DK2066349T3 - Humaniseret anti-cd19-antistoffer og anvendelse heraf i behandling af tumorer, transplantation og autoimmune sygdomme - Google Patents

Humaniseret anti-cd19-antistoffer og anvendelse heraf i behandling af tumorer, transplantation og autoimmune sygdomme

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Publication number
DK2066349T3
DK2066349T3 DK07842083.3T DK07842083T DK2066349T3 DK 2066349 T3 DK2066349 T3 DK 2066349T3 DK 07842083 T DK07842083 T DK 07842083T DK 2066349 T3 DK2066349 T3 DK 2066349T3
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Denmark
Prior art keywords
treatment
antibodies
transplantation
tumors
autoimmune diseases
Prior art date
Application number
DK07842083.3T
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Danish (da)
English (en)
Inventor
Melissa Damschroder
Peter Kiener
Herren Wu
Acqua William Dall
Ronald Herbst
Anthony Coyle
Original Assignee
Medimmune Llc
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Application filed by Medimmune Llc filed Critical Medimmune Llc
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Publication of DK2066349T3 publication Critical patent/DK2066349T3/da

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    • C07K16/28Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
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    • C07K16/28Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
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DK07842083.3T 2006-09-08 2007-09-07 Humaniseret anti-cd19-antistoffer og anvendelse heraf i behandling af tumorer, transplantation og autoimmune sygdomme DK2066349T3 (da)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US84293506P 2006-09-08 2006-09-08
US86691706P 2006-11-22 2006-11-22
US91139707P 2007-04-12 2007-04-12
US91530907P 2007-05-01 2007-05-01
US93942907P 2007-05-22 2007-05-22
PCT/US2007/077916 WO2008031056A2 (fr) 2006-09-08 2007-09-07 Anticorps anti-cd19 humanisés, et leur utilisation dans le traitement de l'oncologie, de la transplantation et de la maladie auto-immune

Publications (1)

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DK2066349T3 true DK2066349T3 (da) 2012-07-09

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DK07842083.3T DK2066349T3 (da) 2006-09-08 2007-09-07 Humaniseret anti-cd19-antistoffer og anvendelse heraf i behandling af tumorer, transplantation og autoimmune sygdomme

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US (5) US8323653B2 (fr)
EP (1) EP2066349B1 (fr)
JP (1) JP5401314B2 (fr)
KR (1) KR101456728B1 (fr)
CN (1) CN103694349A (fr)
AT (1) ATE551071T1 (fr)
AU (1) AU2007294575B2 (fr)
CA (1) CA2662340C (fr)
CY (1) CY1112883T1 (fr)
DK (1) DK2066349T3 (fr)
ES (1) ES2383710T3 (fr)
FR (1) FR22C1052I2 (fr)
HU (1) HUS2200044I1 (fr)
LT (1) LTPA2022520I1 (fr)
MX (1) MX2009002414A (fr)
NL (1) NL301196I2 (fr)
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Families Citing this family (118)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7902338B2 (en) * 2003-07-31 2011-03-08 Immunomedics, Inc. Anti-CD19 antibodies
EP2287328A3 (fr) * 2004-07-16 2011-06-08 INSERM (Institut National de la Santé et de la Recherche Médicale) Phospholipase A2 sécrétoire comme marqueur prognostique et diagnostique de maladies cardio-vasculaires
US20100104564A1 (en) * 2005-03-29 2010-04-29 Genevieve Hansen Altered Antibody Fc Regions and Uses Thereof
US9486408B2 (en) 2005-12-01 2016-11-08 University Of Massachusetts Lowell Botulinum nanoemulsions
US11046784B2 (en) 2006-03-31 2021-06-29 Chugai Seiyaku Kabushiki Kaisha Methods for controlling blood pharmacokinetics of antibodies
EP1884571A1 (fr) * 2006-07-31 2008-02-06 INSERM (Institut National de la Santé et de la Recherche Médicale) utilisation de l'activité de spla2 pour le diagnose des maladies cardiovasculaires
DK2059536T3 (da) 2006-08-14 2014-04-14 Xencor Inc Optimerede antistoffer, der er rettet mod cd19
MX2009002414A (es) * 2006-09-08 2009-05-20 Medimmune Llc Anticuerpos anti-cd19 humanizados y su uso en el tratamiento de oncologia, transplante y enfermedad autoinmunitaria.
US20100061980A1 (en) * 2006-12-01 2010-03-11 Cedars-Sinai Medical Center Assays to predict and monitor antibody mediated rejection of transplanted allografts
ES2659517T3 (es) 2007-05-30 2018-03-16 Xencor, Inc. Métodos y composiciones para inhibir células que expresan CD32B
MX369784B (es) 2007-09-26 2019-11-21 Chugai Pharmaceutical Co Ltd Metodo de modificacion del punto isoelectrico de anticuerpos mediante la sustitucion de aminoacidos en region de determinacion de complementariedad (cdr).
EP2211904B1 (fr) 2007-10-19 2016-08-17 Seattle Genetics, Inc. Agents de liaison au cd19 et utilisations de ceux-ci
US8697384B2 (en) 2008-01-23 2014-04-15 Herlev Hospital YKL-40 as a general marker for non-specific disease
CN107551270A (zh) 2008-04-11 2018-01-09 中外制药株式会社 与多个分子的抗原反复结合的抗原结合分子
EP2280997A2 (fr) * 2008-04-18 2011-02-09 Xencor, Inc. Anticorps monoclonaux d équivalent humain conçus à partir de régions variables non humaines
CA2726811C (fr) 2008-06-06 2019-11-26 The United States Of America, As Represented By The Secretary, Dept. Of Health And Human Services Indice de survie pour un lymphome a grandes cellules b diffus
WO2010019702A2 (fr) * 2008-08-12 2010-02-18 Oncomed Pharmaceuticals, Inc. Agents de liaison à ddr1 et leurs méthodes d'utilisation
CN102317783A (zh) 2008-09-15 2012-01-11 海莱乌医院 作为胃肠癌的标记的ykl-40
JP5933975B2 (ja) * 2008-11-12 2016-06-15 メディミューン,エルエルシー 抗体製剤
EP2403532A4 (fr) * 2009-03-06 2012-12-05 Medimmune Llc Formulations d'anticorps humanisés anti-cd19
JP5863115B2 (ja) * 2009-04-16 2016-02-16 シャリテ−ウニヴェルズィテートメディツィーン ベルリン 疾患の処置方法に使用するためのbリンパ球ターゲティング剤
CA3067609A1 (fr) 2009-09-03 2011-03-10 Merck Sharp & Dohme Corp. Anticorps anti-gitr
SG10201408415PA (en) * 2009-12-21 2015-01-29 Regeneron Pharma HUMANIZED FCγ R MICE
WO2011147834A1 (fr) 2010-05-26 2011-12-01 Roche Glycart Ag Anticorps contre cd19 et utilisations associées
US8192429B2 (en) 2010-06-29 2012-06-05 Theravant, Inc. Abnormality eradication through resonance
EP2409989A1 (fr) * 2010-07-19 2012-01-25 International-Drug-Development-Biotech Procédé pour améliorer le profile de glycosylation d'un anticorps
EP2409712A1 (fr) 2010-07-19 2012-01-25 International-Drug-Development-Biotech Anticorps Anti-CD19 doté de fonctions ADCC et CDC et d'un profil de glycosylation amélioré
EP2409993A1 (fr) 2010-07-19 2012-01-25 International-Drug-Development-Biotech Anticorps Anti-CD19 doté d'une fonction ADCC et d'un profil de glycosylation amélioré
DK2632954T4 (da) 2010-10-27 2021-08-09 Amgen Res Munich Gmbh Midler og fremgangsmåder til behandling af dlbcl
KR20130130726A (ko) * 2010-11-15 2013-12-02 메디뮨 엘엘씨 B 세포 림프종을 위한 병용 요법
RU2658504C9 (ru) 2010-11-30 2018-08-21 Чугаи Сейяку Кабусики Кайся Антигенсвязывающая молекула, способная многократно связываться с множеством антигенных молекул
WO2012143497A2 (fr) 2011-04-21 2012-10-26 Bayer Intellectual Property Gmbh Nouveaux conjugués liant-principe actif (adc) et leur utilisation
EP2524929A1 (fr) * 2011-05-17 2012-11-21 Sanofi Utilisation d'anticorps immunoconjugués anti-CD19 maytansinoïdes pour le traitement de symptômes de malignités CD19+lymphocytes B
EP2550975A1 (fr) * 2011-07-29 2013-01-30 Sanofi Polythérapie pour le traitement de symptômes de malignités CD19+lymphocytes B comprenant un immunoconjugué anti-CD19 maytansinoïde et du rituximab
JP6114273B2 (ja) 2011-08-16 2017-04-12 モルフォシス・アー・ゲー 抗−cd19抗体とプリン類似体の併用治療
PL2744515T3 (pl) 2011-08-16 2022-05-30 Morphosys Ag Terapia skojarzona przeciwciałem anty-cd19 i iperytem azotowym
US9447194B2 (en) 2012-02-13 2016-09-20 Seattle Children's Hospital Bispecific chimeric antigen receptors and encoding polynucleotides thereof
JP2015515456A (ja) * 2012-03-12 2015-05-28 メディミューン,エルエルシー 抗cd19抗体による多発性硬化症の治療
JP6391564B2 (ja) * 2012-04-30 2018-09-19 メディミューン,エルエルシー 低減されたエフェクター機能及び延長された半減期を有する分子、組成物、並びにそれらの使用
WO2013177187A2 (fr) 2012-05-22 2013-11-28 Massachusetts Institute Of Technology Traitement de tumeur synergique avec du pk il-2 étendu et des agents thérapeutiques
AU2013274144A1 (en) * 2012-06-13 2015-01-22 University of Virginia Patent Foundation, d/b/a University of Virginia Licensing & Ventures Group Compositions and methods for treating cancer
SG11201408787PA (en) 2012-07-13 2015-01-29 Univ Pennsylvania Enhancing activity of car t cells by co-introducing a bispecific antibody
KR20210084688A (ko) 2012-08-24 2021-07-07 추가이 세이야쿠 가부시키가이샤 FcγRIIb 특이적 Fc영역 개변체
EP3597747B1 (fr) 2012-08-24 2023-03-15 Chugai Seiyaku Kabushiki Kaisha Anticorps fc spécifiques fcgammarii de souris
US9534044B2 (en) * 2013-02-28 2017-01-03 United Arab Emirates University Alpha-synuclein antibodies and uses thereof
AR095496A1 (es) * 2013-03-15 2015-10-21 Bayer Healthcare Llc Formulaciones de anticuerpos anti-receptor de prolactina
WO2014163101A1 (fr) 2013-04-02 2014-10-09 中外製薬株式会社 Variant de région fc
EP3035903B1 (fr) 2013-08-20 2018-08-22 Anutra Medical, Inc. Système de remplissage de seringue et procédé associé
ES2815098T3 (es) 2013-12-23 2021-03-29 Bayer Pharma AG Conjugados de ligadores (ADCs) con inhibidores de KSP
AU2015227251A1 (en) * 2014-03-04 2016-10-20 Medlmmune, Llc Compositions and methods for identifying B cell malignancies responsive to B cell depleting therapy
USD774182S1 (en) 2014-06-06 2016-12-13 Anutra Medical, Inc. Anesthetic delivery device
USD750768S1 (en) 2014-06-06 2016-03-01 Anutra Medical, Inc. Fluid administration syringe
USD763433S1 (en) 2014-06-06 2016-08-09 Anutra Medical, Inc. Delivery system cassette
WO2016025647A1 (fr) 2014-08-12 2016-02-18 Massachusetts Institute Of Technology Traitement tumoral synergique avec l'il-2, un anticorps thérapeutique, et un vaccin contre le cancer
TWI751102B (zh) * 2014-08-28 2022-01-01 美商奇諾治療有限公司 對cd19具專一性之抗體及嵌合抗原受體
DK3227336T3 (da) 2014-12-05 2019-09-16 Hoffmann La Roche Anti-CD79b-antistoffer og fremgangsmåder til anvendelse
TWI808330B (zh) 2014-12-19 2023-07-11 日商中外製藥股份有限公司 抗肌抑素之抗體、含變異Fc區域之多胜肽及使用方法
CN105837689B (zh) * 2015-01-13 2020-06-19 博生吉安科细胞技术有限公司 抗cd19单克隆抗体及其制备方法
SG10201907215QA (en) 2015-02-05 2019-09-27 Chugai Pharmaceutical Co Ltd Antibodies Comprising An Ion Concentration Dependent Antigen-Binding Domain, Fc Region Variants, Il-8-Binding Antibodies, And Uses Therof
US10722523B2 (en) 2015-03-17 2020-07-28 The Regents Of The University Of California Chemoimmunotherapy for epithelial cancer
US10617691B2 (en) 2015-05-26 2020-04-14 Morphosys Ag Combination of an anti-CD19 antibody and a Bruton's tyrosine kinase inhibitor and uses thereof
TW201709929A (zh) * 2015-06-12 2017-03-16 宏觀基因股份有限公司 治療癌症的聯合療法
PE20180610A1 (es) 2015-06-22 2018-04-09 Bayer Pharma AG CONJUGADOS DE LIGADOR-PRINCIPIO ACTIVO (ADCs) Y CONJUGADOS DE LIGADOR-PROFARMACO (APDCs) CON GRUPOS ENZIMATICAMENTE ESCINDIBLES
EP3322735A4 (fr) 2015-07-15 2019-03-13 Zymeworks Inc. Constructions bispécifiques de liaison à un antigène conjuguées à un médicament
HUE056408T2 (hu) 2015-08-21 2022-02-28 Morphosys Ag Kombinációk és alkalmazásaik
MA44909A (fr) 2015-09-15 2018-07-25 Acerta Pharma Bv Association thérapeutique d'un inhibiteur du cd19 et d'un inhibiteur de la btk
CN113372443A (zh) * 2015-09-18 2021-09-10 中外制药株式会社 Il-8-结合抗体及其应用
AR106188A1 (es) 2015-10-01 2017-12-20 Hoffmann La Roche Anticuerpos anti-cd19 humano humanizados y métodos de utilización
EP3356405A1 (fr) * 2015-10-02 2018-08-08 H. Hoffnabb-La Roche Ag Anticorps anti-humain cd19 à affinité élevée
WO2017060322A2 (fr) 2015-10-10 2017-04-13 Bayer Pharma Aktiengesellschaft Conjugué anticorps-médicament (adc) inhibiteur de ptefb
MX2018004515A (es) * 2015-10-13 2019-04-15 Eureka Therapeutics Inc Agentes de anticuerpo especificos para cd19 humano y usos de los mismos.
IL295398A (en) 2015-10-23 2022-10-01 Eureka Therapeutics Inc Antibody/t-cell receptor chimera structures and their uses
JP7141336B2 (ja) 2015-12-25 2022-09-22 中外製薬株式会社 抗ミオスタチン抗体および使用方法
RU2018136778A (ru) 2016-03-24 2020-04-24 Байер Фарма Акциенгезельшафт Пролекарства цитотоксических лекарственных средств, содержащие ферментативно расщепляемые группы
KR102412803B1 (ko) * 2016-03-28 2022-06-24 도레이 카부시키가이샤 암의 치료 및/또는 예방용 의약 조성물
US10519243B2 (en) * 2016-05-27 2019-12-31 Abbvie Biotherapeutics Inc. Anti-CD40 antibodies
JP7066639B2 (ja) 2016-05-30 2022-05-13 モルフォシス・アーゲー 患者における抗cd19治療の治療的有用性を予測するための方法
HUE064454T2 (hu) 2016-06-08 2024-03-28 Xencor Inc IgG4-gyel kapcsolatos betegségek kezelése CD32B-vel keresztkötõ, CD-19 elleni ellenanyagokkal
JP7022707B2 (ja) 2016-06-15 2022-02-18 バイエル・ファルマ・アクティエンゲゼルシャフト Ksp阻害剤および抗cd123抗体を含む特異的抗体-薬物-コンジュゲート(adc)
PT3475303T (pt) 2016-06-27 2021-06-25 Morphosys Ag Formulações de anticorpos anti-cd19
SG11201801024XA (en) 2016-08-05 2018-05-30 Chugai Pharmaceutical Co Ltd Therapeutic or preventive compositions for il-8-related diseases
SG10201607778XA (en) 2016-09-16 2018-04-27 Chugai Pharmaceutical Co Ltd Anti-Dengue Virus Antibodies, Polypeptides Containing Variant Fc Regions, And Methods Of Use
US11636924B2 (en) * 2016-09-30 2023-04-25 Molecular Devices, Llc Computer device for detecting an optimal candidate compound and methods thereof
MX2019004942A (es) 2016-10-28 2019-08-12 Morphosys Ag Combinacion de anticuerpo anti cd19 con un inhibidor de bcl-2 y usos de la misma.
KR102487144B1 (ko) 2016-11-21 2023-01-12 에이리온 테라퓨틱스, 인코포레이티드 큰 물질의 경피 전달
CN106977605A (zh) * 2016-12-13 2017-07-25 无锡傲锐东源生物科技有限公司 抗cd19蛋白单克隆抗体及其用途
WO2018114798A1 (fr) 2016-12-21 2018-06-28 Bayer Aktiengesellschaft Promédicaments de principes actifs cytotoxiques contenant des groupes divisibles par voie enzymatique
CA3047522A1 (fr) 2016-12-21 2018-06-28 Bayer Pharma Aktiengesellschaft Conjugues anticorps-principe actif (adc) specifiques renfermant des inhibiteurs de ksp
RU2761390C2 (ru) 2016-12-21 2021-12-07 Байер Фарма Акциенгезельшафт Конъюгаты связующего и активного вещества (adc), имеющие ферментативно расщепляемые группы
WO2018134787A2 (fr) * 2017-01-20 2018-07-26 Magenta Therapeutics, Inc. Compositions et procédés pour la déplétion des cellules cd137+
US11344578B2 (en) 2017-04-19 2022-05-31 Board Of Regents, The University Of Texas System Immune cells expressing engineered antigen receptors
SG10201913656TA (en) 2017-04-26 2020-03-30 Eureka Therapeutics Inc Cells expressing chimeric activating receptors and chimeric stimulating receptors and uses thereof
BR112019025034A2 (pt) 2017-05-31 2020-06-30 Morphosys Ag combinação
US11634488B2 (en) 2017-07-10 2023-04-25 International—Drug—Development—Biotech Treatment of B cell malignancies using afucosylated pro-apoptotic anti-CD19 antibodies in combination with anti CD20 antibodies or chemotherapeutics
CN109535253B (zh) * 2017-09-21 2022-11-04 上海药明生物技术有限公司 新型抗cd19抗体
WO2019125070A1 (fr) * 2017-12-22 2019-06-27 앱클론(주) Anticorps ou fragment de liaison à l'antigène de celui-ci reconnaissant spécifiquement des tumeurs malignes de lymphocytes b, récepteur antigénique chimérique le comprenant, et utilisations associées
EP3728330A4 (fr) * 2017-12-23 2021-12-08 Uwell Biopharma Inc. Composition pharmaceutique de récepteur chimérique et procédé associé
TWI827585B (zh) 2018-03-15 2024-01-01 日商中外製藥股份有限公司 對茲卡病毒具有交叉反應性的抗登革病毒抗體及其使用方法
CN113272327A (zh) 2018-12-30 2021-08-17 豪夫迈·罗氏有限公司 抗兔cd19抗体及其使用方法
WO2020154032A1 (fr) 2019-01-23 2020-07-30 Massachusetts Institute Of Technology Schéma posologique de dosage d'immunothérapie combinée pour un blocage de points de contrôle immunitaires
CN110009008B (zh) * 2019-03-18 2020-11-06 四川大学 基于提取的免疫固定电泳图特征对其进行自动分类的方法
SG11202111429UA (en) * 2019-04-24 2021-11-29 Viela Bio Inc Use of an anti-cd19 antibody to treat autoimmune disease
EA202193024A1 (ru) 2019-05-03 2022-02-09 МорфоСис АГ Анти-cd19-терапия у пациентов с ограниченным числом естественных клеток-киллеров
US20210038684A1 (en) 2019-06-11 2021-02-11 Alkermes Pharma Ireland Limited Compositions and Methods for Cancer Immunotherapy
US11642409B2 (en) 2019-06-26 2023-05-09 Massachusetts Insttute of Technology Immunomodulatory fusion protein-metal hydroxide complexes and methods thereof
EP4038194A1 (fr) 2019-10-04 2022-08-10 Ultragenyx Pharmaceutical Inc. Procédés pour une utilisation thérapeutique améliorée d'aav recombinant
TW202131949A (zh) 2019-10-31 2021-09-01 德商莫菲西斯公司 包含抗CD19抗體及γδ T細胞之抗腫瘤組合療法
BR112022017162A2 (pt) 2019-10-31 2022-10-18 Morphosys Ag Terapia anti-cd19 em combinação com lenalidomida para o tratamento de leucemia ou linfoma
TWI790548B (zh) 2020-02-28 2023-01-21 美商美國禮來大藥廠 抗人類cd19抗體
CR20220637A (es) 2020-06-19 2023-01-31 Hoffmann La Roche Anticuerpos que se unen a cd3 y cd19
KR20230030636A (ko) 2020-06-22 2023-03-06 모르포시스 아게 항-CD19 항체, 및 SIRPα-CD47 선천성 면역 체크포인트를 차단하는 폴리펩티드를 포함하는 항-종양 조합 요법
AU2021357805A1 (en) 2020-10-06 2023-05-04 Xencor, Inc. Biomarkers, methods, and compositions for treating autoimmune disease including systemic lupus erythematous (sle)
AU2021391623A1 (en) 2020-12-04 2023-06-29 Incyte Corporation Anti-cd19 combination therapy
IL308296A (en) 2021-05-07 2024-01-01 Viela Bio Inc Use of anti-CD19 antibody to treat myasthenia gravis
WO2023019200A1 (fr) 2021-08-11 2023-02-16 Viela Bio, Inc. Inébilizumab et ses méthodes d'utilisation dans le traitement ou la prévention d'une maladie liée aux igg4
WO2023073645A1 (fr) 2021-10-29 2023-05-04 Takeda Pharmaceutical Company Limited Thérapie avec un anticorps anti-cd19 et un inhibiteur enzymatique activateur de sumo
WO2024025602A1 (fr) 2022-07-27 2024-02-01 Viela Bio, Inc. Inebilizumab et ses méthodes d'utilisation pour une déplétion prolongée de lymphocytes b
WO2024038115A1 (fr) 2022-08-17 2024-02-22 Morphosys Ag Thérapie comprenant un anticorps anti-cd19 et des modulateurs d'ezh2

Family Cites Families (91)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL85035A0 (en) 1987-01-08 1988-06-30 Int Genetic Eng Polynucleotide molecule,a chimeric antibody with specificity for human b cell surface antigen,a process for the preparation and methods utilizing the same
JP3101690B2 (ja) 1987-03-18 2000-10-23 エス・ビィ・2・インコーポレイテッド 変性抗体の、または変性抗体に関する改良
US5677425A (en) 1987-09-04 1997-10-14 Celltech Therapeutics Limited Recombinant antibody
US5506126A (en) * 1988-02-25 1996-04-09 The General Hospital Corporation Rapid immunoselection cloning method
GB8824869D0 (en) 1988-10-24 1988-11-30 Stevenson G T Synthetic antibody
US5530101A (en) * 1988-12-28 1996-06-25 Protein Design Labs, Inc. Humanized immunoglobulins
WO1991013974A1 (fr) 1990-03-14 1991-09-19 The Biomembrane Institute Anticorps monoclonal et immunoconjugues de traitement et de detection de troubles des lymphocytes b
GB9022543D0 (en) 1990-10-17 1990-11-28 Wellcome Found Antibody production
ATE255131T1 (de) 1991-06-14 2003-12-15 Genentech Inc Humanisierter heregulin antikörper
DK1266965T3 (da) 1991-07-25 2006-09-25 Biogen Idec Inc Rekombinante antistoffer til human terapi
DE69333807T2 (de) 1992-02-06 2006-02-02 Chiron Corp., Emeryville Marker für krebs und biosynthetisches bindeprotein dafür
US5714350A (en) * 1992-03-09 1998-02-03 Protein Design Labs, Inc. Increasing antibody affinity by altering glycosylation in the immunoglobulin variable region
AU4116793A (en) 1992-04-24 1993-11-29 Board Of Regents, The University Of Texas System Recombinant production of immunoglobulin-like domains in prokaryotic cells
US5686072A (en) * 1992-06-17 1997-11-11 Board Of Regents, The University Of Texas Epitope-specific monoclonal antibodies and immunotoxins and uses thereof
WO1994009363A1 (fr) 1992-10-14 1994-04-28 Board Of Regents, The University Of Texas System Diagnostic et therapie contre le cancer
US5885573A (en) 1993-06-01 1999-03-23 Arch Development Corporation Methods and materials for modulation of the immunosuppressive activity and toxicity of monoclonal antibodies
WO1994029351A2 (fr) 1993-06-16 1994-12-22 Celltech Limited Anticorps
US5417972A (en) * 1993-08-02 1995-05-23 The Board Of Trustees Of The Leland Stanford Junior University Method of killing B-cells in a complement independent and an ADCC independent manner using antibodies which specifically bind CDIM
US5831142A (en) * 1994-01-07 1998-11-03 Dana Farber Cancer Institute, Inc. Regulatory elements controlling tissue-specific gene expression
US5605793A (en) 1994-02-17 1997-02-25 Affymax Technologies N.V. Methods for in vitro recombination
US5837458A (en) 1994-02-17 1998-11-17 Maxygen, Inc. Methods and compositions for cellular and metabolic engineering
US5834252A (en) 1995-04-18 1998-11-10 Glaxo Group Limited End-complementary polymerase reaction
US6121022A (en) 1995-04-14 2000-09-19 Genentech, Inc. Altered polypeptides with increased half-life
US5869046A (en) 1995-04-14 1999-02-09 Genentech, Inc. Altered polypeptides with increased half-life
EP0835134A1 (fr) 1995-05-17 1998-04-15 Regents Of The University Of Minnesota Immunoconjugues comprenant des fragments monocatenaires de regions variables d'anticorps anti-cd-19
US6410690B1 (en) * 1995-06-07 2002-06-25 Medarex, Inc. Therapeutic compounds comprised of anti-Fc receptor antibodies
US6277375B1 (en) 1997-03-03 2001-08-21 Board Of Regents, The University Of Texas System Immunoglobulin-like domains with increased half-lives
JP3988200B2 (ja) * 1997-03-14 2007-10-10 株式会社ジェイテクト 衝撃吸収式ステアリング装置
US6306393B1 (en) * 1997-03-24 2001-10-23 Immunomedics, Inc. Immunotherapy of B-cell malignancies using anti-CD22 antibodies
US6368596B1 (en) * 1997-07-08 2002-04-09 Board Of Regents, The University Of Texas System Compositions and methods for homoconjugates of antibodies which induce growth arrest or apoptosis of tumor cells
JP2003525016A (ja) * 1998-02-19 2003-08-26 エクサイト セラピーズ, インコーポレイテッド リンパ球活性化を調節するための組成物および方法
US6194551B1 (en) 1998-04-02 2001-02-27 Genentech, Inc. Polypeptide variants
US6528624B1 (en) 1998-04-02 2003-03-04 Genentech, Inc. Polypeptide variants
DE69942021D1 (de) * 1998-04-20 2010-04-01 Glycart Biotechnology Ag Glykosylierungs-engineering von antikörpern zur verbesserung der antikörperabhängigen zellvermittelten zytotoxizität
US7112324B1 (en) * 1998-04-21 2006-09-26 Micromet Ag CD 19×CD3 specific polypeptides and uses thereof
DE19819846B4 (de) * 1998-05-05 2016-11-24 Deutsches Krebsforschungszentrum Stiftung des öffentlichen Rechts Multivalente Antikörper-Konstrukte
GB9809951D0 (en) 1998-05-08 1998-07-08 Univ Cambridge Tech Binding molecules
US6737056B1 (en) 1999-01-15 2004-05-18 Genentech, Inc. Polypeptide variants with altered effector function
PL220113B1 (pl) 1999-01-15 2015-08-31 Genentech Inc Wariant macierzystego polipeptydu zawierającego region Fc, polipeptyd zawierający wariant regionu Fc o zmienionym powinowactwie wiązania receptora Fc gamma (FcγR), polipeptyd zawierający wariant regionu Fc o zmienionym powinowactwie wiązania noworodkowego receptora Fc (FcRn), kompozycja, wyizolowany kwas nukleinowy, wektor, komórka gospodarza, sposób otrzymywania wariantu polipeptydu, zastosowanie wariantu polipeptydu i sposób otrzymywania wariantu regionu Fc
EP2270150B2 (fr) * 1999-04-09 2019-08-07 Kyowa Hakko Kirin Co., Ltd. Methode de regulation de l'activite d'une molecule immunologiquement fonctionnelle
US7820161B1 (en) 1999-05-07 2010-10-26 Biogen Idec, Inc. Treatment of autoimmune diseases
DE05075555T1 (de) * 1999-06-09 2007-02-08 Immunomedics, Inc. Immuntherapie von Autoimmunerkrankungen durch die Verwendung von B-Zell-spezifischen Antikörpern
US6451284B1 (en) * 1999-08-11 2002-09-17 Idec Pharmaceuticals Corporation Clinical parameters for determining hematologic toxicity prior to radioimmunotheraphy
AU6929100A (en) 1999-08-23 2001-03-19 Biocrystal Limited Methods and compositions for immunotherapy of b cell involvement in promotion ofa disease condition comprising multiple sclerosis
AU7950400A (en) 1999-10-19 2001-04-30 Kyowa Hakko Kogyo Co. Ltd. Process for producing polypeptide
FR2801056B1 (fr) * 1999-11-12 2003-03-28 Commissariat Energie Atomique Proteine presente a la surface des cellules souches hematopoietiques de la lignee lymphoide et des cellules nk, et ses applications
CN1981868A (zh) * 2000-03-31 2007-06-20 拜奥根Idec公司 抗细胞因子抗体或拮抗剂与抗-cd20在b细胞淋巴瘤治疗中的联合应用
JP2003531149A (ja) * 2000-04-13 2003-10-21 ザ・ロツクフエラー・ユニバーシテイ 抗体由来の免疫応答の増強
MXPA03002262A (es) * 2000-09-18 2003-10-15 Idec Pharma Corp Terapia de combinacion para tratamiento de enfermedades autoinmunes usando una combinacion de anticuerpos inmunorreguladores/supresores de celulas b.
US7064191B2 (en) * 2000-10-06 2006-06-20 Kyowa Hakko Kogyo Co., Ltd. Process for purifying antibody
US6946292B2 (en) * 2000-10-06 2005-09-20 Kyowa Hakko Kogyo Co., Ltd. Cells producing antibody compositions with increased antibody dependent cytotoxic activity
JP5312721B2 (ja) * 2000-11-07 2013-10-09 シティ・オブ・ホープ Cd19特異的再指向免疫細胞
ES2727425T3 (es) 2000-12-12 2019-10-16 Medimmune Llc Moléculas con semividas prolongadas, composiciones y usos de las mismas
DE10063048A1 (de) 2000-12-18 2002-07-11 Deutsches Krebsforsch Einzelketten-Antikörper mit verbesserter Stabilität
US7829084B2 (en) 2001-01-17 2010-11-09 Trubion Pharmaceuticals, Inc. Binding constructs and methods for use thereof
WO2002079255A1 (fr) * 2001-04-02 2002-10-10 Idec Pharmaceuticals Corporation Anticorps recombinants co-exprimes avec gntiii
US6661602B2 (en) * 2001-09-10 2003-12-09 Hewlett-Packard Development Company, L.P. Methods and apparatus for transporting data cartridges between adjacent cartridge libraries
BR0213303A (pt) * 2001-10-15 2005-06-07 Immunomedics Inc Proteìnas de ligação de alvejamento direto
WO2003035835A2 (fr) * 2001-10-25 2003-05-01 Genentech, Inc. Compositions de glycoproteine
EP1314741B1 (fr) * 2001-11-14 2007-03-07 Affimed Therapeutics AG Anticorps bispécifiques dirigés contre CD19 et CD16 et leur utilisation
US20040002587A1 (en) 2002-02-20 2004-01-01 Watkins Jeffry D. Fc region variants
US7317091B2 (en) * 2002-03-01 2008-01-08 Xencor, Inc. Optimized Fc variants
US20040132101A1 (en) 2002-09-27 2004-07-08 Xencor Optimized Fc variants and methods for their generation
CA2495251C (fr) * 2002-08-14 2018-03-06 Macrogenics, Inc. Anticorps specifiques du recepteur fc.gamma.riib et procedes d'utilisation de ces anticorps
CA2832136C (fr) 2002-09-27 2015-11-17 Xencor Variants fc optimises et methodes destinees a leur generation
CA2499826C (fr) 2002-09-27 2015-03-24 Bioe, Inc. Compositions et procedes de separation de cellules
WO2004060317A2 (fr) * 2002-12-31 2004-07-22 Genta Incorporated Combinaison de composes a base de gallium et d'agents anticancereux non chimiotherapeutiques destinee au traitement de la neoplasie
CA2512729C (fr) 2003-01-09 2014-09-16 Macrogenics, Inc. Identification et elaboration d'anticorps avec des regions du variant fc et procedes d'utilisation associes
MXPA05010778A (es) * 2003-04-09 2005-12-12 Genentech Inc Terapia para enfermedad autoinmune en un paciente con una respuesta inadecuada a un inhibidor tnf-alfa.
US7374762B2 (en) * 2003-05-14 2008-05-20 Immunogen, Inc. Drug conjugate composition
AU2004242846A1 (en) * 2003-05-31 2004-12-09 Micromet Ag Pharmaceutical compositions comprising bispecific anti-CD3, anti-CD19 antibody constructs for the treatment of B-cell related disorders
CA2534639C (fr) * 2003-07-31 2013-07-30 Immunomedics, Inc. Anticorps anti-cd19
EP1689435A4 (fr) * 2003-10-22 2007-10-03 Univ Rochester Antiserum anti-thymocyte et son utilisation pour declencher l'apoptose des cellules b
ES2341252T3 (es) * 2003-11-28 2010-06-17 Micromet Ag Composiciones que comprenden polipeptidos.
CA3052445C (fr) 2004-07-10 2023-08-22 Kerry S. Campbell Lignees de cellules tueuses, naturelles, humaines et genetiquement modifiees
CN1775808A (zh) * 2004-11-15 2006-05-24 中国医学科学院血液学研究所 用于靶向结合淋巴细胞白血病细胞的抗cd19的工程抗体及其用途
CA2597924C (fr) * 2005-02-15 2018-10-02 Duke University Anticorps anti-cd19 et leur utilisation en oncologie
JP2008538365A (ja) * 2005-04-15 2008-10-23 イミュノジェン・インコーポレーテッド 腫瘍内の不均一または混合細胞集団を排除する方法
EP2221316A1 (fr) * 2005-05-05 2010-08-25 Duke University Traitements des maladies auto-immunes par des anticorps anti-cd19
US20060263367A1 (en) * 2005-05-23 2006-11-23 Fey Georg H Bispecific antibody devoid of Fc region and method of treatment using same
EP1904101A4 (fr) * 2005-06-08 2011-06-15 Univ Duke Therapie a anticorps diriges contre cd19 a des fins de transplantation
CA2611814A1 (fr) 2005-06-20 2007-01-04 Medarex, Inc. Anticorps cd19 et utilisations
US7612181B2 (en) * 2005-08-19 2009-11-03 Abbott Laboratories Dual variable domain immunoglobulin and uses thereof
AU2006291069A1 (en) * 2005-09-12 2007-03-22 Alza Corporation Liposomes for treatment of multiple myeloma
US7759076B2 (en) * 2005-10-14 2010-07-20 Esoterix, Inc. Quantitative ZAP-70 assay
KR101397290B1 (ko) 2005-12-30 2014-05-21 메르크 파텐트 게엠베하 감소한 면역원성을 가지는 항-cd19 항체
US20070166306A1 (en) 2006-01-17 2007-07-19 Fey Georg H M Anti-CD19 antibody composition and method
US20100266620A1 (en) * 2006-01-20 2010-10-21 Le Sun Immunoconjugates for treatment of infectious diseases
US20070178103A1 (en) 2006-01-30 2007-08-02 Fey Georg H CD19-specific immunotoxin and treatment method
DE602007005366D1 (de) * 2006-04-07 2010-04-29 Chimeros Inc Zusammensetzungen und verfahren zur behandlung von b-zellen-malignomen
MX2009002414A (es) * 2006-09-08 2009-05-20 Medimmune Llc Anticuerpos anti-cd19 humanizados y su uso en el tratamiento de oncologia, transplante y enfermedad autoinmunitaria.

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BRPI0716611A8 (pt) 2022-08-09
PL2066349T3 (pl) 2012-09-28
US9896505B2 (en) 2018-02-20
WO2008031056A3 (fr) 2008-10-30
KR20090059149A (ko) 2009-06-10
HUS2200044I1 (hu) 2022-11-28
CA2662340A1 (fr) 2008-03-13
AU2007294575B2 (en) 2013-06-27
KR101456728B1 (ko) 2014-10-31
ES2383710T3 (es) 2012-06-25
EP2066349A2 (fr) 2009-06-10
RU2009112723A (ru) 2010-10-20
EP2066349A4 (fr) 2010-08-04
ATE551071T1 (de) 2012-04-15
PT2066349E (pt) 2012-07-02
US20160145335A1 (en) 2016-05-26
CN103694349A (zh) 2014-04-02
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US20080138336A1 (en) 2008-06-12
FR22C1052I2 (fr) 2023-12-15
US8323653B2 (en) 2012-12-04
WO2008031056A2 (fr) 2008-03-13
NL301196I2 (nl) 2023-07-05
CA2662340C (fr) 2016-08-02
RU2495882C2 (ru) 2013-10-20
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US20130115657A1 (en) 2013-05-09
CY1112883T1 (el) 2016-04-13
AU2007294575A1 (en) 2008-03-13
EP2066349B1 (fr) 2012-03-28
MX2009002414A (es) 2009-05-20
FR22C1052I1 (fr) 2022-12-16
BRPI0716611A2 (pt) 2018-10-30
US20180273621A1 (en) 2018-09-27
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US20210061906A1 (en) 2021-03-04
JP2010502232A (ja) 2010-01-28

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