DK2207429T4 - Lipidsammensætninger til behandling af gastro-intestinale sygdomme - Google Patents

Lipidsammensætninger til behandling af gastro-intestinale sygdomme Download PDF

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Publication number
DK2207429T4
DK2207429T4 DK08808110.4T DK08808110T DK2207429T4 DK 2207429 T4 DK2207429 T4 DK 2207429T4 DK 08808110 T DK08808110 T DK 08808110T DK 2207429 T4 DK2207429 T4 DK 2207429T4
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composition
fatty acids
diet
acid residues
use according
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DK08808110.4T
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DK2207429T3 (da
Inventor
Yosef Fabiana Bar
Dror Gai Ben
Tzafra Cohen
Yael Lifshitz
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Enzymotec Ltd
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    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/115—Fatty acids or derivatives thereof; Fats or oils
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23D—EDIBLE OILS OR FATS, e.g. MARGARINES, SHORTENINGS, COOKING OILS
    • A23D7/00—Edible oil or fat compositions containing an aqueous phase, e.g. margarines
    • A23D7/001—Spread compositions
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K20/00—Accessory food factors for animal feeding-stuffs
    • A23K20/10—Organic substances
    • A23K20/158—Fatty acids; Fats; Products containing oils or fats
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K50/00—Feeding-stuffs specially adapted for particular animals
    • A23K50/10—Feeding-stuffs specially adapted for particular animals for ruminants
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K50/00—Feeding-stuffs specially adapted for particular animals
    • A23K50/40—Feeding-stuffs specially adapted for particular animals for carnivorous animals, e.g. cats or dogs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A21—BAKING; EDIBLE DOUGHS
    • A21D—TREATMENT, e.g. PRESERVATION, OF FLOUR OR DOUGH, e.g. BY ADDITION OF MATERIALS; BAKING; BAKERY PRODUCTS; PRESERVATION THEREOF
    • A21D2/00—Treatment of flour or dough by adding materials thereto before or during baking
    • A21D2/08—Treatment of flour or dough by adding materials thereto before or during baking by adding organic substances
    • A21D2/14—Organic oxygen compounds
    • A21D2/16—Fatty acid esters
    • A21D2/165—Triglycerides
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23D—EDIBLE OILS OR FATS, e.g. MARGARINES, SHORTENINGS, COOKING OILS
    • A23D7/00—Edible oil or fat compositions containing an aqueous phase, e.g. margarines
    • A23D7/003—Compositions other than spreads
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/115—Fatty acids or derivatives thereof; Fats or oils
    • A23L33/12—Fatty acids or derivatives thereof
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/40—Complete food formulations for specific consumer groups or specific purposes, e.g. infant formula
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
    • A61K31/23—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin of acids having a carboxyl group bound to a chain of seven or more carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
    • A61K31/23—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin of acids having a carboxyl group bound to a chain of seven or more carbon atoms
    • A61K31/231—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin of acids having a carboxyl group bound to a chain of seven or more carbon atoms having one or two double bonds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
    • A61K31/23—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin of acids having a carboxyl group bound to a chain of seven or more carbon atoms
    • A61K31/232—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin of acids having a carboxyl group bound to a chain of seven or more carbon atoms having three or more double bonds, e.g. etretinate

Claims (14)

  1. LIPIDSAMMENSÆTNINGER TIL BEHANDLING AF GASTRO-INTESTINALE SYGDOMME PATENTKRAV
    1. Lipidsammensætning, der omfatter mindst ét syntetisk triglycerid med den følgende formel I:
    hvor R1; R2 og R3 kan være identiske eller forskellige, og hver især er uafhængigt udvalgt fra H eller en acylgruppe, hvor acylgruppen er udvalgt fra en gruppe, der består af mættede, mono-umættede og poly-umættede fedtsyrerester, og hvor det samlede palmitinsyrerestindhold er fra omkring 15 % til omkring 55 % af de samlede fedtsyrerester i sammensætningen, hvor mindst 30 % af de samlede palmitinsyrerester er bundet til sn-2 positionen af triglyceridhovedkæden, til anvendelse i forebyggelse og behandling af korttarmssyndrom, inflammatorisk tarmsygdom og nekrotiserende enterokolit.
  2. 2. Sammensætning til anvendelse ifølge krav 1, hvor R2 er en mættet fedtsyrerest.
  3. 3. Sammensætning til anvendelse ifølge krav 2, hvor den mættede fedtsyre er en palmitinsyrerest.
  4. 4. Sammensætning til anvendelse ifølge krav 1, hvor mindst 13 % af de samlede fedtsyrer ved sn-2 positionen af triglyceridhovedkæden er palmitinsyrerester.
  5. 5. Sammensætning til anvendelse ifølge krav 1, hvor Ri og R3 er umættede fedtsyrerester.
  6. 6. Sammensætning til anvendelse ifølge krav 5, hvor mindst 50 % af den samlede fedtsyrerest ved sn- 1- og sn-3 positionerne af triglyceridhovedkæden er umættede.
  7. 7. Sammensætning til anvendelse ifølge krav 6, hvor mindst 35 % af den umættede fedtsyrerest ved sn-1 - og sn-3-positionerne er oliesyrerester.
  8. 8. Sammensætning til anvendelse ifølge krav 7, hvor mindst 4 % af de umættede fedtsyrerester ved sn-1- og sn-3-positionerne er linoliesyrerester.
  9. 9. Sammensætning til anvendelse ifølge krav 8, hvor mindst 6 % af de umættede fedtsyrerester ved sn-1 - og sn-3 -positionerne er linoliesyrerester.
  10. 10. Sammensætning til anvendelse ifølge krav 1, hvor lipidet består af 0-10 % C8:0 fedtsyrer ud af de samlede fedtsyrer; 0-10 % 00:0 fedtsyrer ud af de samlede fedtsyrer; 0-22 % 02:0 fedtsyrer ud af de samlede fedtsyrer; 0- 15 % 04:0 fedtsyrerud af de samlede fedtsyrer; 15-55 % 06:0 fedtsyrerud af de samlede fedtsyrer; hvor mindst 30 % ved sn-2-position; 1- 7 % 08:0 fedtsyrerud af de samlede fedtsyrer; 20-75 % 08:1 fedtsyrerud af de samlede fedtsyrer; 2- 40 % 08:2 fedtsyrer ud af de samlede fedtsyrer; 0-8 % 08:3 fedtsyrer ud af de samlede fedtsyrer; andre fedtsyrer er til stede i niveauer på mindre end 8 % af de samlede fedtsyrer.
  11. 11. Sammensætninger til anvendelse ifølge et hvilket som helst af kravene 1 til 10, hvor lipidsammensætningen fremstilles fra en naturlig, syntetisk eller halvsyntetisk kilde.
  12. 12. Sammensætning til anvendelse ifølge krav 11, hvor fremstillingen af lipidsammensætningen involverede en enzymatisk katalyse.
  13. 13. Sammensætning til anvendelse ifølge krav 1, hvor sammensætningen er en emæringsmæssig sammensætning, en farmaceutisk sammensætning, en nutraceutisk sammensætning eller en funktionel fødevare.
  14. 14. Sammensætning til anvendelse ifølge krav 13, hvor den ernæringsmæssige sammensætning er udvalgt fra human mælke fedtsubstitut, modermælkserstatning, mælkeprodukter, is, småkage, sojaprodukt, bagværk, kager og brød, sauce, suppe, færdigretter, frosne fødevarer, krydderier, konfekt, olier og fedt, margarine, smørepålæg, fyldninger, kornprodukter, instantprodukter, babymad, bømemad, barrer, snacks, slik og chokoladeprodukter.
DK08808110.4T 2007-10-09 2008-10-02 Lipidsammensætninger til behandling af gastro-intestinale sygdomme DK2207429T4 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US96066407P 2007-10-09 2007-10-09
PCT/IL2008/001311 WO2009047754A2 (en) 2007-10-09 2008-10-02 Lipid compositions for the treatment of gastro-intestinal disorders and the promotion of intestinal development and maturation

Publications (2)

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DK2207429T3 DK2207429T3 (da) 2013-09-08
DK2207429T4 true DK2207429T4 (da) 2017-04-10

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US (3) US9107439B2 (da)
EP (1) EP2207429B2 (da)
KR (1) KR101354547B1 (da)
CN (1) CN101896073B (da)
AU (1) AU2008309140B9 (da)
BR (1) BRPI0818079B8 (da)
CA (1) CA2701161C (da)
DK (1) DK2207429T4 (da)
ES (1) ES2426591T5 (da)
MX (1) MX2010003651A (da)
RU (1) RU2469545C2 (da)
WO (1) WO2009047754A2 (da)

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AU2008309140B2 (en) 2013-05-09
EP2207429B1 (en) 2013-06-05
CN101896073A (zh) 2010-11-24
RU2469545C2 (ru) 2012-12-20
US8980949B2 (en) 2015-03-17
US9561207B2 (en) 2017-02-07
KR101354547B1 (ko) 2014-01-22
RU2010117211A (ru) 2011-11-20
CA2701161A1 (en) 2009-04-16
ES2426591T3 (es) 2013-10-24
US20160030377A1 (en) 2016-02-04
WO2009047754A3 (en) 2009-05-22
EP2207429A2 (en) 2010-07-21
MX2010003651A (es) 2010-07-05
US20100273881A1 (en) 2010-10-28
CN101896073B (zh) 2013-11-20
DK2207429T3 (da) 2013-09-08
WO2009047754A2 (en) 2009-04-16
US9107439B2 (en) 2015-08-18
BRPI0818079A2 (pt) 2017-06-13
US20140187632A1 (en) 2014-07-03
BRPI0818079A8 (pt) 2017-10-03
CA2701161C (en) 2014-01-14
KR20100106951A (ko) 2010-10-04
EP2207429B2 (en) 2016-12-28
AU2008309140A1 (en) 2009-04-16
AU2008309140B9 (en) 2013-07-04
ES2426591T5 (es) 2017-08-16
BRPI0818079B8 (pt) 2021-07-27
BRPI0818079B1 (pt) 2019-11-05

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