DK2264043T3 - Heterobifunktionelle pan-selektin-inhibitorer - Google Patents
Heterobifunktionelle pan-selektin-inhibitorerInfo
- Publication number
- DK2264043T3 DK2264043T3 DK10011660.7T DK10011660T DK2264043T3 DK 2264043 T3 DK2264043 T3 DK 2264043T3 DK 10011660 T DK10011660 T DK 10011660T DK 2264043 T3 DK2264043 T3 DK 2264043T3
- Authority
- DK
- Denmark
- Prior art keywords
- selectin
- compounds
- class
- selectin inhibitors
- benzyl amino
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
- A61K47/549—Sugars, nucleosides, nucleotides or nucleic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/16—Central respiratory analeptics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/04—Antipruritics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/04—Drugs for disorders of the muscular or neuromuscular system for myasthenia gravis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/20—Carbocyclic rings
- C07H15/22—Cyclohexane rings, substituted by nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/26—Acyclic or carbocyclic radicals, substituted by hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Immunology (AREA)
- Physical Education & Sports Medicine (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- Rheumatology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Diabetes (AREA)
- Pulmonology (AREA)
- Oncology (AREA)
- Hematology (AREA)
- Epidemiology (AREA)
- Dermatology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Urology & Nephrology (AREA)
- Neurology (AREA)
- Vascular Medicine (AREA)
- Communicable Diseases (AREA)
- Neurosurgery (AREA)
- Obesity (AREA)
- Transplantation (AREA)
- Endocrinology (AREA)
- Emergency Medicine (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US71399405P | 2005-09-02 | 2005-09-02 | |
| EP06814078A EP1934236B1 (en) | 2005-09-02 | 2006-09-01 | Heterobifunctional pan-selectin inhibitors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK2264043T3 true DK2264043T3 (da) | 2018-01-29 |
Family
ID=37603124
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK10011660.7T DK2264043T3 (da) | 2005-09-02 | 2006-09-01 | Heterobifunktionelle pan-selektin-inhibitorer |
| DK06814078.9T DK1934236T3 (da) | 2005-09-02 | 2006-09-01 | Heterobifunktionelle pan-selektininhibitorer |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK06814078.9T DK1934236T3 (da) | 2005-09-02 | 2006-09-01 | Heterobifunktionelle pan-selektininhibitorer |
Country Status (16)
Families Citing this family (41)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103626813B (zh) | 2005-09-02 | 2017-05-03 | 糖模拟物有限公司 | 异型双功能全选择素抑制剂 |
| JP5298020B2 (ja) * | 2006-10-12 | 2013-09-25 | グリコミメティクス， インコーポレイテッド | ヘキソースおよびｎ−アセチルヘキソサミンの糖模倣体置換 |
| CA2677747A1 (en) * | 2007-02-09 | 2008-08-21 | Glycomimetics, Inc. | Methods of use of glycomimetics with replacements for hexoses and n-acetyl hexosamines |
| US8039442B2 (en) * | 2007-07-18 | 2011-10-18 | Glycomimetics, Inc. | Compounds and methods for treatment of sickle cell disease or complications associated therewith |
| AU2008336249B2 (en) | 2007-12-10 | 2015-01-29 | The University Of Queensland | Treatment and prophylaxis |
| WO2009126556A1 (en) | 2008-04-08 | 2009-10-15 | Glycomimetics, Inc. | Pan-selectin inhibitor with enhanced pharmacokinetic activity |
| EP2318015B1 (en) * | 2008-06-13 | 2013-08-07 | GlycoMimetics, Inc. | Treatment of cancers of the blood using selected glycomimetic compounds |
| JP5726171B2 (ja) * | 2009-05-01 | 2015-05-27 | グリコミメティックス インコーポレイテッド | Ｅ−セレクチンおよびｃｘｃｒ４ケモカイン受容体のヘテロ二官能性阻害剤 |
| WO2012037034A1 (en) | 2010-09-14 | 2012-03-22 | Glycomimetics, Inc. | E-selectin antagonists |
| WO2012061662A1 (en) | 2010-11-03 | 2012-05-10 | Glycomimetics, Inc. | Glycomimetic-peptidomimetic inhibitors of e-selectins and cxcr4 chemokine receptors |
| US9109002B2 (en) * | 2011-12-22 | 2015-08-18 | Glycomimetics, Inc. | E-selectin antagonist compounds, compositions, and methods of use |
| US20140059130A1 (en) * | 2012-08-22 | 2014-02-27 | Mainsoft R&D Ltd. | System and method for updating connections in social networks |
| ES2668045T3 (es) * | 2012-12-07 | 2018-05-16 | Glycomimetics, Inc. | Compuestos, composiciones y métodos que usan antagonistas de la E-selectina para la movilización de las células hematopoyéticas |
| EP3052510A4 (en) * | 2013-09-30 | 2017-03-29 | GlycoMimetics, Inc. | Methods and compositions for treating and/or preventing mucositis |
| EP3227310B1 (en) | 2014-12-03 | 2019-07-31 | GlycoMimetics, Inc. | Heterobifunctional inhibitors of e-selectins and cxcr4 chemokine receptors |
| WO2016164394A1 (en) | 2015-04-08 | 2016-10-13 | Glycomimetics, Inc. | 2-halo-galactose-containing selectin antagonists |
| US20160331775A1 (en) * | 2015-05-14 | 2016-11-17 | The Regents Of The University Of Michigan | E-selectin inhibition works in combination with low-molecular weight heparin to decrease venous thrombosis and bleeding risk |
| US10924177B2 (en) | 2015-05-29 | 2021-02-16 | Nike, Inc. | System for operating multiple transceiver modules concurrently |
| US20200171005A9 (en) * | 2015-12-02 | 2020-06-04 | Glycomimetics, Inc. | Heterobifunctional Pan-Selectin Antagonists Having a Triazole Linker |
| US11058769B2 (en) | 2015-12-07 | 2021-07-13 | Merck Patent Gmbh | Aqueous pharmaceutical formulation comprising anti-PD-L1 antibody Avelumab |
| US11045485B2 (en) | 2016-01-22 | 2021-06-29 | Glycomimetics, Inc. | Glycomimetic inhibitors of PA-IL and PA-IIL lectins |
| US11291678B2 (en) | 2016-03-02 | 2022-04-05 | Glycomimetics, Inc | Methods for the treatment and/or prevention of cardiovascular disease by inhibition of E-selectin |
| US20200316100A1 (en) | 2016-05-24 | 2020-10-08 | GycoMimetics, Inc. | Haloalkyl fucose-containing selectin antagonists |
| WO2018031445A1 (en) | 2016-08-08 | 2018-02-15 | Glycomimetics, Inc. | Combination of t-cell checkpoint inhibitors with inhibitors of e-selectin or cxcr4, or with heterobifunctional inhibitors of both e-selectin and cxcr4 |
| JP7069136B2 (ja) | 2016-10-07 | 2022-05-17 | グリコミメティクス， インコーポレイテッド | 極めて強力な多量体ｅ－セレクチンアンタゴニスト |
| EP3596096A1 (en) | 2017-03-15 | 2020-01-22 | GlycoMimetics, Inc. | Galactopyranosyl-cyclohexyl derivatives as e-selectin antagonists |
| US11712446B2 (en) | 2017-11-30 | 2023-08-01 | Glycomimetics, Inc. | Methods of mobilizing marrow infiltrating lymphocytes and uses thereof |
| WO2019133878A1 (en) | 2017-12-29 | 2019-07-04 | Glycomimetics, Inc. | Heterobifunctional inhibitors of e-selectin and galectin-3 |
| AU2019230013A1 (en) | 2018-03-05 | 2020-09-10 | Glycomimetics, Inc. | Methods for treating acute myeloid leukemia and related conditions |
| EP3893936A2 (en) | 2018-12-10 | 2021-10-20 | GlycoMimetics, Inc. | Methods of treating hiv and aids and the elimination of latent reservoirs of hiv infection using selectin, galectin, and siglec antagonists |
| US11845771B2 (en) | 2018-12-27 | 2023-12-19 | Glycomimetics, Inc. | Heterobifunctional inhibitors of E-selectin and galectin-3 |
| WO2020150263A1 (en) | 2019-01-14 | 2020-07-23 | Magnani John L | Selectin or galectin antagonists for treating cytokine release syndrome and crs-induced neurotoxicity |
| KR20220012246A (ko) | 2019-04-24 | 2022-02-03 | 글리코미메틱스, 인크. | E-셀렉틴, 갈렉틴-3, 및/또는 cxcr4 케모카인 수용체의 갈락토오스 연결된 다량체성 글리코모방체 억제제 |
| WO2020219419A1 (en) | 2019-04-24 | 2020-10-29 | Glycomimetics, Inc. | Multimeric pan–selectin antagonists |
| WO2021011435A1 (en) | 2019-07-12 | 2021-01-21 | Magnani John L | Methods for use of gene expression as an indicator of e-selectin inhibitor efficacy and clinical outcome for multiple tumor types |
| AU2020321976A1 (en) | 2019-07-31 | 2022-03-10 | Glycomimetics, Inc. | Use of E-selectin antagonists to enhance the survival of reconstituted, bone marrow-depleted hosts |
| WO2021195465A1 (en) * | 2020-03-27 | 2021-09-30 | Magnani John L | Treatment of acute respiratory distress syndrome and related conditions with antagonists of e-selectin |
| JP2023527411A (ja) | 2020-05-31 | 2023-06-28 | グリコミメティクス， インコーポレイテッド | がん細胞の負荷を減少させ、正常な造血を保護するための化合物および方法 |
| IL298977A (en) | 2020-06-14 | 2023-02-01 | Glycomimetics Inc | Preparations and methods for overcoming microenvironment-mediated immunity by targeting selectin-E |
| EP4214218A1 (en) * | 2020-09-17 | 2023-07-26 | GlycoMimetics, Inc. | E-selectin targeting agents |
| WO2023014690A1 (en) | 2021-08-03 | 2023-02-09 | Glycomimetics, Inc. | Compositions and methods for overcoming microenvironment-mediated resistance via e-selectin targeting |
Family Cites Families (187)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2510745A (en) * | 1945-11-15 | 1950-06-06 | Charles R Kilgore | Cover for electric service outlets |
| US2514745A (en) * | 1946-12-19 | 1950-07-11 | Heyer Ind Inc | Changeable scale electrical testing instrument |
| US2757817A (en) * | 1954-04-29 | 1956-08-07 | Warren R Egan | Electrical outlet box |
| US2983399A (en) * | 1959-04-20 | 1961-05-09 | Frank E Slater | Seal for electric outlet box |
| US4109095A (en) * | 1976-10-28 | 1978-08-22 | Mulberry Metal Products, Inc. | Weatherproof electrical outlet box cover |
| US4098423A (en) * | 1977-03-10 | 1978-07-04 | Louis Marrero | Self-aligning outlet box assembly |
| US4145857A (en) * | 1977-10-28 | 1979-03-27 | Concast, Inc. | Base for mounting electrical equipment |
| US4276730A (en) * | 1979-07-02 | 1981-07-07 | Lewis David M | Building wall construction |
| US4320606A (en) * | 1979-12-06 | 1982-03-23 | Home Crafts Corporation | Reinforced concrete panels and building constructed therewith |
| US4331832A (en) * | 1980-01-10 | 1982-05-25 | Sedco Pipe Products, Inc. | Electrical outlet box |
| DE3020441A1 (de) | 1980-05-29 | 1981-12-03 | Bayer Ag, 5090 Leverkusen | Verfahren zur herstellung von nitronaphthalin-sulfonsaeuren |
| US4458460A (en) * | 1981-05-26 | 1984-07-10 | Raceway Components, Inc. | Cable module device |
| US4471057A (en) | 1981-06-30 | 1984-09-11 | The Wistar Institute | Detection of colorectal carcinoma |
| US4443654A (en) * | 1981-10-19 | 1984-04-17 | Butler Manufacturing Company | Flush floor fitting |
| US4424407A (en) * | 1981-11-30 | 1984-01-03 | Barbic Mark J | Electrical outlet safety cover |
| US4505403A (en) * | 1984-05-29 | 1985-03-19 | Slater Electric, Inc. | Weatherproof electrical receptacle cover |
| US4603789A (en) * | 1985-01-09 | 1986-08-05 | Medlin Sr Lewis B | Extension bracket for mounting electrical outlet box |
| DK17885D0 (da) | 1985-01-14 | 1985-01-14 | Karlsson Karl Anders | Antiviralt middel |
| US4876199A (en) | 1985-04-04 | 1989-10-24 | Fred Hutchinson Cancer Research Center | Hybridomas producing monoclonal antibodies to mono-, di-, and trifucosylated type 2 chain |
| CA1260596A (en) * | 1985-06-20 | 1989-09-26 | Christopher Teron | Electrical box |
| US4634015A (en) * | 1985-07-15 | 1987-01-06 | Taylor Jerald M | Adjustable electric outlet box |
| US4851511A (en) | 1986-01-30 | 1989-07-25 | Fred Hutchinson Cancer Research Center | Monoclonal antibody that specifically binds to disialosyl Lea |
| US4925796A (en) | 1986-03-07 | 1990-05-15 | Massachusetts Institute Of Technology | Method for enhancing glycoprotein stability |
| ES2058070T3 (es) | 1986-05-09 | 1994-11-01 | Pulverer Gerhard | Utilizacion de monosacaridos especificos para la preparacion de un medicamento para impedir metastasis de tumores malignos. |
| US4988832A (en) * | 1987-06-29 | 1991-01-29 | Shotey Michael J | Recessed electrical outlet with cover |
| US4803307A (en) * | 1987-06-29 | 1989-02-07 | Shotey Michael J | Weatherproof outlet cover |
| US5538724A (en) | 1987-08-11 | 1996-07-23 | The Board Of Trustees For The Leland Stanford Junior Univ. | Method of control leukocyte extravasation |
| US5079353A (en) | 1987-12-02 | 1992-01-07 | Chembiomed, Ltd. | Sialic acid glycosides, antigens, immunoadsorbents, and methods for their preparation |
| US4918259A (en) * | 1988-08-19 | 1990-04-17 | Hanson William L | Electrical outlet box extension cover |
| US4931597A (en) * | 1988-12-12 | 1990-06-05 | Square D Company | Junction boxes |
| EP0381310A1 (en) | 1989-01-30 | 1990-08-08 | The Biomembrane Institute | Monoclonal antibodies directed to tumor-associated gangliosides and fucogangliosides and method for production thereof |
| US5012043A (en) * | 1989-02-21 | 1991-04-30 | Seymour Michael R | Adjustable outlet box assembly and method of application |
| US5464778A (en) | 1989-03-08 | 1995-11-07 | Board Of Regents Of The University Of Oklahoma | Glycoprotein ligand for P-selectin and methods of use thereof |
| US5272263A (en) | 1989-04-28 | 1993-12-21 | Biogen, Inc. | DNA sequences encoding vascular cell adhesion molecules (VCAMS) |
| EP0585963A1 (en) | 1989-05-23 | 1994-03-09 | Otsuka Pharmaceutical Co., Ltd. | Monoclonal antibodies to CMP-170 antigen on activated endothelial cells |
| US5117996A (en) * | 1989-06-22 | 1992-06-02 | Mcshane William J | Electrical box extension |
| US5119606A (en) * | 1989-06-22 | 1992-06-09 | Graham Tom S | Insulated concrete wall panel |
| US6033665A (en) | 1989-09-27 | 2000-03-07 | Elan Pharmaceuticals, Inc. | Compositions and methods for modulating leukocyte adhesion to brain endothelial cells |
| US5088246A (en) * | 1990-04-10 | 1992-02-18 | Brown Noel S | Access box for conduits |
| US6280932B1 (en) | 1990-06-11 | 2001-08-28 | Gilead Sciences, Inc. | High affinity nucleic acid ligands to lectins |
| US6001988A (en) | 1990-06-11 | 1999-12-14 | Nexstar Pharmaceuticals, Inc. | High affinity nucleic acid ligands to lectins |
| US5576305A (en) | 1990-06-15 | 1996-11-19 | Cytel Corporation | Intercellular adhesion mediators |
| AU8007791A (en) | 1990-06-15 | 1992-01-07 | Cytel Corporation | Intercellular adhesion mediators |
| US5753631A (en) | 1990-06-15 | 1998-05-19 | Cytel Corporation | Intercellular adhesion mediators |
| US6387884B1 (en) | 1990-06-18 | 2002-05-14 | Stanford University | Leukocyte homing modulation |
| US6391857B1 (en) | 1990-06-18 | 2002-05-21 | Stanford University | Methods and compositions for endothelial binding |
| CA2086323C (en) | 1990-07-17 | 2002-05-14 | Rodger P. Mcever | Functionally active selectin-derived peptides and ligand for gmp-140 |
| US5143712A (en) | 1990-07-30 | 1992-09-01 | Glycomed Incorporated | Method of determining a site of inflammation utilizing elam-1 ligands |
| US5648344A (en) | 1990-07-30 | 1997-07-15 | Glycomed Incorporated | Methods of treating inflammation using selection binding compounds |
| US5211937A (en) | 1990-07-30 | 1993-05-18 | Glycomed Incorporated | Method of determining a site of inflammation utilizing elam-1 ligands |
| US5789573A (en) | 1990-08-14 | 1998-08-04 | Isis Pharmaceuticals, Inc. | Antisense inhibition of ICAM-1, E-selectin, and CMV IE1/IE2 |
| NZ240316A (en) | 1990-10-25 | 1996-12-20 | Univ Michigan | Compound for treating disease mediated by the elaboration of elam-1 on endothelial cells |
| EP0640129A1 (en) | 1990-11-23 | 1995-03-01 | The General Hospital Corporation | Inhibition of cell adhesion protein-carbohydrate interactions |
| US5151360A (en) | 1990-12-31 | 1992-09-29 | Biomembrane Institute | Effect of n,n,n-trimethylsphingosine on protein kinase-c activity, melanoma cell growth in vitro, metastatic potential in vivo and human platelet aggregation |
| US6309639B1 (en) | 1991-02-05 | 2001-10-30 | The Board Of Regents Of The University Of Oklahoma | Method for inhibiting an inflammatory response using antibodies to P-selectin glycoprotein ligand |
| US6124267A (en) | 1991-02-05 | 2000-09-26 | Southpac Trust Internationals, Inc. | O-glycan inhibitors of selectin mediated inflammation derived from PSGL-1 |
| US5222338A (en) * | 1991-03-12 | 1993-06-29 | Hull Harold L | Prefabricated concrete wall |
| US6121233A (en) | 1991-04-19 | 2000-09-19 | John L. Magnani | Methods for the inhibition of cancer metastasis mediated by endothelial adhesion molecules |
| EP0584229B1 (en) | 1991-05-06 | 2003-07-23 | Genentech, Inc. | A selectin ligand |
| US5318890A (en) | 1991-05-06 | 1994-06-07 | The Regents Of The University Of California | Assays for inhibitors of leukocyte adhesion |
| US5646123A (en) | 1991-06-10 | 1997-07-08 | Alberta Research Council | Time dependent administration of oligosaccharide glycosides related to blood group determinants having a type I or type II core structure in reducing inflammation in a sensitized mammal arising form exposure to an antigen |
| US5580858A (en) | 1991-06-10 | 1996-12-03 | Alberta Research Council | Immunosuppressive and tolerogenic modified Lewisx compounds |
| US5352670A (en) | 1991-06-10 | 1994-10-04 | Alberta Research Council | Methods for the enzymatic synthesis of alpha-sialylated oligosaccharide glycosides |
| EP0608260A1 (en) | 1991-09-10 | 1994-08-03 | Centocor, Inc. | Peptide inhibitors of inflammation mediated by selectins |
| US5268364A (en) | 1991-12-12 | 1993-12-07 | The Biomembrane Institute | Method for inhibiting selectin-dependent adhesion of leukocytes and platelets by O-glycosylation modification |
| CA2104099A1 (en) | 1991-12-18 | 1993-06-19 | George A. Heavner | Peptide inhibitors of inflammation mediated by selectins |
| US5591835A (en) | 1992-06-29 | 1997-01-07 | Glycomed Incorporated | Substituted lactose derivatives |
| CA2100412A1 (en) | 1992-07-15 | 1994-01-16 | Yutaka Yamada | Glycolipid derivatives |
| US5753617A (en) | 1992-09-08 | 1998-05-19 | Centocor, Inc. | Peptide inhibitors of cellular adhesion |
| US5519008A (en) | 1992-09-10 | 1996-05-21 | Glycomed Incorporated | Derivatives of triterpenoid acids as inhibitors of cell-adhesion molecules ELAM-1 (E-selectin) and LECAM-1 (L-selectin) |
| US5695752A (en) | 1992-09-11 | 1997-12-09 | The Regents Of The University Of California | Treating inflammation via the administration of specific sulfatase enzymes and/or sulfation inhibitor |
| WO1994006442A1 (en) | 1992-09-11 | 1994-03-31 | The Regents Of The University Of California | Sulfated ligands for l-selectins and use of chlorates and or sulfatases for the treatment of inflammation |
| US5293003A (en) * | 1992-10-08 | 1994-03-08 | Prairie Jr Marshall J | Electrical box extender |
| US6277975B1 (en) | 1992-10-23 | 2001-08-21 | Genetics Institute, Inc. | Fusions of P-selectin ligand protein and polynucleotides encoding same |
| US5843707A (en) | 1992-10-23 | 1998-12-01 | Genetics Institute, Inc. | Nucleic acid encoding a novel P-selectin ligand protein |
| EP0601417A3 (de) | 1992-12-11 | 1998-07-01 | Hoechst Aktiengesellschaft | Physiologisch verträglicher und physiologisch abbaubarer, Kohlenhydratrezeptorblocker auf Polymerbasis, ein Verfahren zu seiner Herstellung und seine Verwendung |
| WO1994014836A1 (en) | 1992-12-18 | 1994-07-07 | Centocor, Inc. | Peptide inhibitors of selectin binding |
| JP3887011B2 (ja) | 1992-12-29 | 2007-02-28 | ジェネンテク，インコーポレイテッド | ＩＦＮ−γインヒビターによる炎症性腸疾患の処置 |
| US5412123A (en) | 1993-02-08 | 1995-05-02 | Glycomed Incorporated | Anthraquinone and anthracene derivatives as inhibitors of the cell-adhesion molecules of the immune system |
| US5763413A (en) | 1993-03-04 | 1998-06-09 | Mect Corporation | Lewis-associated compound, process for producing the same, and anti-inflammatory |
| US5527890A (en) | 1993-04-16 | 1996-06-18 | Glycomed Incorporated | Derivatives of triterpenoid acids and uses thereof |
| US5854218A (en) | 1993-05-14 | 1998-12-29 | Cytel Corporation | Sialyl Lex analogues as inhibitors of cellular adhesion |
| HUT74506A (en) | 1993-05-14 | 1997-01-28 | Cytel Corp | Sialyl lewis-x analogues as inhibitors of cellular adhesion |
| SE9301677L (sv) | 1993-05-14 | 1994-11-18 | Kurt G I Nilsson | Syntesmetod |
| US5527785A (en) | 1993-05-14 | 1996-06-18 | The Regents Of The University Of California | Selectin receptor modulating compositions |
| US5811404A (en) | 1993-05-14 | 1998-09-22 | Cytel Corporation | Sialyl Lex analogues as inhibitors of cellular adhesion |
| ATE215094T1 (de) | 1993-05-17 | 2002-04-15 | Avant Immunotherapeutics Inc | Komplement verwandte proteine und kohlenhydrate enthaltende zusammensetzungen und methoden zur herstellung und verwendung dieser zusammensetzungen |
| US5976540A (en) | 1993-05-17 | 1999-11-02 | T Cell Sciences, Inc. | Compositions comprising complement related proteins and carbohydrates, and methods for producing and using said compositions |
| US5646248A (en) | 1993-06-08 | 1997-07-08 | La Jolla Cancer Research Foundation | E-selection binding soluble lamp-1 polypeptide |
| US5789385A (en) | 1993-06-16 | 1998-08-04 | Glycomed Incorporated | Sialyl Lewisx mimetics containing phenyl backbones |
| US5837689A (en) | 1993-06-16 | 1998-11-17 | Glycomed Incorporated | Sialyl lewis-x mimetics containing naphthyl backbones |
| US5750508A (en) | 1993-06-16 | 1998-05-12 | Glycomed Incorporated | Sialic acid/fucose based medicaments |
| US5658880A (en) | 1993-06-16 | 1997-08-19 | Glycomed Incorporated | Sialic acid/fucose based medicaments |
| US5679321A (en) | 1993-06-17 | 1997-10-21 | Glycomed Incorporated | Sialic acid/fucose based medicaments |
| US5559103A (en) | 1993-07-21 | 1996-09-24 | Cytel Corporation | Bivalent sialyl X saccharides |
| US5508387A (en) | 1993-08-04 | 1996-04-16 | Glycomed Incorporated | Selectin binding glycopeptides |
| US5420376A (en) * | 1993-08-06 | 1995-05-30 | The Lamson & Sessions Co. | Plastic electrical box for installation in poured concrete |
| US5827837A (en) | 1993-08-20 | 1998-10-27 | The Regents Of The University Of California | Polyanion anti-inflammatory agents |
| US5464815A (en) | 1993-09-08 | 1995-11-07 | Genentech, Inc. | Inhibition of heparin-binding |
| US5434359A (en) * | 1993-09-20 | 1995-07-18 | Hubbell Incorporated | Electrical box |
| JPH09504522A (ja) | 1993-10-12 | 1997-05-06 | グリコメド・インコーポレイテッド | 細胞接着インヒビターの同定に有用なグリコ−ペプチドのライブラリー |
| US5783693A (en) | 1993-11-19 | 1998-07-21 | The Regents Of The University Of California | Methods for synthesizing sulfated disaccharide inhibitors of selectins |
| WO1995014787A1 (en) | 1993-11-22 | 1995-06-01 | Centocor, Inc. | Peptide inhibitors of selecting binding |
| US5663151A (en) | 1994-03-04 | 1997-09-02 | Bristol-Myers Squibb Company | Sulfated α-glycolipid derivatives as cell adhesion inhibitors |
| DE4408248A1 (de) | 1994-03-11 | 1995-09-14 | Hoechst Ag | Physiologisch verträgliche und physiologisch abbaubare Kohlenhydrat-Mimetika, ein Verfahren zur Herstellung und ihre Verwendung |
| EP0671409A3 (de) | 1994-03-11 | 1996-06-12 | Hoechst Ag | Malonsäurederivate mit antiadhäsiven Eigenschaften. |
| US5444050A (en) | 1994-04-29 | 1995-08-22 | Texas Biotechnology Corporation | Binding of E-selectin or P-selectin to sialyl Lewisx or sialyl-Lewisa |
| HUT77345A (hu) | 1994-04-29 | 1998-03-30 | Texas Biotechnology Corporation | E-szelektin, P-szelektin vagy L-szelektin szialil-Lewis x-hez vagy szialil-Lewis a-hoz kapcsolódását gátló mannopiranoziloxi-bifenil származékok és ezeket tartalmazó gyógyszerkészítmények |
| US5486536A (en) | 1994-08-15 | 1996-01-23 | The Regents Of The University Of Michigan | Sulfatides as anti-inflammatory compounds |
| JPH0899989A (ja) | 1994-09-30 | 1996-04-16 | Akira Hasegawa | 新規糖脂質誘導体およびその製造用中間体 |
| US5906287A (en) * | 1994-10-03 | 1999-05-25 | Kohnen; Stephen J. | Junction box construction for use in curved structures |
| DE4436164A1 (de) | 1994-10-10 | 1996-04-11 | Hoechst Ag | Neue Kohlenhydratkonjugate als Inhibitoren der Zelladhäsion |
| US5686426A (en) | 1994-11-17 | 1997-11-11 | Bristol-Myers Squibb Company | Dicarboxymethylated glycolipid derivatives as cell adhesion inhibitors |
| US6492332B1 (en) | 1995-12-12 | 2002-12-10 | Omeros Corporation | Irrigation solution and methods for inhibition of tumor cell adhesion, pain and inflammation |
| US5639734A (en) | 1994-12-20 | 1997-06-17 | Esko; Jeffrey D. | Disaccharide inflammation inhibitors and uses thereof |
| CN1176644A (zh) | 1994-12-28 | 1998-03-18 | 住友制药株式会社 | 路易斯x衍生物及其制备方法 |
| US5648248A (en) * | 1994-12-30 | 1997-07-15 | Boehringer Ingelheim International Gmbh | Methods for producing differentiated cells from immature hematopoietic cells |
| US5883331A (en) * | 1995-01-12 | 1999-03-16 | Reiker; Kenneth H. | Electrical box with fixture support having an extension thereon |
| US20020040008A1 (en) | 1995-01-24 | 2002-04-04 | Wagner Denisa D. | Method for treating and preventing atherosclerosis |
| US6207894B1 (en) * | 1995-01-31 | 2001-03-27 | Reiker Enterprises Of Northwest Florida Inc. | Load supporting electrical box system suited for installation in concrete and having enlarged cavity therein |
| US5527936A (en) | 1995-02-17 | 1996-06-18 | E. I. Du Pont De Nemours And Company | Hydrosilylation of unsaturated compounds |
| GB9504065D0 (en) | 1995-03-01 | 1995-04-19 | Pharmacia Spa | Poly-pyrrolecarboxamidonaphthalenic acid derivatives |
| US5509560A (en) * | 1995-06-01 | 1996-04-23 | Nash; William L. | Gangable plastic box for electrical outlets |
| US5736533A (en) | 1995-06-07 | 1998-04-07 | Neose Technologies, Inc. | Bacterial inhibition with an oligosaccharide compound |
| PL185372B1 (pl) | 1995-06-29 | 2003-04-30 | Texas Biotechnology Corp | Inhibitory selektyny i kompozycja farmaceutyczna |
| SI9620099A (sl) | 1995-06-29 | 1998-08-31 | Novartis Ag | Diglikozilirani 1,2-dioli kot mimetiki sialil-Lewis X in sialil-Lewis A |
| US5876715A (en) | 1995-08-17 | 1999-03-02 | The Biomembrane Institute | Antibodies that bind novel carbohydrate ligands (myelorollins) that cause E-selectin dependent cell rolling, and uses thereof |
| DE19532902A1 (de) | 1995-09-06 | 1997-03-13 | Hoechst Ag | Neuartige Glycomimetika als Selektin-Antagonisten und daraus hergestellte entzündungshemmend wirkende Arzneimittel |
| DE19537334A1 (de) | 1995-10-09 | 1997-04-10 | Hoechst Ag | Antiadhäsive Piperidin- und Pyrrolidin-Carbonsäuren |
| US5778625A (en) * | 1995-10-13 | 1998-07-14 | Bega/Us, Inc. | Recessed lighting fixture and method of installing |
| AU7445796A (en) | 1995-10-18 | 1997-05-07 | Cytel Corporation | Sialyl lex analogues as inhibitors of cellular adhesion |
| US5919769A (en) | 1995-10-26 | 1999-07-06 | Kanebo, Ltd | Fucose derivatives, drugs containing the same as active ingredient, and intermediates for producing the same |
| US5747463A (en) | 1995-11-13 | 1998-05-05 | Bristol-Myers Squibb Company | Malonate derivatives of glycolipids as cell adhesion inhibitors |
| DE19602355A1 (de) | 1996-01-24 | 1997-07-31 | Hoechst Ag | Mehrfach fucosylierte Dicarbonsäuren mit antiadhäsiven Eigenschaften |
| DE69738731D1 (de) | 1996-01-30 | 2008-07-10 | Glycomimetics Inc | SIALYL-LEWISa UND SIALYL-LEWISx EPITOPE ANALOGE |
| WO1997028173A1 (en) | 1996-01-30 | 1997-08-07 | Novartis Ag | SIALYL-LEWISa AND SIALYL-LEWISx EPITOPE ANALOGUES |
| US5710023A (en) | 1996-03-01 | 1998-01-20 | Genetics Institute, Inc. | IL-13 cytokine receptor chain |
| DE69712754T2 (de) | 1996-03-01 | 2002-10-17 | Univ California | Hemmung der selectinbindung |
| US5654412A (en) | 1996-05-29 | 1997-08-05 | Glycomed Incorporated | Processes for the synthesis of sialyl Lewisx compounds |
| CA2197058A1 (en) | 1996-06-05 | 1997-12-06 | Avery B. Nathens | Anti-inflammatory agent |
| US5919768A (en) | 1996-06-26 | 1999-07-06 | Texas Biotechnology Corporation | Di- and trivalent small molecule selectin inhibitors |
| WO1998006730A1 (en) | 1996-08-08 | 1998-02-19 | Novartis Ag | Modified oligosaccharides |
| US5830871A (en) | 1996-10-28 | 1998-11-03 | The Scripps Research Institute | Inhibitors of E-, P- and L-selectin binding |
| GB9618520D0 (en) | 1996-09-05 | 1996-10-16 | Chiroscience Ltd | Compounds and their therapeutic use |
| AU4594297A (en) | 1996-09-27 | 1998-04-17 | Trustees Of Columbia University In The City Of New York, The | Methods for treating an ischemic disorder and improving stroke outcome |
| US6110897A (en) | 1996-10-10 | 2000-08-29 | Glycorex Ab | Antiinflammatory cell adhesion inhibitors |
| AU733692B2 (en) | 1997-02-28 | 2001-05-24 | Regents Of The University Of California, The | Inhibition of cell-cell binding by lipid assemblies |
| US6120751A (en) | 1997-03-21 | 2000-09-19 | Imarx Pharmaceutical Corp. | Charged lipids and uses for the same |
| SE9701127D0 (sv) | 1997-03-26 | 1997-03-26 | Karolinska Innovations Ab | Antigenic fusionprotein carrying GALal, 3GAL epitopes |
| US5916910A (en) | 1997-06-04 | 1999-06-29 | Medinox, Inc. | Conjugates of dithiocarbamates with pharmacologically active agents and uses therefore |
| US6193973B1 (en) | 1997-08-22 | 2001-02-27 | B. David Tuttle | Dietary supplement for boosting energy and increasing muscular strength |
| US5948628A (en) | 1997-09-05 | 1999-09-07 | The Board Of Regents Of The University Of Oklahoma | Methods of screening for compounds which mimic galectin-1 |
| US6194657B1 (en) * | 1998-10-24 | 2001-02-27 | Arlington Industries, Inc. | Mounting device |
| US6239368B1 (en) * | 1998-01-03 | 2001-05-29 | Arlington Industries, Inc. | Siding box |
| US7018637B2 (en) | 1998-02-23 | 2006-03-28 | Aventis Pasteur, Inc | Multi-oligosaccharide glycoconjugate bacterial meningitis vaccines |
| WO1999043356A1 (en) | 1998-02-25 | 1999-09-02 | Hsc Research Development Limited Partnership | Antibiotic-ligand conjugates and methods of use thereof |
| WO1999043353A2 (en) | 1998-02-26 | 1999-09-02 | Boehringer Ingelheim Pharmaceuticals, Inc. | Combination anti-selectin and immunosuppressant therapy |
| US6365365B1 (en) | 1998-03-20 | 2002-04-02 | The Regents Of The University Of California | Method of determining whether an agent modulates glycosyl sulfotransferase-3 |
| US6265192B1 (en) | 1998-03-20 | 2001-07-24 | The Regents Of The University Of California | Glycosly sulfortransferase-3 |
| US6037333A (en) | 1998-05-07 | 2000-03-14 | Trustees Of Tufts College | Microbe-inhibiting compositions |
| US6061983A (en) * | 1998-06-01 | 2000-05-16 | Mccleskey; Michael | Removable utility connection floor box and method |
| WO1999065712A2 (en) | 1998-06-16 | 1999-12-23 | The Board Of Regents Of The University Of Oklahoma | Glycosulfopeptides and methods of synthesis and use thereof |
| US6111197A (en) * | 1998-09-04 | 2000-08-29 | Layne; Harry R. | Embeddable mounting device |
| US6503885B1 (en) | 1998-09-21 | 2003-01-07 | Otsuka Pharmaceutical Co., Ltd. | Carboxymethylgalactose derivatives |
| EP1131106B1 (en) | 1998-11-12 | 2009-06-24 | Novolytics Inc. | Compositions and methods for producing vascular occlusion |
| US6167671B1 (en) * | 1998-12-21 | 2001-01-02 | Steven D. Wilson | Prefabricated concrete wall form system |
| US6172298B1 (en) * | 1999-04-08 | 2001-01-09 | Steven D. Norvelle | Telescoping electrical distribution panel |
| DE60118362T2 (de) | 2000-05-19 | 2007-05-24 | The Center for Blood Research, Inc., Boston | VERFAHREN ZUR BEHANDLUNG VON HÄMOSTATISCHEN STÖRUNGEN DURCH LöSLICHES P-SELECTIN |
| AU2000274809A1 (en) | 2000-09-12 | 2002-03-26 | Genetics Institute Llc | Inhibition of stenosis or restenosis by p-selectin antagonists |
| US7422733B2 (en) | 2000-11-29 | 2008-09-09 | Bracco International B.V. | Linkable sialyl Lewis X analogs |
| US20020132220A1 (en) | 2000-12-27 | 2002-09-19 | Berens Kurt L. | Use of selectin antagonists in organ preservation solutions |
| US20030198639A1 (en) | 2002-04-16 | 2003-10-23 | Frenette Paul S. | Methods of treating sickle cell disease |
| US7087212B2 (en) | 2001-08-17 | 2006-08-08 | Mallinckrodt, Inc | Multicomponent assemblies having enhanced binding properties for diagnosis and therapy |
| US20040072796A1 (en) | 2002-04-18 | 2004-04-15 | Embury Stephen H. | Method and composition for preventing pain in sickle cell patients |
| JP5183010B2 (ja) | 2002-05-16 | 2013-04-17 | グリコミメティクス， インコーポレイテッド | セレクチンによって媒介される機能を阻害するための化合物および方法 |
| US6858802B2 (en) * | 2002-06-14 | 2005-02-22 | Randl Industries, Inc. | Extension ring for electrical junction box installations |
| CA2490703A1 (en) | 2002-07-03 | 2004-01-15 | Glycomimetics, Inc. | Compositions and methods for diagnosis and therapy of medical conditions involving angiogenesis |
| EP1575619A1 (en) * | 2002-12-20 | 2005-09-21 | Glycomimetics, Inc. | Oligosaccharides and conjugates thereof for the treatement of pseudomonas bacteria infection |
| US20040219158A1 (en) * | 2003-05-02 | 2004-11-04 | Glycomimetics, Inc. | Compositions and methods for diagnosis and therapy of medical conditions involving infection with pseudomonas bacteria |
| US6737576B1 (en) * | 2003-05-16 | 2004-05-18 | Thomas & Betts International, Inc. | Electrical box assembly |
| JP2007524658A (ja) | 2003-11-19 | 2007-08-30 | グリコミメティクス， インコーポレイテッド | Ｅ−およびｐ−セレクチンの両方のための糖模倣物アンタゴニスト |
| ATE383367T1 (de) * | 2003-11-19 | 2008-01-15 | Glycomimetics Inc | Spezifischer antagonist sowohl für e- als auch p- selektine |
| WO2005116088A2 (en) | 2004-05-25 | 2005-12-08 | The Johns Hopkins University | Methods and compositions for treating diseases and disorders associated with siglec-8 expressing cells |
| US20060217303A1 (en) | 2005-03-25 | 2006-09-28 | Wisconsin Alumni Research Foundation | Compounds and Methods for Treating Seizure Disorders |
| WO2006127906A1 (en) * | 2005-05-25 | 2006-11-30 | Glycomimetics, Inc. | Heterobifunctional compounds for selectin inhibition |
| US20060287253A1 (en) | 2005-06-17 | 2006-12-21 | Kriegler Steven M | Compounds and methods for treating seizure disorders |
| CN103626813B (zh) | 2005-09-02 | 2017-05-03 | 糖模拟物有限公司 | 异型双功能全选择素抑制剂 |
-
2006
- 2006-09-01 CN CN201310464420.0A patent/CN103626813B/zh active Active
- 2006-09-01 US US11/515,343 patent/US7728117B2/en not_active Ceased
- 2006-09-01 PT PT68140789T patent/PT1934236E/pt unknown
- 2006-09-01 AU AU2006284578A patent/AU2006284578B2/en active Active
- 2006-09-01 DK DK10011660.7T patent/DK2264043T3/da active
- 2006-09-01 PL PL10011660T patent/PL2264043T3/pl unknown
- 2006-09-01 DK DK06814078.9T patent/DK1934236T3/da active
- 2006-09-01 SI SI200631510T patent/SI1934236T1/sl unknown
- 2006-09-01 CN CN200680037714.3A patent/CN101287741B/zh active Active
- 2006-09-01 PT PT100116607T patent/PT2264043T/pt unknown
- 2006-09-01 CA CA002670130A patent/CA2670130A1/en not_active Abandoned
- 2006-09-01 SI SI200632228T patent/SI2264043T1/en unknown
- 2006-09-01 PL PL06814078T patent/PL1934236T3/pl unknown
- 2006-09-01 LT LTEP10011660.7T patent/LT2264043T/lt unknown
- 2006-09-01 JP JP2008529320A patent/JP5209476B2/ja active Active
- 2006-09-01 EP EP06814078A patent/EP1934236B1/en active Active
- 2006-09-01 WO PCT/US2006/034274 patent/WO2007028050A1/en active Application Filing
- 2006-09-01 EP EP10011660.7A patent/EP2264043B1/en active Active
- 2006-09-01 ES ES10011660.7T patent/ES2651929T3/es active Active
- 2006-09-01 ES ES06814078T patent/ES2397850T3/es active Active
- 2006-09-01 HU HUE10011660A patent/HUE038246T2/hu unknown
-
2009
- 2009-03-10 HK HK09102286.0A patent/HK1122041A1/xx unknown
-
2010
- 2010-04-20 US US12/764,027 patent/US7989601B2/en active Active
-
2011
- 2011-06-21 US US13/165,609 patent/US8633303B2/en active Active
-
2012
- 2012-05-30 US US13/484,020 patent/USRE44778E1/en active Active
- 2012-07-03 JP JP2012149401A patent/JP2012184268A/ja not_active Withdrawn
-
2013
- 2013-12-13 US US14/106,662 patent/US20140178303A1/en not_active Abandoned
-
2016
- 2016-06-14 US US15/181,725 patent/US20160361332A1/en not_active Abandoned
-
2017
- 2017-12-27 CY CY20171101350T patent/CY1119721T1/el unknown
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| DK2264043T3 (da) | Heterobifunktionelle pan-selektin-inhibitorer | |
| WO2003097658A3 (en) | Compounds and methods for inhibiting selectin-mediated function | |
| WO2005054264A3 (en) | Glycomimetic antagonists for both e- and p-selectins | |
| WO2008002449A3 (en) | Glycomimetic inhibitors of siglec-8 | |
| WO2007143689A3 (en) | Compositions and methods for modulating vascular development | |
| NO20200671A1 (no) | Sammensetninger og fremgangsmåter for modulering av hemostase | |
| DK2024347T3 (da) | Phenylamino-benzoxazol substituerede carboxylsyrer, fremgangsmåde til deres fremstilling og deres anvendelse som lægemiddel | |
| WO2005051920A3 (en) | Specific antagonist for both e- and p-selectins | |
| WO2005117870A3 (en) | Combination of proton pump inhibitor, buffering agent, and prokinetic agent | |
| FI20065865A0 (fi) | Usean toimitilan amplitudimodulaattorin ohjausmenetelmä | |
| WO2007077561A3 (en) | Compositions and methods for enhancing in-vivo uptake of pharmaceutical agents | |
| WO2007081755A3 (en) | Indole-benzimidazole and indazole inhibitors of tyrosine phosphatases | |
| IL189553A0 (en) | Methods for bone treatment by modulating an arachidonic acid metabolic or signaling pathway | |
| WO2007087609A3 (en) | Formulations and methods for treating dry eye | |
| WO2010045388A3 (en) | Use of mmp-9 and mmp-12 binding proteins for the treatment and prevention of systemic sclerosis | |
| WO2007121186A3 (en) | Crac modulators and use of same for drug discovery | |
| BRPI0908855A8 (pt) | Comestíveis revestidos e processos para sua preparação | |
| WO2008070310A3 (en) | Method to enhance tissue regeneration | |
| WO2010034011A3 (en) | Phenylthiophenyldihydrobenzothiazepine inhibitors of store operated calcium release | |
| WO2009094577A3 (en) | Mesophasic forms of calcium-salts of (3s)-aminomethyl-b-methyl-hexanoic acids and methods of use | |
| CL2011000341A1 (es) | Compuestos derivados de pirrolidinona sustituida, moduladores de la actividad de ar para la inhibicion de ntd; procedimiento de preparacion; composicion farmaceutica; y uso para el tratamiento de cancer, acne, hirsutismo, entre otras. | |
| WO2010034003A3 (en) | Benzylthiotetrazole inhibitors of store operated calcium release | |
| ZA200709488B (en) | Benzoic acid derivatives that are modulators or agonists of GLyR | |
| BRPI0607985A2 (pt) | modulador da dscr1, métodos de tratamento, método de melhoria de efeitos colaterais e método de inibição do crescimento de tumores | |
| WO2010055072A3 (en) | Treating cancer by modulating a mnk |