DK2428205T3 - Modificerede formuleringer indeholdende lægemiddel-ionbytterharpikskomplekser - Google Patents
Modificerede formuleringer indeholdende lægemiddel-ionbytterharpikskomplekserInfo
- Publication number
- DK2428205T3 DK2428205T3 DK11192711.7T DK11192711T DK2428205T3 DK 2428205 T3 DK2428205 T3 DK 2428205T3 DK 11192711 T DK11192711 T DK 11192711T DK 2428205 T3 DK2428205 T3 DK 2428205T3
- Authority
- DK
- Denmark
- Prior art keywords
- exchange resin
- ion exchange
- resin complex
- formulations containing
- containing pharmaceutical
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5005—Wall or coating material
- A61K9/5021—Organic macromolecular compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, cocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
- A61K31/137—Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/155—Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (N=C(OH)—NH2), isothiourea (—N=C(SH)—NH2)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/216—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acids having aromatic rings, e.g. benactizyne, clofibrate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/235—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids having an aromatic ring attached to a carboxyl group
- A61K31/24—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids having an aromatic ring attached to a carboxyl group having an amino or nitro group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4402—Non condensed pyridines; Hydrogenated derivatives thereof only substituted in position 2, e.g. pheniramine, bisacodyl
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4458—Non condensed piperidines, e.g. piperocaine only substituted in position 2, e.g. methylphenidate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/485—Morphinan derivatives, e.g. morphine, codeine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/58—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. poly[meth]acrylate, polyacrylamide, polystyrene, polyvinylpyrrolidone, polyvinylalcohol or polystyrene sulfonic acid resin
- A61K47/585—Ion exchange resins, e.g. polystyrene sulfonic acid resin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
- A61K47/6921—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a particulate, a powder, an adsorbate, a bead or a sphere
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
- A61K47/6921—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a particulate, a powder, an adsorbate, a bead or a sphere
- A61K47/6927—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a particulate, a powder, an adsorbate, a bead or a sphere the form being a solid microparticle having no hollow or gas-filled cores
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
- A61K47/6921—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a particulate, a powder, an adsorbate, a bead or a sphere
- A61K47/6927—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a particulate, a powder, an adsorbate, a bead or a sphere the form being a solid microparticle having no hollow or gas-filled cores
- A61K47/6929—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a particulate, a powder, an adsorbate, a bead or a sphere the form being a solid microparticle having no hollow or gas-filled cores the form being a nanoparticle, e.g. an immuno-nanoparticle
- A61K47/6931—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a particulate, a powder, an adsorbate, a bead or a sphere the form being a solid microparticle having no hollow or gas-filled cores the form being a nanoparticle, e.g. an immuno-nanoparticle the material constituting the nanoparticle being a polymer
- A61K47/6933—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a particulate, a powder, an adsorbate, a bead or a sphere the form being a solid microparticle having no hollow or gas-filled cores the form being a nanoparticle, e.g. an immuno-nanoparticle the material constituting the nanoparticle being a polymer the polymer being obtained by reactions only involving carbon to carbon, e.g. poly(meth)acrylate, polystyrene, polyvinylpyrrolidone or polyvinylalcohol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
- A61K9/0056—Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
- A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1635—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1664—Compounds of unknown constitution, e.g. material from plants or animals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/167—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction with an outer layer or coating comprising drug; with chemically bound drugs or non-active substances on their surface
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2013—Organic compounds, e.g. phospholipids, fats
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/2027—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/2031—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyethylene oxide, poloxamers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
- A61K9/2077—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
- A61K9/2077—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets
- A61K9/2081—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets with microcapsules or coated microparticles according to A61K9/50
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4841—Filling excipients; Inactive ingredients
- A61K9/4866—Organic macromolecular compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5005—Wall or coating material
- A61K9/5021—Organic macromolecular compounds
- A61K9/5026—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Emergency Medicine (AREA)
- Zoology (AREA)
- Nanotechnology (AREA)
- Physiology (AREA)
- Nutrition Science (AREA)
- Dispersion Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Biophysics (AREA)
- Botany (AREA)
- Molecular Biology (AREA)
- Immunology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Inorganic Chemistry (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US78318106P | 2006-03-16 | 2006-03-16 | |
EP07753217A EP2018160B1 (en) | 2006-03-16 | 2007-03-15 | Modified release formulations containing drug-ion exchange resin complexes |
Publications (1)
Publication Number | Publication Date |
---|---|
DK2428205T3 true DK2428205T3 (da) | 2012-10-22 |
Family
ID=38512117
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK07753217.4T DK2018160T3 (da) | 2006-03-16 | 2007-03-15 | Modificeret depotformuleringer indeholdende lægemiddel-ionbytterharpikskomplekser |
DK11192711.7T DK2428205T3 (da) | 2006-03-16 | 2007-03-15 | Modificerede formuleringer indeholdende lægemiddel-ionbytterharpikskomplekser |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK07753217.4T DK2018160T3 (da) | 2006-03-16 | 2007-03-15 | Modificeret depotformuleringer indeholdende lægemiddel-ionbytterharpikskomplekser |
Country Status (14)
Country | Link |
---|---|
US (23) | US8062667B2 (da) |
EP (2) | EP2428205B1 (da) |
JP (1) | JP5479086B2 (da) |
KR (1) | KR101495146B1 (da) |
CN (2) | CN102488652B (da) |
AT (1) | ATE536867T1 (da) |
BR (1) | BRPI0709606B8 (da) |
CA (1) | CA2645855C (da) |
DK (2) | DK2018160T3 (da) |
ES (2) | ES2396039T3 (da) |
IL (1) | IL194042A (da) |
RU (1) | RU2435569C2 (da) |
TW (1) | TW200812649A (da) |
WO (1) | WO2007109104A2 (da) |
Cited By (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US11400065B2 (en) | 2019-03-01 | 2022-08-02 | Flamel Ireland Limited | Gamma-hydroxybutyrate compositions having improved pharmacokinetics in the fed state |
US11504347B1 (en) | 2016-07-22 | 2022-11-22 | Flamel Ireland Limited | Modified release gamma-hydroxybutyrate formulations having improved pharmacokinetics |
US11583510B1 (en) | 2022-02-07 | 2023-02-21 | Flamel Ireland Limited | Methods of administering gamma hydroxybutyrate formulations after a high-fat meal |
US11602512B1 (en) | 2016-07-22 | 2023-03-14 | Flamel Ireland Limited | Modified release gamma-hydroxybutyrate formulations having improved pharmacokinetics |
US11602513B1 (en) | 2016-07-22 | 2023-03-14 | Flamel Ireland Limited | Modified release gamma-hydroxybutyrate formulations having improved pharmacokinetics |
US11779557B1 (en) | 2022-02-07 | 2023-10-10 | Flamel Ireland Limited | Modified release gamma-hydroxybutyrate formulations having improved pharmacokinetics |
US11839597B2 (en) | 2016-07-22 | 2023-12-12 | Flamel Ireland Limited | Modified release gamma-hydroxybutyrate formulations having improved pharmacokinetics |
US11986451B1 (en) | 2016-07-22 | 2024-05-21 | Flamel Ireland Limited | Modified release gamma-hydroxybutyrate formulations having improved pharmacokinetics |
Families Citing this family (126)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1429739A1 (en) | 2001-09-21 | 2004-06-23 | Egalet A/S | Polymer release system |
US20040253310A1 (en) | 2001-09-21 | 2004-12-16 | Gina Fischer | Morphine polymer release system |
EP1610767B1 (en) | 2003-03-26 | 2011-01-19 | Egalet A/S | Morphine controlled release system |
US7201920B2 (en) | 2003-11-26 | 2007-04-10 | Acura Pharmaceuticals, Inc. | Methods and compositions for deterring abuse of opioid containing dosage forms |
US8343546B2 (en) * | 2005-09-13 | 2013-01-01 | Coating Place, Inc. | Ion exchange resin treated to control swelling |
DK2018160T3 (da) | 2006-03-16 | 2012-02-06 | Tris Pharma Inc | Modificeret depotformuleringer indeholdende lægemiddel-ionbytterharpikskomplekser |
WO2008042218A1 (en) | 2006-10-03 | 2008-04-10 | Tris Pharma, Inc. | Formulations containing an ionic mineral-ion exchange resin complex and uses thereof |
WO2008129501A2 (en) * | 2007-04-20 | 2008-10-30 | Wockhardt Research Centre | Pharmaceutical compositions of duloxetine |
US8202542B1 (en) | 2007-05-31 | 2012-06-19 | Tris Pharma | Abuse resistant opioid drug-ion exchange resin complexes having hybrid coatings |
US8821928B2 (en) | 2007-06-04 | 2014-09-02 | Egalet Ltd. | Controlled release pharmaceutical compositions for prolonged effect |
BRPI0815387B8 (pt) * | 2007-08-13 | 2021-05-25 | Abuse Deterrent Pharmaceutical Llc | composição farmacêutica, método para fazer uma composição farmacêutica e uso da composição farmacêutica |
USRE48948E1 (en) | 2008-04-18 | 2022-03-01 | Warsaw Orthopedic, Inc. | Clonidine compounds in a biodegradable polymer |
EP2265259A1 (en) * | 2008-04-25 | 2010-12-29 | Cadila Healthcare Limited | Rapidly disintegrating oral compositions of tramadol |
GB0814466D0 (en) * | 2008-08-07 | 2008-09-10 | Rosemont Pharmaceuticals Ltd | Sertraline composition |
CA2638240C (en) * | 2008-08-29 | 2010-02-02 | Alexander Macgregor | Method of treating dysglycemia and glucose excursions |
WO2010089132A1 (en) | 2009-02-06 | 2010-08-12 | Egalet A/S | Immediate release composition resistant to abuse by intake of alcohol |
US20100280059A1 (en) * | 2009-05-01 | 2010-11-04 | Atley Pharmaceuticals, Inc. | Compositions comprising an antihistamine, antitussive and decongestant in extended release formulations |
WO2010127100A1 (en) * | 2009-05-01 | 2010-11-04 | Atley Pharmaceuticals, Inc. | Compositions comprising an antihistamine, antitussive and decongestant in extented release formulations |
EP2445487A2 (en) | 2009-06-24 | 2012-05-02 | Egalet Ltd. | Controlled release formulations |
AU2010300641B2 (en) | 2009-09-30 | 2016-03-17 | Acura Pharmaceuticals, Inc. | Methods and compositions for deterring abuse |
US20120076865A1 (en) | 2010-03-24 | 2012-03-29 | Jazz Pharmaceuticals, Inc. | Controlled release dosage forms for high dose, water soluble and hygroscopic drug substances |
US9211292B2 (en) * | 2010-04-21 | 2015-12-15 | Alitair Pharmaceuticals Inc | Preventing or reducing drug abuse and overdose events |
US8617602B2 (en) * | 2010-09-03 | 2013-12-31 | William Wayne Howard | Immediate release compositions and methods for delivering drug formulations using weak acid ion exchange resins in abnormally high pH environments |
US8623409B1 (en) | 2010-10-20 | 2014-01-07 | Tris Pharma Inc. | Clonidine formulation |
US20130230587A1 (en) | 2010-11-10 | 2013-09-05 | Rubicon Research Private Limited | Sustained release compositions |
US8287903B2 (en) * | 2011-02-15 | 2012-10-16 | Tris Pharma Inc | Orally effective methylphenidate extended release powder and aqueous suspension product |
AU2011359405A1 (en) * | 2011-02-15 | 2013-08-22 | Tris Pharma, Inc. | Extended release powder and aqueous suspension comprising methylphenidate |
WO2013003622A1 (en) * | 2011-06-28 | 2013-01-03 | Neos Therapeutics, Lp | Dosage forms for oral administration and methods of treatment using the same |
WO2013003845A1 (en) * | 2011-06-30 | 2013-01-03 | Neos Therapeutics, Lp | Abuse resistant drug forms |
US20130105399A1 (en) * | 2011-11-02 | 2013-05-02 | University Of Illinois Urbana Champaign | Polymer-encapsulated liquid exchange media |
WO2013088271A1 (en) * | 2011-12-14 | 2013-06-20 | Wockhardt Limited | Modified release liquid pharmaceutical composition comprising bromopheniramine, pseudoephedrine and dextromethorphan |
WO2013119231A1 (en) * | 2012-02-09 | 2013-08-15 | Tris Pharma, Inc. | Abuse resistant opioid drug - ion exchange resin complexes having hybrid coatings |
JP6067100B2 (ja) | 2012-04-18 | 2017-01-25 | マリンクロッド エルエルシー | 即放性乱用抑止医薬組成物 |
ES2728850T3 (es) | 2012-05-02 | 2019-10-29 | Capsugel Belgium Nv | Dispersiones acuosas de acetato acetato succinato de hidroxipropilmetilcelulosa (HPMCAS) |
JP2015521988A (ja) | 2012-07-06 | 2015-08-03 | イガレット・リミテッド | 制御放出用乱用防止性医薬組成物 |
DK2884961T3 (da) | 2012-08-15 | 2019-04-23 | Tris Pharma Inc | Methylphenidat-tyggetablet med forlænget frigivelse |
CN102885791B (zh) * | 2012-09-24 | 2015-03-04 | 浙江万晟药业有限公司 | 一种制备盐酸非索非那定口腔崩解片的方法 |
JP5922851B2 (ja) | 2012-11-30 | 2016-05-24 | アキュラ・ファーマシューティカルズ・インコーポレーテッド | 活性医薬成分の自己制御放出 |
WO2014095818A1 (en) * | 2012-12-20 | 2014-06-26 | Synthon B.V. | Formulation comprising amorphous agomelatine |
EP2749309B1 (en) | 2012-12-28 | 2016-04-27 | Cook Medical Technologies LLC | Ion exchange ureteral stent |
US9180104B2 (en) | 2013-03-13 | 2015-11-10 | Tris Pharma, Inc. | Benzonatate modified release solid tablets and capsules |
EP2968151B1 (en) | 2013-03-13 | 2017-04-19 | Tris Pharma, Inc. | Benzonatate modified release solid tablets and capsules |
US20140275038A1 (en) | 2013-03-15 | 2014-09-18 | Inspirion Delivery Technologies, Llc | Abuse deterrent compositions and methods of use |
US20140271891A1 (en) * | 2013-03-15 | 2014-09-18 | Mcneil-Ppc, Inc. | Phenylephrine resinate particles and use thereof in pharmaceutical formulations |
US20140271893A1 (en) | 2013-03-15 | 2014-09-18 | Mcneil-Ppc, Inc. | Coated phenylephrine particles and use thereof in pharmaceutical formulations |
CA2901802C (en) | 2013-03-15 | 2021-03-02 | Mallinckrodt Llc | Abuse deterrent solid dosage form for immediate release with functional score |
US20140271892A1 (en) * | 2013-03-15 | 2014-09-18 | Mcneil-Ppc, Inc. | Phenylephrine resinate particles having good auc |
US10420729B2 (en) * | 2013-03-15 | 2019-09-24 | R.P. Scherer Technologies, Llc | Abuse resistant capsule |
US9782516B2 (en) * | 2013-03-15 | 2017-10-10 | Abbott Cardiovascular Systems Inc. | Tissue adhesive coatings for drug coated balloon |
US20140309270A1 (en) | 2013-04-11 | 2014-10-16 | Richard Louis Price | Diagnosis and treatment of a form of autistic spectrum disorder |
US20170348417A1 (en) | 2013-04-11 | 2017-12-07 | Richard Louis Price | Treatment of attention deficit disorders and associated symptoms |
US9211284B2 (en) | 2013-04-11 | 2015-12-15 | Richard Louis Price | Diagnosis and treatment of P.R.I.C.E. syndrome |
US9603812B2 (en) | 2013-04-11 | 2017-03-28 | Richard Louis Price | Treatment of autistic spectrum disorder |
US10098848B2 (en) | 2013-04-11 | 2018-10-16 | Richard Louis Price | Inositol-containing comestible units and methods of treatment using the same |
US10195153B2 (en) | 2013-08-12 | 2019-02-05 | Pharmaceutical Manufacturing Research Services, Inc. | Extruded immediate release abuse deterrent pill |
US9770514B2 (en) | 2013-09-03 | 2017-09-26 | ExxPharma Therapeutics LLC | Tamper-resistant pharmaceutical dosage forms |
WO2015037019A2 (en) * | 2013-09-15 | 2015-03-19 | Rubicon Research Private Limited | Modified release pharmaceutical formulations |
EP3065720A1 (en) | 2013-11-04 | 2016-09-14 | Capsugel Belgium NV | Methods and systems for improved bioavailability of active pharmaceutical ingredients including esomeprazole |
WO2015076821A1 (en) * | 2013-11-22 | 2015-05-28 | Tris Pharma, Inc. | Novel clonidine formulation |
EP2875817B1 (en) * | 2013-11-26 | 2020-03-18 | Synhton B.V. | Pharmaceutical formulation comprising amorphous lenalidomide |
WO2015088990A1 (en) | 2013-12-09 | 2015-06-18 | Durect Corporation | Pharmaceutically active agent complexes, polymer complexes, and compositions and methods involving the same |
US10172797B2 (en) | 2013-12-17 | 2019-01-08 | Pharmaceutical Manufacturing Research Services, Inc. | Extruded extended release abuse deterrent pill |
US9492444B2 (en) | 2013-12-17 | 2016-11-15 | Pharmaceutical Manufacturing Research Services, Inc. | Extruded extended release abuse deterrent pill |
WO2015120201A1 (en) * | 2014-02-05 | 2015-08-13 | Kashiv Pharma, Llc | Abuse-resistant drug formulations with built-in overdose protection |
CN103860464B (zh) * | 2014-03-19 | 2016-03-16 | 广州帝奇医药技术有限公司 | 一种抗过敏药物缓释混悬剂及其制备方法 |
US9616029B2 (en) | 2014-03-26 | 2017-04-11 | Sun Pharma Advanced Research Company Ltd. | Abuse deterrent immediate release coated reservoir solid dosage form |
US9962336B2 (en) | 2014-05-01 | 2018-05-08 | Sun Pharmaceutical Industries Limited | Extended release suspension compositions |
US20180104197A9 (en) | 2014-05-01 | 2018-04-19 | Sun Pharmaceutical Industries Limited | Extended release liquid compositions of metformin |
WO2015166473A1 (en) | 2014-05-01 | 2015-11-05 | Sun Pharmaceutical Industries Limited | Extended release suspension compositions |
US10258583B2 (en) | 2014-05-01 | 2019-04-16 | Sun Pharmaceutical Industries Limited | Extended release liquid compositions of guanfacine |
CA2952223C (en) * | 2014-06-13 | 2023-08-01 | United Therapeutics Corporation | Treprostinil formulations |
CN104027306A (zh) * | 2014-06-25 | 2014-09-10 | 万特制药(海南)有限公司 | 帕罗西汀口服混悬液及其制备方法 |
WO2016001937A2 (en) * | 2014-06-30 | 2016-01-07 | Rubicon Research Private Limited | Modified release pharmaceutical preparations |
MX2017000041A (es) | 2014-07-03 | 2017-05-01 | Mallinckrodt Llc | Formulaciones de liberacion inmediata disuasivas de abuso que comprenden polisacaridos no celulosicos. |
EP4134070A1 (en) * | 2014-07-17 | 2023-02-15 | Pharmathen S.A. | Pediatric powder for oral suspension containing antiviral agent and method for the preparation thereof |
JP6371463B2 (ja) | 2014-07-17 | 2018-08-08 | ファーマシューティカル マニュファクチュアリング リサーチ サービシズ,インコーポレーテッド | 即時放出性乱用抑止性液体充填剤形 |
MX2017001332A (es) | 2014-07-30 | 2017-08-02 | Sun Pharmaceutical Ind Ltd | Envase con camara.doble. |
US10729685B2 (en) | 2014-09-15 | 2020-08-04 | Ohemo Life Sciences Inc. | Orally administrable compositions and methods of deterring abuse by intranasal administration |
EP3209282A4 (en) | 2014-10-20 | 2018-05-23 | Pharmaceutical Manufacturing Research Services, Inc. | Extended release abuse deterrent liquid fill dosage form |
MA41152A (fr) * | 2014-12-12 | 2017-10-17 | Johnson & Johnson Consumer Inc | Procédé de fabrication de particules de résinate de phényléphrine ; particules de résinate de phényléphrine et utilisation des particules de résinate de phényléphrine dans des formulations pharmaceutiques |
CN104628587B (zh) * | 2015-02-12 | 2016-06-22 | 艾美科健(中国)生物医药有限公司 | 一种回收阿莫西林生产废液中d-对羟基苯甘氨酸的方法 |
US10398662B1 (en) | 2015-02-18 | 2019-09-03 | Jazz Pharma Ireland Limited | GHB formulation and method for its manufacture |
EP3288539A4 (en) * | 2015-05-01 | 2019-07-10 | Sun Pharmaceutical Industries Ltd | EXTENDED RELEASE LIQUID METFORMIN COMPOSITIONS |
WO2017040607A1 (en) | 2015-08-31 | 2017-03-09 | Acura Pharmaceuticals, Inc. | Methods and compositions for self-regulated release of active pharmaceutical ingredient |
US11590228B1 (en) * | 2015-09-08 | 2023-02-28 | Tris Pharma, Inc | Extended release amphetamine compositions |
US9849125B1 (en) | 2015-11-03 | 2017-12-26 | Banner Lifie Sciences LLC | Anti-overingestion dosage forms |
US10358894B2 (en) * | 2015-12-11 | 2019-07-23 | Dreco Energy Services Ulc | System for placing a tracer in a well |
CN105663038B (zh) * | 2016-02-03 | 2019-06-14 | 北京诺康达医药科技股份有限公司 | 一种液体缓释制剂及其制备方法 |
US11938224B1 (en) | 2016-04-08 | 2024-03-26 | Tris Pharma Inc | Benzonatate modified release solid tablets and capsules |
ES2814296T3 (es) | 2016-04-21 | 2021-03-26 | Fertin Pharma As | Producto para administración de nicotina, usos relacionados y formas de dosificación oral y métodos de producción |
US10238803B2 (en) | 2016-05-02 | 2019-03-26 | Sun Pharmaceutical Industries Limited | Drug delivery device for pharmaceutical compositions |
US10369078B2 (en) | 2016-05-02 | 2019-08-06 | Sun Pharmaceutical Industries Limited | Dual-chamber pack for pharmaceutical compositions |
BR112018072602A2 (pt) * | 2016-05-03 | 2019-02-19 | Spectrix Therapeutics, LLC | composições e métodos para prover hormônio da tiroide ou análogos do mesmo |
CA3039920A1 (en) | 2016-10-10 | 2018-04-19 | Rhodes Pharmaceuticals L.P. | Pharmaceutical resinate compositions and methods of making and using thereof |
GB2555442B (en) | 2016-10-27 | 2022-06-01 | Oxford Pharmascience Ltd | Modifier system for compositions containing layered double hydroxide |
CN106344522B (zh) * | 2016-11-11 | 2019-04-09 | 河北利华药业有限公司 | 一种兽用阿莫西林颗粒及其制备方法 |
US9855228B1 (en) * | 2016-12-14 | 2018-01-02 | Taho Pharmaceuticals Ltd. | Oral solution comprising atomoxetine hydrochloride and methods thereof |
CN106632804A (zh) * | 2016-12-31 | 2017-05-10 | 重庆文理学院 | 绿色阳离子交换树脂制备方法 |
US20180263936A1 (en) | 2017-03-17 | 2018-09-20 | Jazz Pharmaceuticals Ireland Limited | Gamma-hydroxybutyrate compositions and their use for the treatment of disorders |
US10335375B2 (en) | 2017-05-30 | 2019-07-02 | Patheon Softgels, Inc. | Anti-overingestion abuse deterrent compositions |
WO2019032975A1 (en) * | 2017-08-10 | 2019-02-14 | Mec Device Pharma International Llc | ANTI-ABUSE MEDICINAL FORMULATIONS |
US11590081B1 (en) | 2017-09-24 | 2023-02-28 | Tris Pharma, Inc | Extended release amphetamine tablets |
KR20200097685A (ko) * | 2017-10-09 | 2020-08-19 | 로도스 파머시티컬스 엘.피. | 약학 수지산염 조성물 및 그 제조 및 사용 방법 |
GR1009534B (el) * | 2017-11-21 | 2019-05-31 | Laboserve Φαρμακευτικη Βιομηχανια Α.Ε. | Ποσιμα φαρμακευτικα διαλυματα που περιλαμβανουν υδροχλωρικη οξυβουτυνινη |
WO2019126214A1 (en) | 2017-12-18 | 2019-06-27 | Tris Pharma, Inc. | Pharmaceutical composition comprising ghb gastro-retentive raft forming systems having trigger pulse drug release |
US11666546B2 (en) | 2017-12-18 | 2023-06-06 | Tris Pharma, Inc | GHB pharmaceutical compositions comprising a floating interpenetrating polymer network forming system |
WO2019126218A1 (en) | 2017-12-18 | 2019-06-27 | Tris Pharma, Inc. | Modified release drug powder composition comprising gastro-retentive raft forming systems having trigger pulse drug release |
CN108030770A (zh) * | 2017-12-18 | 2018-05-15 | 中国药科大学 | 含有药物树脂复合物的释药可控的干混悬剂及其制备方法 |
CN108014120A (zh) * | 2017-12-18 | 2018-05-11 | 中国药科大学 | 一种释药速度可控的阿奇霉素树脂复合物及其掩味干混悬剂 |
CA3097737A1 (en) | 2017-12-18 | 2019-06-27 | Tris Pharma, Inc. | Pharmaceutical compositions comprising a floating interpenetrating polymer network forming system |
EP3727339A1 (en) * | 2017-12-22 | 2020-10-28 | DDP Specialty Electronic Materials US, Inc. | Pharmaceutical composition containing resin particles |
FR3079303A1 (fr) | 2018-03-20 | 2019-09-27 | Ab7 Innovation | Procede pour la detection de la presence d'un traceur dans les excrements |
US11478426B2 (en) | 2018-09-25 | 2022-10-25 | SpecGx LLC | Abuse deterrent immediate release capsule dosage forms |
AU2019383389A1 (en) | 2018-11-19 | 2021-05-06 | Jazz Pharmaceuticals Ireland Limited | Alcohol-resistant drug formulations |
US11602507B2 (en) | 2019-05-27 | 2023-03-14 | Trikona Pharmaceuticals Pvt. Ltd | Extended release oral composition of memantine or its salt and its process for the preparation |
WO2020264092A1 (en) * | 2019-06-26 | 2020-12-30 | Celista Pharmaceuticals Llc | Atomoxetine hydrochloride extended release compositions and methods of use |
EP4041309A4 (en) * | 2019-10-10 | 2023-11-01 | Brillian Pharma Inc. | PHARMACEUTICAL COMPOSITION BASED ON MICRONIZED ACTIVE RESINATE AND METHOD FOR THE PRODUCTION THEREOF |
WO2021240330A1 (en) * | 2020-05-23 | 2021-12-02 | Lyrus Life Sciences Pvt Ltd | Pharmaceutical composition of extended-release oral suspension and process for preparation thereof |
CN111617032A (zh) * | 2020-07-08 | 2020-09-04 | 江苏四环生物制药有限公司 | 一种布洛芬药物纤维混悬剂及其制备方法 |
US11918689B1 (en) | 2020-07-28 | 2024-03-05 | Tris Pharma Inc | Liquid clonidine extended release composition |
CN112362765B (zh) * | 2020-10-13 | 2022-06-17 | 长沙都正生物科技股份有限公司 | 一种多塞平及其代谢产物n-去甲多塞平固相萃取、检测方法及试剂盒 |
CN114088680B (zh) * | 2021-10-14 | 2023-06-27 | 安徽中科赛飞尔科技有限公司 | 一种染发样品中痕量毒品的快速检测方法 |
WO2023147443A2 (en) * | 2022-01-26 | 2023-08-03 | Tulex Pharmaceuticals Inc. | Novel compositions |
CN115350152A (zh) * | 2022-07-27 | 2022-11-18 | 武汉科福新药有限责任公司 | 一种普萘洛尔缓释口服混悬液及其制备方法 |
WO2024023785A1 (en) | 2022-07-29 | 2024-02-01 | Berlia Sushma Paul | A stable pharmaceutical oral liquid formulation of an antispasmodic agent |
WO2024163966A1 (en) | 2023-02-03 | 2024-08-08 | Tris Pharma, Inc. | Low sodium oxybate once nightly composition |
Family Cites Families (223)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US659463A (en) | 1899-11-18 | 1900-10-09 | E & A H Batcheller Company | Heel-attaching machine. |
US692988A (en) | 1901-05-20 | 1902-02-11 | Seneca Falls Mfg Company | Drill-chuck. |
US2099402A (en) | 1934-01-17 | 1937-11-16 | Pratt Food Company | Pill or tablet |
US2507631A (en) * | 1944-01-19 | 1950-05-16 | Ciba Pharm Prod Inc | Pyridine and piperidine compounds and process of making same |
US2957880A (en) * | 1953-12-23 | 1960-10-25 | Ciba Pharm Prod Inc | Process for the conversion of stereoisomers |
US2830933A (en) | 1955-07-14 | 1958-04-15 | Pfizer & Co C | Vitamin b12 products and preparation thereof |
US2809918A (en) | 1955-10-17 | 1957-10-15 | Victor M Hermelin | Sustained release pharmaceutical preparations |
US2990332A (en) | 1958-04-02 | 1961-06-27 | Wallace & Tiernan Inc | Pharmaceutical preparations comprising cation exchange resin adsorption compounds and treatment therewith |
US3048526A (en) | 1958-08-04 | 1962-08-07 | Wander Company | Medicinal tablet |
US3146919A (en) | 1960-10-17 | 1964-09-01 | Story F Chappell | Ball follower dispenser |
US3138525A (en) | 1961-06-16 | 1964-06-23 | Hoffmann La Roche | Castor wax-amprotropine-resin compositions |
US3499960A (en) | 1965-01-25 | 1970-03-10 | Merck & Co Inc | Palatable coated particles of an anion exchange resin |
US3365365A (en) | 1965-08-09 | 1968-01-23 | Hoffmann La Roche | Repeat action pharmaceutical compositions in the form of discrete beadlets |
US3594470A (en) | 1968-02-19 | 1971-07-20 | Abbott Lab | Chewable tablets including coated particles of pseudoephedrine-weak cation exchange resin |
GB1218102A (en) | 1968-03-15 | 1971-01-06 | Philips Nv | Improvements in medicaments comprising drug/ion-exchange resin compounds |
US3567079A (en) | 1968-08-08 | 1971-03-02 | Cleone H Weigand | Dispenser container with metering neck |
LU63060A1 (da) | 1971-04-26 | 1971-08-26 | ||
DE2246037B2 (de) | 1972-09-20 | 1975-02-27 | Taeschner & Co, 8831 Kipfenberg | Peroral anwendbares Arzneimittel mit verzögerter Resorbierbarkeit in Suspensionsform |
DE2322883A1 (de) | 1973-05-07 | 1974-11-28 | Roehm Gmbh | Wasserloesliche polymerisate |
US4221778A (en) * | 1979-01-08 | 1980-09-09 | Pennwalt Corporation | Prolonged release pharmaceutical preparations |
US4363323A (en) | 1980-12-04 | 1982-12-14 | Geiss Alan C | Nasogastric tube adapted to avoid pressure necrosis |
JPS5941574U (ja) | 1982-09-07 | 1984-03-17 | 三菱鉛筆株式会社 | ボ−ルペン |
CH655507B (da) * | 1983-01-12 | 1986-04-30 | ||
US4459278A (en) * | 1983-03-07 | 1984-07-10 | Clear Lake Development Group | Composition and method of immobilizing emetics and method of treating human beings with emetics |
US4765989A (en) | 1983-05-11 | 1988-08-23 | Alza Corporation | Osmotic device for administering certain drugs |
US4762709A (en) * | 1983-09-16 | 1988-08-09 | Pennwalt Corporation | Liquid prolonged release pharmaceutical formulations containing ionic constituents |
IE56999B1 (en) | 1983-12-22 | 1992-03-11 | Elan Corp Plc | Pharmaceutical formulation |
US4894240A (en) | 1983-12-22 | 1990-01-16 | Elan Corporation Plc | Controlled absorption diltiazem formulation for once-daily administration |
US4876094A (en) * | 1984-01-13 | 1989-10-24 | Battelle Development Corporation | Controlled release liquid dosage formulation |
US4552899A (en) | 1984-04-09 | 1985-11-12 | Analgesic Associates | Cough/cold mixtures comprising non-steroidal anti-inflammatory drugs |
US4847077A (en) | 1984-07-18 | 1989-07-11 | Pennwalt Corporation | Controlled release pharmaceutical preparations |
IE58110B1 (en) | 1984-10-30 | 1993-07-14 | Elan Corp Plc | Controlled release powder and process for its preparation |
US4600645A (en) | 1985-01-31 | 1986-07-15 | Warner-Lambert Company | Process for treating dosage forms |
US4619673A (en) | 1985-05-15 | 1986-10-28 | Multiform Desiccants, Inc. | Adsorbent device |
EP0227814A1 (en) | 1985-07-02 | 1987-07-08 | The Upjohn Company | Therapeutic formulations with bimodal release characteristics |
GB8518301D0 (en) | 1985-07-19 | 1985-08-29 | Fujisawa Pharmaceutical Co | Hydrodynamically explosive systems |
JPS62103012A (ja) | 1985-10-23 | 1987-05-13 | Eisai Co Ltd | 多重顆粒 |
US4775536A (en) | 1986-02-24 | 1988-10-04 | Bristol-Myers Company | Enteric coated tablet and process for making |
US4794001A (en) | 1986-03-04 | 1988-12-27 | American Home Products Corporation | Formulations providing three distinct releases |
DE3617432A1 (de) | 1986-05-23 | 1987-11-26 | Standard Elektrik Lorenz Ag | Elektronenstrahlerzeugungssystem |
US4859461A (en) * | 1986-07-30 | 1989-08-22 | Fisons Corporation | Coatable ion exchange resins |
US4752470A (en) | 1986-11-24 | 1988-06-21 | Mehta Atul M | Controlled release indomethacin |
GB2201395B (en) | 1986-12-17 | 1990-05-02 | English Glass Co Ltd | Liquid dosing device |
US4910932A (en) | 1987-01-05 | 1990-03-27 | Honigman Michael L | Modular building system |
US4894239A (en) * | 1987-06-02 | 1990-01-16 | Takeda Chemical Industries, Ltd. | Sustained-release preparation and production thereof |
US4808411A (en) | 1987-06-05 | 1989-02-28 | Abbott Laboratories | Antibiotic-polymer compositions |
GB2206880B (en) | 1987-07-16 | 1991-04-24 | Farmos Oy | Optical isomers of an imidazole derivative |
IL87710A (en) | 1987-09-18 | 1992-06-21 | Ciba Geigy Ag | Covered floating retard form for controlled release in gastric juice |
IL90245A (en) | 1988-05-11 | 1994-04-12 | Glaxo Group Ltd | Resin adsorption containing ranitidine together with synthetic resin replaces cations, its preparation and pharmaceutical preparations containing it |
US5219563A (en) * | 1988-05-11 | 1993-06-15 | Glaxo Group Limited | Drug adsorbates |
JPH01287270A (ja) | 1988-05-13 | 1989-11-17 | Matsushita Electric Ind Co Ltd | スパッタリング装置 |
JPH0217912A (ja) | 1988-07-06 | 1990-01-22 | Matsushita Electric Ind Co Ltd | 空気清浄機 |
US5296236A (en) | 1988-09-16 | 1994-03-22 | Recordati S.A., Chemical And Pharmaceutical Company | Controlled release therapeutic system for a liquid pharmaceutical formulations |
US4996047A (en) * | 1988-11-02 | 1991-02-26 | Richardson-Vicks, Inc. | Sustained release drug-resin complexes |
CA2002492A1 (en) | 1988-11-11 | 1990-05-11 | Sandra T. A. Malkowska | Pharmaceutical ion exchange resin composition |
US4999189A (en) | 1988-11-14 | 1991-03-12 | Schering Corporation | Sustained release oral suspensions |
US5186930A (en) | 1988-11-14 | 1993-02-16 | Schering Corporation | Sustained release oral suspensions |
US5275819A (en) | 1989-02-06 | 1994-01-04 | Amer Particle Technologies Inc. | Drug loaded pollen grains with an outer coating for pulsed delivery |
JPH0818971B2 (ja) | 1989-02-16 | 1996-02-28 | ブリティッシュ・テクノロジー・グループ・リミテッド | 投与製剤 |
JP3126127B2 (ja) | 1989-04-28 | 2001-01-22 | アジレント・テクノロジー株式会社 | 試験データ圧縮方式 |
NZ234143A (en) * | 1989-06-28 | 1991-10-25 | Mcneil Ppc Inc | Aqueous pharmaceutical suspension formulation for administering substantially insoluble pharmaceutical agents |
US5158777A (en) | 1990-02-16 | 1992-10-27 | E. R. Squibb & Sons, Inc. | Captopril formulation providing increased duration of activity |
US5156850A (en) | 1990-08-31 | 1992-10-20 | Alza Corporation | Dosage form for time-varying patterns of drug delivery |
US5422121A (en) | 1990-11-14 | 1995-06-06 | Rohm Gmbh | Oral dosage unit form |
US5275820A (en) | 1990-12-27 | 1994-01-04 | Allergan, Inc. | Stable suspension formulations of bioerodible polymer matrix microparticles incorporating drug loaded ion exchange resin particles |
US5431922A (en) * | 1991-03-05 | 1995-07-11 | Bristol-Myers Squibb Company | Method for administration of buspirone |
US5242428A (en) | 1991-10-04 | 1993-09-07 | Aubrey Palestrant | Apparatus for wetting hydrophilic-coated guide wires and catheters |
US5273760A (en) * | 1991-12-24 | 1993-12-28 | Euroceltigue, S.A. | Stabilized controlled release substrate having a coating derived from an aqueous dispersion of hydrophobic polymer |
US5286493A (en) * | 1992-01-27 | 1994-02-15 | Euroceltique, S.A. | Stabilized controlled release formulations having acrylic polymer coating |
US5968551A (en) * | 1991-12-24 | 1999-10-19 | Purdue Pharma L.P. | Orally administrable opioid formulations having extended duration of effect |
US5580578A (en) * | 1992-01-27 | 1996-12-03 | Euro-Celtique, S.A. | Controlled release formulations coated with aqueous dispersions of acrylic polymers |
ES2135461T3 (es) | 1991-12-27 | 1999-11-01 | Kos Pharma Inc | Alivio o prevencion del inicio de cefaleas migrañosas con agentes de bloqueo de la desgranulacion de mastocitos. |
US7070806B2 (en) * | 1992-01-27 | 2006-07-04 | Purdue Pharma Lp | Controlled release formulations coated with aqueous dispersions of acrylic polymers |
US5322073A (en) | 1992-01-30 | 1994-06-21 | Sandoz Ltd. | Feeding tube retaining strap |
US5272137A (en) * | 1992-02-14 | 1993-12-21 | Mcneil-Pfc, Inc. | Aqueous pharmaceutical suspension for pharmaceutical actives |
JP3207494B2 (ja) | 1992-04-02 | 2001-09-10 | ロート製薬株式会社 | 水性懸濁製剤 |
JP3278192B2 (ja) * | 1992-04-03 | 2002-04-30 | ロート製薬株式会社 | 徐放性液剤 |
US5260068A (en) | 1992-05-04 | 1993-11-09 | Anda Sr Pharmaceuticals Inc. | Multiparticulate pulsatile drug delivery system |
DE4319649A1 (de) * | 1993-03-18 | 1994-09-22 | Asta Medica Ag | Feste Flupirtin enthaltende orale Darreichungsformen mit kontrollierter Wirkstoffabgabe |
IL109460A (en) * | 1993-05-10 | 1998-03-10 | Euro Celtique Sa | Controlled release formulation comprising tramadol |
JP2916978B2 (ja) | 1993-08-25 | 1999-07-05 | エスエス製薬株式会社 | 放出開始制御型製剤 |
US5411745A (en) | 1994-05-25 | 1995-05-02 | Euro-Celtique, S.A. | Powder-layered morphine sulfate formulations |
DE69632569T2 (de) | 1995-06-09 | 2005-08-18 | Euroceltique S.A. | Formulierungen und verfahren für eine verlängerte lokalanästhesie |
GB9514451D0 (en) * | 1995-07-14 | 1995-09-13 | Chiroscience Ltd | Sustained-release formulation |
JP3397209B2 (ja) * | 1995-08-29 | 2003-04-14 | エクソンモービル・ケミカル・パテンツ・インク | 耐輻射線性ポリプロピレン及びその有用な製品 |
US6355656B1 (en) * | 1995-12-04 | 2002-03-12 | Celgene Corporation | Phenidate drug formulations having diminished abuse potential |
US5908850A (en) * | 1995-12-04 | 1999-06-01 | Celgene Corporation | Method of treating attention deficit disorders with d-threo methylphenidate |
US6486177B2 (en) * | 1995-12-04 | 2002-11-26 | Celgene Corporation | Methods for treatment of cognitive and menopausal disorders with D-threo methylphenidate |
US5837284A (en) | 1995-12-04 | 1998-11-17 | Mehta; Atul M. | Delivery of multiple doses of medications |
JPH09323180A (ja) | 1996-06-04 | 1997-12-16 | Asahi Optical Co Ltd | スケーリング補正機能を持つレーザ描画装置 |
PT932388E (pt) | 1996-09-30 | 2006-07-31 | Alza Corp | Forma de dosagem e metodo para administracao de farmacos |
CN1179450A (zh) * | 1996-10-15 | 1998-04-22 | 罗姆和哈斯公司 | 含有离子交换树脂的涂料组合物 |
US6919373B1 (en) * | 1996-11-12 | 2005-07-19 | Alza Corporation | Methods and devices for providing prolonged drug therapy |
US5900882A (en) | 1996-11-15 | 1999-05-04 | Samsung Electronics Co., Ltd. | Determining texture coordinates in computer graphics |
CA2269679A1 (en) * | 1996-12-20 | 1998-07-02 | Warner-Lambert Company | Antitussive drugs delivered by partially coated ion exchange resins |
DE19709663A1 (de) * | 1997-03-10 | 1998-09-17 | Basf Ag | Verwendung von redispergierbaren Polymerpulvern oder Polymergranulaten als Bindemittel zur Herstellung von festen pharmazeutischen Darreichungsformen |
DE19709532A1 (de) * | 1997-03-10 | 1998-09-17 | Basf Ag | Verwendung von redispergierbaren Polymerpulvern oder Polymergranulaten zum Überziehen von pharmazeutischen oder agrochemischen Darreichungsformen |
US5980882A (en) * | 1997-04-16 | 1999-11-09 | Medeva Pharmaceuticals Manufacturing | Drug-resin complexes stabilized by chelating agents |
GB9707934D0 (en) * | 1997-04-18 | 1997-06-04 | Danbiosyst Uk | Improved delivery of drugs to mucosal surfaces |
US6210710B1 (en) | 1997-04-28 | 2001-04-03 | Hercules Incorporated | Sustained release polymer blend for pharmaceutical applications |
DE19732903A1 (de) * | 1997-07-30 | 1999-02-04 | Falk Pharma Gmbh | Pellet-Formulierung zur Behandlung des Intestinaltraktes |
EP1041988A4 (en) * | 1997-12-22 | 2002-03-13 | Euro Celtique Sa | METHOD FOR PREVENTING ABUSE OF OPIOID DOSES FORMS |
EP0943341A1 (en) | 1998-02-18 | 1999-09-22 | Oscar Gold | Procedure to prepare granulated compositions that contain erythromycin macrolides and procedure to prepare pharmaceutical compositions that contain said macrolides |
IT1304271B1 (it) | 1998-03-17 | 2001-03-13 | Tecno 5 S R L | Gruppo serigrafico polifunzionale per macchine a giostra per la stampa serigrafica a piu' colori di contenitori con superfici curve. |
US6905707B2 (en) * | 1998-05-28 | 2005-06-14 | Medical Research Institute | Controlled release arginine alpha ketoglutarate |
US6322819B1 (en) | 1998-10-21 | 2001-11-27 | Shire Laboratories, Inc. | Oral pulsed dose drug delivery system |
PL205109B1 (pl) * | 1998-11-02 | 2010-03-31 | Elan Pharma Int Ltd | Wielocząstkowa kompozycja metylofenidatu o modyfikowanym uwalnianiu i jej zastosowanie |
US20070160675A1 (en) | 1998-11-02 | 2007-07-12 | Elan Corporation, Plc | Nanoparticulate and controlled release compositions comprising a cephalosporin |
US20060240105A1 (en) | 1998-11-02 | 2006-10-26 | Elan Corporation, Plc | Multiparticulate modified release composition |
PL348193A1 (en) * | 1998-12-11 | 2002-05-06 | Pharmasolutions | Self-emulsifying compositions for drugs poorly soluble in water |
US6419960B1 (en) * | 1998-12-17 | 2002-07-16 | Euro-Celtique S.A. | Controlled release formulations having rapid onset and rapid decline of effective plasma drug concentrations |
US6673367B1 (en) * | 1998-12-17 | 2004-01-06 | Euro-Celtique, S.A. | Controlled/modified release oral methylphenidate formulations |
US7083808B2 (en) * | 1998-12-17 | 2006-08-01 | Euro-Celtique S.A. | Controlled/modified release oral methylphenidate formulations |
CA2355829A1 (en) * | 1999-01-07 | 2000-07-13 | Louise Templeton | Multiparticulate oral dosage forms |
US6248363B1 (en) | 1999-11-23 | 2001-06-19 | Lipocine, Inc. | Solid carriers for improved delivery of active ingredients in pharmaceutical compositions |
WO2000059481A1 (en) * | 1999-04-06 | 2000-10-12 | Pharmaquest Ltd. | PHARMACEUTICAL DOSAGE FORM FOR PULSATILE DELIVERY OF d-threo-METHYLPHENIDATE AND A SECOND CNS STIMULANT |
DE19927689A1 (de) * | 1999-06-17 | 2000-12-21 | Gruenenthal Gmbh | Orale Darreichungsformen zur Verabreichung einer fixen Kombination von Tramadol und Diclofenac |
US6384020B1 (en) | 1999-07-14 | 2002-05-07 | Shire Laboratories, Inc. | Rapid immediate release oral dosage form |
MXPA02000725A (es) * | 1999-07-29 | 2003-07-14 | Roxane Lab Inc | Formulacion opioide de liberacion sostenida. |
DE19961897A1 (de) * | 1999-12-20 | 2001-06-28 | Basf Ag | Verwendung eines Filmüberzuges als geschmacksmaskierendes Coating von pharmazeutischen Darreichungsformen |
DE60115840T2 (de) | 2000-01-19 | 2006-07-13 | Mannkind Corp., Danbury | Formulierung mit mehrfach gepulster wirkstofffreisetzung |
EP2517710B1 (en) * | 2000-02-08 | 2015-03-25 | Euro-Celtique S.A. | Tamper-resistant oral opioid agonist formulations |
US6322011B1 (en) | 2000-03-14 | 2001-11-27 | Illinois Tool Works Inc. | Electrostatic coating system and dual lip bell cup therefor |
US7067116B1 (en) | 2000-03-23 | 2006-06-27 | Warner-Lambert Company Llc | Fast dissolving orally consumable solid film containing a taste masking agent and pharmaceutically active agent at weight ratio of 1:3 to 3:1 |
DE10015479A1 (de) | 2000-03-29 | 2001-10-11 | Basf Ag | Feste orale Darreichungsformen mit retardierter Wirkstofffreisetzung und hoher mechanischer Stabilität |
SE0001151D0 (sv) * | 2000-03-31 | 2000-03-31 | Amarin Dev Ab | Method for producing a controlled-release composition |
US6670058B2 (en) * | 2000-04-05 | 2003-12-30 | University Of Central Florida | Thermocatalytic process for CO2-free production of hydrogen and carbon from hydrocarbons |
US6551617B1 (en) * | 2000-04-20 | 2003-04-22 | Bristol-Myers Squibb Company | Taste masking coating composition |
US6419954B1 (en) * | 2000-05-19 | 2002-07-16 | Yamanouchi Pharmaceutical Co., Ltd. | Tablets and methods for modified release of hydrophilic and other active agents |
JP3380536B2 (ja) | 2000-08-25 | 2003-02-24 | 日本圧着端子製造株式会社 | 圧接コネクタの受取装置及びこれを備えた自動圧接機 |
IL145106A0 (en) | 2000-08-30 | 2002-06-30 | Pfizer Prod Inc | Intermittent administration of a geowth hormone secretagogue |
US6344215B1 (en) * | 2000-10-27 | 2002-02-05 | Eurand America, Inc. | Methylphenidate modified release formulations |
GB0030460D0 (en) | 2000-12-14 | 2001-01-24 | Isis Innovation | Drug delivery system |
DE10108122A1 (de) * | 2001-02-21 | 2002-10-02 | Gruenenthal Gmbh | Arzneimittel auf Basis von Tramadol |
DE60212475T2 (de) | 2001-03-14 | 2007-07-05 | Pfizer Products Inc., Groton | Pharmazeutische Tablette und ein Verfahren zu ihrer Herstellung |
DE60232290D1 (de) * | 2001-04-09 | 2009-06-25 | Rohm & Haas | Kontrollierte Auflösung von Wirkstoffen |
AU2002303718B2 (en) * | 2001-05-11 | 2008-02-28 | Endo Pharmaceuticals, Inc. | Abuse-resistant opioid dosage form |
EP1277896A1 (en) | 2001-07-16 | 2003-01-22 | Ulf Palmberg | Floorboards |
US7144587B2 (en) * | 2001-08-06 | 2006-12-05 | Euro-Celtique S.A. | Pharmaceutical formulation containing opioid agonist, opioid antagonist and bittering agent |
WO2003020242A1 (en) | 2001-08-29 | 2003-03-13 | Srl Technologies, Inc. | Sustained release preparations |
US6997358B2 (en) | 2001-09-12 | 2006-02-14 | Anthony Charles Lammond Wass | Liquid dosing device |
US8105626B2 (en) * | 2001-10-17 | 2012-01-31 | Takeda Pharmaceutical Company Limited | Granules containing acid-unstable chemical in large amount |
US20040126428A1 (en) * | 2001-11-02 | 2004-07-01 | Lyn Hughes | Pharmaceutical formulation including a resinate and an aversive agent |
US7700561B2 (en) | 2002-02-22 | 2010-04-20 | Shire Llc | Abuse-resistant amphetamine prodrugs |
DE10211289A1 (de) * | 2002-03-14 | 2003-09-25 | Basf Ag | Kombination von Polyvinylacetat von wasserunlöslichen, säureunlöslichen oder alkaliunlöslichen Polymeren zur Hestellung von Filmüberzügen mit sehr kontrollierter Freisetzung und hoher Stabilität |
CA2480826C (fr) | 2002-04-09 | 2012-02-07 | Flamel Technologies | Formulation pharmaceutique orale sous forme de suspension aqueuse de microcapsules permettant la liberation modifiee de principe(s) actif(s) |
US7125563B2 (en) * | 2002-04-12 | 2006-10-24 | Dava Pharmaceuticals, Inc. | Sustained release pharmaceutical preparations and methods for producing the same |
US6939029B1 (en) * | 2002-05-28 | 2005-09-06 | Kuryakyn Holdings, Inc. | Modular light assembly for decorative lights |
JP2005528910A (ja) | 2002-06-05 | 2005-09-29 | ベイラー カレッジ オブ メディシン | T細胞レセプターcdr3配列および検出のための方法 |
NZ537853A (en) | 2002-07-16 | 2007-02-23 | Amura Therapeutics Ltd | Inhibitors of cathepsin K and related cysteine protesases of the CA clan |
US8216609B2 (en) | 2002-08-05 | 2012-07-10 | Torrent Pharmaceuticals Limited | Modified release composition of highly soluble drugs |
US8268352B2 (en) * | 2002-08-05 | 2012-09-18 | Torrent Pharmaceuticals Limited | Modified release composition for highly soluble drugs |
JP2006500395A (ja) * | 2002-09-09 | 2006-01-05 | エンド ファーマシューティカルズ インコーポレーテッド | 組み合わされた即時放出及び徐放の鎮痛組成物 |
US6913768B2 (en) * | 2002-09-24 | 2005-07-05 | Shire Laboratories, Inc. | Sustained release delivery of amphetamine salts |
EP1549153B1 (en) | 2002-09-24 | 2012-12-05 | Gumlink A/S | Chewing gum having improved release of chewing gum ingredients |
CA2509429A1 (en) | 2002-11-26 | 2004-06-10 | University Of Maryland, Baltimore | Aqueous sustained-release drug delivery system for highly water-soluble electrolytic drugs |
US20060018972A1 (en) * | 2002-11-26 | 2006-01-26 | Upm Pharmaceuticals, Inc. | Aqueous sustained-release drug delivery system for highly water-soluble electrolytic drugs |
FR2848564B1 (fr) * | 2002-12-13 | 2006-12-01 | Inst Rech Developpement Ird | Souches bacteriennes du genre exiguobacterium, procede de culture et applications |
EP1581196A4 (en) | 2002-12-23 | 2007-08-22 | Celltech Americas Inc | ACID LABILIC DRUG COMPOSITIONS |
WO2004060354A1 (en) * | 2002-12-31 | 2004-07-22 | Augsburger Larry L | Methods for making pharmaceutical dosage forms containing active cushioning components |
US6780126B2 (en) * | 2003-01-02 | 2004-08-24 | Acushnet Company | Golf ball with large inner core |
JP2006515008A (ja) * | 2003-01-28 | 2006-05-18 | コレギウム ファーマシューティカル, インコーポレイテッド | 経口投与のためのミルナシプランの多粒子状組成物 |
CH712083B1 (de) * | 2003-02-05 | 2017-07-31 | Siegfried Ag | Verfahren zur Herstellung von d-threo-2-Phenyl-2-piperidin-2-yl-essigsäureestern. |
EP1626709B1 (en) | 2003-02-10 | 2007-09-05 | Shire Biochem Inc. | Enantiomeric amphetamine compositions for the treatment of adhd |
EP1620075B1 (en) * | 2003-05-07 | 2020-06-24 | Samyang Biopharmaceuticals Corporation | Highly plastic granules for making fast melting tablets |
US20060115529A1 (en) * | 2003-05-07 | 2006-06-01 | Seonghoon Jeong | Fast-melting tablets having taste-masking and sustained release properties |
WO2004101027A2 (en) | 2003-05-12 | 2004-11-25 | Medical Instill Technologies, Inc. | Dispenser and apparatus for fillling a dispenser |
US20040259809A1 (en) | 2003-06-17 | 2004-12-23 | Pediamed Pharmaceuticals, Inc. | Pharmaceutical compositions including an antihistamine and a stimulant and method of use thereof |
US20050036977A1 (en) * | 2003-08-11 | 2005-02-17 | Dilip Gole | Taste-masked resinate and preparation thereof |
AU2004270188B8 (en) * | 2003-09-03 | 2010-04-29 | Mallinckrodt Inc. | Granular sustained release preparation and production thereof |
CA2540052C (en) * | 2003-10-08 | 2012-04-10 | Mallinckrodt Inc. | Methylphenidate solution and associated methods of administration and production |
US20050220881A1 (en) | 2003-10-10 | 2005-10-06 | Bvm Holding Co. | Pharmaceutical composition |
US20050266032A1 (en) * | 2003-12-17 | 2005-12-01 | Sovereign Pharmaceuticals, Ltd. | Dosage form containing multiple drugs |
US20060029664A1 (en) * | 2004-08-04 | 2006-02-09 | Sovereign Pharmaceuticals, Ltd. | Dosage form containing carbetapentane and another drug |
US20050232986A1 (en) * | 2003-12-17 | 2005-10-20 | David Brown | Dosage form containing promethazine and another drug |
US9492541B2 (en) * | 2004-09-14 | 2016-11-15 | Sovereign Pharmaceuticals, Llc | Phenylepherine containing dosage form |
US20050232987A1 (en) * | 2004-03-12 | 2005-10-20 | Viswanathan Srinivasan | Dosage form containing a morphine derivative and another drug |
US20050142097A1 (en) | 2003-12-29 | 2005-06-30 | Deepak Thassu | Multiple active drug resin conjugate |
US20050181050A1 (en) | 2004-01-28 | 2005-08-18 | Collegium Pharmaceutical, Inc. | Dosage forms using drug-loaded ion exchange resins |
JP2005306778A (ja) * | 2004-04-21 | 2005-11-04 | Basf Ag | 徐放性製剤及びその製造方法 |
US20050266031A1 (en) | 2004-05-25 | 2005-12-01 | Jay Dickerson | Pharmaceutical suspension composition |
US20050265955A1 (en) * | 2004-05-28 | 2005-12-01 | Mallinckrodt Inc. | Sustained release preparations |
US9592197B2 (en) * | 2004-12-16 | 2017-03-14 | Sovereign Pharmaceuticals, Llc | Dosage form containing diphenhydramine and another drug |
WO2006022996A2 (en) | 2004-08-04 | 2006-03-02 | Sovereign Pharmaceuticals, Ltd. | Dosage form containing multiple drugs |
PL1791530T3 (pl) | 2004-08-23 | 2009-01-30 | Pejo Iserlohn Heilmittel Und Diaet Gmbh & Co Kg | Kompozycja farmaceutyczna zawierająca psychostymulant |
ES2531735T3 (es) | 2004-10-15 | 2015-03-18 | Supernus Pharmaceuticals, Inc. | Preparaciones farmacéuticas con menor potencial de abuso |
US7173497B1 (en) * | 2004-11-05 | 2007-02-06 | Rockwell Collins, Inc. | Sampling voltage controlled oscillator |
EP1830851A2 (en) | 2004-12-06 | 2007-09-12 | Themis Laboratories Private Limited | Rapid disintegrating taste masked compositions and a process for its preparations |
US8318210B2 (en) | 2005-02-28 | 2012-11-27 | Neos Therapeutics, Lp | Compositions and methods of making sustained release liquid formulations |
US7276794B2 (en) | 2005-03-02 | 2007-10-02 | Endevco Corporation | Junction-isolated vias |
WO2006135362A1 (en) | 2005-06-09 | 2006-12-21 | Upm Pharmaceuticals, Inc. | Aqueous sustained-release drug delivery system for highly water-soluble electrolytic drugs |
JP2008546835A (ja) | 2005-06-28 | 2008-12-25 | ユ セ ベ ソシエテ アノニム | 複数の活性薬物−樹脂抱合体 |
MX2008000084A (es) | 2005-06-29 | 2008-03-18 | Panacea Biotec Ltd | Composiciones farmaceuticas de liberacion sostenida y procedimientos de las mismas. |
US8343546B2 (en) | 2005-09-13 | 2013-01-01 | Coating Place, Inc. | Ion exchange resin treated to control swelling |
FR2891459B1 (fr) | 2005-09-30 | 2007-12-28 | Flamel Technologies Sa | Microparticules a liberation modifiee d'au moins un principe actif et forme galenique orale en comprenant |
US20070092553A1 (en) | 2005-10-21 | 2007-04-26 | Pfab Lp | Compositions and methods of making rapidly dissolving lonically masked formulations |
US20090221552A1 (en) | 2006-02-28 | 2009-09-03 | The Mclean Hospital Corporation | Methods for the Treatment of ADHD and Related Disorders |
DK2018160T3 (da) * | 2006-03-16 | 2012-02-06 | Tris Pharma Inc | Modificeret depotformuleringer indeholdende lægemiddel-ionbytterharpikskomplekser |
US8846100B2 (en) | 2006-05-12 | 2014-09-30 | Shire Llc | Controlled dose drug delivery system |
US20080064694A1 (en) | 2006-09-11 | 2008-03-13 | Auriga Laboratories, Inc. | Multi-Phase Release Methscopolamine Compositions |
WO2008042218A1 (en) | 2006-10-03 | 2008-04-10 | Tris Pharma, Inc. | Formulations containing an ionic mineral-ion exchange resin complex and uses thereof |
US20080118570A1 (en) * | 2006-11-20 | 2008-05-22 | Zhi Liu | Polymer coated drug-ion exchange resins and methods |
CN101534795B (zh) * | 2006-11-21 | 2013-04-03 | 麦克内尔-Ppc股份有限公司 | 改进释放的镇痛悬浮液 |
US7776917B2 (en) | 2006-12-11 | 2010-08-17 | Mickle Travis C | Non-standard amino acid conjugates of amphetamine and processes for making and using the same |
CA2678806C (en) | 2007-02-21 | 2017-05-16 | Connected Health Systems, Llc | Treating adhd and other diseases involving inflammation |
US8313770B2 (en) * | 2007-05-30 | 2012-11-20 | Neos Therapeutics, Lp | Modifying drug release in suspensions of ionic resin systems |
US8202542B1 (en) | 2007-05-31 | 2012-06-19 | Tris Pharma | Abuse resistant opioid drug-ion exchange resin complexes having hybrid coatings |
JP5279246B2 (ja) | 2007-12-05 | 2013-09-04 | 京セラドキュメントソリューションズ株式会社 | 画像形成装置および印刷システム |
US20100260844A1 (en) * | 2008-11-03 | 2010-10-14 | Scicinski Jan J | Oral pharmaceutical dosage forms |
EP2376451A1 (en) | 2009-01-09 | 2011-10-19 | Mallinckrodt LLC | Synthesis of methylphenidate and analogs thereof |
CA2767576C (en) | 2009-07-08 | 2020-03-10 | Charleston Laboratories Inc. | Pharmaceutical compositions comprising an antiemetic and an opioid analgesic |
US8470375B1 (en) | 2010-01-05 | 2013-06-25 | Neos Therapeutics, Lp | Method of formulating and designing liquid drug suspensions containing ion exchange resin particles |
GB201002612D0 (en) | 2010-02-16 | 2010-03-31 | Jagotec Ag | Improvements in or relating to organic compounds |
JP2013523651A (ja) | 2010-03-24 | 2013-06-17 | ノースイースタン ユニヴァーシティ | 多重コンパートメントのマクロファージ送達 |
US8623409B1 (en) | 2010-10-20 | 2014-01-07 | Tris Pharma Inc. | Clonidine formulation |
AU2011359405A1 (en) | 2011-02-15 | 2013-08-22 | Tris Pharma, Inc. | Extended release powder and aqueous suspension comprising methylphenidate |
US8287903B2 (en) | 2011-02-15 | 2012-10-16 | Tris Pharma Inc | Orally effective methylphenidate extended release powder and aqueous suspension product |
WO2013003622A1 (en) | 2011-06-28 | 2013-01-03 | Neos Therapeutics, Lp | Dosage forms for oral administration and methods of treatment using the same |
US20140214431A1 (en) | 2011-07-01 | 2014-07-31 | Dolby Laboratories Licensing Corporation | Sample rate scalable lossless audio coding |
CA2758556A1 (en) | 2011-11-17 | 2013-05-17 | Pharmascience Inc. | Pharmaceutical composition of amphetamine mixed salts |
DK2884961T3 (da) | 2012-08-15 | 2019-04-23 | Tris Pharma Inc | Methylphenidat-tyggetablet med forlænget frigivelse |
CA2887893C (en) | 2012-10-09 | 2021-07-06 | Douglas SEARS | Therapeutic treatment for attention deficit disorder |
US9180104B2 (en) | 2013-03-13 | 2015-11-10 | Tris Pharma, Inc. | Benzonatate modified release solid tablets and capsules |
-
2007
- 2007-03-15 DK DK07753217.4T patent/DK2018160T3/da active
- 2007-03-15 EP EP11192711A patent/EP2428205B1/en active Active
- 2007-03-15 CA CA2645855A patent/CA2645855C/en not_active Expired - Fee Related
- 2007-03-15 US US11/724,966 patent/US8062667B2/en active Active
- 2007-03-15 JP JP2009500494A patent/JP5479086B2/ja active Active
- 2007-03-15 WO PCT/US2007/006572 patent/WO2007109104A2/en active Application Filing
- 2007-03-15 KR KR1020087024357A patent/KR101495146B1/ko active IP Right Grant
- 2007-03-15 TW TW096108854A patent/TW200812649A/zh unknown
- 2007-03-15 AT AT07753217T patent/ATE536867T1/de active
- 2007-03-15 CN CN201110371263.XA patent/CN102488652B/zh active Active
- 2007-03-15 RU RU2008140944/15A patent/RU2435569C2/ru active
- 2007-03-15 ES ES11192711T patent/ES2396039T3/es active Active
- 2007-03-15 CN CN2007800092088A patent/CN101400343B/zh active Active
- 2007-03-15 DK DK11192711.7T patent/DK2428205T3/da active
- 2007-03-15 ES ES07753217T patent/ES2378573T3/es active Active
- 2007-03-15 BR BRPI0709606A patent/BRPI0709606B8/pt active IP Right Grant
- 2007-03-15 EP EP07753217A patent/EP2018160B1/en active Active
-
2008
- 2008-09-11 IL IL194042A patent/IL194042A/en active IP Right Grant
-
2010
- 2010-03-12 US US12/722,857 patent/US8337890B2/en active Active
-
2011
- 2011-09-26 US US13/244,748 patent/US8202537B2/en active Active
-
2012
- 2012-11-01 US US13/666,424 patent/US8491935B2/en active Active
-
2013
- 2013-01-22 US US13/746,654 patent/US8597684B2/en active Active
- 2013-10-02 US US14/044,105 patent/US8790700B2/en active Active
- 2013-10-29 US US14/065,842 patent/US8747902B2/en active Active
-
2014
- 2014-01-15 US US14/155,410 patent/US8883217B2/en active Active
- 2014-10-07 US US14/508,613 patent/US9522191B2/en active Active
-
2015
- 2015-06-10 US US14/735,526 patent/US9198864B2/en active Active
-
2016
- 2016-02-18 US US15/047,388 patent/US9549989B2/en active Active
- 2016-07-01 US US15/200,748 patent/US9675703B2/en active Active
- 2016-07-01 US US15/200,617 patent/US20160310478A1/en not_active Abandoned
- 2016-07-01 US US15/200,786 patent/US9675704B2/en active Active
- 2016-12-19 US US15/383,474 patent/US10172958B2/en active Active
-
2017
- 2017-06-12 US US15/619,637 patent/US10086087B2/en active Active
- 2017-09-15 US US15/706,234 patent/US20180000954A1/en not_active Abandoned
-
2019
- 2019-01-07 US US16/241,287 patent/US10668163B2/en active Active
- 2019-01-16 US US16/249,415 patent/US20190151460A1/en not_active Abandoned
- 2019-12-18 US US16/719,121 patent/US10933143B2/en active Active
-
2020
- 2020-07-14 US US16/928,739 patent/US20210038734A1/en not_active Abandoned
-
2021
- 2021-01-12 US US17/147,200 patent/US20210162055A1/en not_active Abandoned
-
2022
- 2022-02-18 US US17/675,842 patent/US20220168432A1/en not_active Abandoned
Cited By (18)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US11839597B2 (en) | 2016-07-22 | 2023-12-12 | Flamel Ireland Limited | Modified release gamma-hydroxybutyrate formulations having improved pharmacokinetics |
US12109186B2 (en) | 2016-07-22 | 2024-10-08 | Flamel Ireland Limited | Modified release gamma-hydroxybutyrate formulations having improved pharmacokinetics |
US11896572B2 (en) | 2016-07-22 | 2024-02-13 | Flamel Ireland Limited | Modified release gamma-hydroxybutyrate formulations having improved pharmacokinetics |
US11986451B1 (en) | 2016-07-22 | 2024-05-21 | Flamel Ireland Limited | Modified release gamma-hydroxybutyrate formulations having improved pharmacokinetics |
US11602513B1 (en) | 2016-07-22 | 2023-03-14 | Flamel Ireland Limited | Modified release gamma-hydroxybutyrate formulations having improved pharmacokinetics |
US11766418B2 (en) | 2016-07-22 | 2023-09-26 | Flamel Ireland Limited | Modified release gamma-hydroxybutyrate formulations having improved pharmacokinetics |
US12115143B2 (en) | 2016-07-22 | 2024-10-15 | Flamel Ireland Limited | Modified release gamma-hydroxybutyrate formulations having improved pharmacokinetics |
US11826335B2 (en) | 2016-07-22 | 2023-11-28 | Flamel Ireland Limited | Modified release gamma-hydroxybutyrate formulations having improved pharmacokinetics |
US12115145B2 (en) | 2016-07-22 | 2024-10-15 | Flamel Ireland Limited | Modified release gamma-hydroxybutyrate formulations having improved pharmacokinetics |
US12115144B2 (en) | 2016-07-22 | 2024-10-15 | Flamel Ireland Limited | Modified release gamma-hydroxybutyrate formulations having improved pharmacokinetics |
US11602512B1 (en) | 2016-07-22 | 2023-03-14 | Flamel Ireland Limited | Modified release gamma-hydroxybutyrate formulations having improved pharmacokinetics |
US12097176B2 (en) | 2016-07-22 | 2024-09-24 | Flamel Ireland Limited | Modified release gamma-hydroxybutyrate formulations having improved pharmacokinetics |
US12097175B2 (en) | 2016-07-22 | 2024-09-24 | Flamel Ireland Limited | Modified release gamma-hydroxybutyrate formulations having improved pharmacokinetics |
US11504347B1 (en) | 2016-07-22 | 2022-11-22 | Flamel Ireland Limited | Modified release gamma-hydroxybutyrate formulations having improved pharmacokinetics |
US12115142B2 (en) | 2016-07-22 | 2024-10-15 | Flamel Ireland Limited | Modified release gamma-hydroxybutyrate formulations having improved pharmacokinetics |
US11400065B2 (en) | 2019-03-01 | 2022-08-02 | Flamel Ireland Limited | Gamma-hydroxybutyrate compositions having improved pharmacokinetics in the fed state |
US11583510B1 (en) | 2022-02-07 | 2023-02-21 | Flamel Ireland Limited | Methods of administering gamma hydroxybutyrate formulations after a high-fat meal |
US11779557B1 (en) | 2022-02-07 | 2023-10-10 | Flamel Ireland Limited | Modified release gamma-hydroxybutyrate formulations having improved pharmacokinetics |
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
DK2428205T3 (da) | Modificerede formuleringer indeholdende lægemiddel-ionbytterharpikskomplekser | |
WO2008064163A3 (en) | Polymer coated drug-ion exchange resins and methods | |
ME00482B (me) | Čvrste farmaceutske kompozicije koje sadrže pregabalin sredstvo za formiranje matriksa i sredstvo za bubrenje | |
CL2007001194A1 (es) | Preparacion farmaceutica solida que comprende particulas que comprenden (i) particulas de nucleo con excipiente y (ii) pioglitazona o una sal de la misma y un polimero soluble en acido, como copolimero de aminoalquil metacrilato e o dietilaminoacetato de polivinilacetal, ambos recubriendo el nucleo | |
ATE455534T1 (de) | Verwendung einer hydrophilen matrix mit einem polyacrylsäurederivat, einem celluloseether und einem sprengmittel zur herstellung eines medikaments zur behandlung von erkrankungen der weiblichen genitalorgane | |
JP2009522296A5 (da) | ||
BR112018077503A2 (pt) | formulações de liberação modificada de 2-[3-[4-amino-3-(2-fluoro-4- fenoxi-fenil)pirazolo [3,4-d]pirimidin-1-il]piperidino-1- carbonil]-4-metil-4-[4-(oxetan-3-il)piperazin-1-il] pent-2-enenitrila | |
AR062321A1 (es) | Sistema de liberacion controlada y metodo para fabricarlo | |
RS52891B (en) | GASTRORE-RESISTANT PHARMACEUTICAL FORMULATIONS CONTAINING RIFAXIMINE | |
CL2012001404A1 (es) | Composicion farmaceutica que comprende microparticulas compresibles recubiertas de farmaco, un recubrimiento de liberacion modificada, enmascarador del sabor, que comprende un polimero insoluble en agua y un recubrimiento compresible con un edulcorante no polimero sobre ella; composicion de tabletas de rapida desintegracion oral; metodo de preparacion. | |
IL187535A0 (en) | Use of polymer mixtures for the production of coated pharmaceutical formulations and pharmaceutical formulation with mixed polymeric coating | |
MX2011010324A (es) | Tableta recubierta que se desintegra oralmente. | |
WO2012091153A3 (en) | Orally disintegrating tablet | |
WO2007133583A3 (en) | Zero-order modified release solid dosage forms | |
IL196854A (en) | Indole compounds and their appropriate pharmaceutical salts and their use in the preparation of @ drugs | |
NO20091501L (no) | Farmasoytiske sammensetninger | |
WO2009090484A3 (en) | Mesalazine tablet | |
DE602006004610D1 (de) | Carvedilol enthaltende pharmazeutische zusammensetzung mit kontrollierter freisetzung | |
ATE525065T1 (de) | Pharmazeutische zubereitung für die orale verabreichung mit gesteuerter wirkstofffreisetzung im dünndarm und verfahren zu ihrer herstellung | |
EA201001244A1 (ru) | Система доставки лекарственного средства со стабилизирующим эффектом | |
DK2083638T3 (da) | Smagsfrigivende kerner og deres anvendelse i tyggegummi | |
DE60022332D1 (de) | Ketoprofen mikrogranulat, verfahren zur herstellung desselben sowie pharmazeutische zusammensetzungen | |
WO2009026315A3 (en) | Use of carbon nanotube for drug delivery | |
WO2009149058A8 (en) | Modified release niacin formulations | |
WO2012092486A3 (en) | Modified release benzimidazole formulations |