroxy-l,l-bis-hydroxymethyl-ethyl)-3-methyl-4-{2-[4-oxo-2-(3-trifluormethyl-phenyl)-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl]-ethyl>-benzensulfonamid; (855) 8-{2-[4-(3,4-dihydroxy-butoxy)-3,5-dimethyl-phenyl]-ethansulfonyl}-2-(3-trifluormethoxy-phenyl)-l,3,8-triaza-spiro[4.5]dec-l-en-4-on; (856) 2-(4-fluor-3-trifluormethyl-phenyl)-8-{2-[2-methyl-4-(pyrrolidin-l-carbonyl)-phenyl]-ethansulfonyl}-l,3,8-triaza-spiro[4.5]dec-l-en-4-on; (857) 2-(4-fluor-3-trifluormethyl-phenyl)-8-{2-[4-((R)-2-hydroxymethyl-5-oxo-pyrrolidin-l-yl)-2-methyl-phenyl]-ethansulfonyl>-l,3,8-triaza-spiro[4.5]dec-l-en-4-on; (858) 2-(4-fluor-3-trifluormethyl-phenyl)-8-{2-[4-((S)-2-hydroxymethyl-5-oxo-pyrrolidin-l-yl)-2-methyl-phenyl]-ethansulfonyl}-l,3,8-triaza-spiro[4.5]dec-l-en-4-on; (859) 4-(3-methyl-4-{2-[4-oxo-2-(3-trifluormethoxy-phenyl)-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl]-ethyl}-phenoxy)-piperidin-l-carboxylsyre-tert-butylester; (860) 8-{2-[4-(3,4-dihydroxy-butoxy)-3,5-difluor-phenyl]-ethansulfonyl>-2-(3-trifluormethoxy-phenyl)-l,3,8-triaza-spiro[4.5]dec-l-en-4-on; (861) 2-cyclohexyl-8-{2-[2-methyl-4-(2-oxo-azetidin-l-yl)-phenyl]-ethansulfonyl>-l,3,8-triaza-spiro[4.5]dec-l-en-4-on; (862) l-methyl-3-(3-methyl-4-{2-[2-(4-methyl-cyclohexyl)-4-oxo-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl]-ethyl}-phenyl)-imidazoliden-2,4-dion; (863) 5,5-dimethyl-3-(3-methyl-4-{2-[2-(4-methyl-cyclohexyl)-4-oxo-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl]-ethyl>-phenyl)-imidazoliden-2,4-dion; (864) 5,5-dimethyl-3-[3-methyl-4-(2-{4-oxo-2-[4-(3,3,3-trifluor-propyl)-cyclohexyl]-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl>-ethyl)-phenyl]-imidazoliden-2,4-dion; (865) 2-(4-methyl-cyclohexyl)-8-{2-[2-methyl-4-(2-oxo-oxazolidin-3-yl)-phenyl]-ethansulfonyl>-l,3,8-triaza-spiro[4.5]dec-l-en-4-on; (866) 2-(4-methyl-cyclohexyl)-8-{2-[2-methyl-4-(4-oxo-oxazolidin-3-yl)-phenyl]-ethansulfonyl>-l,3,8-triaza-spiro[4.5]dec-l-en-4-on; (867) 8-{2-[l-((R)-2,3-dihydroxy-propyl)-lH-indol-4-yl]-ethansulfonyl>-2-[4-(3,3,3-trifluor-propyl)-cyclohexyl]-l,3,8-triaza-spiro[4.5]dec-l-en-4-on; (868) 8-(2-{4-[(lH-imidazol-2-yl)-methyl-amino]-2,6-dimethyl-phenyl>-ethansulfonyl)-2-(4-methyl-cyclohexyl)-l,3,8-triaza-spiro[4.5]dec-l-en-4-on; (869) 3-(3,5-dimethyl-4-{2-[2-(4-methyl-cydohexyl)-4-oxo-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl]-ethyl>-phenyl)-5,5-dimethyl-imidazoliden-2,4-dion; (870) 2-(4-methyl-cyclohexyl)-8-{2-[2-methyl-4-(2-oxo-piperazin-l-yl)-phenyl]-ethansulfonyl>-l,3,8-triaza-spiro[4.5]dec-l-en-4-on; (872) 2-cyclohexyl-8-{2-[l-((S)-2,3-dihydroxy-propyl)-lH-indol-5-yl]-ethansulfonyl>-l,3,8-triaza-spiro[4.5]dec-l-en-4-on; (873) N-(2-fluor-5-methyl-4-{2-[4-oxo-2-(3-trifluormethoxy-phenyl)-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl]-ethyl>-phenyl)-N-(2-hydroxy-ethyl)-acetamid; (874) N-(3-methyl-4-{2-[4-oxo-2-(3-trifluormethoxyphenyl)-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl]-ethyl}-phenyl)-sulfamid; (875) N-(3-hydroxy-propyl)-N'-(3-methyl-4-{2-[4-oxo-2-(3-trifluormethoxy-phenyl)-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl]-ethyl>-phenyl)-sulfamid; (876) l-cyanomethyl-l-(3-methyl-4-{2-[4-oxo-2-(3-trifluormethoxy-phenyl)- l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl]-ethyl>-phenyl)-urinstof; (877) l-(3-methyl-4-{2-[4-oxo-2-(3-trifluormethoxyphenyl)-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl]-ethyl}-phenyl)-l-(2,2,2-trifluor-ethyl)-urinstof; (878) l-(4-{2-[2-(4-ethyl-cyclohexyl)-4-oxo-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl]-ethyl}-3-methyl-phenyl)-imidazoliden-2,4-dion; (879) l-(4-{2-[2-(4-ethyl-cyclohexyl)-4-oxo-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl]-ethyl}-3-methyl-phenyl)-5-methyl-imidazoliden-2,4-dion; (880) 3-(4-{2-[2-(4-butyl-cyclohexyl)-4-oxo-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl]-ethyl}-3-methyl-phenyl)-imidazoliden-2,4-dion; (881) 3-(3-methyl-4-{2-[2-(4-methyl-cyclohexyl)-4-oxo-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl]-ethyl>-phenyl)-imidazoliden-2,4-dion; (882) 3-(4-{2-[2-(4-isopropyl-cyclohexyl)-4-oxo-l,3,8-tnaza-spiro[4.5]dec-l-en-8-sulfonyl]-ethyl}-3-methyl-phenyl)-imidazoliden-2,4-dion; (883) 3-(3,5-dimethyl-4-{2-[2-(4-methyl-cyclohexyl)-4-oxo-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl]-ethyl}-phenyl)-imidazoliden-2,4-dion; (884) 3-(4-{2-[2-(4-isopropyl-cyclohexyl)-4-oxo-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl]-ethyl>-3,5-dimethyl-phenyl)-imidazoliden-2,4-dion; (885) 3-(3,5-dimethyl-4-{2-[2-(4-methyl-cyclohexyl)-4-oxo-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl]-ethyl}-phenyl)-l,5,5-trimethyl-imidazoliden-2,4-dion; (886) (S)-2-amino-3-hydroxy-N-(3-methyl-4-{2-[4-oxo-2-(3-trifluormethyl-phenyl)-li3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl]-ethyl}-phenyl)-propionamid; (887) l-(4-{2-[2-(4-ethyl-cyclohexyl)-4-oxo-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl]-ethyl>-3-methyl-phenyl)-5,5-dimethyl-imidazoliden-2,4-dion; (888) 3,5-dimethyl-4-(2-{4-oxo-2-[4-(3,3,3-trifluor-propyl)-cyclohexyl]-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl>-ethyl)-benzoesyre-N,N'-dimethyl-hydrazid; (889) 8-{2-[2-methyl-4-(piperidin-4-yloxy)-phenyl]-ethansulfonyl)--2-(3-trifluormethoxy-phenyl)-l,3,8-triaza-spiro[4.5]dec-l-en-4-on-hydrochlond; (890) 4-{2-[2-(4,4-difluor-cyclohexyl)-4-oxo-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl]-ethyl}-3,N,N-trimethyl-benzannid; (891) 4-{2-[2-(4-methansulfonyl-phenyl)-4-oxo-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl]-ethyl>-3,N,N-trimethyl-benzannid; (892) 3,N,N-tnmethyl-4-(2-{4-oxo-2-[(E)-2-(3-tnfluormethyl-phenyl)-vinyl]-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl>-ethyl)-benzannid; (893) 3,N,N-trimethyl-4-[2-(4-oxo-2-phenylethynyl-l,3,8-tnaza-spiro[4.5]dec-l-en-8-sulfonyl)-ethyl]-benzamid; (894) 4-{2-[2-(4-butyl-cyclohexyl)-4-oxo-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl]-ethyl>-3,N,N-trimethyl-benzamid; (895) 4-{2-[2-(4-tert-butyl-cyclohexyl)-4-oxo-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl]-ethyl>-3,N,N-trimethyl-benzamid; (896) 4-{2-[2-(4-ethyl-cyclohexyl)-4-oxo-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl]-ethyl>-3,N,N-trimethyl-benzannid; (897) 3,N,N-trimethyl-4-(2-{4-oxo-2-[4-(4,4,4-tnfluor-butyl)-cyclohexyl]-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl>-ethyl)-benzannid; (898) 4-{2-[4-(cyclohexylmethyl-amino)-2-(3-trifluormethoxy-phenyl)-l,3,8-tnaza-spiro[4.5]deca-l,3-dien-8-sulfonyl]-ethyl>-3,N,N-trimethyl-benzamid; (899) 4-{2-[4-dimethylamino-2-(3-tnfluormethoxy-phenyl)-l,3,8-triaza-spiro[4.5]deca-l,3-dien-8-sulfonyl]-ethyl>-3,N,N-trimethyl-benzannid; (900) 4-{2-[4-[(Z)-hydroxyimino]-2-(3-tnfluormethoxy-phenyl)-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl]-ethyl}-3,N,N-trimethyl-benzamid; (901) 4-{2-[4-[(Z)-methoxyimino]-2-(3-trifluormethoxy-phenyl)-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl]-ethyl>-3,N,N-trimethyl-benzamid; (902) 4-(2-{2-[4-(2-methoxy-ethyl)-cyclohexyl]-4-oxo-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl>-ethyl)-3,N,N-trimethyl-benzamid; (903) N-{4-[2-(2-cyclopentyl-4-oxo-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl)-ethyl]-3-methyl-phenyl>-acetamid; (904) N-(3-methyl-4-{2-[4-oxo-2-(4-trifluormethyl-cyclohexyl)-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl]-ethyl}-phenyl)-acetamid; (905) N-(4-{2-[2-(4-butyl-cyclohexyl)-4-oxo-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl]-ethyl}-3-methyl-phenyl)-acetamid; (906) N-(4-{2-[2-(4-cyano-phenyl)-4-oxo-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl]-ethyl)-3-methyl-phenyl)-acetamid; (907) N-(4-{2-[2-(3-cyano-phenyl)-4-oxo-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl]-ethyl>-3-methyl-phenyl)-acetamid; (908) N-(4-{2-[2-(2-cyano-phenyl)-4-oxo-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl]-ethyl}-3-methyl-phenyl)-acetamid; (909) N-(4-{2-[2-(4-tert-butyl-cyclohexyl)-4-oxo-l,3,8-tnaza-spiro[4.5]dec-l-en-8-sulfonyl]-ethyl}-3-methyl-phenyl)-acetamid; (910) N-(4-{2-[2-(4-ethoxymethyl-cyclohexyl)-4-oxo-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl]-ethyl>-3-methyl-phenyl)-acetamid; (911) N-(3-methyl-4-{2-[4-oxo-2-(4-propoxy-cyclohexyl)-l,3,8-tnaza-spiro[4.5]dec-l-en-8-sulfonyl]-ethyl)--phenyl)-acetamid; (912) N-(4-{2-[2-(4-butoxy-cyclohexyl)-4-oxo-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl]-ethyl>-3-methylphenyl)-acetamid; (913) N-(4-{2-[2-(4-isopropoxymethyl-cyclohexyl)-4-oxo-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl]-ethyl>-3-methyl-phenyl)-acetamid; (914) N-[4-(2-{2-[4-(3-fluor-propoxy)-cyclohexyl]-4-oxo-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl}-ethyl)-3-methyl-phenyl]-acetamid; (915) N-[4-(2-{2-[4-(3-fluor-propoxy)-cyclohexyl]-4-oxo-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl>-ethyl)-3-methyl-phenyl]-acetannid; (916) N-[4-(2-{2-[4-((E)-3,3-difluor-propenyl)-cyclohexyl]-4-oxo-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl>-ethyl)-3-methyl-phenyl]-acetannid; (917) N-{4-[2-(2-cycloheptyl-4-oxo-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl)-ethyl]-3-methyl-phenyl>-acetamid; (918) N-{4-[2-(2-adamantan-l-yl-4-oxo-l,3,8-tnaza-spiro[4.5]dec-l-en-8-sulfonyl)-ethyl]-3-methyl-phenyl}-acetamid; (919) N-[3-methyl-4-(2-{4-oxo-2-[4-(2,2,2-tnfluor-ethoxymethyl)-cyclohexyl]- l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl}-ethyl)-phenyl]-acetamid; (920) N-[4-(2-{2-[4-(4-chlor-phenyl)-cyclohexyl]-4-oxo-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl}-ethyl)-3-methyl-phenyl]-acetamid; (921) N-[3-methyl-4-(2-{4-oxo-2-[4-(3,3,3-trifluor-propoxy)-cyclohexyl]-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl}-ethyl)-phenyl]-acetamid; (922) N-[3-methyl-4-(2-{4-oxo-2-[4-(2,2,2-trifluorethyl)-cyclohexyl]-1,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl>-ethyl)-phenyl]-acetamid; (923) N-(3-methyl-4-{2-[4-oxo-2-((lS,3R)-3-propylcyclohexyl)-l,3,8-triaza-spiro[4.5] dec-l-en-8-sulfonyl]-ethyl>-phenyl)-acetamid; (924) N-(3-methyl-4-{2-[2-((lS,3R)-3-methyl-cyclohexyl)-4-oxo-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl]-ethyl>-phenyl)-acetamid; (925) N-(4-{2-[2-(4,4-dimethyl-cyclohexyl)-4-oxo-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl]-ethyl>-3-methyl-phenyl)-acetamid; (926) N-(3-methyl-4-{2-[4-oxo-2-(3,3,5,5-tetrannethyl-cydohexyl)-l,3,8-tnaza-spiro[4.5]dec-l-en-8-sulfonyl]-ethyl>-phenyl)-acetamid; (927) N-[4-(2-{2-[4-(2-methoxy-ethyl)-cyclohexyl]-4-oxo-l,3,8-tnaza-spiro[4.5]dec-l-en-8-sulfonyl>-ethyl)-3-methyl-phenyl]-acetamid; (928) [3-methyl-4-(2-{4-oxo-2-[4-(3,3,3-trifluor-propyl)-cyclohexyl]-1,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl>-ethyl)-benzyl]-carbaminsyre-tert-butylester; (929) N-(2-hydroxy-ethyl)-N-(3-methyl-4-{2-[4-oxo-2-(3-trifluormethoxy-phenyl)- l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl]-ethyl>-phenyl)-isobutylamid; (930) 2-hydroxy-N-(2-hydroxy-ethyl)-N-(3-methyl-4-{2-[4-oxo-2-(3-trifluormethoxy-phenyl)-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl]-ethyl}-phenyl)-acetamid; (931) N-(3,5-dimethyl-4-{2-[2-(4-methyl-cyclohexyl)-4-oxo-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl]-ethyl}-phenyl)-2,2,2-trifluor-N-methyl-acetamid; (932) N-(3,5-dimethyl-4-{2-[2-((lS,3R)-3-methyl-cyclohexyl)-4-oxo-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl]-ethyl}-phenyl)-2,2,2-trifluor-N-methyl-acetamid; (933) N-(3,5-dimethyl-4-{2-[4-oxo-2-(3,3,5,5-tetramethyl-cyclohexyl)-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl]-ethyl>-phenyl)-2,2,2-trifluor-N-methyl-acetamid; (934) l-14-[2-(2-cycloheptyl-4-oxo-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl)-ethyl]-3,5-dimethyl-phenyl}-l-methyl-urinstof; (935) l-(3,5-dimethyl-4-{2-[4-oxo-2-(3-trifluormethoxy-phenyl)-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl]-ethyl}-phenyl)-l-methyl-urinstof; (936) l-[3,5-dimethyl-4-(2-{4-oxo-2-[4-(2,2,2-trifluorethyl>-cyclohexyl]-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl}-ethyl)-phenyl]-l-methyl-urinstof; (937) l-[2-chlor-3,5-dimethyl-4-(2-{4-oxo-2-[4-(2,2,2-trifluor-ethyl)-cyclohexyl]- 1.3.8- triaza-spiro[4.5]dec-l-en-8-sulfonyl}-ethyl)-phenyl]-l-methyl-urinstof; (938) l-(4-{2-[2-(4,4-dimethyl-cyclohexyl)-4-oxo-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl]-ethyl}-3,5-dimethyl-phenyl)-l-methyl-urinstof; (939) l-[3,5-dimethyl-4-(2-{4-oxo-2-[4-(3,3,3-trifluor-propyliden)-cyclohexyl]- 1.3.8- triaza-spiro[4.5]dec-l-en-8-sulfonyl}-ethyl)-phenyl]-l-methyl-urinstof; (940) l-[4-(2-{2-[4-(3,3-difluor-allyl)-cyclohexyl]-4-oxo-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl>-ethyl)-3,5-dimethyl-phenyl]-l-methyl-urinstof; (941) l-(3,5-dimethyl-4-{2-[8-oxo-6-(3-trifluormethoxyphenyl)-2,5,7-triaza-spiro[3.4]oct-5-en-2-sulfonyl]-ethyl}-phenyl)-l-methyl-urinstof; (942) N-(4-{(E)-l-fluor-2-[2-(4-methyl-cyclohexyl)-4-oxo-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl]-vinyl>-3-methyl-phenyl)-N-methyl-acetamid; (943) 3-[3-methyl-4-(2-{4-oxo-2-[4-(3,3,3-trifluor-propyl)-cyclohexyl]-l,3,8-tnaza-spiro[4.5]dec-l-en-8-sulfonyl}-ethyl)-phenyl]-imidazoliden-2,4-dion; (944) 3-[3-methyl-4-(2-{4-oxo-2-[4-(4,4,4-trifluor-butyl)-cyclohexyl]-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl>-ethyl)-phenyl]-imidazoliden-2,4-dion; (945) 3-[4-(2-{2-[4-((E)-3,3-difluor-propenyl)-cyclohexyl]-4-oxo-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl>-ethyl)-3-methyl-phenyl]-imidazoliden-2,4-dion; (946) 3-[4-(2-{2-[4-(3,3-difluor-allyl)-cyclohexyl]-4-oxo-l,3,8-tnaza-spiro[4.5]dec-l-en-8-sulfonyl}-ethyl)-3-methyl-phenyl]-imidazoliden-2,4-dion; (947) 3-(3-methyl-4-{2-[4-oxo-2-(4-trifluormethyl-cyclohexyl)-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl]-ethyl>-phenyl)-imidazoliden-2,4-dion; (948) 3-[3-methyl-4-(2-{4-oxo-2-[4-(2,2,2-trifluor-ethyl)-cyclohexyl]-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl>-ethyl)-phenyl]-imidazoliden-2,4-dion; (949) 3-(3-methyl-4-{2-[4-oxo-2-((lS,3R)-3-propyl-cyclohexyl)-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl]-ethyl}-phenyl)-imidazoliden-2,4-dion; (950) 3-(3-methyl-4-{2-[2-((lS,3R)-3-methyl-cyclohexyl)-4-oxo-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl]-ethyl}-phenyl)-imidazoliden-2,4-dion; (951) 3-(4-{2-[2-(4,4-dimethyl-cyclohexyl)-4-oxo-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl]-ethyl}-3-methyl-phenyl)-imidazoliden-2,4-dion; (952) 3-(3-methyl-4-{2-[4-oxo-2-(3,3,5,5-tetramethyl-cyclohexyl)-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl]-ethyl}-phenyl)-imidazoliden-2,4-dion; (953) N-(2-chlor-4-{2-[2-(4-ethyl-cyclohexyl)-4-oxo-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl]-ethyl}-5-methyl-phenyl)-acetamid; (954) N-(2-chlor-4-{2-[2-(4-ethyl-cyclohexyl)-4-oxo-l,3,8-tnaza-spiro[4.5]dec-l-en-8-sulfonyl]-ethyl>-3-methyl-phenyl)-acetamid; (955) N-[4-(2-{2-[4-(3,3-difluor-propyl)-cyclohexyl]-4-oxo-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl>-ethyl)-3-methyl-phenyl]-acetamid; (956) 3-[4-(2-{2-[4-(3,3-difluor-propyl)-cyclohexyl]-4-oxo-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl}-ethyl)-3-methyl-phenyl]-imidazoliden-2,4-dion; (957) 2-(2-cyclohexyl-4-oxo-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl)-N-phenyl-benzamid; (958) 8-(2-{2-methyl-4-[4-(l-methyl-piperidin-4-yl)-piperazin-l-carbonyl]-phenyl}-ethansulfonyl-2-(3-trifluormethyl-phenyl)-l,3,8-triaza-spiro[4.5]dec-l-en-4-on; (959) 8-{(E)-2-[4-((R)-3-fluor-pyrrolidin-l-carbonyl)-2,6-dimethyl-phenyl]-ethensulfonyl>-2-(3-trifluormethoxy-phenyl)-l,3,8-triaza-spiro[4.5]dec-l-en-4-on; (960) 8-{(E)-2-[4-(4-hydroxymethyl-piperidin-l-carbonyl)-2,6-dimethyl-phenyl]-ethensulfonyl>-2-(3-trifluormethoxy-phenyl)-l,3,8-tnaza-spiro[4.5]dec-l-en-4-on; (961) 3,5,N,N-tetramethyl-4-{(E)-2-[4-oxo-2-(3-trifluormethoxy-phenyl)-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl]-vinyl>-benzamid; (962) 3,5-dimethyl-4-{(E)-2-[4-oxo-2-(3-trifluormethoxyphenyl)-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl]-vinyl}-benzamid; (963) 8-{(E)-2-[4-(3-fluor-azetidin-l-carbonyl)-2,6-dimethyl-phenyl]-ethensulfonyl>-2-(3-trifluormethoxy-phenyl)-l,3,8-triaza-spiro[4.5]dec-l-en-4-on; (964) 8-{2-[4-(4-hydroxy-piperidin-l-carbonyl)-2,6-dimethyl-phenyl]-ethansulfonyl>-2-(3-trifluormethoxyphenyl)-l,3,8-triaza-spiro[4.5]dec-l-en-4-on; (965) 8-{2-[4-(3-hydroxy-azetidin-l-carbonyl)-2,6-dimethyl-phenyl]-ethansulfonyl}-2-(3-trifluormethoxy-phenyl)-l,3,8-triaza-spiro[4.5]dec-l-en-4-on; (966) 8-{2-[4-(4-hydroxymethyl-piperidin-l-carbonyl)-2,6-dimethyl-phenyl]-ethansulfonyl>-2-(3-trifluormethoxy-phenyl)-l,3,8-triaza-spiro[4.5]dec-l-en-4-on; (967) 8-{(E)-2-[2,6-dimethyl-4-(2-oxa-6-aza-spiro[3.3]heptan-6-carbonyl)-phenyl]-ethensulfonyl>-2-(4-fluor-3-trifluormethyl-phenyl)-l,3,8-triaza-spiro[4.5]dec-l-en-4-on; (968) 8-{(E)-2-[2,6-dimethyl-4-(3-oxo-piperazin-l-carbonyl)-phenyl]-ethensulfonyl}-2-(4-fluor-3-trifluormethyl-phenyl)-l,3,8-triaza-spiro[4.5]dec-l-en-4-on; (969) 8-{(E)-2-[4-((3R,5S)-3,5-dimethyl-piperazin-l-carbonyl)-2,6-dimethyl-phenyl]-ethensulfonyl>-2-(4— fluor-3-trifluormethyl-phenyl)-l,3,8-triaza-spiro[4.5]dec-l-en-4-on; (970) 2-(4-fluor-3-trifluormethyl-phenyl)-8-{(E)-2-[4-(3-hydroxy-3-methyl-azetidin-l-carbonyl)-2,6-dimethyl-phenyl]-ethensulfonyl>-l,3,8-triaza-spiro[4.5]dec-l-en-4-on; (971) 2-(4-fluor-3-trifluormethyl-phenyl)-8-{(E)-2-[4-(4-hydroxy-4-hydroxymethyl-piperidin-l-carbonyl)-2,6-dimethyl-phenyl]-ethensulfonyl>-l,3,8-tnaza-spiro[4.5]dec-l-en-4-on; (972) 8-{(E)-2-[2,6-dimethyl-4-(4-oxo-piperidin-l-carbonyl)-phenyl]-ethensulfonyl>-2-(4-fluor-3-tnfluormethyl-phenyl)-l,3,8-tnaza-spiro[4.5]dec-l-en-4-on; (973) 2-[4-(3,3-difluor-allyl)-cyclohexyl]-8-{2-[4-(4-fluor-4-hydroxymethyl-piperidin-l-carbonyl)-2-methyl-phenyl]-ethansulfonyl}-l,3,8-triaza-spiro[4.5]dec-l-en-4-on; (974) 2-[4-(3,3-difluor-allyl)-cyclohexyl]-8-{2-[4-(4-fluormethyl-4-hydroxy-pipendin-l-carbonyl)-2-methyl-phenyl]-ethansulfonyl>-l,3,8-triaza-spiro[4.5]dec-l-en-4-on; (975) 2-(4-ethyl-cyclohexyl)-8-(2-{4-[4-(2-fluor-ethyl)-piperazin-l-carbonyl]-2-methyl-phenyl>-ethansulfonyl)-l,3,8-triaza-spiro[4.5]dec-l-en-4-on; (976) 2-(4-ethyl-cyclohexyl)-8-{2-[2-methyl-4-(4-oxetan-3-yl-piperazin-l-carbonyl)-phenyl]-ethansulfonyl}-l,3,8-triaza-spiro[4.5]dec-l-en-4-on; (977) 8-{2-[2-methyl-4-(pyrrolidin-l-carbonyl)-phenyl]-ethansulfonyl>-2-nonyl- 1.3.8- triaza-spiro[4.5]dec-l-en-4-on; (978) 8-{2-[4-(azetidin-l-carbonyl)-2-methyl-phenyl]-ethansulfonyl>-2-nonyl- 1.3.8- triaza-spiro[4.5]dec-l-en-4-on; (979) 8-{2-[4-((R)-3-hydroxy-pyrrolidin-l-carbonyl)-2-methyl-phenyl]-ethansulfonyl)-2-nonyl-l,3,8-triaza-spiro[4.5]dec-l-en-4-on; (980) 8-{2-[2,6-dimethyl-4-(pyrrolidin-l-carbonyl)-phenyl]-ethansulfonyl>-2-nonyl-l,3,8-triaza-spiro[4.5]dec-l-en-4-on; (981) 8-{2-[4-((R)-3-hydroxy-pyrrolidin-l-carbonyl)-2,6-dimethyl-phenyl]-ethansulfonyl>-2-nonyl-l,3,8-triaza-spiro[4.5]dec-l-en-4-on; (982) 8-{2-[4-(azetidin-l-carbonyl)-2,6-dimethyl-phenyl]-ethansulfonyl>-2-nonyl- 1.3.8- triaza-spiro[4.5]dec-l-en-4-on; (983) 8-{2-[2,6-dimethyl-4-(piperidin-l-carbonyl)-phenyl]-ethansulfonyl}-2-nonyl- 1.3.8- triaza-spiro[4.5]dec-l-en-4-on; (984) 8-{2-[4-(4-hydroxy-piperidin-l-carbonyl)-2,6-dimethyl-phenyl]-ethansulfonyl>-2-nonyl-l,3,8-triaza-spiro[4.5]dec-l-en-4-on; (985) 8-{2-[4-(3-hydroxy-azetidin-l-carbonyl)-2,6-dimethyl-phenyl]-ethansulfonyl>-2-nonyl-l,3,8-triaza-spiro[4.5]dec-l-en-4-on; (986) 8-{2-[2,6-dimethyl-4-(4-methyl-piperazin-l-carbonyl)-phenyl]-ethansulfonyl>-2-nonyl-l,3,8-triaza-spiro[4.5]dec-l-en-4-on; (987) N,N-dimethyl-2-(3-methyl-4-{(E)-2-[2-(4-methyl-cyclohexyl)-4-oxo-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl]-vinyl >-phenyl)-acetamid; (988) N-methoxy-2-(3-methyl-4-{(E)-2-[2-(4-methyl-cyclohexyl)-4-oxo-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl)-vinyl>-phenyl)-acetamid; (989) 8-{(E)-2-[4-(4-hydroxy-4-methyl-piperidin-l-carbonyl)-2,6-dimethyl-phenyl]-ethensulfonyl}-2-[4-(3,3,3-trifluor-propyl)-cyclohexyl]-l,3,8-triaza-spiro[4.5]dec-l-en-4-on; (990) 8-{(E)-2-[4-(4-fluormethyl-4-hydroxy-piperidin-l-carbonyl)-2,6-dimethyl-phenyl]-ethensulfonyl}-2-[4-(3,3,3-trifluor-propyl)-cyclohexyl]-l,3,8-triaza-spiro[4.5]dec-l-en-4-on; (991) 8-{(E)-2-[2,6-dimethyl-4-(4-methyl-piperazin-l-carbonyl)-phenyl]-ethensulfonyl>-2-[4-(3,3,3-trifluor-propyl)-cyclohexyl]-l,3,8-triaza-spiro[4.5]dec- 1- en-4-on; (992) 8-{(E)-2-[4-(isoxazoliden-2-carbonyl)-2,6-dimethyl-phenyl]-ethensulfonyl}- 2- [4-(3,3,3-trifluorpropyl)-cyclohexyl]-l,3,8-triaza-spiro[4.5]dec-l-en-4-on; (993) 8-((E)-2-{4-[4-((R)-2,3-dihydroxy-propoxy)-piperidin-l-carbonyl]-2,6-dimethyl-phenyl>-ethensulfonyl)-2-[4-(3,3,3-trifluor-propyl)-cyclohexyl]-l,3,8-triaza-spiro[4.5]dec-l-en-4-on; (994) 3,5,N,N-tetramethyl-4-((E)-2-{4-oxo-2-[4-(3,3,3-tnfluor-propyl)-cyclohexyl]-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl}-vinyl)-benzamid; (995) 8-{2-[2,6-dimethyl-4-(4-methyl-piperazin-l-carbonyl)-phenyl]-ethansulfonyl >-2-[4-(3,3,3-trifluor-propyl)-cy clohexyl]-1,3,8-triaza-spiro[4.5]dec- 1- en-4-on; (996) 3,5-dimethyl-4-((E)-2-{4-oxo-2-[4-(3,3,3-trifluor-propyl)-cyclohexyl]-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl}-vinyl)-benzoesyre-hydrazid; (997) 8-{(E)-2-[2,6-dimethyl-4-(pyrazoliden-l-carbonyl)-phenyl]-ethensulfonyl}- 2- [4-(3,3,3-trifluor-propyl)-cy clohexyl]-!,3,8-triaza-spiro[4.5]dec-l-en-4-on; (998) N-methoxy-3,5,N-trimethyl-4-{(E)-2-[2-(4-methylcyclohexyl)-4-oxo-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl]-vinyl>-benzamid; (999) 8-{(E)-2-[4-(4-hydroxy-4-methyl-piperidin-l-carbonyl)-2,6-dimethyl-phenyl]-ethensulfonyl>-2-(4-methyl-cyclohexyl)-l,3,8-triaza-spiro[4.5]dec-l-en-4-on; (1000) 8-{(E)-2-[4-(4-fluormethyl-4-hydroxy-piperidin-l-carbonyl)-2,6-dimethyl-phenyl]-ethensulfonyl>-2-(4-methyl-cyclohexyl)-l,3,8-triaza-spiro[4.5]dec-l-en-4-on; (1001) 8-{(E)-2-[4-(isoxazoliden-2-carbonyl)-2,6-dimethyl-phenyl]-ethensulfonyl}-2-(4-methyl-cyclohexyl)-l,3,8-triaza-spiro[4.5]dec-l-en-4-on; (1002) 8-{(E)-2-[4-(l,l-dioxo-lA5-thiomorpholin-4-carbonyl)-2,6-dimethyl-phenyl]-ethensulfonyl>-2-(4-methyl-cyclohexyl)-l,3,8-triaza-spiro[4.5]dec-l-en-4-on; (1003) 3,5,N,N-tetramethyl-4-((E)-2-[2-(4-methyl-cyclohexyl)-4-oxo-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl]-vinyl}-benzamid; (1006) 2-cyclohexyl-8-{(E)-2-[4-(4-hydroxy-4-trifluormethyl-piperidin-l-carbonyl)-2,6-dimethyl-phenyl]-ethensulfonyl>-l,3,8-triaza-spiro[4.5]dec-l-en-4-on; (1007) 2-cyclohexyl-8-{(E)-2-[2,6-dimethyl-4-(2-oxo-oxazoliden-3-carbonyl)-phenyl]-ethensulfonyl>-l,3,8-triaza-spiro[4.5]dec-l-en-4-on; (1008) 2-(4-butyl-cyclohexyl)-8-((E)-2-{4-[4-(2-hydroxy-ethoxy)-piperidin-l-carbonyl]-2,6-dimethyl-phenyl>-ethensulfonyl)-l,3,8-triaza-spiro[4.5]dec-l-en-4-on; (1009) 2-(4-butyl-cyclohexyl)-8-[(E)-2-(4-{4-[2-(2-hydroxy-ethoxy)-ethoxy]-piperidin-l-carbonyl>-2,6-dimethyl-phenyl)-ethensulfonyl]-l,3,8-triaza-spiro[4.5]dec-l-en-4-on; (1010) 8-((E)-2-{4-[4-((R)-2,3-dihydroxy-propoxy)-piperidin-l-carbonyl]-2,6-dimethyl-phenyl}-ethensulfonyl)-2-(9,9,9-trifluor-nonyl)-l,3,8-triaza-spiro[4.5]dec-l-en-4-on; (1011) 2-amino-N-(3,5-dimethyl-4-{(E)-2-[4-oxo-2-(3-trifluormethoxy-phenyl)- 1.3.8- triaza-spiro[4.5]dec-l-en-8-sulfonyl]-vinyl>-phenyl)-N-methyl-acetamid; (1012) (3,5-dimethyl-4-{(E)-2-[4-oxo-2-(3-trifluormethoxy-phenyl)-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl]-vinyl>-phenyl)-methyl-carbaminsyre-2-hydroxy-ethylester; (1013) l-(3,5-dimethyl-4-{(E)-2-[4-oxo-2-(3-trifluormethoxy-phenyl)-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl]-vinyl}-phenyl)-l,3,3-trimethyl-urinstof; (1014) l-(3,5-dimethyl-4-{(E)-2-[4-oxo-2-(3-trifluormethoxy-phenyl)-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl]-vinyl}-phenyl)-l,3-dimethyl-urinstof; (1015) l-(3,5-dimethyl-4-{(E)-2-[4-oxo-2-(3-trifluormethoxy-phenyl)-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl]-vinyl}-phenyl)-l-methyl-urinstof; (1016) 8-[(E)-2-(2,6-dimethyl-4-methylamino-phenyl)-ethensulfonyl]-2-(3-trifluormethylsulfanyl-phenyl)-li3,8-triaza-spiro[4.5]dec-l-en-4-on; (1017) l-(4-{(E)-2-[2-(4-fluor-3-trifluormethyl-phenyl)-4-oxo-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl]-vinyl}-3,5-dimethyl-phenyl)-l-methyl-urinstof; (1018) l-[3,5-dimethyl-4-((E)-2-{4-oxo-2-[3-(l,l,2,2-tetrafluor-ethoxy)-phenyl]- 1.3.8- triaza-spiro[4.5]dec-l-en-8-sulfonyl}-vinyl)-phenyl]-l-methyl-urinstof; (1019) l-[3,5-dimethyl-4-((E)-2-{4-oxo-2-[3-(4,4,4-trifluor-butoxy)-phenyl]- 1.3.8- triaza-spiro[4.5]dec-l-en-8-sulfonyl}-vinyl)-phenyl]-l-methyl-urinstof; (1020) l-[3,5-dimethyl-4-((E)-2-(4-oxo-2-[4-(4,4,4-trifluor-butoxy)-phenyl]- 1.3.8- triaza-spiro[4.5]dec-l-en-8-sulfonyl>-vinyl)-phenyl]-l-methyl-urinstof; (1021) l-(3,5-dimethyl-4-{(E)-2-[4-oxo-2-(4-pentyl-phenyl)-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl]-vinyl>-phenyl)-l-methyl-urinstof; (1022) l-(3,5-dimethyl-4-{(E)-2-[2-(7-methylsulfanyl-heptyl)-4-oxo-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl]-vinyl>-phenyl)-l-methyl-urinstof; (1023) l-[3,5-dimethyl-4-((E)-2-{2-[8-(3-methyl-oxetan-3-yl)-octyl]-4-oxo-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl>-vinyl)-phenyl]-l-methyl-urinstof; (1024) l-{3,5-dimethyl-4-[(E)-2-(2-non-4-ynyl-4-oxo-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl)-vinyl]-phenyl>-l-methyl-urinstof; (1025) l-{3,5-dimethyl-4-[(E)-2-(2-non-3-ynyl-4-oxo-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl)-vinyl]-phenyl>-l-methyl-urinstof; (1026) l-[3,5-dimethyl-4-((E)-2-{2-[10-(3-methyl-oxetan-3-yl)-decyl]-4-oxo- l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl>-vinyl)-phenyl]-l-methyl-urinstof; (1027) l-{3,5-dimethyl-4-[(E)-2-(2-non-l-ynyl-4-oxo-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl)-vinyl]-phenyl>-1-methyl-urinstof; (1028) l-(4-{2-[2-(4-fluor-3-trifluornnethoxy-phenyl)-4-oxo-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl]-ethyl>-3,5-dimethyl-phenyl)-1-methyl-urinstof; (1029) l-(4-{2-[2-(2,2-difluor-benzo[l,3]dioxol-5-yl)-4-oxo-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl]-ethyl>-3,5-dimethyl-phenyl)-1-methyl-urinstof; (1030) l-(4-{2-[2-(4-tert-butyl-phenyl)-4-oxo-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl]-ethyl}-3,5-dimethyl-phenyl)-l-methyl-urinstof (1031) l-[3,5-dimethyl-4-(2-{2-[8-(3-methyl-oxetan-3-yl)-octyl]-4-oxo-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl}-ethyl)-phenyl]-l-methyl-urinstof; (1032) l-[3,5-dimethyl-4-(2-{2-[10-(3-methyl-oxetan-3-yl)-decyl]-4-oxo-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl}-ethyl)-phenyl]-l-methyl-urinstof; (1033) 2-(8-(2-[4-(tert-butoxycarbonyl-methyl-amino)-2,6-dimethyl-phenyl]-ethansulfonyl >-4-oxo-1,3,8-triaza-spiro[4.5]dec-l-en-2-yl)-pyrrolidin-l-carboxylsyre-tert-butylester; (1034) (4-{2-[2-(l,l-difluor-ethyl)-4-oxo-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl]-ethyl>-3,5-dimethyl-phenyl)-methyl-carbaminsyre-tert-butylester; (1035) 8-[2-(2,6-dimethyl-4-methylamino-phenyl)-ethansulfonyl]-2-(8,8,9,9,9-pentafluor-nonyl)-l,3,8-triaza-spiro[4.5]dec-l-en-4-on; (1036) 8-[2-(2,6-dimethyl-4-methylamino-phenyl)-ethansulfonyl]-2-(3-trifluormethylsulfanyl-phenyl)-l,3,8-triaza-spiro[4.5]dec-l-en-4-on; (1037) 8-[2-(2,6-dimethyl-4-methylamino-phenyl)-ethansulfonyl]-2-(4-isopropyliden-cyclohexyl)-l,3,8-tnaza-spiro[4.5]dec-l-en-4-on; (1038) l-[3,5-dimethyl-4-(2-{4-oxo-2-[3-(l,l/2,2-tetrafluor-ethoxy)-phenyl]- l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl}-ethyl)-phenyl]-l-methyl-urinstof; (1039) l-(3,5-dimethyl-4-{2-[4-oxo-2-(5,6,7,8-tetrahydro-naphthalen-2-yl)-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl]-ethyl}-phenyl)-l-methyl-urinstof; (1040) l-(4-{2-[2-((lS,3S,5R)-3,5-dimethyl-cyclohexyl)-4-oxo-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl]-ethyl}-3,5-dimethyl-phenyl)-l-methyl-urinstof; (1041) l-(3,5-dimethyl-4-{2-[4-oxo-2-(l-propyl-butyl)-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl]-ethyl}-phenyl)-l-methyl-urinstof; (1042) l-[3,5-dimethyl-4-(2-{4-oxo-2-[4-(2,2,3,3,3-pentafluor-propyl)-cyclohexyl]-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl}-ethyl)-phenyl]-l-methyl-urinstof; (1043) l-(3,5-dimethyl-4-{2-[4-oxo-2-(6,6,7,7,7-pentafluor-heptyl)-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl]-ethyl}-phenyl)-l-methyl-urinstof; (1044) N-(3,5-dimethyl-4-{2-[4-oxo-2-(7,7,7-trifluor-heptyl)-l,3,8-tnaza-spiro[4.5]dec-l-en-8-sulfonyl]-ethyl>-phenyl)-N-methyl-acetamid; (1045) l-(3,5-dimethyl-4-{2-[4-oxo-2-(7,7,7-trifluor-heptyl)-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl]-ethyl>-phenyl)-l-methyl-urinstof; (1046) l-(3,5-dimethyl-4-{2-[4-oxo-2-(9,9,9-trifluor-nonyl)-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl]-ethyl>-phenyl)-l-methyl-urinstof; (1047) N-(3,5-dimethyl-4-{2-[4-oxo-2-(9,9,9-trifluor-nonyl)-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl]-ethyl>-phenyl)-N-methyl-acetamid; (1048) l-[3,5-dimethyl-4-(2-{4-oxo-2-[l-(4,4,4-trifluor-butyl)-cyclopropyl]-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl}-ethyl)-phenyl]-l-methyl-urinstof; (1050) l-(3,5-dimethyl-4-{2-[4-oxo-2-(3-trifluormethyl-cyclohexyl)-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl]-ethyl}-phenyl)-l-methyl-urinstof; (1051) l-(4-{2-[2-(cis-3,4-dimethyl-cyclopentyl)-4-oxo-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl]-ethyl}-3,5-dimethyl-phenyl)-l-methyl-urinstof; (1052) l-{4-[2-(2-dicyclopropylmethyl-4-oxo-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl)-ethyl]-3,5-dimethyl-phenyl}-l-methyl-urinstof; (1053) l-{4-[2-(2-bicyclo[3.3.1]non-9-yl-4-oxo-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl)-ethyl]-3,5-dimethyl-phenyl>-l-methyl-urinstof; (1054) l-{4-[2-((lR,5S)-2-bicyclo[3.2.1]oct-3-yl-4-oxo-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl)-ethyl]-3,5-dimethyl-phenyl>-l-methyl-urinstof; (1055) l-(3,5-dimethyl-4-{2-[2-(3-methyl-cyclopentyl)-4-oxo-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl]-ethyl>-phenyl)-l-methyl-urinstof; (1056) l-{4-[2-(2-bicyclo[2.2.1]hept-7-yl-4-oxo-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl)-ethyl]-3,5-dimethyl-phenyl>-l-methyl-urinstof; (1057) l-(4-{2-[2-((lS,2S)-2-hexyl-cyclohexyl)-4-oxo-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl]-ethyl}-3,5-dimethyl-phenyl)-l-methyl-urinstof; (1058) l-{3,5-dimethyl-4-[2-(4-oxo-2-spiro[2.5]oct-6-yl-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl)-ethyl]-phenyl>-l-methyl-urinstof; (1059) l-(4-{2-[2-(4-difluormethylen-cyclohexyl)-4-oxo-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl]-ethyl>-3,5-dimethyl-phenyl)-l-methyl-urinstof; (1060) N-[4-(2-{2-[4-(2,2-difluor-ethyl)-cyclohexyl]-4-oxo-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl>-ethyl)-3-methyl-phenyl]-acetamid; (1061) N-[4-(2-{2-[4-(2-fluor-ethyl)-cyclohexyl]-4-oxo-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl}-ethyl)-3-methyl-phenyl]-acetamid; (1062) N-(4-{2-[2-(4-butyl-4-fluor-cyclohexyl)-4-oxo-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl]-ethyl}-3-methyl-phenyl)-acetamid; (1063) N-[4-(2-{2-[4-((E)-3-fluor-propenyl)-cyclohexyl]-4-oxo-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl>-ethyl)-3-methyl-phenyl]-acetamid; (1064) N-[4-(2-{2-[4-(3-fluor-propyl)-cyclohexyl]-4-oxo-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl}-ethyl)-3-methyl-phenyl]-acetamid; (1065) N-[4-(2-{2-[4-(3-chlor-propyl)-cyclohexyl]-4-oxo-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl}-ethyl)-3-methyl-phenyl]-acetamid; (1066) N-[4-(2-{2-[4-(3-fluor-propyliden)-cyclohexyl]-4-oxo-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl}-ethyl)-3-methyl-phenyl]-acetamid; (1067) N-[4-(2-{2-[4-(3,3-difluor-allyl)-cyclohexyl]-4-oxo-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl}-ethyl)-3-methyl-phenyl]-acetamid; (1068) N-[4-(2-{2-[4-(3,3-difluor-allyl)-cyclohexyl]-4-oxo-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl}-ethyl)-3-methyl-phenyl]-acetamid; (1069) N-[3-methyl-4-(2-{4-oxo-2-[4-(2,2,3,3,3-pentafluor-propyl)-cyclohexyl]- l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl>-ethyl)-phenyl]-acetamid; (1070) N-[4-(2-{2-[4-((E)-3-fluor-allyl)-cyclohexyl]-4-oxo-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl}-ethyl)-3-methyl-phenyl]-acetamid; (1071) N-[4-(2-{2-[4-(2,2-difluor-ethyl)-cyclohexyl]-4-oxo-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl}-ethyl)-3-methyl-phenyl]-acetamid; (1072) N-[4-(2-{2-[4-(2-fluor-ethyl)-cyclohexyl]-4-oxo-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl>-ethyl)-3-methyl-phenyl]-acetamid; (1073) N-[4-(2-{2-[4-fluor-4-(3-fluor-propyl)-cyclohexyl]-4-oxo-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl>-ethyl)-3-methyl-phenyl]-acetamid; (1074) N-(4-{2-[2-(4-ethynyl-cyclohexyl)-4-oxo-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl]-ethyl}-3-methyl-phenyl)-acetamid; (1075) N-(4-{2-[2-(4-difluormethyl-cyclohexyl)-4-oxo-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl]-ethyl}-3-methyl-phenyl)-acetamid; (1076) N-[4-(2-{2-[4-(3,3-difluor-propyliden)-cyclohexyl]-4-oxo-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl>-ethyl)-3-methyl-phenyl]-acetamid; (1077) N-[4-(2-{2-[4-(2-fluor-propyl)-cyclohexyl]-4-oxo-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl}-ethyl)-3-methyl-phenyl]-acetamid; (1078) N-[4-(2-{2-[4-(l-fluor-l-methyl-ethyl)-cyclohexyl]-4-oxo-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl>-ethyl)-3-methyl-phenyl]-acetamid; (1079) N-(4-{2-[2-(4-butyliden-cyclohexyl)-4-oxo-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl]-ethyl>-3-methyl-phenyl)-acetamid; (1080) N-[3-methyl-4-(2-{4-oxo-2-[4-(2,2,3,3,3-pentafluor-propyl)-cyclohexyl]- l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl>-ethyl)-phenyl]-acetannid; (1081) l-{3,5-dimethyl-4-[2-(2-non-4-ynyl-4-oxo-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl)-ethyl]-phenyl>-l-methyl-urinstof; (1082) l-{3,5-dimethyl-4-[2-(2-non-3-ynyl-4-oxo-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl)-ethyl]-phenyl}-l-methyl-urinstof; (1083) l-{3,5-dimethyl-4-[2-(2-non-l-ynyl-4-oxo-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl)-ethyl]-phenyl}-l-methyl-urinstof; (1084) l-(3,5-dimethyl-4-{l-[4-oxo-2-(3-trifluormethoxy-phenyl)-l,3,8-triaza-spiro[4.5]-dec-l-en-8-sulfonyl]-cyclopropylmethyl>-phenyl)-l-methyl-urinstof; (1085) l-(4-{2,2-difluor-2-[4-oxo-2-(3-trifluormethoxy-phenyl)-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl]-ethyl}-3,5-dimethyl-phenyl)-l-methyl-urinstof; (1086) l-{4-[2,2-difluor-2-(2-nonyl-4-oxo-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl)-ethyl]-3,5-dimethyl-phenyl>-l-methyl-urinstof; (1087) l-{3,5-dimethyl-4-[2-(4-oxo-2-[l,l,;2',l"]terphenyl-3-yl-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl)-ethyl]-phenyl>-l-methyl-urinstof; (1088) l-[3,5-dimethyl-4-((E)-2-{4-oxo-2-[4-(4,4,4-trifluor-butyl)-phenyl]-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl>-vinyl)-phenyl]-l-nnethyl-urinstof; (1089) l-[3,5-dimethyl-4-((E)-2-{4-oxo-2-[3-(4,4,4-trifluor-butyl)-phenyl]-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl>-vinyl)-phenyl]-l-nnethyl-urinstof; (1090) l-(3,5-dinnethyl-4-{2-[4-oxo-2-(3-trifluornnethoxy-phenyl)-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl]-propyl}-phenyl)-l-methyl-urinstof; (1091) 2-[4-fluor-3-(4,4,5,5,5-pentafluor-pentyloxy)-phenyl]-8-{(E)-2-[4-(4-hydroxy-piperidin-l-carbonyl)-2,6-dimethyl-phenyl]-ethensulfonyl>-l,3,8-triaza-spiro[4.5]dec-l-en-4-on; (1092) 2-[4-fluor-3-(4,4,5,5,5-pentafluor-pentyloxy)-phenyl]-8-{(E)-2-[4-(4-hydroxy-4-methyl-pipendin-l-carbonyl)-2,6-dimethyl-phenyl]-ethensulfonyl>- l,3,8-triaza-spiro[4.5]dec-l-en-4-on; (1093) 2-(4-chlor-3-trifluormethoxy-phenyl)-8-{(E)-2-[4-(4-hydroxy-4-methyl-piperidin-l-carbonyl)-2,6-dimethyl-phenyl]-ethensulfonyl>-l,3,8-tnaza-spiro[4.5]dec-l-en-4-on; (1094) 2-(3-fluor-4-trifluormethoxy-phenyl)-8-{(E)-2-[4-(4-hydroxy-4-methyl-piperidin-l-carbonyl)-2,6-dimethyl-phenyl]-ethensulfonyl>-1,3,8-triaza-spiro[4.5]dec-l-en-4-on; (1095) 2-(3,4-bis-trifluormethyl-phenyl)-8-{(E)-2-[4-(4-hydroxy-4-methyl-piperidin-l-carbonyl)-2,6-dimethyl-phenyl]-ethensulfonyl>-l,3,8-tnaza-spiro[4.5]dec-l-en-4-on; (1096) 8-{(E)-2-[4-(4-hydroxy-4-methyl-pipendin-l-carbonyl)-2,6-dimethyl-phenyl]-ethensulfonyl>-2-[3-(4,4,5,5,5-pentafluor-pentyloxy)-phenyl]-l,3,8-triaza-spiro[4.5]dec-l-en-4-on; (1097) 8-{(E)-2-[4-(4-hydroxy-4-methyl-piperidin-l-carbonyl)-2,6-dimethyl-phenyl]-ethensulfonyl}-2-[3-(2,2,2-trifluor-ethyl)-phenyl]-l,3,8-triaza-spiro[4.5]dec-l-en-4-on; (1098) 2-(4-fluor-3-methyl-phenyl)-8-{(E)-2-[4-(4-hydroxy-4-methyl-piperidin-l-carbonyl)-2,6-dimethyl-phenyl]-ethensulfonyl}-l,3,8-triaza-spiro[4.5]dec-l-en-4-on; (1099) 2-(4-fluor-3-trifluormethoxy-phenyl)-8-{(E)-2-[4-(4-hydroxy-4-methyl-piperidin-l-carbonyl)-2,6-dimethyl-phenyl]-ethensulfonyl>-l,3,8-triaza-spiro[4.5]dec-l-en-4-on; (1100) 8-{(E)-2-[4-(4-hydroxy-4-methyl-piperidin-l-carbonyl)-2,6-dimethyl-phenyl]-ethensulfonyl>-2-[3-(l,l/2,2-tetrafluor-ethoxy)-phenyl]-l,3,8-triaza-spiro[4.5]dec-l-en-4-on; (1101) 8-{l,l-difluor-2-[4-(4-hydroxy-piperidin-l-carbonyl)-2,6-dimethyl-phenyl]-ethansulfonyl>-2-(3-trifluormethoxy-phenyl)-l,3,8-triaza-spiro[4.5]dec-l-en-4-on; (1102) 2-(4-fluor-3-trifluormethoxy-phenyl)-8-{(E)-2-[4-(3-hydroxy-azetidin-l-carbonyl)-2,6-dimethyl-phenyl]-ethensulfonyl>-l,3,8-triaza-spiro[4.5]dec-l-en-4-on; (1103) 8-{(E)-2-[4-((R)-2,3-dihydroxy-propoxy)-2,6-dimethyl-phenyl]-ethensulfonyl}-2-[3-(4,4,5,5,5-pentafluor-pentyloxy)-phenyl]-l,3,8-triaza-spiro[4.5]dec-l-en-4-on; (1104) 6-(4-methyl-cyclohexyl)-2-(2-naphthalen-l-yl-ethansulfonyl)-2,5,7-triaza-spiro[3.4]oct-5-en-8-on; (1106) (ll-{8-[(E)-2-(2,6-dimethyl-4-methylamino-phenyl)-ethensulfonyl]-4-oxo- 1.3.8- triaza-spiro[4.5]dec-l-en-2-yl}-undecyl)-carbaminsyre-tert-butylester; (1107) 8-[(E)-2-(2,6-dimethyl-4-methylamino-phenyl)-ethensulfonyl]-2-(9-hydroxy-nonyl)-l,3,8-triaza-spiro[4.5]dec-l-en-4-on; (1108) l-(3,5-dimethyl-4-{(E)-2-[4-oxo-2-((lS,3R)-3-propyl-cyclohexyl)-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl]-vinyl>-phenyl)-l-methyl-urinstof; (1109) 14-(8-{(E)-2-[2,6-dimethyl-4-(l-methyl-ureido)-phenyl]-ethensulfonyl}-4-oxo-l,3,8-triaza-spiro[4.5]dec-l-en-2-yl)-tetradecansyre; (1110) l-(3,5-dimethyl-4-{(E)-2-[2-(4-[ll,l-2H3]methyl-(4-2Hi]cyclohexyl)-4-oxo- 1.3.8- tnaza-spiro[4.5]dec-l-en-8-sulfonyl]-vinyl>-phenyl)-l-methyl-urinstof; (1111) l-(4-{(E)-2-[2-(4-fluor-3-trifluormethoxy-phenyl)-4-oxo-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl]-vinyl>-3,5-dimethyl-phenyl)-l-methyl-urinstof; (1112) l-(3,5-dimethyl-4-{(E)-2-[2-(3-nonafluorbutyl-phenyl)-4-oxo-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl]-vinyl>-phenyl)-l-methyl-urinstof; (1113) l-(4-{(E)-2-[2-(4-chlor-3-trifluormethyl-phenyl)-4-oxo-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl]-vinyl>-3,5-dimethyl-phenyl)-l-methyl-urinstof; (1114) l-(3,5-dimethyl-4-{(E)-2-[4-oxo-2-(4'-propyl-biphenyl-3-yl)-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl]-vinyl>-phenyl)-l-methyl-urinstof; (1115) l-(4-{(E)-2-[2-(6-ethoxy-hexyl)-4-oxo-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl]-vinyl}-3,5-dimethyl-phenyl)-l-methyl-urinstof; (1116) l-[3,5-dimethyl-4-((E)-2-{4-oxo-2-[3-(6,6,6-trifluor-hexyl)-phenyl]-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl>-vinyl)-phenyl]-l-methyl-urinstof; (1117) l-[3,5-dimethyl-4-((E)-2-{4-oxo-2-[4-(6,6,6-trifluor-hexyl)-phenyl]-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl>-vinyl)-phenyl]-l-methyl-urinstof; (1118) l-(4-{(E)-2-[2-(ll-fluor-undecyl)-4-oxo-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl]-vinyl}-3,5-dimethyl-phenyl)-l-nnethyl-urinstof; (1119) l-{4-[(E)-2-(2-hex-5-enyl-4-oxo-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl)-vinyl]-3,5-dimethyl-phenyl)--l-nnethyl-urinstof; (1120) l-(3,5-dimethyl-4-{(E)-2-[4-oxo-2-((E)-6-phenyl-hex-5-enyl)-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl]-vinyl>-phenyl)-l-nnethyl-urinstof; (1121) l-(3,5-dimethyl-4-{(E)-2-[4-oxo-2-((E)-9-phenyl-non-8-enyl)-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl]-vinyl>-phenyl)-l-nnethyl-urinstof; (1122) l-(3,5-dimethyl-4-{(E)-2-[4-oxo-2-(5-propylsulfanyl-pentyl)-1,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl]-vinyl>-phenyl)-l-nnethyl-urinstof; (1123) l-(4-{(E)-2-[2-(7-methoxy-heptyl)-4-oxo-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl]-vinyl>-3,5-dimethyl-phenyl)-l-methyl-urinstof; (1124) l-(3,5-dimethyl-4-{(E)-2-[4-oxo-2-(5-propoxy-pentyl)-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl]-vinyl}-phenyl)-l-methyl-urinstof; (1125) l-(4-{(E)-2-[2-(ll,ll-difluor-undecyl)-4-oxo-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl]-vinyl)-3,5-dimethyl-phenyl)-l-methyl-urinstof; (1126) l-(3,5-dimethyl-4-{(E)-2-[4-oxo-2-(3-propyl-nonyl)-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl]-vinyl}-phenyl)-l-methyl-urinstof; (1127) l-(3,5-dimethyl-4-{(E)-2-[4-oxo-2-(2-propyl-benzofuran-6-yl)-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl]-vinyl>-phenyl)-l-methyl-urinstof; (1128) l-(4-{(E)-2-[2-(3-methoxy-4-pentyl-phenyl)-4-oxo-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl]-vinyl>-3,5-dimethyl-phenyl)-l-nnethyl-uri nstof; (1129) l-(4-{(E)-2-[2-(4-[l,l,2,2,2-2H5]ethyl-cyclohex-3-enyl)-4-oxo-l/3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl]-vinyl>-3,5-dinnethyl-phenyl)-l-nnethyl-urinstof; (1130) l-(4-{(E)-2-[2-(4-[l,l,2,2,2-2H5]ethyl-[4-2Hi]cyclohexyl)-4-oxo-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl]-vinyl>-3,5-dimethyl-phenyl)-l-methyl-urinstof; (1131) 12-(8-{(E)-2-[2,6-dimethyl-4-(l-methyl-ureido)-phenyl]-ethensulfonyl>-4-oxo-l,3,8-triaza-spiro[4.5]dec-l-en-2-yl)-dodecansyre; (1132) 12-(8-{(E)-2-[2,6-dimethyl-4-(l-methyl-ureido)-phenyl]-ethensulfonyl>-4-oxo-l,3,8-triaza-spiro[4.5]dec-l-en-2-yl)-dodecansyreethylester; (1133) l-(3,5-dimethyl-4-{(E)-2-[4-oxo-2-(5-phenyl-pentyl)-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl]-vinyl>-phenyl)-l-methyl-urinstof; (1134) l-(3,5-dimethyl-4-{(Z)-2-[4-oxo-2-(5-phenyl-pentyl)-l,3,8-triaze-spiro[4.5]dec-l-en-8-sulfonyl]-vinyl>-phenyl)-l-methyl-urinstof; (1135) l-[3,5-dimethyl-4-(2-{4-oxo-2-[3-(4,4,5,5,5-pentafluor-pentyloxy)-phenyl]-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl>-ethyl)-phenyl]-l-methyl-urinstof; (1136) l-(3,5-dimethyl-4-{2-[4-oxo-2-(3'-propyl-biphenyl-3-yl)-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl]-ethyl>-phenyl)-l-methyl-urinstof; (1137) l-(3,5-dimethyl-4-{2-[4-oxo-2-(4-trimethylsilanyl-cyclohexyl)-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl]-ethyl}-phenyl)-l-methyl-urinstof; (1138) l-(4-{2-[2-((lR,3R,5S)-3,5-bis-trifluormethyl-cyclohexyl)-4-oxo-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl]-ethyl>-3,5-dimethyl-phenyl)-l-methyl-urinstof; (1139) l-(3,5-dimethyl-4-{2-[4-oxo-2-(4-trimethylsilanyl-phenyl)-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl]-ethyl>-phenyl)-l-methyl-urinstof; (1140) l-{3,5-dimethyl-4-[2-(4-oxo-2-tridecyl-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl)-ethyl]-phenyl>-l-methyl-urinstof; (1141) l-{3,5-dimethyl-4-[2-(4-oxo-2-undecyl-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl)-ethyl]-phenyl>-l-methyl-urinstof; (1142) l-{3,5-dimethyl-4-[2-(2-octyl-4-oxo-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl)-ethyl]-phenyl>-l-methyl-urinstof; (1143) l-(4-{2-[2-((lS,3R)-3-hexyl-cyclohexyl)-4-oxo-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl]-ethyl )--3,5-dimethyl-phenyl)-l-methyl-urinstof; (1144) l-[3,5-dimethyl-4-(2-{2-[3-(3-methyl-butyl)-phenyl]-4-oxo-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl}-ethyl)-phenyl]-l-methyl-urinstof; (1145) l-(4-{2-[2-((lS,3R)-3-butyl-cyclohexyl)-4-oxo-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl]-ethyl>-3,5-dimethyl-phenyl)-l-methyl-urinstof; (1146) l-[3,5-dimethyl-4-(2-{2-((lS,3S)-3-(3-methyl-butyl)-cyclohexyl]-4-oxo- l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl>-ethyl)-phenyl]-l-methyl-urinstof; (1147) l-(3,5-dimethyl-4-12-[4-oxo-2-(3,3,9,9,9-pentafluor-nonyl)-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl]-ethyl>-phenyl)-l-methyl-urinstof; (1148) l-(4-{2-[2-(4-[l,l,2,2,2-2H5]ethyl-[4-2Hi] cyclohexyl)-4-oxo-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl]-ethyl>-3,5-dimethyl-phenyl)-l-methyl-urinstof; (1149) l-(4-{2-[2-(4-[l,l,2,2,2-2H5]ethyl-cyclohex-3-enyl)-4-oxo-l,3,8-tnaza-spiro[4.5]dec-l-en-8-sulfonyl]-ethyl>-3,5-dimethyl-phenyl)-l-methyl-urinstof; (1150) l-(4-{2-[2-(4-chlor-3-trifluormethyl-phenyl)-4-oxo-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl]-ethyl}-3,5-dimethyl-phenyl)-l-methyl-urinstof; (1151) l-(3,5-dimethyl-4-12-[4-oxo-2-(l,9,9,9-tetrafluor-nonyl)-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl]-ethyl}-phenyl)-l-methyl-urinstof; (1152) l-(3,5-dimethyl-4-{2-[4-oxo-2-(4'-propyl-biphenyl-3-yl)-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl]-ethyl>-phenyl)-l-methyl-urinstof; (1153) l-(4-{2-[2-(ll-fluor-undecyl)-4-oxo-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl]-ethyl>-3,5-dimethyl-phenyl)-l-methyl-urinstof; (1154) l-(4-{2-[2-(6-ethylsulfanyl-hexyl)-4-oxo-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl]-ethyl>-3,5-dimethyl-phenyl)-l-methyl-urinstof; (1155) l-{3,5-dimethyl-4-[2-(4-oxo-2-[l,l,;3,,l"]terphenyl-3-yl-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl)-ethyl]-phenyl>-l-methyl-urinstof; (1156) l-(4-{2-[2-(ll,ll-difluor-undecyl)-4-oxo-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl]-ethyl}-3,5-dimethyl-phenyl)-l-methyl-urinstof; (1157) l-{3,5-dimethyl-4-[(E)-2-(4-oxo-2-[l,l';3',l"]terphenyl-3-yl-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl)-vinyl]-phenyl}-l-methyl-urinstof; (1158) 8-{(E)-2-[4-(4-hydroxy-piperidin-l-carbonyl)-2,6-dimethyl-phenyl]-ethensulfonyl}-2-[3-(4,4,5,5,5-pentafluor-pentyloxy)-phenyl]-l,3,B-triaza-spiro[4.5]dec-l-en-4-on; (1159) 2-(4-fluor-3-trifluormethoxy-phenyl)-8-{(E)-2-[4-(4-hydroxy-piperidin-l-carbonyl)-2,6-dimethyl-phenyl]-ethensulfonyl}-l,3,8-triaza-spiro[4.5]dec-l-en-4-on; (1160) 2-(2,2-difluor-benzo[l,3]dioxol-5-yl)-8-{(E)-2-[4-(4-hydroxy-piperidin-l-carbonyl)-2,6-dimethyl-phenyl]-ethensulfonyl}-l,3,8-triaza-spiro[4.5]dec-l-en-4-on; (1161) 2-(4-fluor-3-trifluormethoxy-phenyl)-8-{(E)-2-[4-(4-hydroxymethyl-piperidin-l-carbonyl)-2,6-dimethyl-phenyl]-ethensulfonyl)-1,3,8-triaza-spiro[4.5]dec-l-en-4-on; (1162) 2-(4-fluor-3-trifluornnethyl-phenyl)-8-{(E)-2-[4-(4-hydroxymethyl-piperidin-l-carbonyl)-2,6-dinnethyl-phenyl]-ethensulfonyl}-l,3,8-triaza-spiro[4.5]dec-l-en-4-on; (1163) 2-(2,2-difluor-benzo[l,3]dioxol-5-yl)-8-{(E)-2-[4-(4-hydroxy-4-methyl-piperidin-l-carbonyl)-2,6-dimethyl-phenyl]-ethensulfonyl}-l,3,8-triaza-spiro[4.5]dec-l-en-4-on; (1164) 8-{(E)-2-[4-((R)-2,3-dihydroxy-propoxy)-2,6-dimethyl-phenyl]-ethensulfonyl>-2-(4-fluor-3-trifluormethoxy-phenyl)-l,3,8-triaza-spiro[4.5]dec-l-en-4-on; (1165) 2-(2,2-difluor-benzo[l,3]dioxol-5-yl)-8-{(E)-2-[4-((R)-2,3-dihydroxy-propoxy)-2,6-dimethyl-phenyl]-ethensulfonyl>-l,3,8-tnaza-spiro[4.5]dec-l-en-4-on; (1166) 8-{(E)-2-[4-(3,4-dihydroxy-butoxy)-2-met:hyl-phenyl]-ethensulfonyl}-2-(4-fluor-3-trifluornnethoxy-phenyl)-l,3,8-tnaza-spiro[4.5]dec-l-en-4-on; (1167) 2-(2,2-difluor-benzo[l,3]dioxol-5-yl)-8-{(E)-2-[4-(3,4-dihydroxy-butoxy)-2-methyl-phenyl]-ethensulfonyl}-l,3,8-triaza-spiro[4.5]dec-l-en-4-on; (1168) {4-[(E)-2-(2-cyclohexyl-4-oxo-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl)-vinyl]-indol-l-yl}-eddikesyre; (1169) [3-(3-methyl-4-{(E)-2-[2-(4-methyl-cyclohexyl)-4-oxo-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl]-vinyl}-phenyl)-ureido]-eddikesyre; (1170) 12-(8-{2-[2,6-dimethyl-4-(l-methyl-ureido)-phenyl]-ethansulfonyl>-4-oxo- 1.3.8- triaza-spiro[4.5]dec-l-en-2-yl)-dodecansyre; (1171) 10-(8-{(E)-2-[2,6-dimethyl-4-(l-methyl-ureido)-phenyl]-ethensulfonyl)-4-oxo-l,3,8-triaza-spiro[4.5]dec-l-en-2-yl)-decansyre; (1172) 10-(8-{(E)-2-[2,6-dimethyl-4-(l-methyl-ureido)-phenyl]-ethensulfonyl>-4-oxo-l,3,8-triaza-spiro[4.5]dec-l-en-2-yl)-decansyreannid; (1173) 12-(8-{(E)-2-[2,6-dimethyl-4-(l-methyl-ureido)-phenyl]-ethensulfonyl>-4-oxo-l,3,8-triaza-spiro[4.5]dec-l-en-2-yl)-dodecansyreannid; (1174) 12-(8-{2-[2,6-dimethyl-4-(l-methyl-ureido)-phenyl]-ethansulfonyl}-4-oxo- 1.3.8- tnaza-spiro[4.5]dec-l-en-2-yl)-dodecansyreamid; (1175) 14-(8-{(E)-2-[2,6-dimethyl-4-(l-methyl-ureido)-phenyl]-ethensulfonyl}-4-oxo-l,3,8-triaza-spiro[4.5]dec-l-en-2-yl)-tetradecansyreannid; (1176) 14-(8-{2-[2,6-dimethyl-4-(l-methyl-ureido)-phenyl]-ethansulfonyl>-4-oxo- 1.3.8- triaza-spiro[4.5]dec-l-en-2-yl)-tetradecansyreannid; (1178) 8-[2-(2-amino-5,7-dimethyl-benzoxazol-6-yl)-ethansulfonyl]-2-(4-methyl-cyclohexyl)-l,3,8-triaza-spiro[4.5]dec-l-en-4-on; (1179) 2-cyclohexyl-8-{2-[2,6-dimethyl-4-(2-oxo-oxazoliden-3-carbonyl)-phenyl]-ethansulfonyl}-l,3,8-triaza-spiro[4.5]dec-l-en-4-on; (1180) N-methoxy-3,5,N-trimethyl-4-{2-[2-(4-methyl-cyclohexyl)-4-oxo-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl]-ethyl>-benzannid; (1181) 8-{2-[4-(isoxazoliden-2-carbonyl)-2,6-dimethyl-phenyl]-ethansulfonyl>-2-[4-(3,3,3-trifluor-propyl)-cyclohexyl]-l,3,8-tnaza-spiro[4.5]dec-l-en-4-on ; (1182) 8-{2-[4-(isoxazoliden-2-carbonyl)-2,6-dimethyl-phenyl]-ethansulfonyl>-2-(4-methyl-cyclohexyl)-l,3,8-triaza-spiro[4.5]dec-l-en-4-on; (1183) 8-{2-[4-(l,l-dioxo-lA5-thiomorpholin-4-carbonyl) - 2,6-dimethyl-phenyl]-ethansulfonyl}-2-(4-methylcyclohexyl)-l,3,8-triaza-spiro[4.5]dec-l-en-4-on; (1184) 8-(2-{4-[4-((R)-2,3-dihydroxy-propoxy)-piperidin-l-carbonyl]-2,6-dimethyl-phenyl>-ethansulfonyl)-2-(9,9,9-trifluor-nonyl)-l,3,8-triaza-spiro[4.5]dec-l-en-4-on; (1185) 2-(3,4-dichlor-phenyl)-8-{(E)-2-[4-(4-hydroxy-4-methyl-piperidin-l-carbonyl)-2,6-dimethyl-phenyl]-ethensulfonyl}-l,3,8-triaza-spiro[4.5]dec-l-en-4-on; (1186) 2-(3-chlor-4-fluor-phenyl)-8-{(E)-2-[4-(4-hydroxy-4-methyl-piperidin-l-carbonyl)-2,6-dimethyl-phenyl]-ethensulfonyl}-l,3,8-triaza-spiro[4.5]dec-l-en-4-on; (1187) [3-(8-{(E)-2-[4-(4-hydroxy-4-methyl-piperidin-l-carbonyl)-2,6-dimethyl-phenyl]-ethensulfonyl}-4-oxo-l,3,8-triaza-spiro[4.5]dec-l-en-2-yl)-phenyl]-acetonitril; (1188) 2-(3-chlor-4-trifluormethyl-phenyl)-8-{(E)-2-[4-(4-hydroxy-4-methyl-piperidiri-l-carbonyl)-2,6-dimethyl-phenyl]-ethensulfonyl>-l,3,8-triaza-spiro[4.5]dec-l-en-4-on; (1189) 8-{(E)-2-[4-(4-hydroxy-4-methyl-piperidin-l-carbonyl)-2,6-dimethyl-phenyl]-ethensulfonyl>-2-(4-pentafluorsulfanyl-phenyl)-l,3,8-triaza-spiro[4.5]dec-l-en-4-on; (1190) 8-{(E)-2-[4-(4-hydroxy-4-methyl-piperidin-l-carbonyl)-2,6-dimethyl-phenyl]-ethensulfonyl>-2-(3-pentafluorsulfanyl-phenyl)-l,3,8-triaza-spiro[4.5]dec-l-en-4-on; (1191) 8-{(E)-2-[4-(4-hydroxy-4-methyl-piperidin-l-carbonyl)-2,6-dimethyl-phenyl]-ethensulfonyl>-2-[4-(3-trifluormethyl-phenoxymethyl)-phenyl]-l,3,8-triaza-spiro[4.5]dec-l-en-4-on; (1192) 2-(4-fluor-2,3-dimethyl-phenyl)-8-{(E)-2-[4-(4-hydroxy-4-methyl-piperidin-l-carbonyl)-2,6-dimethyl-phenyl]-ethensulfonyl>-l,3,8-tnaza-spiro[4.5]dec-l-en-4-on; (1193) 8-{(E)-2-[4-(4-hydroxy-4-methyl-piperidin-l-carbonyl)-2,6-dimethyl-phenyl]-ethensulfonyl>-2-(3-methyl-4-trifluormethyl-phenyl)-l,3,8-triaza-spiro[4.5]dec-l-en-4-on; (1194) 2-benzo[l,3]dioxol-5-yl-8-{(E)-2-[4-(4-hydroxy-4-methyl-piperidin-l-carbonyl)-2,6-dimethyl-phenyl]-ethensulfonyl>-l,3,8-triaza-spiro[4.5]dec-l-en-4-on; (1195) 8-{(E)-2-[4-(4-hydroxy-4-methyl-piperidin-l-carbonyl)-2,6-dimethyl-phenyl]-ethensulfonyl>-2-(4-pentafluorethyl-phenyl)-l,3,8-triaza-spiro[4.5]dec-l-en-4-on; (1196) 8-{(E)-2-[4-(4-hydroxy-4-methyl-piperidin-l-carbonyl)-2,6-dimethyl-phenyl]-ethensulfonyl>-2-(3-pentafluorethyl-phenyl)-l,3,8-triaza-spiro[4.5]dec-l-en-4-on; (1197) 8-{(E)-2-[4-(4-hydroxy-4-methyl-piperidin-l-carbonyl)-2,6-dimethyl-phenyl]-ethensulfonyl>-2-[4-(2,2,2-trifluor-l,l-dimethyl-ethoxy)-3-trifluormethylphenyl]-l,3,8-triaza-spiro[4.5]dec-l-en-4-on; (1198) 8-{(E)-2-[4-(4-hydroxy-4-methyl-piperidin-l-carbonyl)-2,6-dimethyl-phenyl]-ethensulfonyl >-2-(4-trifluormethoxy-phenyl)-l,3,8-triaza-spiro[4.5]dec-l-en-4-on; (1199) 8-{(E)-2-[4-(4-hydroxy-4-methyl-piperidin-l-carbonyl)-2,6-dimethyl-phenyl]-ethensulfonyl>-2-[4-(2,2,3,3-tetrafluor-propoxy)-3-trifluormethyl-phenyl]- l,3,8-triaza-spiro[4.5]dec-l-en-4-on; (1200) 8-{(E)-2-[4-(4-hydroxy-4-methyl-piperidin-l-carbonyl)-2,6-dinnethyl-phenyl]-ethensulfonyl}-2-[4-(2,2,2-tnfluor-ethoxy)-3-trifluornnethyl-phenyl]-l,3,8-triaza-spiro[4.5]dec-l-en-4-on; (1201) 2-[3-chlor-4-(2,2,3,3-tetrafluor-propoxy)-phenyl]-8-{(E)-2-[4-(4-hydroxy-4-methyl-piperidin-l-carbonyl)-2,6-dimethyl-phenyl]-ethensulfonyl >-1,3,8-triaza-spiro[4.5]dec-l-en-4-on; (1202) 8-{(E)-2-[4-(4-hydroxy-4-methyl-pipendin-l-carbonyl)-2,6-dinnethyl-phenyl]-ethensulfonyl>-2-[4-(4,4,5,5,5-pentafluor-pentyloxy)-3-trifluormethyl-phenyl]-l,3,8-triaza-spiro[4.5]dec-l-en-4-on; (1203) 8-{(E)-2-[4-(4-hydroxy-4-methyl-piperidin-l-carbonyl)-2,6-dimethyl-phenyl]-ethensulfonyl >-2-[4-(2,2,3,3,3-pentafluor-propoxy)-3-trifluormethyl-phenyl]-l,3,8-triaza-spiro[4.5]dec-l-en-4-on; (1204) 8-{(E)-2-[4-(4-hydroxy-4-methyl-piperidin-l-carbonyl)-2,6-dimethyl-phenyl]-ethensulfonyl}-2-[4-(4,4,4-trifluor-butoxy)-3-trifluornnethyl-phenyl]-1,3,8-triaza-spiro[4.5]dec-l-en-4-on; (1205) 8-{(E)-2-[4-(4-hydroxy-4-methyl-piperidin-l-carbonyl)-2,6-dimethyl-phenyl]-ethensulfonyl }-2-[3-(3-trifluormethyl-phenoxymethyl)-phenyl] -1,3,8-triaza-spiro[4.5]dec-l-en-4-on; (1206) 2-[3-(l,l-difluor-ethyl)-phenyl]-8-{(E)-2-[4-(4-hydroxy-4-methyl-piperidi n-1-ca rbonyl)-2,6-dimethyl-phenyl]-ethensulfonyl}-1,3,8-triaza-spiro[4.5]dec-l-en-4-on; (1207) 2-[3-fluor-4-(4,4,5,5,5-pentafluor-pentyloxy)-phenyl]-8-{(E)-2-[4-(4-hydroxy-4-methyl-piperidin-l-carbonyl)-2,6-dimethyl-phenyl]-ethensulfonyl}- 1.3.8- triaza-spiro[4.5]dec-l-en-4-on; (1208) 8-{(E)-2-[4-(4-hydroxy-4-methyl-piperidin-l-carbonyl)-2,6-dimethyl-phenyl]-ethensulfonyl}-2-(lH-indol-6-yl)-l,3,8-triaza-spiro[4.5]dec-l-en-4-on; (1209) 8-{(E)-2-[4-(4-hydroxy-4-methyl-piperidin-l-carbonyl)-2,6-dimethyl-phenyl]-ethensulfonyl>-2-[3-(2,2,2-trifluor-l,l-dimethyl-ethoxy)-4-trifluormethylphenyl]-l,3,8-triaza-spiro[4.5]dec-l-en-4-on; (1210) 2-[4-chlor-3-(2,2,2-trifluor-l,l-dimethyl-ethoxy)-phenyl]-8-{(E)-2-[4-(4-hydroxy-4-methyl-piperidin-l-carbonyl)-2,6-dimethyl-phenyl]-ethensulfonyl}- 1.3.8- triaza-spiro[4.5]dec-l-en-4-on; (1211) 2-(3-[l,l,2,2,3,3,4,4,4-2H9]butoxy-4-fluor-phenyl)-8-{(E)-2-[4-(4-hydroxy-4-methyl-piperidin-l-carbonyl)-2,6-dimethyl-phenyl]-ethensulfonyl}- 1.3.8- triaza-spiro[4.5]dec-l-en-4-on; (1212) 8-{(E)-2-[4-(4-hydroxy-4-methyl-piperidin-l-carbonyl)-2,6-dimethyl-phenyl]-ethensulfonyl>-2-(2,2,3,3-tetrafluor-2,3-dihydro-benzo[l,4]dioxin-6-yl)- 1.3.8- triaza-spiro[4.5]dec-l-en-4-on; (1213) 8-{(E)-2-[4-(4-hydroxy-4-methyl-piperidin-l-carbonyl)-2,6-dimethyl-phenyl]-ethensulfonyl>-2-[4-(l,l,2/2-tetrafluor-ethoxy)-phenyl]-l,3,8-triaza-spiro[4.5]dec-l-en-4-on; (1214) 8-{(E)-2-[4-(4-hydroxy-4-methyl-piperidin-l-carbonyl)-2,6-dimethyl-phenyl]-ethensulfonyl>-2-(3-methyl-4-trifluormethoxy-phenyl)-l,3,8-triaza-spiro[4.5]dec-l-en-4-on; (1215) 2-[4-fluor-3-(3-fluor-propoxy)-phenyl]-8-{(E)-2-[4-(4-hydroxy-4-methyl-piperidin-l-carbonyl)-2,6-dimethyl-phenyl]-ethensulfonyl}-l,3,8-triaza-spiro[4.5]dec-l-en-4-on; (1216) 2-[3-chlor-4-(2,2,2-trifluor-ethoxy)-phenyl]-8-{(E)-2-[4-(4-hydroxy-4-methyl-piperidin-l-carbonyl)-2,6-dimethyl-phenyl]-ethensulfonyl}-l,3,8-triaza-spiro[4.5]dec-l-en-4-on; (1217) 2-(3-difluormethyl-4-fluor-phenyl)-8-{(E)-2-[4-(4-hydroxy-4-methyl-piperidin-l-carbonyl)-2,6-dimethyl-phenyl]-ethensulfonyl}-l,3,8-triaza-spiro[4.5]dec-l-en-4-on; (1218) 2-[4-fluor-3-(4,4,4-trifluor-butoxy)-phenyl]-8-{(E)-2-[4-(4-hydroxy-4-methyl-pipendin-l-carbonyl)-2,6-dimethyl-phenyl]-ethensulfonyl}-l,3,8-triaza-spiro[4.5]dec-l-en-4-on; (1219) 2-(4-difluormethyl-3-fluor-phenyl)-8-{(E)-2-[4-(4-hydroxy-4-methyl-pipendin-l-carbonyl)-2,6-dimethyl-phenyl]-ethensulfonyl>-l,3,8-triaza-spiro[4.5]dec-l-en-4-on; (1220) 2-(4-[l,l/2,2,3,3,4,4,4-2H9]butoxy-3-trifluormethyl-phenyl)-8-{(E)-2-[4-(4-hydroxy-4-methyl-pipendin-l-carbonyl)-2,6-dimethyl-phenyl]-ethensulfonyl>- 1.3.8- triaza-spiro[4.5]dec-l-en-4-on; (1221) 2-(4-[l,l,2,2,2-2H5]ethoxy-3-tnfluormethyl-phenyl)-8-{(E)-2-[4-(4-hydroxy-4-methyl-pipendin-l-carbonyl)-2,6-dimethyl-phenyl]-ethensulfonyl>- 1.3.8- triaza-spiro[4.5]dec-l-en-4-on; (1222) 8-{(E)-2-[4-(4-hydroxy-4-methyl-piperidin-l-carbonyl)-2,6-dimethyl-phenyl]-ethensulfonyl>-2-(4-[l,2,2,2,2,2,2-2H7]isopropoxy-3-trifluormethyl-phenyl)-l,3,8-triaza-spiro[4.5]dec-l-en-4-on; (1223) 8-{(E)-2-[4-(4-hydroxy-4-methyl-piperidin-l-carbonyl)-2,6-dimethyl-phenyl]-ethensulfonyl>-2-[3-(2,2,3,3-tetrafluor-propoxy)-4-trifluormethyl-phenyl]- 1.3.8- triaza-spiro[4.5]dec-l-en-4-on; (1224) 2-(3-[l,l,2,2,2-2H5]ethoxy-4-fluor-phenyl)-8-{(E)-2-[4-(4-hydroxy-4-methyl-piperidin-l-carbonyl)-2,6-dimethyl-phenyl]-ethensulfonyl>-l,3,8-tnaza-spiro[4.5]dec-l-en-4-on; (1225) 2-(4-fluor-3-[l,2,2,2,2,2,2-2H7]isopropoxy-phenyl)-8-{(E)-2-[4-(4-hydroxy-4-methyl-pipendin-l-carbonyl)-2,6-dimethyl-phenyl]-ethensulfonyl>- 1.3.8- triaza-spiro[4.5]dec-l-eri-4-on; (1226) 8-{(E)-2-[4-(4-hydroxy-4-methyl-piperidin-l-carbonyl)-2,6-dimethyl-phenyl]-ethensulfonyl>-2-[3-(2,2,3,3-tetrafluor-propoxy)-5-trifluormethyl-phenyl]- 1.3.8- triaza-spiro[4.5]dec-l-en-4-on; (1227) 2-[4-chlor-3-(4,4,4-trifluor-butoxy)-phenyl]-8-{(E)-2-[4-(4-hydroxy-4-methyl-piperidin-l-carbonyl)-2,6-dimethyl-phenyl]-ethensulfonyl}-l,3,8-triaza-spiro[4.5]dec-l-en-4-on; (1228) 8-{(E)-2-[4-(4-hydroxy-4-methyl-piperidin-l-carbonyl)-2,6-dimethyl-phenyl]-ethensulfonyl>-2-[3-(2,2,3,3,3-pentafluor-propoxy)-4-tri fluormethyl-phenyl]-l,3,8-triaza-spiro[4.5]dec-l-en-4-on; (1229) 2-[4-chlor-3-(2,2,3,3-tetrafluor-propoxy)-phenyl]-8-{(E)-2-[4-(4-hydroxy-4-methyl-piperidin-l-carbonyl)-2,6-dimethyl-phenyl]-ethensulfonyl>-l,3,8-triaza-spiro[4.5]dec-l-en-4-on; (1230) 2-[4-chlor-3-(2,2,3,3,3-pentafluor-propoxy)-phenyl]-8-{(E)-2-[4-(4-hydroxy-4-methyl-piperidin-l-carbonyl)-2,6-dimethyl-phenyl]-ethensulfonyl>- 1.3.8- triaza-spiro[4.5]dec-l-en-4-on; (1231) 2-(3-[l,l,2,2,3,3,4,4,4-2H9]butoxy-4-chlorphenyl)-8-{(E)-2-[4-(4-hydroxy-4-methyl-piperidin-l-carbonyl)-2,6-dimethyl-phenyl]-ethensulfonyl>-l,3,8-triaza-spiro[4.5]dec-l-en-4-on; (1232) 8-{(E)-2-[4-(4-hydroxy-4-methyl-piperidin-l-carbonyl)-2,6-dimethyl-phenyl]-ethensulfonyl>-2-[3-(4,4,4-trifluor-butoxy)-4-trifluormethoxy-phenyl]- 1.3.8- triaza-spiro[4.5]dec-l-en-4-on; (1233) 2-(3-[l,l,2,2,3,3,4,4,4-2H9]butoxy-5-trifluormethyl-phenyl)-8-{(E)-2-[4-(4-hydroxy-4-methyl-piperidin-l-carbonyl)-2,6-dimethyl-phenyl]-ethensulfonyl>- l,3,8-triaza-spiro[4.5]dec-l-en-4-on; (1234) 8-{2-[4-(4-hydroxy-4-methyl-piperidin-l-carbonyl)-2,6-dimethyl-phenyl]-ethansulfonyl>-2-(4-trifluormethoxy-phenyl)-l,3,8-triaza-spiro[4.5]dec-l-en-4-on; (1235) 8-{2-[4-(4-hydroxy-4-methyl-piperidin-l-carbonyl)-2,6-dimethyl-phenyl]-ethansulfonyl>-2-(3-methyl-4-trifluormethyl-phenyl)-l,3,8-triaza-spiro[4.5]dec-l-en-4-on; (1236) 2-(3-chlor-4-trifluormethyl-phenyl)-8-{2-[4-(4-hydroxy-4-methyl-piperidin-l-carbonyl)-2,6-dimethyl-phenyl]-ethansulfonyl)-l,3,8-triaza-spiro[4.5]dec-l-en-4-on; (1237) 2-(3,4-dimethyl-phenyl)-8-{(E)-2-[4-(4-hydroxy-4-methyl-piperidin-l-carbonyl)-2,6-dimethyl-phenyl]-ethensulfonyl}-l,3,8-triaza-spiro[4.5]dec-l-en-4-on; (1238) 8-{(E)-2-[4-(4-hydroxy-4-methyl-piperidin-l-carbonyl)-2,6-dimethyl-phenyl]-ethensulfonyl}-2-(4-methoxy-3-methyl-phenyl)-l,3,8-triaza-spiro[4.5]dec-l-en-4-on; (1239) 2-(4-fluor-2,5-dimethyl-phenyl)-8-{(E)-2-[4-(4-fluormethyl-4-hydroxy-piperidin-l-carbonyl)-2,6-dimethyl-phenyl]-ethensulfonyl}-l,3,8-triaza-spiro[4.5]dec-l-en-4-on; (1240) 2-(4-fluor-2,3-dimethyl-phenyl)-8-{(E)-2-[4-(4-fluormethyl-4-hydroxy-pipendin-l-carbonyl)-2,6-dimethyl-phenyl]-ethensulfonyl>-l,3,8-triaza-spiro[4.5]dec-l-en-4-on; (1241) 2-(3-chlor-4-trifluormethyl-phenyl)-8-{(E)-2-[4-(4-fluormethyl-4-hydroxy-piperidin-l-carbonyl)-2,6-dimethyl-phenyl]-ethensulfonyl>-l,3,8-tnaza-spiro[4.5]dec-l-en-4-on; (1242) 2-(3-chlor-4-fluor-phenyl)-8-{(E)-2-[4-(4-fluormethyl-4-hydroxy-piperidin-l-carbonyl)-2,6-dimethyl-phenyl]-ethensulfonyl>-l,3,8-triaza-spiro[4.5]dec-l-en-4-on; (1243) 8-{(E)-2-[4-(4-fluormethyl-4-hydrc>xy-piperidin-l-carbonyl)-2,6-dimethyl-phenyl]-ethensulfonyl}-2-(3-pentafluorethyl-phenyl)-l,3,8-triaza-spiro[4.5]dec-l-en-4-on; (1244) 8-{(E)-2-[4-(4-fluormethyl-4-hydroxy-piperidin-l-carbonyl)-2,6-dimethyl-phenyl]-ethensulfonyl}-2-(4-pentafluorethyl-phenyl)-l,3,8-triaza-spiro[4.5]dec-l-en-4-on; (1245) 8-{(E)-2-[4-(4-fluormethyl-4-hydroxy-piperidin-l-carbonyl)-2,6-dimethyl-phenyl]-ethensulfonyl>-2-(4-pentafluorsulfanyl-phenyl)-l,3,8-triaza-spiro[4.5]dec-l-en-4-on; (1246) 2-[3-chlor-4-(2,2,2-trifluor-ethoxy)-phenyl]-8-{(E)-2-[4-(4-fluormethyl-4-hydroxy-piperidin-l-carbonyl)-2,6-dimethyl-phenyl]-ethensulfonyl>-l,3,8-triaza-spiro[4.5]dec-l-en-4-on; (1247) 2-[3-chlor-4-(2,2,3,3-tetrafluor-propoxy)-phenyl]-8-{(E)-2-[4-(4-fluormethyl-4-hydroxy-piperidin-l-carbonyl)-2,6-dimethyl-phenyl]-ethensulfonyl>- 1.3.8- triaza-spiro[4.5]dec-l-en-4-on; (1248) 8-{(E)-2-[4-(4-fluomnethyl-4-hydroxy-piperidin-l-carbonyl)-2,6-dimethyl-phenyl]-ethensulfonyl }-2-[4-(2,2,2-trifluor-ethoxy)-3-trifluormethyl-phenyl]-l,3,8-triaza-spiro[4.5]dec-l-en-4-on; (1249) 8-{(E)-2-[4-(4-fluomnethyl-4-hydroxy-piperidin-l-carbonyl)-2,6-dimethyl-phenyl]-ethensulfonyl>-2-[4-(2,2,3,3,3-pentafluor-propoxy)-3-trifluormethyl-phenyl]-l,3,8-triaza-spiro[4.5]dec-l-en-4-on; (1250) 8-{(E)-2-[4-(4-fluormethyl-4-hydroxy-piperidin-l-carbonyl)-2,6-dinnethyl-phenyl]-ethensulfonyl>-2-[4-(4,4,4-trifluor-butoxy)-3-tnfluornnethyl-phenyl]-l,3,8-triaza-spiro[4.5]dec-l-en-4-on; (1251) 8-{(E)-2-[4-(4-fluomnethyl-4-hydroxy-piperidin-l-carbonyl)-2,6-dinnethyl-phenyl]-ethensulfonyl>-2-[4-(2,2,3,3-tetrafluor-propoxy)-3-trifluormethyl-phenyl]- 1.3.8- triaza-spiro[4.5]dec-l-en-4-on; (1252) 8-{(E)-2-[4-(4-fluomnethyl-4-hydroxy-piperidin-l-carbonyl)-2,6-dinnethyl-phenyl]-ethensulfonyl>-2-[4-(4,4,5,5,5-pentafluor-pentyloxy)-3-trifluormethyl-phenyl]-l,3,8-triaza-spiro[4.5]dec-l-en-4-on; (1253) 2-(4-[l,l/2,2,2-2H5]ethoxy-3-trifluormethyl-phenyl)-8-{(E)-2-[4-(4-fluormethyl-4-hydroxy-piperidin-l-carbonyl)-2,6-dimethyl-phenyl]-ethensulfonyl>- l,3,8-triaza-spiro[4.5]dec-l-en-4-on; (1254) 8-{(E)-2-[4-(4-fluormethyl-4-hydroxy-piperidin-l-carbonyl)-2,6-dimethyl-phenyl]-ethensulfonyl>-2-(3-methyl-4-trifluormethyl-phenyl)-l,3,8-triaza-spiro[4.5]dec-l-en-4-on; (1255) 2-(4-difluormethyl-3-fluor-phenyl)-8-{(E)-2-[4-(4-fluormethyl-4-hydroxy-piperidin-l-carbonyl)-2,6-dimethyl-phenyl]-ethensulfonyl}-l,3,8-triaza-spiro[4.5]dec-l-en-4-on; (1256) 2-(3-difluormethyl-4-fluor-phenyl)-8-{(E)-2-[4-(4-fluormethyl-4-hydroxy-piperidin-l-carbonyl)-2,6-dimethyl-phenyl]-ethensulfonyl}-l,3,8-triaza-spiro[4.5]dec-l-en-4-on; (1257) 2-(3,4-dichlor-phenyl)-8-{(E)-2-[4-(4-fluormethyl-4-hydroxy-piperidin-l-carbonyl)-2,6-dimethyl-phenyl]-ethensulfonyl}-l,3,8-triaza-spiro[4.5]dec-l-en-4-on; (1258) 8-{(E)-2-[4-(4-fluormethyl-4-hydroxy-piperidin-l-carbonyl)-2,6-dimethyl-phenyl]-ethensulfonyl>-2-(3-methyl-4-trifluormethoxy-phenyl)-l,3,8-triaza-spiro[4.5]dec-l-en-4-on; (1259) 8-{(E)-2-[4-(4-fluormethyl-4-hydroxy-piperidin-l-carbonyl)-2,6-dimethyl-phenyl]-ethensulfonyl>-2-(2-methyl-4-trifluormethyl-phenyl)-l,3,8-triaza-spiro[4.5]dec-l-en-4-on (1260) 8-{(E)-2-[4-(4-fluormethyl-4-hydroxy-piperidin-l-carbonyl)-2,6-dimethyl-phenyl]-ethensulfonyl>-2-[3-fluor-4-(2,2,2-trifluor-ethoxy)-phenyl]-l,3,8-triaza-spiro[4.5]dec-l-en-4-on; (1261) 2-(4-[l,l,2,2,3,3,4,4,4-2H9]butoxy-3-trifluormethyl-phenyl)-8-{(E)-2-[4-(4-fluormethyl-4-hydroxy-piperidin-l-carbonyl)-2,6-dimethyl-phenyl]-ethensulfonyl>-l,3,8-triaza-spiro[4.5]dec-l-en-4-on: (1262) 8-{(E)-2-[4-(4-fluormethyl-4-hydroxy-piperidin-l-carbonyl)-2,6-dimethyl-phenyl]-ethensulfonyl>-2-(4-[l,2,2,2,2,2,2-2H7]isopropoxy-3-trifluormethyl-phenyl)-l,3,8-triaza-spiro[4.5]dec-l-en-4-on; (1263) 8-{(E)-2-[4-(4-fluormethyl-4-hydroxy-piperidin-l-carbonyl)-2,6-dimethyl-phenyl]-ethensulfonyl}-2-[4-fluor-3-(4,4,5,5,5-pentafluor-pentyloxy)-phenyl]- 1.3.8- triaza-spiro[4.5]dec-l-en-4-on; (1264) 2-[4-fluor-3-(3-fluor-propoxy)-phenyl]-8-{(E)-2-[4-(4-fluormethyl-4-hydroxy-piperidin-l-carbonyl)-2,6-dimethyl-phenyl]-ethensulfonyl}-l,3,8-tnaza-spiro[4.5]dec-l-en-4-on; (1265) 8-{(E)-2-[4-(4-fluormethyl-4-hydroxy-piperidin-l-carbonyl)-2,6-dimethyl-phenyl]-ethensulfonyl}-2-[4-(2,2,2-trifluor-l,l-dimethyl-ethoxy)-3-trifluormethylphenyl]-l,3,8-triaza-spiro[4.5]dec-l-en-4-on; (1266) 8-{(E)-2-[4-(4-fluomnethyl-4-hydroxy-piperidin-l-carbonyl)-2,6-dimethyl-phenyl]-ethensulfonyl}-2-[3-(2,2,2-trifluor-l,l-dimethyl-ethoxy)-4-trifluormethyl-phenyl]-l,3,8-triaza-spiro[4.5]dec-l-en-4-on; (1267) 2-[3-(l,l-difluor-ethyl)-phenyl]-8-{(E)-2-[4-(4-fluormethyl-4-hydroxy-piperidin-l-carbonyl)-2,6-dimethyl-phenyl]-ethensulfonyl}-l,3,8-triaza-spiro[4.5]dec-l-en-4-on; (1268) 8-{(E)-2-[4-(4-fluormethyl-4-hydroxy-piperidin-l-carbonyl)-2,6-dimethyl-phenyl]-ethensulfonyl>-2-(lH-indol-6-yl)-l,3,8-triaza-spiro[4.5]dec-l-en-4-on; (1269) 8-{(E)-2-[4-(4-fluormethyl-4-hydroxy-piperidin-l-carbonyl)-2,6-dimethyl-phenyl]-ethensulfonyl>-2-(4-trifluormethoxy-phenyl)-l,3,8-triaza-spiro[4.5]dec-l-en-4-on; (1270) 2-[4-chlor-3-(2,2,3,3,3-pentafluor-propoxy)-phenyl]-8-{(E)-2-[4-(4-fluormethyl-4-hydroxy-piperidin-l-carbonyl)-2,6-dimethyl-phenyl]-ethensulfonyl>- 1.3.8- triaza-spiro[4.5]dec-l-en-4-on; (1271) 2-[4-chlor-3-(2,2,2-trifluor-l,l-dimethyl-ethoxy)-phenyl]-8-{(E)-2-[4-(4-fluormethyl-4-hydroxy-piperidin-l-carbonyl)-2,6-dimethyl-phenyl]-ethensulfonyl>- 1.3.8- triaza-spiro[4.5]dec-l-en-4-on; (1272) 2-(3-[l,l,2,2,2-2H5]ethoxy-4-fluor-phenyl)-8-{(E)-2-[4-(4-fluormethyl-4-hydroxy-piperidin-l-carbonyl)-2,6-dimethyl-phenyl]-ethensulfonyl}-l,3,8-triaza-spiro[4.5]dec-l-en-4-on; (1273) 8-{(E)-2-[4-(4-fluormethyl-4-hydroxy-piperidin-l-carbonyl)-2,6-dimethyl-phenyl]-ethensulfonyl}-2-[3-(4,4,4-trifluor-butoxy)-4-trifluormethoxy-phenyl]- 1.3.8- triaza-spiro[4.5]dec-l-en-4-on; (1274) 8-{(E)-2-[4-(4-fluormethyl-4-hydroxy-pipendin-l-carbonyl)-2,6-dimethyl-phenyl]-ethensulfonyl>-2-[3-(2,2,3,3-tetrafluor-propoxy)-4-trifluormethyl-phenyl]- 1.3.8- triaza-spiro[4.5]dec-l-en-4-on; (1275) 2-(2,2-difluor-benzo[l,3]dioxol-5-yl)-8-{2-[4-(4-fluormethyl-4-hydroxy-piperidin-l-carbonyl)-2,6-dimethyl-phenyl]-ethansulfonyl>-1,3,8-triaza-spiro[4.5]dec-l-en-4-on; (1276) 8-{2-[4-(4-fluormethyl-4-hydroxy-pipendin-l-carbonyl)-2,6-dimethyl-phenyl]-ethansulfonyl>-2-(4-trifluormethoxy-phenyl)-l,3,8-triaza-spiro[4.5]dec-l-en-4-on; (1277) 8-{2-[4-(4-fluormethyl-4-hydroxy-piperidin-l-carbonyl)-2,6-dimethyl-phenyl]-ethansulfonyl>-2-(3-methyl-4-trifluormethyl-phenyl)-l,3,8-triaza-spiro[4.5]dec-l-en-4-on; (1278) 2-(3-chlor-4-trifluormethyl-phenyl)-8-{2-[4-(4-fluormethyl-4-hydroxy-pipendin-l-carbonyl)-2,6-dimethyl-phenyl]-ethansulfonyl>-l,3,8-triaza-spiro[4.5]dec-l-en-4-on; (1279) 8-{2-[4-(4-fluormethyl-4-hydroxy-piperidin-l-carbonyl)-2,6-dimethyl-phenyl]-ethansulfonyl>-2-[3-(2,2,3,3-tetrafluor-propoxy)-4-trifluormethyl-phenyl]- 1.3.8- triaza-spiro[4.5]dec-l-en-4-on; (1280) 2-(2,2-difluor-benzo[l,3]dioxol-5-yl)-8-{(E)-2-[4-(4-fluormethyl-4-hydroxy-pipendin-l-carbonyl)-2,6-dimethyl-phenyl]-ethensulfonyl}-l,3,8-triaza-spiro[4.5]dec-l-en-4-on; (1281) 8-{2-[4-(4-fluormethyl-4-hydroxy-piperidin-l-carbonyl)-2,6-dimethyl-phenyl]-ethansulfonyl>-2-(2,2,3,3-tetrafluor-2,3-dihydro-benzo[l,4]dioxin-6-yl)- 1.3.8- triaza-spiro[4.5]dec-l-en-4-on; (1282) [3-(8-{(E)-2-[4-(4-hydroxy-pipendin-l-carbonyl)-2,6-dimethyl-phenyl]-ethensulfonyl>-4-oxo-l,3,8-tnaza-spiro[4.5]dec-l-en-2-yl)-phenyl]-acetonitril; (1283) 8-{(E)-2-[2-methyl-4-(piperidin-4-yloxy)-phenyl]-ethensulfonyl>-2-(3-trifluormethoxy-phenyl)-l,3,8-tnaza-spiro[4.5]dec-l-en-4-on; (1284) 8-[2-(4-aminomethyl-2-methyl-phenyl)-ethansulfonyl]-2-[4-(3,3i3-trifluor-propyl)-cyclohexyl]-l,3,8-triaza-spiro[4.5]dec-l-en-4-on; (1285) 2-(4-methyl-cyclohexyl)-8-{(E)-2-[2-methyl-4-(2-oxo-piperazin-l-yl)-phenyl]-ethensulfonyl}-l,3,8-triaza-spiro[4.5]dec-l-en-4-on; (1286) 8-[2-(2,6-dimethyl-4-methylamino-phenyl)-ethansulfonyl]-2-pyrrolidin-2-yl-l,3,8-triaza-spiro[4.5]dec-l-en-4-on-hydrochlorid; (1287) 2-(l,l-difluor-ethyl)-8-[2-(2,6-dimethyl-4-methylamino-phenyl)-ethansulfonyl]-l,3,8-triaza-spiro[4.5]dec-l-en-4-on-hydrochlorid; (1288) 8-[(E)-2-(2,6-dimethyl-4-[l,l,l-2H3]methylamino-phenyl)-ethensulfonyl]-2-(4-fluor-3-trifluormethyl-phenyl)-l,3,8-triaza-spiro[4.5]dec-l-en-4-on-hydrochlorid; (1289) 8-[(E)-2-(2,6-dimethyl-4-methylaminomethyl-phenyl)-ethensulfonyl]-2-(4-methyl-cyclohexyl)-l,3,8-triaza-spiro[4.5]dec-l-en-4-on; (1290) 8-[(E)-2-(4-aminomethyl-2,6-dimethyl-phenyl)-ethensulfonyl]-2-[4-(3,3,3-trifluor-propyl)-cyclohexyl]-l,3,8-triaza-spiro[4.5]dec-l-en-4-on; (1291) 8-[(E)-2-(4-aminomethyl-2,6-dimethyl-phenyl)-ethensulfonyl]-2-(4-methyl-cyclohexyl)-l,3,8-triaza-spiro[4.5]dec-l-en-4-on; (1292) 8-[(E)-2-(2,6-dimethyl-4-methylaminomethyl-phenyl)-ethensulfonyl]-2-[4-(3,3,3-trifluor-propyl)-cyclohexyl]-l,3,8-triaza-spiro[4.5]dec-l-en-4-on; (1293) 8-[2-(4-amino-3-chlor-2-methyl-phenyl)-ethansulfonyl]-2-(4-ethyl-cyclohexyl)-l,3,8-triaza-spiro[4.5]dec-l-en-4-on; (1294) N-(l-acetyl-piperidin-4-yl)-N-(3-methyl-4-{(E)-2-[4-oxo-2-(3-trifluormethoxy-phenyl)-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl]-vinyl}-phenyl)-acetamid; (1295) 8-{2-[4-(4,5-dihydro-thiazol-2-ylamino)-2-methyl-phenyl]-ethansulfonyl}-2-(4-ethyl-cyclohexyl)-l,3,8-triaza-spiro[4.5]dec-l-en-4-on; (1296) N-[4-(2-(2-[4-(4-fluor-butyl)-cyclohexyl]-4-oxo-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl}-ethyl)-3-methyl-phenyl]-acetamid; (1297) l-(3,5-dimethyl-4-{2-[2-((lS,3R)-3-methyl-cyclohexyl)-4-oxo-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl]-ethyl}-phenyl)-l-methyl-unnstof; (1298) l-(3,5-dimethyl-4-{2-[4-oxo-2-(3,3,5,5-tetramethyl-cyclohexyl)-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl]-ethyl>-phenyl)-l-methyl-unnstof; (1299) 3-(3,5-dimethyl-4-{2-[2-(4-methyl-cyclohexyl)-4-oxo-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl]-ethyl>-phenyl)-5-hydroxymethyl-imidazoliden-2,4-dion; (1300) l-[3/5-dimethyl-4-((E)-2-14-oxo-2-[4-(3,3,3-trifluor-propyl)-cyclohexyl]- l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl}-vinyl)-benzyl]-l-methyl-urinstof; (1301) l-(3,5-dimethyl-4-{(E)-2-[2-(4-methyl-cyclohexyl)-4-oxo-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl]-vinyl}-benzyl)-l-methyl-urinstof; (1302) l-(3,5-dimethyl-4-{2-[4-oxo-2-(8,8,9,9,9-pentafluor-nonyl)-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl]-ethyl}-phenyl)-l-methyl-urinstof; (1303) l-(3,5-dimethyl-4-{(E)-2-[4-oxo-2-(8,8,9,9,9-pentafluor-nonyl)-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl]-vinyl}-phenyl)-l-methyl-urinstof; (1304) l-(3,5-dimethyl-4-{(E)-2-[4-oxo-2-(9,9,9-trifluor-nonyl)-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl]-vinyl>-phenyl)-l-methyl-urinstof; (1305) l-(3,5-dimethyl-4-{(E)-2-[4-oxo-2-(3-trifluormethylsulfanyl-phenyl)-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl]-vinyl>-phenyl)-l-methyl-urinstof; (1306) l-(3,5-dimethyl-4-{2-[4-oxo-2-(3-trifluormethylsulfanyl-phenyl)-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl]-ethyl>-phenyl)-l-methyl-urinstof; (1307) l-(4-{(E)-2-[2-(ll-hydroxy-undecyl)-4-oxo-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl]-vinyl>-3,5-dimethyl-phenyl)-l-methyl-urinstof; (1308) [ll-(8-{(E)-2-[2,6-dimethyl-4-(l-methyl-ureido)-phenyl]-ethensulfonyl>-4-oxo-l,3,8-triaza-spiro[4.5]dec-l-en-2-yl)-undecyl]-carbaminsyre-tert-butylester; (1309) l-(4-{(E)-2-[2-(9-hydroxy-nonyl)-4-oxo-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl]-vinyl}-3,5-dimethyl-phenyl)-l-methyl-urinstof; (1310) l-(4-{2-[2-(4-isopropyliden-cyclohexyl)-4-oxo-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl]-ethyl}-3,5-dimethyl-phenyl)-l-methyl-urinstof; (1311) l-(4-{2-[2-(l,l-difluor-ethyl)-4-oxo-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl]-ethyl}-3,5-dimethyl-phenyl)-l-methyl-urinstof; (1312) l-(4-{(E)-2-[2-(4-fluor-3-trifluornnethyl-phenyl)-4-oxo-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl]-vinyl>-3,5-dimethyl-phenyl)-l-[l,l,l-2H3]methyl-urinstof; (1313) [3,5-dimethyl-4-(2-{4-oxo-2-[4-(3,3,3-trifluor-propyl)-cyclohexyl]-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl>-ethyl)-benzyl]-urinstof; (1314) (3,5-dimethyl-4-{2-[2-(4-methyl-cyclohexyl)-4-oxo-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl]-ethyl}-benzyl)-urinstof; (1315) l-(4-{(E)-2-[2-(ll-amino-undecyl)-4-oxo-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl]-vinyl}-3,5-dimethyl-phenyl)-l-methyl-urinstof; (1316) l-[3,5-dimethyl-4-((E)-2-{4-oxo-2-[5-(propan-l-sulfinyl)-pentyl]-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl}-vinyl)-phenyl]-l-methyl-urinstof; (1317) l-(4-{2-[2-(6-ethansulfinyl-hexyl)-4-oxo-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl]-ethyl>-3,5-dimethyl-phenyl)-l-methyl-urinstof; (1318) l-[3,5-dimethyl-4-((E)-2-{4-oxo-2-[5-(propan-l-sulfonyl)-pentyl]-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl>-vinyl)-phenyl]-l-methyl-urinstof; (1319) l-(4-{(E)-2-[2-(7-methansulfonyl-heptyl)-4-oxo-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl]-vinyl>-3,5-dimethyl-phenyl)-l-methyl-urinstof; (1320) l-(4-{2-[2-(6-ethansulfonyl-hexyl)-4-oxo-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl]-ethyl}-3,5-dimethyl-phenyl)-l-methyl-urinstof; (1321) l-(4-{(E)-2-[2-(9,9-difluor-nonyl)-4-oxo-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl]-vinyl >-3,5-dimethyl-phenyl)-l-methyl-urinstof; (1322) l-(4-{2-[2-(9-hydroxy-nonyl)-4-oxo-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl]-ethyl}-3,5-dimethyl-phenyl)-l-methyl-urinstof; (1323) l-(4-{2-[2-(9,9-difluor-nonyl)-4-oxo-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl]-ethyl}-3,5-dimethyl-phenyl)-l-methyl-urinstof; (1324) l-(4-(2-[2-(9-amino-nonyl)-4-oxo-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl]-ethyl)-3,5-dimethyl-phenyl)-l-methyl-urinstof; (1325) l-(4-{(E)-2-[2-(9-fluor-nonyl)-4-oxo-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl]-vinyl>-3,5-dimethyl-phenyl)-l-methyl-urinstof; (1326) l-(4-{(Z)-2-[2-(9-fluor-nonyl)-4-oxo-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl]-vinyl>-3,5-dimethyl-phenyl)-l-methyl-urinstof; (1327) l-(4-{2-[2-(9-fluor-nonyl)-4-oxo-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl]-ethyl>-3,5-dimethyl-phenyl)-l-methyl-urinstof (1328) 8-{2-[4-((R)-2,3-dihydroxy-propoxy)-2,6-dimethyl-phenyl]-ethansulfonyl>-2-[3-(4,4,5,5,5-pentafluor-pentyloxy)-phenyl]-l,3,8-triaza-spiro[4.5]dec-l-en-4-on; (1329) 8-{2-[4-((R)-2,3-dihydroxy-propoxy)-2,6-dimethyl-phenyl]-ethansulfonyl>-2-(4-fluor-3-trifluomnethoxy-phenyl)-l,3,8-triaza-spiro[4.5]dec-l-en-4-on; (1330) 2-(2,2-difluor-benzo[l,3]dioxol-5-yl)-8-{2-[4-((R)-2,3-dihydroxy-propoxy)- 2,6-dimethyl-phenyl]-ethansulfonyl}-l,3,8-triaza-spiro[4.5]dec-l-en-4-on; (1331) 2-(2,2-difluor-benzo[l,3]dioxol-5-yl)-8-{2-[4-(3,4-dihydroxy-butoxy)-2-methyl-phenyl]-ethansulfonyl}-l,3,8-triaza-spiro[4.5]dec-l-en-4-on; (1332) 8-{2-[4-(3,4-dihydroxy-butoxy)-2-methyl-phenyl]-ethansulfonyl>-2-(4-fluor-3-trifluormethoxy-phenyl)-l,3,8-triaza-spiro[4.5]dec-l-en-4-on; (1333) 2-(2,2-difluor-benzo[l,3]dioxol-5-yl)-8-{2-[4-(4-hydroxy-piperidin-l-carbonyl)-2,6-dimethyl-phenyl]-ethansulfonyl>-l,3,8-triaza-spiro[4.5]dec-l-en-4-on; (1334) 2-(4-fluor-3-trifluormethoxy-phenyl)-8-{2-[4-(4-hydroxy-piperidin-l-carbonyl)-2,6-dimethyl-phenyl]-ethansulfonyl}-l,3,8-triaza-spiro[4.5]dec-l-en-4-on; (1335) 2-(4-fluor-3-trifluormethoxy-phenyl)-8-{2-[4-(4-hydroxy-4-nnethyl- piperidin-l-carbonyl)-2,6-dimethyl-phenyl]-ethansulfonyl}-l,3,8-triaza- spiro[4.5]dec-l-en-4-on; (1336) 2-(2,2-difluor-benzo[l,3]dioxol-5-yl)-8-{2-[4-(4-hydroxy-4-methyl-piperidin-l-carbonyl)-2,6-dimethylphenyl]-ethansulfonyl}-l,3,8-triaza-spiro[4.5]dec-l-en-4-on; (1337) 2-(4-fluor-3-trifluormethoxy-phenyl)-8-{2-[4-(3-hydroxy-azetidin-l-carbonyl)-2,6-dimethyl-phenyl]-ethansulfonyl}-l,3,8-triaza-spiro[4.5]dec-l-en-4-on; (1338) l-[3,5-dimethyl-4-(2-{4-oxo-2-[3-(4,4,4-trifluor-butoxy)-phenyl]-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl>-ethyl)-phenyl]-l-methyl-unnstof; (1339) l-[3,5-dimethyl-4-(2-{4-oxo-2-[4-(4,9,4-trifluor-butoxy)-phenyl]-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl}-ethyl)-phenyl]-l-methyl-urinstof; (1340) l-(3,5-dimethyl-4-{2-[4-oxo-2-(5-phenyl-pentyl)-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl]-ethyl}-phenyl)-l-methyl-urinstof; (1341) l-(3,5-dimethyl-4-{2-[2-(3-nonafluorbutyl-phenyl)-4-oxo-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl]-ethyl>-phenyl)-l-methyl-urinstof; (1342) l-(3,5-dimethyl-4-{2-[4-oxo-2-(4-pentyl-phenyl)-l,3,8-tnaza-spiro[4.5]dec-l-en-8-sulfonyl]-ethyl>-phenyl)-l-methyl-urinstof; (1343) l-(3,5-dimethyl-4-{2-[4-oxo-2-((lS,3R)-3-propylcyclohexyl)-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl] - ethyl}-phenyl)-l-methyl-urinstof; (1344) l-(4-{2-[2-(6-ethoxy-hexyl)-4-oxo-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl]-ethyl>-3,5-dimethyl-phenyl)-l-methyl-urinstof; (1345) l-[3,5-dimethyl-4-(2-{4-oxo-2-[3-(6,6,6-trifluor-hexyl)-phenyl]-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl}-ethyl)-phenyl]-l-methyl-urinstof; (1346) l-[3,5-dimethyl-4-(2-{4-oxo-2-[4-(6,6,6-trifluor-hexyl)-phenyl]-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl>-ethyl)-phenyl]-l-nnethyl-urinstof; (1347) 12-(8-{2-[2,6-dimethyl-4-(l-methyl-ureido)-phenyl]-ethansulfonyl}-4-oxo- l,3,8-triaza-spiro[4.5]dec-l-en-2-yl)-dodecansyreethylester; (1348) l-(3,5-dimethyl-4-{2-[4-oxo-2-(9-phenyl-nonyl)-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl]-ethyl}-phenyl)-l-methyl-urinstof; (1349) l-(3,5-dimethyl-4-{2-[4-oxo-2-(6-phenyl-hexyl)-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl]-ethyl}-phenyl)-l-methyl-urinstof; (1350) 14-(8-{2-[2,6-dimethyl-4-(l-methyl-ureido)-phenyl]-ethansulfonyl}-4-oxo- l,3,8-triaza-spiro[4.5]dec-l-en-2-yl)-tetradecansyre; (1351) l-(4-{2-[2-(7-methoxy-heptyl)-4-oxo-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl]-ethyl}-3,5-dimethyl-phenyl)-l-methyl-urinstof; (1352) l-(3,5-dimethyl-4-{2-[4-oxo-2-(5-propoxy-pentyl)-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl]-ethyl>-phenyl)-l-methyl-urinstof; (1353) l-(3,5-dimethyl-4-{2-[4-oxo-2-(3-propyl-nonyl)-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl]-ethyl>-phenyl)-l-methyl-urinstof; (1354) l-(4-{2-[2-(3-methoxy-4-pentyl-phenyl)-4-oxo-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl]-ethyl}-3,5-dimethyl-phenyl)-l-methyl-urinstof; (1355) l-(3,5-dimethyl-4-{2-[4-oxo-2-(2-propyl-benzofuran-6-yl)-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl]-ethyl>-phenyl)-l-methyl-urinstof; (1356) l-[3,5-dimethyl-4-(2-{4-oxo-2-[5-(propan-l-sulfonyl)-pentyl]-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl>-ethyl)-phenyl]-l-methyl-urinstof; (1357) l-(4-{2-[2-(7-methansulfonyl-heptyl)-4-oxo-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl]-ethyl>-3,5-dimethyl-phenyl)-l-methyl-urinstof; (1358) l-[3,5-dimethyl-4-(2-{4-oxo-2-[4-(4,4,4-trifluor-butyl)-phenyl]-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl>-ethyl)-phenyl]-l-methyl-urinstof; (1359) l-[3,5-dimethyl-4-(2-{4-oxo-2-[3-(4,4,4-trifluor-butyl)-phenyl]-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl>-ethyl)-phenyl]-l-methyl-urinstof; (1360) [ll-(8-{2-[2,6-dimethyl-4-(l-methyl-ureido)-phenyl]-ethansulfonyl>-4-oxo-l,3,8-triaza-spiro[4.5]dec-l-en-2-yl)-undecyl]-carbaminsyre-tert-butylester; (1361) l-(4-{2-[2-(ll-hydroxy-undecyl)-4-oxo-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl]-ethyl>-3,5-dimethyl-phenyl)-l-methyl-urinstof; (1362) 10-(8-{2-[2,6-dimethyl-4-(l-methyl-ureido)-phenyl]-ethansulfonyl}-4-oxo- 1.3.8- triaza-spiro[4.5]dec-l-en-2-yl)-decansyre; (1363) 10-(8-{2-[2,6-dimethyl-4-(l-methyl-ureido)-phenyl]-ethansulfonyl>-4-oxo- 1.3.8- triaza-spiro[4.5]dec-l-en-2-yl)-decansyre amid; (1364) l-(3,5-dimethyl-4-{2-[2-(4-[1,1,1-2H3]-methyl-[4-2Hi]cyclohexyl)-4-oxo-1,3, 8-triaza-spiro[4.5]dec-l-en-8-sulfonyl]-ethyl>-phenyl)-l-methyl-urinstof; (1365) l-(3,5-dimethyl-4-{(E)-2-[4-oxo-2-(9-phenyl-nonyl)-l,3,8-tnaza-spiro[4.5]dec-l-en-8-sulfonyl]-vinyl>-phenyl)-l-methyl-urinstof; (1366) l-(4-{2-[2-(ll-amino-undecyl)-4-oxo-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl]-ethyl>-3,5-dimethyl-phenyl)-l-methyl-urinstof; (1367) 3-[(3,5-dimethyl-4-{2-[2-(4-methyl-cyclohexyl)-4-oxo-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl]-ethyl>-phenyl)-methyl-amino]-4-ethoxy-cyclobut-3-en-l,2-dion; (1368) 3-amino-4-[(3,5-dimethyl-4-{2-[2-(4-methyl-cyclohexyl)-4-oxo-1,3,8-triaza-spiro[4.5] dec-l-en-8-sulfonyl]-ethyl>-phenyl)-methyl-amino]-cyclobut-3-en-l,2-dion; (1369) 3-dimethylamino-4-[(3,5-dimethyl-4-{2-[2-(4-methyl-cyclohexyl)-4-oxo- 1.3.8- triaza-spiro[4.5]dec-l-en-8-sulfonyl]-ethyl}-phenyl)-methyl-amino]-cyclobut-3-en-l,2-dion; (1370) N-(4-{2-[2-(4-ethynyl-cyclohexyl)-4-oxo-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl]-ethyl>-3-methyl-phenyl)-acetamid; (1371) l-(4-{2-[4-[(Z)-hydroxyimino]-2-(4-methylcyclohexyl)-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl]-ethyl}-3,5-dimethyl-phenyl)-l-methyl-urinstof; (1372) 2-(4-methyl-cyclohexyl)-4-oxo-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonsyre 2-methyl-benzylamid; (1373) 2-(4-methyl-cyclohexyl)-4-oxo-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonsyre (2-o-tolyl-ethyl)-amid; (1374) 2-cyclohexyl-8-{2-[l-((S)-2,3-dihydroxy-propyl)-lH-indol-4-yl]-2-hydroxy-ethansulfonyl}-l,3,8-triaza-spiro[4.5]dec-l-en-4-on; (1375) 2-cyclohexyl-8-(2-oxo-2-o-tolyl-ethansulfonyl)-l,3,8-triaza-spiro[4.5]dec-l-en-4-on; (1376) 2-cyclohexyl-8-(2-o-tolyl-ethynesulfonyl)-l,3,8-triaza-spiro[4.5]dec-l-en-4-on; (1377) 2-cyclohexyl-8-[2-(lH-indol-4-yl)-ethynesulfonyl]-l,3,8-triaza-spiro[4.5]dec-l-en-4-on; (1378) 3,5,N,N-tetramethyl-4-(2-{4-oxo-2-[4-(3,3,3-trifluor-propyl)-cyclohexyl]- l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl}-ethyl)-benzannid; (1379) 3,5,N,l\l-tetramethyl-4-{2-[2-(4-methyl-cyclohexyl)-4-oxo-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl]-ethyl}-benzamid; (1380) 8-{2-[4-(4-hydroxy-4-methyl-piperidin-l-carbonyl)-2,6-dimethyl-phenyl]-ethansulfonyl>-2-[4-(3,3,3-trifluor-propyl)-cyclohexyl]-l,3,8-triaza-spiro[4.5]dec-l-en-4-on; (1381) 8-{2-[4-(4-fluormethyl-4-hydroxy-piperidin-l-carbonyl)-2,6-dimethyl-phenyl]-ethansulfonyl}-2-[4-(3,3,3-trifluor-propyl)-cyclohexyl]-l,3,8-triaza- spiro[4.5]dec-l-en-4-on; (1382) 8-{2-[4-(4-hydroxy-4-methyl-pipendin-l-carbonyl)-2,6-dimethyl-phenyl]-ethansulfonyl}-2-(4-methyl-cyclohexyl)-l,3,8-triaza-spiro[4.5]dec-l-en-4-on; (1383) 8-{2-[4-(4-fluormethyl-4-hydroxy-piperidin-l-carbonyl)-2,6-dimethyl-phenyl]-ethansulfonyl>-2-(4-methyl-cyclohekyl)-l,3,8-triaza-spiro[4.5]dec-l-en-4-on; (1384) 8-(2-{4-[4-((R)-2,3-dihydroxy-propoxy)-piperidin-l-carbonyl]-2,6-dimethyl-phenyl>-ethansulfonyl)-2-[4-(3,3,3-trifluor-propyl)-cyclohexyl]-l,3,8-triaza-spiro[4.5]dec-l-en-4-on; (1385) 3,5-dimethyl-4-(2-{4-oxo-2-[4-(3,3,3-trifluor-propyl)-cyclohexyl]-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl>-ethyl)-benzoesyre-hydrazid; (1386) 8-{2-[2,6-dimethyl-4-(pyrazoliden-l-carbonyl)-phenyl]-ethansulfonyl}-2-[4-(3,3,3-trifluor-propyl)-cyclohexyl]-l,3,8-triaza-spiro[4.5]dec-l-en-4-on; (1387) N, N-di methyl-2-(3-nnethyl-4-{2-[2-(4-nnethyl-cyclohexyl)-4-oxo-1,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl]-ethyl>-phenyl)-acetannid; (1388) N-methoxy-2-(3-methyl-4-{2-[2-(4-methylcyclohexyl)-4-oxo-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl]-ethyl}-phenyl)-acetamid; (1389) l-[3,5-dimethyl-4-(2-{4-oxo-2-[4-(3,3,3-tnfluor-propyl)-cyclohexyl]-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl>-ethyl)-benzyl]-l-methyl-urinstof; (1390) l-(3,5-dimethyl-4-{2-[2-(4-methyl-cyclohexyl)-4-oxo-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl]-ethyl}-benzyl)-l-methyl-urinstof; (1391) l-(4-{2-[2-(4-fluor-3-trifluormethyl-phenyl)-4-oxo-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl]-ethyl}-3,5-dimethyl-phenyl)-l-[l,l,l-2H3]methyl-urinstof; (1392) 2-cyclohexyl-8-{2-[l-((2S,3S)-2,3,4-trihydroxy-butyl)-lH-indol-4-yl]-ethansulfonyl>-l,3,8-triaza-spiro[4.5]dec-l-en-4-on; (1393) 8-{2-[l-((2S,3S)-4-benzyloxy-2,3-dihydroxy-butyl)-lH-indol-4-yl]-ethansulfonyl>-2-cyclohexyl-l,3,8-triaza-spiro[4.5]dec-l-en-4-on; (1394) N-[3-methyl-4-(2-{4-oxo-2-[4-(3,3,3-trifluor-propyl)-cyclohexyl]-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl}-ethyl)-benzyl]-acetamid; (1395) 3,N,N-trimethyl-4-{2-[4-oxo-2-(3-trifluormethyl-phenylamino)-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl]-ethyl>-benzamid; (1396) 3,N,N-tnmethyl-4-{2-[4-oxo-2-(4-trifluormethyl-phenylamino)-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl>-ethyl]-benzamid; (1397) 3,N,N-tnmethyl-4-{2-[2-(methyl-phenyl-annino)-4-oxo-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl]-ethyl>-benzamid; (1398) 4-{2-[2-(benzyl-methyl-amino)-4-oxo-l,3,8-tnaza-spiro[4.5]dec-l-en-8-sulfonyl]-ethyl>-3,N,N-trimethyl-benzannid; (1399) 4-{2-[2-(cyclohexylmethyl-amino)-4-oxo-l,3,8-tnaza-spiro[4.5]dec-l-en-8-sulfonyl]-ethyl>-3,N,N-trimethyl-benzannid; (1400) 3,N,N-trimethyl-4-(2-{2-[methyl-(4-trifluormethyl-phenyl)-amino]-4-oxo- l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl>-ethyl)-benzamid; (1401) N-(3-methyl-4-{2-[4-oxo-2-(4-trifluornnethyl-phenylannino)-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl]-ethyl>-phenyl)-acetamid; (1402) N-(3-methyl-4-{2-[4-oxo-2-(3-trifluornnethyl-phenylannino)-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl]-ethyl>-phenyl)-acetamid; (1403) 4-{2-[2-(4-butyl-piperidin-l-yl)-4-oxo-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl]-ethyl>-3,N,N-trimethyl-benzannid; (1404) 4-{2-[2-(4-butyl-cyclohexylamino)-4-oxo-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl]-ethyl>-3,N,N-trimethyl-benzannid; (1405) 4-{2-[2-(3-but-3-enyloxy-5-trifluornnethylphenyl)-4-oxo-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl]-ethyl>-3,N-dimethyl-N-pent-4-enyl-benzamid; (1419) N-(2-allyloxy-ethyl)-4-{2-[2-(3-but-3-enyloxy-5-trifluormethyl-phenyl)-4-oxo-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl]-ethyl}-3,N-dimethyl-benzamid; (1443) dec-9-ensyre {4-[2-(2-hex-5-enyl-4-oxo-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl)-ethyl]-3,5-dimethyl-phenyl}-methyl-amid; or (1446) hept-6-ensyre {4-[2-(2-hex-5-enyl-4-oxo-l,3,8-triaza-spiro[4.5]dec-l-en-8-sulfonyl)-ethyl]-3,5-dimethyl-phenyl}-methyl-amid, eller et farmakologisk acceptabelt salt deraf.
11. Forbindelsen eller et farmakologisk acceptabelt salt deraf ifølge et hvilket som helst af kravene 1 til 5, hvor U betegner C1-C6 alkylen eller en hvilken som helst gruppe valgt grupperne betegnet med følgende formel:
(NB: "e" væk fra imidazolon) A er 0; R46 er valgt fra hydrogen, C1-C10 alkyl, C1-C10 haloalkyl og C1-C10 hydroxyalkyl; V er valgt fra:
E er pyrrolidin eller piperidin eventuelt substitueret med en hydroxylgruppe; og R7 er valgt fra: 1) hydrogen, 2) C1-C10 alkyl og 3) C1-C10 hydroxyalkyl.
12. Farmaceutisk sammensætning omfattende forbindelsen eller et farmakologisk acceptabelt salt deraf ifølge et hvilket som helst af kravene 1 til 11 som en aktiv bestanddel.
13. Et profylaktisk eller terapeutisk middel til anvendelse i behandlingen eller forebyggelse af osteoporose, fraktur, osteomalaci, arthritis, trombocytopeni, hypoparathyroidisme, hyperphosphatemi eller tumoral calcinose, omfattende forbindelsen eller et farmakologisk acceptabelt salt deraf ifølge et hvilket som helst af kravene 1 til 11 som en aktiv bestanddel.
14. Anvendelse af forbindelsen eller et farmakologisk acceptabelt salt deraf ifølge et hvilket som helst af kravene 1 til 11 til fremstillingen af et profylaktisk eller terapeutisk middel til anvendelse i behandlingen eller forebyggelse af osteoporose, fraktur, osteomalaci, arthritis, trombocytopeni, hypoparathyroidisme, hyperphosphatemi eller tumoral calcinose.
15. Forbindelsen eller et farmakologisk acceptabelt salt deraf ifølge et hvilket som helst af kravene 1 til 11 til anvendelse i behandlingen eller forebyggelse af osteoporose, fraktur, osteomalaci, arthritis, trombocytopeni, hypoparathyroidisme, hyperphosphatemi eller tumoral calcinose.
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