DK2021337T3 - Inhibitorer af 11-beta-hydroxysteroid-dehydrogenase-1 - Google Patents
Inhibitorer af 11-beta-hydroxysteroid-dehydrogenase-1Info
- Publication number
- DK2021337T3 DK2021337T3 DK07761186.1T DK07761186T DK2021337T3 DK 2021337 T3 DK2021337 T3 DK 2021337T3 DK 07761186 T DK07761186 T DK 07761186T DK 2021337 T3 DK2021337 T3 DK 2021337T3
- Authority
- DK
- Denmark
- Prior art keywords
- beta
- compounds
- inhibitors
- hydroxysteroid dehydrogenase
- formula
- Prior art date
Links
- 102100036506 11-beta-hydroxysteroid dehydrogenase 1 Human genes 0.000 title 1
- 101710186107 11-beta-hydroxysteroid dehydrogenase 1 Proteins 0.000 title 1
- 239000003112 inhibitor Substances 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 4
- 230000000694 effects Effects 0.000 abstract 2
- 208000031226 Hyperlipidaemia Diseases 0.000 abstract 1
- 206010020772 Hypertension Diseases 0.000 abstract 1
- 208000001145 Metabolic Syndrome Diseases 0.000 abstract 1
- 208000008589 Obesity Diseases 0.000 abstract 1
- 201000000690 abdominal obesity-metabolic syndrome Diseases 0.000 abstract 1
- 239000005557 antagonist Substances 0.000 abstract 1
- 206010012601 diabetes mellitus Diseases 0.000 abstract 1
- 201000001421 hyperglycemia Diseases 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 235000020824 obesity Nutrition 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/24—Oxygen or sulfur atoms
- C07D207/26—2-Pyrrolidones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/24—Oxygen or sulfur atoms
- C07D207/26—2-Pyrrolidones
- C07D207/263—2-Pyrrolidones with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms
- C07D207/27—2-Pyrrolidones with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms with substituted hydrocarbon radicals directly attached to the ring nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Diabetes (AREA)
- Public Health (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Endocrinology (AREA)
- Emergency Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pyrrole Compounds (AREA)
- Enzymes And Modification Thereof (AREA)
- Steroid Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US74556906P | 2006-04-25 | 2006-04-25 | |
| PCT/US2007/067296 WO2007127726A2 (en) | 2006-04-25 | 2007-04-24 | Inhibitors of 11-beta-hydroxysteroid dehydrogenase 1 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK2021337T3 true DK2021337T3 (da) | 2010-03-29 |
Family
ID=38564372
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK07761186.1T DK2021337T3 (da) | 2006-04-25 | 2007-04-24 | Inhibitorer af 11-beta-hydroxysteroid-dehydrogenase-1 |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US7994176B2 (OSRAM) |
| EP (1) | EP2021337B1 (OSRAM) |
| JP (1) | JP5189079B2 (OSRAM) |
| CN (1) | CN101454310B (OSRAM) |
| AT (1) | ATE455110T1 (OSRAM) |
| AU (1) | AU2007244904B2 (OSRAM) |
| BR (1) | BRPI0710050A2 (OSRAM) |
| CA (1) | CA2648236C (OSRAM) |
| CY (1) | CY1109842T1 (OSRAM) |
| DE (1) | DE602007004324D1 (OSRAM) |
| DK (1) | DK2021337T3 (OSRAM) |
| EA (1) | EA015516B1 (OSRAM) |
| ES (1) | ES2336849T3 (OSRAM) |
| MX (1) | MX2008013651A (OSRAM) |
| PL (1) | PL2021337T3 (OSRAM) |
| PT (1) | PT2021337E (OSRAM) |
| SI (1) | SI2021337T1 (OSRAM) |
| WO (1) | WO2007127726A2 (OSRAM) |
Families Citing this family (33)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| UA95798C2 (ru) * | 2006-04-21 | 2011-09-12 | Эли Лилли Энд Компани | Производные циклогексилпиразоллактама как ингибиторы 11-бета-гидроксистероиддегидрогеназы 1 |
| AU2007240450B2 (en) | 2006-04-21 | 2011-12-22 | Eli Lilly And Company | Cyclohexylimidazole lactam derivatives as inhibitors of 11-beta-hydroxysteroid dehydrogenase 1 |
| AU2007240458B2 (en) * | 2006-04-21 | 2012-03-15 | Eli Lilly And Company | Biphenyl amide lactam derivatives as inhibitors of 11- beta-hydroxysteroid dehydrogenase 1 |
| PT2029529E (pt) | 2006-04-24 | 2010-09-02 | Lilly Co Eli | Pirrolidinonas substituídas como inibidores de 11 betahidroxiesteróide desidrogenase |
| BRPI0710467A2 (pt) * | 2006-04-24 | 2011-08-16 | Lilly Co Eli | composto, composição farmacêutica, uso de um composto, e, intermediário |
| BRPI0710468A2 (pt) | 2006-04-24 | 2011-08-16 | Lilly Co Eli | composto, e, composição farmacêutica |
| MX2008013656A (es) * | 2006-04-25 | 2008-11-10 | Lilly Co Eli | Inhibidores de 11-beta-hidroxiesteroide deshidrogenasa. |
| DK2035379T3 (da) | 2006-04-25 | 2010-09-06 | Lilly Co Eli | Inhibitorer af 11-beta-hydroxysteroiddehydrogenase 1 |
| PL2049513T3 (pl) | 2006-04-28 | 2012-06-29 | Lilly Co Eli | Pirolidynony podstawione przez piperydynyl jako inhibitory dehydrogenazy 11-beta-hydroksysteroidowej typu 1 |
| EP2025674A1 (de) | 2007-08-15 | 2009-02-18 | sanofi-aventis | Substituierte Tetrahydronaphthaline, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel |
| US8507493B2 (en) | 2009-04-20 | 2013-08-13 | Abbvie Inc. | Amide and amidine derivatives and uses thereof |
| US8440710B2 (en) * | 2009-10-15 | 2013-05-14 | Hoffmann-La Roche Inc. | HSL inhibitors useful in the treatment of diabetes |
| WO2011068927A2 (en) * | 2009-12-04 | 2011-06-09 | Abbott Laboratories | 11-β-HYDROXYSTEROID DEHYDROGENASE TYPE 1 (11B-HSD1) INHIBITORS AND USES THEREOF |
| WO2011107494A1 (de) | 2010-03-03 | 2011-09-09 | Sanofi | Neue aromatische glykosidderivate, diese verbindungen enthaltende arzneimittel und deren verwendung |
| CN103097400B (zh) * | 2010-05-27 | 2015-12-16 | 细胞制药有限公司 | 新的7α-羟类固醇脱氢酶敲除突变体及其用途 |
| EP2582709B1 (de) | 2010-06-18 | 2018-01-24 | Sanofi | Azolopyridin-3-on-derivate als inhibitoren von lipasen und phospholipasen |
| US8530413B2 (en) | 2010-06-21 | 2013-09-10 | Sanofi | Heterocyclically substituted methoxyphenyl derivatives with an oxo group, processes for preparation thereof and use thereof as medicaments |
| TW201215388A (en) | 2010-07-05 | 2012-04-16 | Sanofi Sa | (2-aryloxyacetylamino)phenylpropionic acid derivatives, processes for preparation thereof and use thereof as medicaments |
| TW201221505A (en) | 2010-07-05 | 2012-06-01 | Sanofi Sa | Aryloxyalkylene-substituted hydroxyphenylhexynoic acids, process for preparation thereof and use thereof as a medicament |
| TW201215387A (en) | 2010-07-05 | 2012-04-16 | Sanofi Aventis | Spirocyclically substituted 1,3-propane dioxide derivatives, processes for preparation thereof and use thereof as a medicament |
| US8871758B2 (en) | 2011-03-08 | 2014-10-28 | Sanofi | Tetrasubstituted oxathiazine derivatives, method for producing them, their use as medicine and drug containing said derivatives and the use thereof |
| US8710050B2 (en) | 2011-03-08 | 2014-04-29 | Sanofi | Di and tri- substituted oxathiazine derivatives, method for the production, method for the production thereof, use thereof as medicine and drug containing said derivatives and use thereof |
| EP2683705B1 (de) | 2011-03-08 | 2015-04-22 | Sanofi | Di- und trisubstituierte oxathiazinderivate, verfahren zu deren herstellung, ihre verwendung als medikament sowie sie enthaltendes arzneimittel und deren verwendung |
| WO2012120052A1 (de) | 2011-03-08 | 2012-09-13 | Sanofi | Mit carbozyklen oder heterozyklen substituierte oxathiazinderivate, verfahren zu deren herstellung, diese verbindungen enthaltende arzneimittel und deren verwendung |
| EP2683704B1 (de) | 2011-03-08 | 2014-12-17 | Sanofi | Verzweigte oxathiazinderivate, verfahren zu deren herstellung, ihre verwendung als medikament sowie sie enthaltendes arzneimittel und deren verwendung |
| WO2013012723A1 (en) | 2011-07-13 | 2013-01-24 | Novartis Ag | Novel 2-piperidin-1-yl-acetamide compounds for use as tankyrase inhibitors |
| BR112014000792A2 (pt) * | 2011-07-13 | 2017-10-31 | Novartis Ag | compostos de piperidinila para uso como inibidores da tanquirase |
| US9227982B2 (en) | 2011-07-13 | 2016-01-05 | Novartis Ag | 4-oxo-3,5,7,8-tetrahydro-4H-pyrano[4,3-d]pyrminidinyl compounds for use as tankyrase inhibitors |
| WO2013037390A1 (en) | 2011-09-12 | 2013-03-21 | Sanofi | 6-(4-hydroxy-phenyl)-3-styryl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors |
| EP2760862B1 (en) | 2011-09-27 | 2015-10-21 | Sanofi | 6-(4-hydroxy-phenyl)-3-alkyl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors |
| EA024846B1 (ru) | 2011-10-18 | 2016-10-31 | Астеллас Фарма Инк. | Бициклическое гетероциклическое соединение |
| CN105793264B (zh) * | 2014-03-10 | 2017-09-01 | 四川海思科制药有限公司 | 取代的二氢苯并呋喃‑哌啶‑甲酮衍生物、其制备及用途 |
| CN108046988B (zh) * | 2017-12-25 | 2021-04-16 | 云南民族大学 | 一种高效制备碘代醇的方法 |
Family Cites Families (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2004056744A1 (en) * | 2002-12-23 | 2004-07-08 | Janssen Pharmaceutica N.V. | Adamantyl acetamides as hydroxysteroid dehydrogenase inhibitors |
| EA011097B1 (ru) * | 2004-05-07 | 2008-12-30 | Янссен Фармацевтика Н.В. | Производные пирролидин-2-она и пиперидин-2-она, используемые в качестве ингибиторов 11-бета-гидроксистероид-дегидрогеназы |
| US7687644B2 (en) * | 2004-05-07 | 2010-03-30 | Janssen Pharmaceutica Nv | Adamantyl pyrrolidin-2-one derivatives as 11-beta hydroxysteroid dehydrogenase inhibitors |
| JP2008515956A (ja) | 2004-10-12 | 2008-05-15 | ノボ ノルディスク アクティーゼルスカブ | １１β−ヒドロキシステロイドデヒドロゲナーゼ１型活性スピロ化合物 |
| DK1807072T3 (da) | 2004-10-29 | 2009-03-16 | Lilly Co Eli | Cycloalkyllactamderivater som inhibitorer af 11-beta-hydroxysteroid-dehydrogenase 1 |
| AU2005304560C1 (en) | 2004-11-10 | 2013-05-09 | Incyte Holdings Corporation | Lactam compounds and their use as pharmaceuticals |
| US20080214621A1 (en) | 2004-12-20 | 2008-09-04 | Thomas Daniel Aicher | Cycloalkyl Lactam Derivatives As Inhibitors Of 11-Beta-Hydroxysteroid Dehydrogenase 1 |
| ATE401073T1 (de) | 2004-12-21 | 2008-08-15 | Lilly Co Eli | Cycloalkyl-lactam-derivate als inhibitoren von 11-beta-hydroxysteroiddehydrogenase 1 |
| US20090264650A1 (en) | 2005-03-31 | 2009-10-22 | Nobuo Cho | Prophylactic/Therapeutic Agent for Diabetes |
| WO2007084314A2 (en) | 2006-01-12 | 2007-07-26 | Incyte Corporation | MODULATORS OF 11-ß HYDROXYL STEROID DEHYDROGENASE TYPE 1, PHARMACEUTICAL COMPOSITIONS THEREOF, AND METHODS OF USING THE SAME |
| AU2007240450B2 (en) | 2006-04-21 | 2011-12-22 | Eli Lilly And Company | Cyclohexylimidazole lactam derivatives as inhibitors of 11-beta-hydroxysteroid dehydrogenase 1 |
| UA95798C2 (ru) | 2006-04-21 | 2011-09-12 | Эли Лилли Энд Компани | Производные циклогексилпиразоллактама как ингибиторы 11-бета-гидроксистероиддегидрогеназы 1 |
| AU2007240458B2 (en) | 2006-04-21 | 2012-03-15 | Eli Lilly And Company | Biphenyl amide lactam derivatives as inhibitors of 11- beta-hydroxysteroid dehydrogenase 1 |
| BRPI0710468A2 (pt) | 2006-04-24 | 2011-08-16 | Lilly Co Eli | composto, e, composição farmacêutica |
| PT2029529E (pt) | 2006-04-24 | 2010-09-02 | Lilly Co Eli | Pirrolidinonas substituídas como inibidores de 11 betahidroxiesteróide desidrogenase |
| BRPI0710467A2 (pt) | 2006-04-24 | 2011-08-16 | Lilly Co Eli | composto, composição farmacêutica, uso de um composto, e, intermediário |
| MX2008013656A (es) | 2006-04-25 | 2008-11-10 | Lilly Co Eli | Inhibidores de 11-beta-hidroxiesteroide deshidrogenasa. |
| DK2035379T3 (da) | 2006-04-25 | 2010-09-06 | Lilly Co Eli | Inhibitorer af 11-beta-hydroxysteroiddehydrogenase 1 |
| PL2049513T3 (pl) | 2006-04-28 | 2012-06-29 | Lilly Co Eli | Pirolidynony podstawione przez piperydynyl jako inhibitory dehydrogenazy 11-beta-hydroksysteroidowej typu 1 |
| CL2008001839A1 (es) | 2007-06-21 | 2009-01-16 | Incyte Holdings Corp | Compuestos derivados de 2,7-diazaespirociclos, inhibidores de 11-beta hidroxil esteroide deshidrogenasa tipo 1; composicion farmaceutica que comprende a dichos compuestos; utiles para tratar la obesidad, diabetes, intolerancia a la glucosa, diabetes tipo ii, entre otras enfermedades. |
-
2007
- 2007-04-24 ES ES07761186T patent/ES2336849T3/es active Active
- 2007-04-24 SI SI200730213T patent/SI2021337T1/sl unknown
- 2007-04-24 PL PL07761186T patent/PL2021337T3/pl unknown
- 2007-04-24 DK DK07761186.1T patent/DK2021337T3/da active
- 2007-04-24 MX MX2008013651A patent/MX2008013651A/es active IP Right Grant
- 2007-04-24 EP EP07761186A patent/EP2021337B1/en not_active Not-in-force
- 2007-04-24 BR BRPI0710050-7A patent/BRPI0710050A2/pt not_active IP Right Cessation
- 2007-04-24 PT PT07761186T patent/PT2021337E/pt unknown
- 2007-04-24 EA EA200870474A patent/EA015516B1/ru not_active IP Right Cessation
- 2007-04-24 CN CN2007800148990A patent/CN101454310B/zh not_active Expired - Fee Related
- 2007-04-24 WO PCT/US2007/067296 patent/WO2007127726A2/en not_active Ceased
- 2007-04-24 JP JP2009507926A patent/JP5189079B2/ja not_active Expired - Fee Related
- 2007-04-24 CA CA2648236A patent/CA2648236C/en not_active Expired - Fee Related
- 2007-04-24 US US12/297,964 patent/US7994176B2/en not_active Expired - Fee Related
- 2007-04-24 DE DE602007004324T patent/DE602007004324D1/de active Active
- 2007-04-24 AU AU2007244904A patent/AU2007244904B2/en not_active Ceased
- 2007-04-24 AT AT07761186T patent/ATE455110T1/de active
-
2010
- 2010-02-19 CY CY20101100164T patent/CY1109842T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EP2021337B1 (en) | 2010-01-13 |
| US20090099182A1 (en) | 2009-04-16 |
| EA015516B1 (ru) | 2011-08-30 |
| CN101454310B (zh) | 2013-07-17 |
| WO2007127726A3 (en) | 2008-01-03 |
| CY1109842T1 (el) | 2014-09-10 |
| CN101454310A (zh) | 2009-06-10 |
| MX2008013651A (es) | 2008-11-04 |
| JP5189079B2 (ja) | 2013-04-24 |
| PL2021337T3 (pl) | 2010-06-30 |
| ATE455110T1 (de) | 2010-01-15 |
| AU2007244904A1 (en) | 2007-11-08 |
| ES2336849T3 (es) | 2010-04-16 |
| AU2007244904B2 (en) | 2012-05-31 |
| BRPI0710050A2 (pt) | 2011-08-02 |
| SI2021337T1 (sl) | 2010-05-31 |
| JP2009535356A (ja) | 2009-10-01 |
| EP2021337A2 (en) | 2009-02-11 |
| PT2021337E (pt) | 2010-02-22 |
| CA2648236C (en) | 2013-05-28 |
| WO2007127726A2 (en) | 2007-11-08 |
| DE602007004324D1 (en) | 2010-03-04 |
| CA2648236A1 (en) | 2007-11-08 |
| US7994176B2 (en) | 2011-08-09 |
| EA200870474A1 (ru) | 2009-04-28 |
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| DK2035379T3 (da) | Inhibitorer af 11-beta-hydroxysteroiddehydrogenase 1 | |
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