CY1112883T1 - Εξανθρωπισμενα αντισωματα αντι-cd19 και οι χρησεις τους στην θεραπεια ογκων, μεταμοσχευσης και ασθενειων αυτο-ανοσιας - Google Patents
Εξανθρωπισμενα αντισωματα αντι-cd19 και οι χρησεις τους στην θεραπεια ογκων, μεταμοσχευσης και ασθενειων αυτο-ανοσιαςInfo
- Publication number
- CY1112883T1 CY1112883T1 CY20121100579T CY121100579T CY1112883T1 CY 1112883 T1 CY1112883 T1 CY 1112883T1 CY 20121100579 T CY20121100579 T CY 20121100579T CY 121100579 T CY121100579 T CY 121100579T CY 1112883 T1 CY1112883 T1 CY 1112883T1
- Authority
- CY
- Cyprus
- Prior art keywords
- treatment
- antibodies
- transfection
- self
- prevention
- Prior art date
Links
- 238000001890 transfection Methods 0.000 title 1
- 208000037914 B-cell disorder Diseases 0.000 abstract 2
- 208000009329 Graft vs Host Disease Diseases 0.000 abstract 2
- 208000024908 graft versus host disease Diseases 0.000 abstract 2
- 230000002265 prevention Effects 0.000 abstract 2
- 208000023275 Autoimmune disease Diseases 0.000 abstract 1
- 208000030289 Lymphoproliferative disease Diseases 0.000 abstract 1
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 206010052779 Transplant rejections Diseases 0.000 abstract 1
- 230000010056 antibody-dependent cellular cytotoxicity Effects 0.000 abstract 1
- 239000000427 antigen Substances 0.000 abstract 1
- 102000036639 antigens Human genes 0.000 abstract 1
- 108091007433 antigens Proteins 0.000 abstract 1
- 230000006907 apoptotic process Effects 0.000 abstract 1
- 210000003719 b-lymphocyte Anatomy 0.000 abstract 1
- 230000001024 immunotherapeutic effect Effects 0.000 abstract 1
- 201000001268 lymphoproliferative syndrome Diseases 0.000 abstract 1
- 230000036210 malignancy Effects 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
- 238000002054 transplantation Methods 0.000 abstract 1
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- Communicable Diseases (AREA)
Abstract
Η παρούσα εφεύρεση παρέχει χιμαιρικές και εξανθρωπισμένες παραλλαγές των μονόκλωνων αντισωμάτων αντί-CD 19 ποντικού. Η εφεύρεση σχετίζεται περαιτέρω με φαρμακευτικές συνθέσεις, άνοσο-θεραπευτικές συνθέσεις, και μεθόδους χρήσης θεραπευτικών αντισωμάτων που δεσμεύουν το ανθρώπινο αντιγόνο CD 19 και μπορούν να μεσολαβούν στην ΑDCC, CDC, και/ ή την απόπτωση για την θεραπεία ασθενειών και διαταραχών Β κυττάρων, όπως, αλλά χωρίς περιορισμό, κακοηθειών Β κυττάρων, για την θεραπεία και την πρόληψη ασθένειας αυτό-ανοσίας, και για την θεραπεία και την πρόληψη της ασθένειας μοσχεύματος ενάντια στον ξενιστή (GVHD), της χυμικής απόρριψης και της λεμφοπολλαπλασιαστικής διαταραχής μετά την μεταμόσχευση σε λήπτες ανθρώπινου μοσχεύματος.
Applications Claiming Priority (6)
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US84293506P | 2006-09-08 | 2006-09-08 | |
US86691706P | 2006-11-22 | 2006-11-22 | |
US91139707P | 2007-04-12 | 2007-04-12 | |
US91530907P | 2007-05-01 | 2007-05-01 | |
US93942907P | 2007-05-22 | 2007-05-22 | |
EP07842083A EP2066349B1 (en) | 2006-09-08 | 2007-09-07 | Humanized anti-cd19 antibodies and their use in treatment of tumors, transplantation and autoimmune diseases |
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CY1112883T1 true CY1112883T1 (el) | 2016-04-13 |
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CY20121100579T CY1112883T1 (el) | 2006-09-08 | 2012-06-28 | Εξανθρωπισμενα αντισωματα αντι-cd19 και οι χρησεις τους στην θεραπεια ογκων, μεταμοσχευσης και ασθενειων αυτο-ανοσιας |
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EP (1) | EP2066349B1 (el) |
JP (1) | JP5401314B2 (el) |
KR (1) | KR101456728B1 (el) |
CN (1) | CN103694349A (el) |
AT (1) | ATE551071T1 (el) |
AU (1) | AU2007294575B2 (el) |
CA (1) | CA2662340C (el) |
CY (1) | CY1112883T1 (el) |
DK (1) | DK2066349T3 (el) |
ES (1) | ES2383710T3 (el) |
FR (1) | FR22C1052I2 (el) |
HU (1) | HUS2200044I1 (el) |
LT (1) | LTPA2022520I1 (el) |
MX (1) | MX2009002414A (el) |
NL (1) | NL301196I2 (el) |
PL (1) | PL2066349T3 (el) |
PT (1) | PT2066349E (el) |
RU (1) | RU2495882C2 (el) |
WO (1) | WO2008031056A2 (el) |
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