NO20200671A1 - Sammensetninger og fremgangsmåter for modulering av hemostase - Google Patents

Sammensetninger og fremgangsmåter for modulering av hemostase

Info

Publication number
NO20200671A1
NO20200671A1 NO20200671A NO20200671A NO20200671A1 NO 20200671 A1 NO20200671 A1 NO 20200671A1 NO 20200671 A NO20200671 A NO 20200671A NO 20200671 A NO20200671 A NO 20200671A NO 20200671 A1 NO20200671 A1 NO 20200671A1
Authority
NO
Norway
Prior art keywords
compositions
methods
modulating hemostasis
hemostasis
modulating
Prior art date
Application number
NO20200671A
Other languages
English (en)
Inventor
Rodney M Camire
Original Assignee
Childrens Hospital Philadelphia
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Publication of NO20200671A1 publication Critical patent/NO20200671A1/no
Application filed by Childrens Hospital Philadelphia filed Critical Childrens Hospital Philadelphia

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
    • A61K38/482—Serine endopeptidases (3.4.21)
    • A61K38/4846—Factor VII (3.4.21.21); Factor IX (3.4.21.22); Factor Xa (3.4.21.6); Factor XI (3.4.21.27); Factor XII (3.4.21.38)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/6432—Coagulation factor Xa (3.4.21.6)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/647—Blood coagulation factors not provided for in a preceding group or according to more than one of the proceeding groups
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21—Serine endopeptidases (3.4.21)
    • C12Y304/21006—Coagulation factor Xa (3.4.21.6)
NO20200671A 2005-11-15 2020-06-05 Sammensetninger og fremgangsmåter for modulering av hemostase NO20200671A1 (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US73668005P 2005-11-15 2005-11-15
PCT/US2006/060927 WO2007059513A2 (en) 2005-11-15 2006-11-15 Compositions and methods for modulating hemostasis

Publications (1)

Publication Number Publication Date
NO20200671A1 true NO20200671A1 (no) 2008-07-30

Family

ID=38049397

Family Applications (3)

Application Number Title Priority Date Filing Date
NO20082182A NO345177B1 (no) 2005-11-15 2008-05-13 Sammensetninger og fremgangsmåter for modulering av hemostase
NO20200671A NO20200671A1 (no) 2005-11-15 2020-06-05 Sammensetninger og fremgangsmåter for modulering av hemostase
NO20200670A NO20200670A1 (no) 2005-11-15 2020-06-05 Sammensetninger og fremgangsmåter for modulering av hemostase

Family Applications Before (1)

Application Number Title Priority Date Filing Date
NO20082182A NO345177B1 (no) 2005-11-15 2008-05-13 Sammensetninger og fremgangsmåter for modulering av hemostase

Family Applications After (1)

Application Number Title Priority Date Filing Date
NO20200670A NO20200670A1 (no) 2005-11-15 2020-06-05 Sammensetninger og fremgangsmåter for modulering av hemostase

Country Status (26)

Country Link
US (4) US8383386B2 (no)
EP (4) EP1948690B1 (no)
JP (4) JP5823088B2 (no)
KR (4) KR101827569B1 (no)
CN (1) CN101356192B (no)
AU (1) AU2006315175B2 (no)
BR (1) BRPI0618654B1 (no)
CA (2) CA2629491C (no)
CR (1) CR9956A (no)
DK (1) DK1948690T3 (no)
EC (1) ECSP088452A (no)
ES (2) ES2496567T3 (no)
GT (1) GT200800065A (no)
HK (2) HK1128699A1 (no)
IL (1) IL191310A (no)
MX (3) MX2008006313A (no)
MY (1) MY162181A (no)
NO (3) NO345177B1 (no)
NZ (1) NZ568108A (no)
PL (1) PL1948690T3 (no)
PT (1) PT1948690E (no)
RU (2) RU2008123398A (no)
SI (1) SI1948690T1 (no)
SV (1) SV2008002906A (no)
WO (1) WO2007059513A2 (no)
ZA (1) ZA200804026B (no)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2915564B1 (en) 2007-09-28 2020-11-04 Portola Pharmaceuticals, Inc. Antidotes for factor XA inhibitors and methods of using the same
AU2009314153B2 (en) 2008-11-14 2015-09-17 Alexion Pharmaceuticals, Inc. Antidotes for factor Xa inhibitors and methods of using the same in combination with blood coagulating agents
EP3121271B1 (en) 2009-03-30 2019-07-24 Portola Pharmaceuticals, Inc. Antidotes for factor xa inhibitors and methods of using the same
WO2011008885A1 (en) 2009-07-15 2011-01-20 Portola Pharmaceuticals, Inc. Unit dose formulation of antidotes for factor xa inhibitors and methods of using the same
CA2812888A1 (en) 2010-10-06 2012-04-12 Medimmune Limited Factor ii and fibrinogen for treatment of haemostatic disorders
WO2013049804A1 (en) * 2011-09-30 2013-04-04 The Children's Hospital Of Philadelphia Compositions and methods for modulating hemostasis
BR112015001628A2 (pt) * 2012-07-25 2017-11-07 Catalyst Biosciences Inc polipeptídeos de fator x modificados e uso dos mesmos
MX2015008813A (es) * 2013-01-31 2016-03-31 Pfizer Composiciones y metodos para contrarrestar la inhibicion del factor xa.
FR3001729B1 (fr) * 2013-02-04 2015-03-06 Lab Francais Du Fractionnement Mutants du facteur x
PE20160877A1 (es) * 2013-09-24 2016-09-11 Pfizer Composiciones que comprenden poblaciones heterogeneas de proteinas recombinantes humanas de factor xa de coagulacion
EP3063170A4 (en) * 2013-11-01 2017-06-28 The Children's Hospital of Philadelphia Compositions and methods for increasing the half-life of factor xa
US20160375109A1 (en) 2014-01-24 2016-12-29 Pfizer Inc. Compositions and methods for treating intracerebral hemorrhage
MA40042B1 (fr) * 2014-05-26 2020-08-31 Academisch Ziekenhuis Leiden Protéines prohémostatiques pour le traitement de saignement
WO2016028872A2 (en) 2014-08-19 2016-02-25 The Children's Hospital Of Philadelphia Compositions and methods for modulating factor ix function
EP3490586A4 (en) 2016-07-27 2020-05-20 The Children's Hospital of Philadelphia COMPOSITIONS AND METHODS FOR MODULATING THE FACTOR IX FUNCTION
WO2023118150A1 (en) 2021-12-22 2023-06-29 Royal College Of Surgeons In Ireland A conjugate for use in localising a molecule to the vascular endothelium.

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US6093699A (en) 1987-07-09 2000-07-25 The University Of Manitoba Method for gene therapy involving suppression of an immune response
WO1994017810A1 (en) 1993-02-12 1994-08-18 The Wistar Institute Of Anatomy And Biology Recombinant cytomegalovirus vaccine
CA2160583A1 (en) 1993-04-16 1994-10-27 Stanley A. Plotkin Recombinant cytomegalovirus vaccine
WO1995005864A1 (en) 1993-08-27 1995-03-02 Government Of The United States Of America, Represented By The Secretary Of The Department Of Health And Human Services Convection-enhanced drug delivery
AT401270B (de) 1994-09-26 1996-07-25 Immuno Ag Verfahren zur quantifizierung von genomischer dna
US5998205A (en) 1994-11-28 1999-12-07 Genetic Therapy, Inc. Vectors for tissue-specific replication
WO1996026742A1 (en) 1995-02-28 1996-09-06 The Regents Of The University Of California Gene transfer-mediated angiogenesis therapy
WO1997032481A1 (en) 1996-03-07 1997-09-12 The Regents Of The University Of California Helper-free, totally defective adenovirus for gene therapy
AT405517B (de) 1997-02-27 1999-09-27 Immuno Ag Faktor x-deletionsmutanten und analoge davon
AT405516B (de) 1997-02-27 1999-09-27 Immuno Ag Faktor x-analoge mit modifizierter proteasespaltstelle
AT410216B (de) 1999-08-10 2003-03-25 Baxter Ag Faktor x-analogon mit verbesserter aktivierbarkeit
AU2001249389A1 (en) * 2000-03-22 2001-10-03 The Children's Hospital Of Philadelphia Modified blood clotting factors and methods of use
FR2831170B1 (fr) * 2001-10-19 2004-03-19 Inst Nat Sante Rech Med Proteines c modifiees activables directement par la thrombine
FR2841904B1 (fr) * 2002-07-03 2004-08-20 Inst Nat Sante Rech Med Analogues de facteurs x clivables par la thrombine
EP1728798A1 (en) 2005-06-01 2006-12-06 ZLB Behring GmbH Coagulation factor X polypeptides with modified activation properties
JP5833448B2 (ja) * 2008-12-19 2015-12-16 アンスティチュ ナショナル ドゥ ラ サンテ エ ドゥ ラ ルシェルシュ メディカル セリンプロテアーゼ誘導体および血液凝固疾患の予防または処置における使用

Also Published As

Publication number Publication date
WO2007059513A3 (en) 2007-11-29
RU2008123398A (ru) 2009-12-27
ECSP088452A (es) 2008-07-30
HK1165444A1 (zh) 2012-10-05
AU2006315175B2 (en) 2013-02-07
EP1948690A4 (en) 2009-06-17
KR101827569B1 (ko) 2018-02-09
CN101356192A (zh) 2009-01-28
JP2016005464A (ja) 2016-01-14
PT1948690E (pt) 2014-09-08
US20140120155A1 (en) 2014-05-01
JP6236194B2 (ja) 2017-11-22
JP5823088B2 (ja) 2015-11-25
JP6571735B2 (ja) 2019-09-04
CN101356192B (zh) 2013-09-11
HK1128699A1 (en) 2009-11-06
EP1948690A2 (en) 2008-07-30
WO2007059513A2 (en) 2007-05-24
BRPI0618654B1 (pt) 2021-10-19
CR9956A (es) 2008-08-21
NO345177B1 (no) 2020-10-26
JP2018033459A (ja) 2018-03-08
KR20140005383A (ko) 2014-01-14
MY162181A (en) 2017-05-31
MX2008006313A (es) 2008-11-06
JP2009515559A (ja) 2009-04-16
US20160362673A1 (en) 2016-12-15
EP2423224B1 (en) 2015-08-12
SV2008002906A (es) 2008-10-22
KR20140115374A (ko) 2014-09-30
CA2971971A1 (en) 2007-05-24
EP1948690B1 (en) 2014-06-11
CA2629491A1 (en) 2007-05-24
KR20160029135A (ko) 2016-03-14
EP2423224A1 (en) 2012-02-29
PL1948690T3 (pl) 2014-11-28
MX337059B (es) 2016-02-09
RU2570547C2 (ru) 2015-12-10
IL191310A (en) 2015-06-30
GT200800065A (es) 2008-11-03
AU2006315175A1 (en) 2007-05-24
US9896676B2 (en) 2018-02-20
SI1948690T1 (sl) 2014-09-30
BRPI0618654A8 (pt) 2019-01-15
US8383386B2 (en) 2013-02-26
ES2549929T3 (es) 2015-11-03
JP2014073127A (ja) 2014-04-24
NO20200670A1 (no) 2008-07-30
EP2431389A1 (en) 2012-03-21
BRPI0618654A2 (pt) 2011-09-06
KR101574042B1 (ko) 2015-12-03
CA2629491C (en) 2019-05-07
US20090175931A1 (en) 2009-07-09
KR20080078664A (ko) 2008-08-27
ES2496567T3 (es) 2014-09-19
KR101600158B1 (ko) 2016-03-08
NO20082182L (no) 2008-07-30
DK1948690T3 (da) 2014-09-01
RU2011130932A (ru) 2013-01-27
JP5957167B2 (ja) 2016-07-27
EP2431390B1 (en) 2015-08-12
US20180251745A1 (en) 2018-09-06
MX336958B (es) 2016-02-05
ZA200804026B (en) 2009-10-28
US9410137B2 (en) 2016-08-09
EP2431390A1 (en) 2012-03-21
NZ568108A (en) 2011-09-30

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