DK2211173T3 - Apparat og fremgangsmåde til påvisning af lokaliserede udsving i ionladning under en kemisk reaktion ved hjælp af ion-sensitive felteffekttransistorer - Google Patents

Apparat og fremgangsmåde til påvisning af lokaliserede udsving i ionladning under en kemisk reaktion ved hjælp af ion-sensitive felteffekttransistorer

Info

Publication number
DK2211173T3
DK2211173T3 DK10157896.1T DK10157896T DK2211173T3 DK 2211173 T3 DK2211173 T3 DK 2211173T3 DK 10157896 T DK10157896 T DK 10157896T DK 2211173 T3 DK2211173 T3 DK 2211173T3
Authority
DK
Denmark
Prior art keywords
ion
field effect
chemical reaction
effect transistors
charge during
Prior art date
Application number
DK10157896.1T
Other languages
English (en)
Inventor
Christofer Toumazou
Sunil Purushothaman
Original Assignee
Dna Electronics Ltd
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Publication date
Application filed by Dna Electronics Ltd filed Critical Dna Electronics Ltd
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Publication of DK2211173T3 publication Critical patent/DK2211173T3/da

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6816—Hybridisation assays characterised by the detection means
    • C12Q1/6825—Nucleic acid detection involving sensors
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
    • G01N27/403—Cells and electrode assemblies
    • G01N27/414—Ion-sensitive or chemical field-effect transistors, i.e. ISFETS or CHEMFETS
    • G01N27/4145—Ion-sensitive or chemical field-effect transistors, i.e. ISFETS or CHEMFETS specially adapted for biomolecules, e.g. gate electrode with immobilised receptors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2565/00—Nucleic acid analysis characterised by mode or means of detection
    • C12Q2565/60—Detection means characterised by use of a special device
    • C12Q2565/607—Detection means characterised by use of a special device being a sensor, e.g. electrode

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  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Molecular Biology (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Microbiology (AREA)
  • General Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Microelectronics & Electronic Packaging (AREA)
  • Biotechnology (AREA)
  • Electrochemistry (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Pathology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Investigating Or Analyzing Materials By The Use Of Electric Means (AREA)
DK10157896.1T 2001-03-09 2002-03-11 Apparat og fremgangsmåde til påvisning af lokaliserede udsving i ionladning under en kemisk reaktion ved hjælp af ion-sensitive felteffekttransistorer DK2211173T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB0105831.2A GB0105831D0 (en) 2001-03-09 2001-03-09 Method for dna sequencing utilising enzyme linked field effect transistors
EP02703740A EP1379863A2 (en) 2001-03-09 2002-03-11 Apparatus and method for the detection of localised fluctuations of ionic charge by ion sensitive field effect transistors during a chemical reaction

Publications (1)

Publication Number Publication Date
DK2211173T3 true DK2211173T3 (da) 2014-02-03

Family

ID=9910316

Family Applications (1)

Application Number Title Priority Date Filing Date
DK10157896.1T DK2211173T3 (da) 2001-03-09 2002-03-11 Apparat og fremgangsmåde til påvisning af lokaliserede udsving i ionladning under en kemisk reaktion ved hjælp af ion-sensitive felteffekttransistorer

Country Status (7)

Country Link
US (3) US7686929B2 (da)
EP (2) EP2211173B1 (da)
JP (1) JP4063770B2 (da)
DK (1) DK2211173T3 (da)
ES (1) ES2440571T3 (da)
GB (2) GB0105831D0 (da)
WO (1) WO2003073088A2 (da)

Families Citing this family (140)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7312087B2 (en) * 2000-01-11 2007-12-25 Clinical Micro Sensors, Inc. Devices and methods for biochip multiplexing
GB0105831D0 (en) 2001-03-09 2001-04-25 Toumaz Technology Ltd Method for dna sequencing utilising enzyme linked field effect transistors
US8114591B2 (en) 2001-03-09 2012-02-14 Dna Electronics Ltd. Sensing apparatus and method
US20050106587A1 (en) * 2001-12-21 2005-05-19 Micronas Gmbh Method for determining of nucleic acid analytes
WO2005003750A1 (ja) * 2003-07-02 2005-01-13 Matsushita Electric Industrial Co., Ltd. ピロリン酸検出センサ、核酸の検出方法、および塩基種判別方法
JP3903183B2 (ja) * 2004-02-03 2007-04-11 独立行政法人物質・材料研究機構 遺伝子検出電界効果デバイスおよびこれを用いた遺伝子多型解析方法
US20050218464A1 (en) * 2004-03-18 2005-10-06 Holm-Kennedy James W Biochemical ultrasensitive charge sensing
WO2005090961A1 (ja) * 2004-03-24 2005-09-29 Japan Science And Technology Agency 生体分子に関する形態及び情報をis−fetを利用して検出する測定法およびシステム
US8536661B1 (en) * 2004-06-25 2013-09-17 University Of Hawaii Biosensor chip sensor protection methods
GB2416210B (en) * 2004-07-13 2008-02-20 Christofer Toumazou Ion sensitive field effect transistors
WO2007008246A2 (en) 2004-11-12 2007-01-18 The Board Of Trustees Of The Leland Stanford Junior University Charge perturbation detection system for dna and other molecules
US20090163384A1 (en) * 2007-12-22 2009-06-25 Lucent Technologies, Inc. Detection apparatus for biological materials and methods of making and using the same
KR100773549B1 (ko) * 2006-04-03 2007-11-07 삼성전자주식회사 동일 전계 효과 트랜지스터를 이용하여 생분자를 검출하는방법
KR100773550B1 (ko) * 2006-04-03 2007-11-07 삼성전자주식회사 생분자의 고정 없이 전계 효과 트랜지스터를 이용하여생분자를 검출하는 방법
US20070235348A1 (en) * 2006-04-07 2007-10-11 Nagahara Larry A Conducting polymer nanosensor
US11001881B2 (en) 2006-08-24 2021-05-11 California Institute Of Technology Methods for detecting analytes
US11525156B2 (en) 2006-07-28 2022-12-13 California Institute Of Technology Multiplex Q-PCR arrays
US8048626B2 (en) 2006-07-28 2011-11-01 California Institute Of Technology Multiplex Q-PCR arrays
US11560588B2 (en) 2006-08-24 2023-01-24 California Institute Of Technology Multiplex Q-PCR arrays
WO2008072153A1 (en) * 2006-12-12 2008-06-19 Koninklijke Philips Electronics N. V. Electrochemical sensor device, method of manufacturing the same
US11339430B2 (en) 2007-07-10 2022-05-24 Life Technologies Corporation Methods and apparatus for measuring analytes using large scale FET arrays
EP2092322B1 (en) 2006-12-14 2016-02-17 Life Technologies Corporation Methods and apparatus for measuring analytes using large scale fet arrays
US8262900B2 (en) 2006-12-14 2012-09-11 Life Technologies Corporation Methods and apparatus for measuring analytes using large scale FET arrays
US8349167B2 (en) 2006-12-14 2013-01-08 Life Technologies Corporation Methods and apparatus for detecting molecular interactions using FET arrays
KR101176547B1 (ko) * 2006-12-20 2012-08-24 리전츠 오브 더 유니버스티 오브 미네소타 잡음이 감소된 이온 물질 검출 장치 및 방법
ATE479780T1 (de) * 2007-03-02 2010-09-15 Dna Electronics Ltd Qpcr unter verwendung eines ionen-sensitiven feldeffekt-transistors zur ph-messung
EP2251435B1 (en) 2007-03-02 2013-10-16 DNA Electronics Ltd Sensing apparatus for monitoring nucleic acid amplification, using an ion-sensitive field effect transistor (ISFET) for pH sensing
EP1975246A1 (de) * 2007-03-29 2008-10-01 Micronas Holding GmbH Markierungsfreie Sequenzierung auf einer Festphase mittels Feldeffekttransistoren
US8197650B2 (en) * 2007-06-07 2012-06-12 Sensor Innovations, Inc. Silicon electrochemical sensors
US9170228B2 (en) 2007-06-08 2015-10-27 Bharath R. Takulapalli Nano structured field effect sensor and methods of forming and using same
WO2009074926A1 (en) * 2007-12-13 2009-06-18 Nxp B.V. A biosensor device and a method of sequencing biological particles
GB2461128B (en) * 2008-06-25 2010-12-15 Ion Torrent Systems Inc ChemFET Arrays for Nucleic Acid Sequencing
EP2982437B1 (en) * 2008-06-25 2017-12-06 Life Technologies Corporation Methods and apparatus for measuring analytes using large scale fet arrays
WO2009158006A2 (en) 2008-06-26 2009-12-30 Ion Torrent Systems Incorporated Methods and apparatus for detecting molecular interactions using fet arrays
US20100137143A1 (en) 2008-10-22 2010-06-03 Ion Torrent Systems Incorporated Methods and apparatus for measuring analytes
US20100301398A1 (en) 2009-05-29 2010-12-02 Ion Torrent Systems Incorporated Methods and apparatus for measuring analytes
CN103901090B (zh) * 2008-10-22 2017-03-22 生命技术公司 用于生物和化学分析的集成式传感器阵列
US11951474B2 (en) 2008-10-22 2024-04-09 Life Technologies Corporation Fluidics systems for sequential delivery of reagents
US8546128B2 (en) 2008-10-22 2013-10-01 Life Technologies Corporation Fluidics system for sequential delivery of reagents
US20120261274A1 (en) 2009-05-29 2012-10-18 Life Technologies Corporation Methods and apparatus for measuring analytes
US8776573B2 (en) 2009-05-29 2014-07-15 Life Technologies Corporation Methods and apparatus for measuring analytes
US8673627B2 (en) 2009-05-29 2014-03-18 Life Technologies Corporation Apparatus and methods for performing electrochemical reactions
US8574835B2 (en) 2009-05-29 2013-11-05 Life Technologies Corporation Scaffolded nucleic acid polymer particles and methods of making and using
WO2010144267A1 (en) * 2009-06-12 2010-12-16 Carl Zeiss Nts, Llc Method and system for heating a tip apex of a charged particle source
US9364831B2 (en) * 2009-08-08 2016-06-14 The Regents Of The University Of California Pulsed laser triggered high speed microfluidic switch and applications in fluorescent activated cell sorting
GB201004147D0 (en) 2010-03-12 2010-04-28 Dna Electronics Ltd Method and apparatus for sensing methylation
US20110318820A1 (en) * 2010-06-29 2011-12-29 Life Technologies Corporation Immobilized Buffer Particles and Uses Thereof
US8487790B2 (en) 2010-06-30 2013-07-16 Life Technologies Corporation Chemical detection circuit including a serializer circuit
WO2012003363A1 (en) 2010-06-30 2012-01-05 Life Technologies Corporation Ion-sensing charge-accumulation circuits and methods
CN106932456B (zh) 2010-06-30 2020-02-21 生命科技公司 用于测试isfet阵列的方法和装置
US11307166B2 (en) 2010-07-01 2022-04-19 Life Technologies Corporation Column ADC
EP2589065B1 (en) 2010-07-03 2015-08-19 Life Technologies Corporation Chemically sensitive sensor with lightly doped drains
GB2482666B (en) 2010-08-03 2012-06-20 Dna Electronics Ltd Chemical sensor
US9309569B2 (en) * 2010-08-26 2016-04-12 Intelligent Bio-Systems, Inc. Methods and compositions for sequencing nucleic acid using charge
EP2617061B1 (en) 2010-09-15 2021-06-30 Life Technologies Corporation Methods and apparatus for measuring analytes
US8685324B2 (en) 2010-09-24 2014-04-01 Life Technologies Corporation Matched pair transistor circuits
JP5494396B2 (ja) * 2010-09-28 2014-05-14 大日本印刷株式会社 バイオセンサ
JP5488372B2 (ja) * 2010-09-28 2014-05-14 大日本印刷株式会社 バイオセンサ
US9399217B2 (en) 2010-10-04 2016-07-26 Genapsys, Inc. Chamber free nanoreactor system
KR101963462B1 (ko) 2010-10-04 2019-03-28 제납시스 인크. 재사용 가능한 자동화 평행 생물 반응 시스템 및 방법
US9184099B2 (en) 2010-10-04 2015-11-10 The Board Of Trustees Of The Leland Stanford Junior University Biosensor devices, systems and methods therefor
EP2625287A1 (en) * 2010-10-08 2013-08-14 DNA Electronics Ltd Ionic signal enhancement
GB201018224D0 (en) 2010-10-28 2010-12-15 Dna Electronics Chemical sensing device
WO2012083258A2 (en) 2010-12-16 2012-06-21 Sensor Innovations, Inc. Electrochemical sensors
WO2012109315A1 (en) * 2011-02-08 2012-08-16 Life Technologies Corporation Linking methods, compositions, systems, kits and apparatuses
US9176504B2 (en) 2011-02-11 2015-11-03 The Regents Of The University Of California High-speed on demand droplet generation and single cell encapsulation driven by induced cavitation
ES2827293T3 (es) 2011-03-08 2021-05-20 Univ Laval Dispositivo centrípeto fluídico
US20120264617A1 (en) * 2011-04-14 2012-10-18 Pettit John W Dna sequencing employing nanomaterials
US8585973B2 (en) 2011-05-27 2013-11-19 The Board Of Trustees Of The Leland Stanford Junior University Nano-sensor array
US9926596B2 (en) 2011-05-27 2018-03-27 Genapsys, Inc. Systems and methods for genetic and biological analysis
TWI596340B (zh) * 2011-06-17 2017-08-21 長庚大學 一種氨化感測薄膜之表面處理方法
WO2013009890A2 (en) 2011-07-13 2013-01-17 The Multiple Myeloma Research Foundation, Inc. Methods for data collection and distribution
GB201112140D0 (en) 2011-07-14 2011-08-31 Dna Electronics Nucleic acid amplification
GB2493141A (en) 2011-07-19 2013-01-30 Gene Onyx Ltd Method of selecting a product using a DNA sample
US9670538B2 (en) * 2011-08-05 2017-06-06 Ibis Biosciences, Inc. Nucleic acid sequencing by electrochemical detection
WO2013082619A1 (en) 2011-12-01 2013-06-06 Genapsys, Inc. Systems and methods for high efficiency electronic sequencing and detection
US9970984B2 (en) 2011-12-01 2018-05-15 Life Technologies Corporation Method and apparatus for identifying defects in a chemical sensor array
US8821798B2 (en) 2012-01-19 2014-09-02 Life Technologies Corporation Titanium nitride as sensing layer for microwell structure
US8747748B2 (en) 2012-01-19 2014-06-10 Life Technologies Corporation Chemical sensor with conductive cup-shaped sensor surface
US9515676B2 (en) 2012-01-31 2016-12-06 Life Technologies Corporation Methods and computer program products for compression of sequencing data
US9864846B2 (en) 2012-01-31 2018-01-09 Life Technologies Corporation Methods and computer program products for compression of sequencing data
GB2500658A (en) 2012-03-28 2013-10-02 Dna Electronics Ltd Biosensor device and system
GB2500715A (en) * 2012-03-30 2013-10-02 Gene Onyx Ltd Single nucleotide polymorphism detection using an ISFET array
EP2836828B1 (en) 2012-04-09 2022-12-14 Takulapalli, Bharath Field effect transistor, device including the transistor, and methods of forming and using same
US8786331B2 (en) 2012-05-29 2014-07-22 Life Technologies Corporation System for reducing noise in a chemical sensor array
GB201212775D0 (en) 2012-07-18 2012-08-29 Dna Electronics Ltd Sensing apparatus and method
US9034606B2 (en) 2012-08-23 2015-05-19 New England Biolabs, Inc. Detection of an amplification reaction product using pH-sensitive dyes
US9599586B2 (en) * 2012-08-27 2017-03-21 Infineon Technologies Ag Ion sensor
CN102886280B (zh) * 2012-08-28 2014-06-11 博奥生物有限公司 一种微流控芯片及其应用
US10597650B2 (en) 2012-12-21 2020-03-24 New England Biolabs, Inc. Ligase activity
US10597710B2 (en) 2012-12-21 2020-03-24 New England Biolabs, Inc. Ligase activity
US9080968B2 (en) 2013-01-04 2015-07-14 Life Technologies Corporation Methods and systems for point of use removal of sacrificial material
US9841398B2 (en) 2013-01-08 2017-12-12 Life Technologies Corporation Methods for manufacturing well structures for low-noise chemical sensors
US10451584B2 (en) 2013-01-17 2019-10-22 Hitachi High-Technologies Corporation Biomolecule measuring device
US8962366B2 (en) 2013-01-28 2015-02-24 Life Technologies Corporation Self-aligned well structures for low-noise chemical sensors
US8963216B2 (en) 2013-03-13 2015-02-24 Life Technologies Corporation Chemical sensor with sidewall spacer sensor surface
US8841217B1 (en) 2013-03-13 2014-09-23 Life Technologies Corporation Chemical sensor with protruded sensor surface
EP2972279B1 (en) 2013-03-15 2021-10-06 Life Technologies Corporation Chemical sensors with consistent sensor surface areas
US9809852B2 (en) 2013-03-15 2017-11-07 Genapsys, Inc. Systems and methods for biological analysis
US9835585B2 (en) 2013-03-15 2017-12-05 Life Technologies Corporation Chemical sensor with protruded sensor surface
CA2909687A1 (en) 2013-03-15 2014-09-25 The Regents Of The University Of California High-speed on demand microfluidic droplet generation and manipulation
US9116117B2 (en) 2013-03-15 2015-08-25 Life Technologies Corporation Chemical sensor with sidewall sensor surface
US20140264471A1 (en) 2013-03-15 2014-09-18 Life Technologies Corporation Chemical device with thin conductive element
CN105264366B (zh) 2013-03-15 2019-04-16 生命科技公司 具有一致传感器表面区域的化学传感器
US20140336063A1 (en) 2013-05-09 2014-11-13 Life Technologies Corporation Windowed Sequencing
US10458942B2 (en) 2013-06-10 2019-10-29 Life Technologies Corporation Chemical sensor array having multiple sensors per well
US20150024508A1 (en) * 2013-07-22 2015-01-22 Honeywell International Inc. APPARATUS AND METHOD FOR COMPENSATING pH MEASUREMENT ERRORS DUE TO PRESSURE AND PHYSICAL STRESSES
EP3080300B1 (en) 2013-12-11 2020-09-02 Genapsys Inc. Systems and methods for biological analysis and computation
US20170023555A1 (en) * 2014-04-11 2017-01-26 Credo Biomedical Pte Ltd. Devices and kits for measuring biological results
WO2015161054A2 (en) 2014-04-18 2015-10-22 Genapsys, Inc. Methods and systems for nucleic acid amplification
JP6794350B2 (ja) 2014-07-02 2020-12-02 ライフ テクノロジーズ コーポレーション 半導体センサの表面処理
US10487357B2 (en) * 2014-10-03 2019-11-26 Life Technologies Corporation Methods of nucleic acid analysis using terminator nucleotides
US10544455B2 (en) * 2014-10-03 2020-01-28 Life Technologies Corporation Sequencing methods, compositions and systems using terminator nucleotides
EP3234575B1 (en) 2014-12-18 2023-01-25 Life Technologies Corporation Apparatus for measuring analytes using large scale fet arrays
US10077472B2 (en) 2014-12-18 2018-09-18 Life Technologies Corporation High data rate integrated circuit with power management
CN107250784B (zh) 2014-12-18 2020-10-23 生命科技公司 具有发送器配置的高数据率集成电路
US9835583B2 (en) 2015-04-24 2017-12-05 International Business Machines Corporation Remote sensing using pulse-width modulation
WO2016175840A1 (en) * 2015-04-30 2016-11-03 Hewlett-Packard Development Company, L.P. Sensing a property of a fluid
KR101729685B1 (ko) 2015-05-21 2017-05-11 한국기계연구원 이온 농도 검출 방법 및 장치
WO2017018973A1 (en) * 2015-07-24 2017-02-02 Hewlett-Packard Development Company, L.P. Sensing a property and level of a fluid
USD799715S1 (en) 2015-10-23 2017-10-10 Gene POC, Inc. Fluidic centripetal device
WO2017155858A1 (en) 2016-03-07 2017-09-14 Insilixa, Inc. Nucleic acid sequence identification using solid-phase cyclic single base extension
US11977069B2 (en) 2016-04-19 2024-05-07 Bharath Takulapalli Nanopore sensor, structure and device including the sensor, and methods of forming and using same
WO2018017884A1 (en) 2016-07-20 2018-01-25 Genapsys, Inc. Systems and methods for nucleic acid sequencing
DK3565905T3 (da) 2017-01-04 2022-07-25 Mgi Tech Co Ltd Nukleinsyresekvensering ved hjælp af affinitetsreagenser
WO2018136856A1 (en) 2017-01-23 2018-07-26 Massachusetts Institute Of Technology Multiplexed signal amplified fish via splinted ligation amplification and sequencing
JP6857353B2 (ja) * 2017-03-30 2021-04-14 国立大学法人東北大学 生体分子センサー
US11180804B2 (en) 2017-07-25 2021-11-23 Massachusetts Institute Of Technology In situ ATAC sequencing
SG11202002516WA (en) 2017-09-21 2020-04-29 Genapsys Inc Systems and methods for nucleic acid sequencing
MX2019003148A (es) 2017-11-13 2019-05-27 The Multiple Myeloma Res Foundation Inc Base de datos, de datos moleculares, omicos, de inmunoterapia, metabolicos, epigeneticos y clinicos, integrados.
CN112119300A (zh) * 2018-05-31 2020-12-22 哈希公司 水样的ph测量
US11131615B2 (en) 2018-06-07 2021-09-28 Nanohmics, Inc. Sensor and methods for detecting and quantifying ions and molecules
JP2022525322A (ja) 2019-03-14 2022-05-12 インシリクサ， インコーポレイテッド 時間ゲート蛍光ベースの検出のための方法およびシステム
US10942165B1 (en) 2019-12-20 2021-03-09 Dnae Group Holdings Ltd Methods for preparing cartridges for in vitro diagnostics and related systems
US20220268729A1 (en) * 2021-02-24 2022-08-25 Robert Bosch Gmbh Measuring ion strength using closed-loop electrochemical ph modulation
GB202110485D0 (en) 2021-07-21 2021-09-01 Dnae Diagnostics Ltd Compositions, kits and methods for sequencing target polynucleotides
WO2023002203A1 (en) 2021-07-21 2023-01-26 Dnae Diagnostics Limited Method and system comprising a cartridge for sequencing target polynucleotides
GB202110479D0 (en) 2021-07-21 2021-09-01 Dnae Diagnostics Ltd Compositions, kits and methods for sequencing target polynucleotides
CA3232702A1 (en) 2021-09-23 2023-03-30 Geert Meersseman Nucleic acid detection
GB202215624D0 (en) 2022-10-21 2022-12-07 Dnae Diagnostics Ltd Clonal amplification

Family Cites Families (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4467459A (en) * 1982-01-04 1984-08-21 Texaco Inc. Seismic method improving signal-to-noise ratio
US4555623A (en) * 1983-12-05 1985-11-26 Irvine Sensors Corporation Pre-amplifier in focal plane detector array
DE3513168A1 (de) * 1985-04-12 1986-10-16 Thomas 8000 München Dandekar Biosensor bestehend aus einem halbleiter auf silizium oder kohlenstoffbasis (elektronischer teil) und nukleinbasen (od. anderen biol. monomeren)
GB8528794D0 (en) * 1985-11-22 1985-12-24 Emi Plc Thorn Buffer compensation in enzyme
DK64187A (da) * 1986-02-10 1987-08-11 Terumo Corp Enzym-foeler og fremgangsmaade til fremstilling af en saadan
DE3806955A1 (de) * 1987-03-03 1988-09-15 Res Ass Bio Tech Chem Glucoseempfindlicher fet-sensor und verfahren zu seiner herstellung
JPH01102352A (ja) * 1987-10-16 1989-04-20 Toshiba Corp バイオセンサー
IT1229691B (it) * 1989-04-21 1991-09-06 Eniricerche Spa Sensore con antigene legato chimicamente a un dispositivo semiconduttore.
GB8910880D0 (en) * 1989-05-11 1989-06-28 Amersham Int Plc Sequencing method
JPH02309241A (ja) * 1989-05-24 1990-12-25 Matsushita Electric Ind Co Ltd アドレナリン検出センサ
KR930002824B1 (ko) * 1990-08-21 1993-04-10 손병기 감이온 전계효과 트랜지스터를 이용한 바이오 센서용 측정회로
WO1993008464A1 (en) * 1991-10-21 1993-04-29 Holm Kennedy James W Method and device for biochemical sensing
US5632957A (en) * 1993-11-01 1997-05-27 Nanogen Molecular biological diagnostic systems including electrodes
US5795782A (en) * 1995-03-17 1998-08-18 President & Fellows Of Harvard College Characterization of individual polymer molecules based on monomer-interface interactions
US5827482A (en) * 1996-08-20 1998-10-27 Motorola Corporation Transistor-based apparatus and method for molecular detection and field enhancement
US6060327A (en) * 1997-05-14 2000-05-09 Keensense, Inc. Molecular wire injection sensors
JP2001244376A (ja) * 2000-02-28 2001-09-07 Hitachi Ltd 半導体装置
FR2805826B1 (fr) 2000-03-01 2002-09-20 Nucleica Nouvelles puces a adn
US6413792B1 (en) * 2000-04-24 2002-07-02 Eagle Research Development, Llc Ultra-fast nucleic acid sequencing device and a method for making and using the same
AU2001271401A1 (en) * 2000-06-23 2002-01-08 The United States Of America As Represented By The Secretary Of The Navy Microelectronic device and method for label-free detection and quantification ofbiological and chemical molecules
US8114591B2 (en) * 2001-03-09 2012-02-14 Dna Electronics Ltd. Sensing apparatus and method
GB0105831D0 (en) * 2001-03-09 2001-04-25 Toumaz Technology Ltd Method for dna sequencing utilising enzyme linked field effect transistors
AU2002367849A1 (en) * 2001-04-03 2003-10-20 Clinical Micro Sensors, Inc. Nucleic acid reactions using labels with different redox potentials
WO2002086162A1 (en) 2001-04-23 2002-10-31 Samsung Electronics Co., Ltd. Molecular detection chip including mosfet, molecular detection device employing the chip, and molecular detection method using the device
EP1423687A1 (en) * 2001-08-08 2004-06-02 The Arizona Board of Regents Nucleic acid field effect transistor
JP4195859B2 (ja) 2001-11-16 2008-12-17 株式会社バイオエックス Ｆｅｔ型センサと、そのセンサを用いたイオン濃度検出方法及び塩基配列検出方法
US6953958B2 (en) * 2002-03-19 2005-10-11 Cornell Research Foundation, Inc. Electronic gain cell based charge sensor
CN1500887A (zh) 2002-10-01 2004-06-02 松下电器产业株式会社 引物伸长反应检测方法、碱基种类判别方法及其装置
US7355216B2 (en) 2002-12-09 2008-04-08 The Regents Of The University Of California Fluidic nanotubes and devices

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EP1379863A2 (en) 2004-01-14
JP2005518541A (ja) 2005-06-23
JP4063770B2 (ja) 2008-03-19
WO2003073088A2 (en) 2003-09-04
GB2389424A (en) 2003-12-10
GB0320090D0 (en) 2003-10-01
GB2389424B (en) 2004-11-24
GB2389424C (en) 2009-01-21
WO2003073088A3 (en) 2003-11-20
GB0105831D0 (en) 2001-04-25
EP2211173A1 (en) 2010-07-28
US20080032295A1 (en) 2008-02-07
US20040134798A1 (en) 2004-07-15
US7888015B2 (en) 2011-02-15
US8685228B2 (en) 2014-04-01
EP2211173B1 (en) 2013-10-23
US20100151479A1 (en) 2010-06-17
ES2440571T3 (es) 2014-01-29

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