DK1957647T3 - Immunstimulerende oligoribonukleotider - Google Patents

Immunstimulerende oligoribonukleotider Download PDF

Info

Publication number
DK1957647T3
DK1957647T3 DK06838257T DK06838257T DK1957647T3 DK 1957647 T3 DK1957647 T3 DK 1957647T3 DK 06838257 T DK06838257 T DK 06838257T DK 06838257 T DK06838257 T DK 06838257T DK 1957647 T3 DK1957647 T3 DK 1957647T3
Authority
DK
Denmark
Prior art keywords
seq
orn
immunostimulatory
rna
subject
Prior art date
Application number
DK06838257T
Other languages
English (en)
Inventor
Grayson B Lipford
Alexandra Forsbach
Joerg Vollmer
Original Assignee
Zoetis Belgium S A
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Zoetis Belgium S A filed Critical Zoetis Belgium S A
Application granted granted Critical
Publication of DK1957647T3 publication Critical patent/DK1957647T3/da

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/7105—Natural ribonucleic acids, i.e. containing only riboses attached to adenine, guanine, cytosine or uracil and having 3'-5' phosphodiester links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Liposomes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/117—Nucleic acids having immunomodulatory properties, e.g. containing CpG-motifs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55561—CpG containing adjuvants; Oligonucleotide containing adjuvants
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/17—Immunomodulatory nucleic acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/31—Chemical structure of the backbone
    • C12N2310/315—Phosphorothioates

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Epidemiology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Plant Pathology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Pulmonology (AREA)
  • Mycology (AREA)
  • Transplantation (AREA)
  • Dispersion Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)

Claims (9)

1. Fremgangsmåde til stimulering af en produktion af et pro-inflammatorisk cytokin udvalgt fra TNF-alfa og IL-12, hvilken fremgangsmåde omfatter: at bringe en TLR8-eksprimerende celle in vitro i kontakt med et RNA-oligonukleotid (ORN) omfattende: N-U-R-1-R2, hvor N er et ribonukleotid, og N ikke indeholder et U, U er uracil eller et derivat deraf, og R er et ribonukleotid, hvor mindst et af Ri og R2 er adenosin (A) eller cytosin (C) eller derivater deraf, og hvor R ikke er U, medmindre N-U-R1-R2 indeholder mindst to A, hvor ORN'et er udvalgt fra: GCCACCGAGCCGAAUAUACC SEQ ID NO: 11; AUAUAUAUAUAUAUAUAUAU SEQ ID NO:12; UUAUUAUUAUUAUUAUUAUU SEQ ID NO:13; AAUAAUAAUAAUAAUAAUAA SEQ ID NO:16; AAAUAAAUAAAUAAAUAAAU SEQ ID NO: 17; AAAAUAAAAUAAAAUAAAAU SEQ ID NO:18; CUACUACUACUACUACUACU SEQ ID NO:24; UUAUUAU SEQ ID NO:30; UAUAUAU SEQ ID NO:33; CCGAGCCGCAUAUCCC SEQ ID NO:36; CCGAGCCGCUAUACCC SEQ ID NO:37; CCGAGCCAUAUAUCCC SEQ ID NO:38; CCGAGCCAUAUAUAUC SEQ ID NO:39; CCGAGCCGAAUAACCC SEQ ID NO:40; CCGAGCCGCAUAACCC SEQ ID NO:41; CCGAGCCGAAUACCCC SEQ ID NO:42; CCGAGCCGCCUAACCC SEQ ID NO:43; CCGAGCCGAAUCCCCC SEQ ID NO:44; CCGAGCCGCAUACCCC SEQ ID NO:45; CCGAGCCGCAUCCCCC SEQ ID NO:46; CCGAGCCGCCUACCCC SEQ ID NO:47; CCGAGCCGCAUUACCC SEQ ID NO:48; CCGAGCCGCUAUCCCC SEQ ID NO:55; CCGAGCCGAAUGUACC SEQ ID NO:63; CCGAGCCGAUAUUACC SEQ ID NO:65; CCGAGCCGAAGGUACC SEQ ID NO:82; CCGAGCCGAAGGUGCC SEQ ID NO:83; CCGAGCCGAAGCUCCC SEQ ID NO:84; CCGAGCCGAAGAUACC SEQ ID NO:85; CCGAGCCGAAGCUACC SEQ ID NO:87; og CCGAGCCGAAGCUGCC SEQ ID NO:88; hvor ORN'et eventuelt indeholder mindst en backbone-modifikation; i en virksom mængde til stimulering af en pro-inflammatorisk cytokinprodukti- on, og hvor ingen væsentlig IFN-a-produktion induceres som reaktion på ORN'et i forhold til baggrunden; og endvidere hvor ORN'et er komplekseret til N-[1-(2,3-dioleoyloxy)propyl]-N,N,Ntrimethylammoniummethyl-sulfat (DOTAP).
2. Fremgangsmåde ifølge krav 1, hvorved en IFN-a-produktion som reaktion på ORN'et er mindre end 300 pg/ml.
3. RNA-oligonukleotid (ORN) omfattende: N-U-Ri-R2, hvor N er et ribonu-kleotid, og N ikke indeholder et U, U er uracil eller et derivat deraf, og R er et ribonukleotid, hvor mindst et af Ri og R2 er adenosin (A) eller cytosin (C) eller derivater deraf, og hvor R ikke er U, medmindre N-U-RrR2 indeholder mindst to A, hvor ORN'et er udvalgt fra: GCCACCGAGCCGAAUAUACC SEQ ID NO: 11; AUAUAUAUAUAUAUAUAUAU SEQ ID NO:12; UUAUUAUUAUUAUUAUUAUU SEQ IDNO:13; AAUAAUAAUAAUAAUAAUAA SEQ ID NO:16; AAAUAAAUAAAUAAAUAAAU SEQ ID NO:17; AAAAUAAAAUAAAAUAAAAU SEQ ID NO:18; CUACUACUACUACUACUACU SEQ ID NO:24; UUAUUAU SEQ ID NO:30; UAUAUAU SEQ ID NO:33; CCGAGCCGCAUAUCCC SEQ ID NO:36; CCGAGCCGCUAUACCC SEQ ID NO:37; CCGAGCCAUAUAUCCC SEQ ID NO:38; CCGAGCCAUAUAUAUC SEQ ID NO:39; CCGAGCCGAAUAACCC SEQ ID NO:40; CCGAGCCGCAUAACCC SEQ ID NO:41; CCGAGCCGAAUACCCC SEQ ID NO:42; CCGAGCCGCCUAACCC SEQ ID NO:43; CCGAGCCGAAUCCCCC SEQ ID NO:44; CCGAGCCGCAUACCCC SEQ ID NO:45; CCGAGCCGCAUCCCCC SEQ ID NO:46; CCGAGCCGCCUACCCC SEQ ID NO:47; CCGAGCCGCAUUACCC SEQ ID NO:48; CCGAGCCGCUAUCCCC SEQ ID NO:55; CCGAGCCGAAUGUACC SEQ ID NO:63; CCGAGCCGAUAUUACC SEQ ID NO:65; CCGAGCCGAAGGUACC SEQ ID NO:82; CCGAGCCGAAGGUGCC SEQ ID NO:83; CCGAGCCGAAGCUCCC SEQ ID NO:84; CCGAGCCGAAGAUACC SEQ ID NO:85; CCGAGCCGAAGCUACC SEQ ID NO:87; og CCGAGCCGAAGCUGCC SEQ ID NO:88; hvor ORN'et eventuelt indeholder mindst en backbone-modifikation. 4.0RN ifølge krav 3, yderligere omfattende en farmaceutisk acceptabel bærer. 5.0RN ifølge krav 3, hvor ORN er komplekseret til N-[1-(2,3-dioleoyloxy)propyl]-N,N,Ntrimethylammoniummethyl-sulfat (DOTAP).
6. RNA-oligonukleotid (ORN) ifølge krav 3, hvor oligonukleotidet desuden omfatter internukleotidphosphorothioat-bindinger.
7. Anvendelse af en sammensætning af et ORN ifølge et af kravene 3-6 ved fremstilling af et medikament til behandling af en immunsystemdeficiens, en infektion, en autoimmun sygdom, cancer, en allergisk tilstand, astma, astma forværret af en virusinfektion eller til anvendelse ved behandling af luftvejsremodellering.
8. ORN ifølge et af kravene 3-6 til anvendelse ved behandling af en immunsystemdeficiens, en infektion, en autoimmun sygdom, cancer, en allergisk tilstand, astma, astma forværret af virusinfektion eller til anvendelse ved be- handling af luftvejsremodellering.
9. Fremgangsmåde til nedregulering af immunsuppressive CD4+ regulator (Treg)-celler, hvilken fremgangsmåde omfatter: at bringe in vitro en CD4+ Treg-celle i kontakt med en sammensætning omfattende et ORN ifølge et af kravene 3-6 i en virksom mængde til reduktion af en hæmmende effekt af CD4+ Treg-cellen.
10.ORN ifølge et af kravene 3-6 til anvendelse som et medikament.
11. ORN ifølge et af kravene 3-6 og krav 10 til anvendelse ved stimulering eller modulering af en immunreaktion.
DK06838257T 2005-11-25 2006-11-22 Immunstimulerende oligoribonukleotider DK1957647T3 (da)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US73952905P 2005-11-25 2005-11-25
US77898906P 2006-03-03 2006-03-03
PCT/US2006/045183 WO2007062107A2 (en) 2005-11-25 2006-11-22 Immunostimulatory oligoribonucleotides

Publications (1)

Publication Number Publication Date
DK1957647T3 true DK1957647T3 (da) 2015-04-07

Family

ID=37946151

Family Applications (1)

Application Number Title Priority Date Filing Date
DK06838257T DK1957647T3 (da) 2005-11-25 2006-11-22 Immunstimulerende oligoribonukleotider

Country Status (16)

Country Link
US (3) US7662949B2 (da)
EP (2) EP2883957A1 (da)
JP (1) JP4538522B2 (da)
KR (1) KR20080072934A (da)
CN (1) CN102517292B (da)
AU (2) AU2006318464B2 (da)
BR (2) BRPI0622298A8 (da)
CA (1) CA2630738C (da)
DK (1) DK1957647T3 (da)
ES (1) ES2536103T3 (da)
HK (1) HK1210212A1 (da)
PL (1) PL1957647T3 (da)
PT (1) PT1957647E (da)
SI (1) SI1957647T1 (da)
TW (1) TW200738877A (da)
WO (1) WO2007062107A2 (da)

Families Citing this family (78)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030026782A1 (en) * 1995-02-07 2003-02-06 Arthur M. Krieg Immunomodulatory oligonucleotides
US7935675B1 (en) 1994-07-15 2011-05-03 University Of Iowa Research Foundation Immunostimulatory nucleic acid molecules
US6207646B1 (en) 1994-07-15 2001-03-27 University Of Iowa Research Foundation Immunostimulatory nucleic acid molecules
US6239116B1 (en) * 1994-07-15 2001-05-29 University Of Iowa Research Foundation Immunostimulatory nucleic acid molecules
US6406705B1 (en) 1997-03-10 2002-06-18 University Of Iowa Research Foundation Use of nucleic acids containing unmethylated CpG dinucleotide as an adjuvant
NZ508650A (en) * 1998-05-14 2003-05-30 Coley Pharm Gmbh Regulating hematopoiesis using unmethylated C and G CpG-oligonucleotides with a phosphorothioate modification
DK1077722T3 (da) * 1998-05-22 2006-11-27 Ottawa Health Research Inst Fremgangsmåder og produkter til induktion af mukosaimmunitet
US6949520B1 (en) * 1999-09-27 2005-09-27 Coley Pharmaceutical Group, Inc. Methods related to immunostimulatory nucleic acid-induced interferon
US7585847B2 (en) * 2000-02-03 2009-09-08 Coley Pharmaceutical Group, Inc. Immunostimulatory nucleic acids for the treatment of asthma and allergy
US20030129251A1 (en) * 2000-03-10 2003-07-10 Gary Van Nest Biodegradable immunomodulatory formulations and methods for use thereof
DE60139689D1 (de) * 2000-06-22 2009-10-08 Univ Iowa Res Found Kombination von CpG und Antikörpern gegen CD19,CD20,CD22 oder CD40 zur Prävention oder Behandlung von Krebs.
NZ531194A (en) 2001-08-17 2007-02-23 Coley Pharm Gmbh Combination motif immune stimulatory oligonucleotides with improved activity
US8153141B2 (en) * 2002-04-04 2012-04-10 Coley Pharmaceutical Gmbh Immunostimulatory G, U-containing oligoribonucleotides
US20040053880A1 (en) 2002-07-03 2004-03-18 Coley Pharmaceutical Group, Inc. Nucleic acid compositions for stimulating immune responses
US7576066B2 (en) * 2002-07-03 2009-08-18 Coley Pharmaceutical Group, Inc. Nucleic acid compositions for stimulating immune responses
US7807803B2 (en) 2002-07-03 2010-10-05 Coley Pharmaceutical Group, Inc. Nucleic acid compositions for stimulating immune responses
AR040996A1 (es) 2002-08-19 2005-04-27 Coley Pharm Group Inc Acidos nucleicos inmunoestimuladores
EA008777B1 (ru) 2002-10-29 2007-08-31 Коли Фармасьютикал Груп, Лтд. Способы и продукты, относящиеся к лечению и предупреждению инфекции вируса гепатита c
JP2006512927A (ja) 2002-12-11 2006-04-20 コーリー ファーマシューティカル グループ，インコーポレイテッド ５’ｃｐｇ核酸およびその使用方法
AU2004257149A1 (en) * 2003-06-20 2005-01-27 Coley Pharmaceutical Gmbh Small molecule toll-like receptor (TLR) antagonists
JP4989225B2 (ja) * 2003-09-25 2012-08-01 コーリー ファーマシューティカル グループ，インコーポレイテッド 核酸親油性接合体
UA88457C2 (ru) 2003-10-30 2009-10-26 Коли Фармасьютикал Гмбх Иммуностимулирующая нуклеиновая кислота с улучшенной иммуностимулирующей эффективностью
US20050239733A1 (en) * 2003-10-31 2005-10-27 Coley Pharmaceutical Gmbh Sequence requirements for inhibitory oligonucleotides
US20050256073A1 (en) * 2004-02-19 2005-11-17 Coley Pharmaceutical Group, Inc. Immunostimulatory viral RNA oligonucleotides
EP1716234B1 (de) * 2004-02-20 2013-10-02 Mologen AG Substituiertes, nicht-kodierendes nukleinsäuremolekül zur therapeutischen und prophylaktischen immunstimulation in menschen und höheren tieren
KR100958505B1 (ko) * 2004-07-18 2010-05-17 씨에스엘 리미티드 면역자극 복합체 및 향상된 인터페론-감마 반응을 유도하기위한 올리고뉴클레오티드 제제
MY159370A (en) * 2004-10-20 2016-12-30 Coley Pharm Group Inc Semi-soft-class immunostimulatory oligonucleotides
BRPI0610449A2 (pt) * 2005-04-08 2012-01-10 Coley Pharm Group Inc métodos para tratar asma exarcebada por doença infecciosa
EP1904530A2 (en) * 2005-07-07 2008-04-02 Coley Pharmaceutical Group, Inc. Anti-ctla-4 antibody and cpg-motif-containing synthetic oligodeoxynucleotide combination therapy for cancer treatment
KR20080047463A (ko) * 2005-09-16 2008-05-28 콜리 파마슈티칼 게엠베하 뉴클레오티드 변형에 의한 짧은 간섭 리보핵산(ｓｉｒｎａ)의 면역자극 특성의 조절
BRPI0616235A2 (pt) * 2005-09-16 2011-06-14 Coley Pharm Gmbh acido ribonuclÉico monofilamentado imunoestimulante com cadeia principal de fosfodiÉster
CN102517292B (zh) 2005-11-25 2014-12-24 佐蒂斯比利时股份有限公司 免疫刺激性寡核糖核苷酸
AU2007235231B2 (en) 2006-04-07 2012-04-12 Idera Pharmaceuticals, Inc. Stabilized immune modulatory RNA (SIMRA) compounds for TLR7 and TLR8
MX2009003398A (es) 2006-09-27 2009-08-12 Coley Pharm Gmbh Analogos de oligonucleotidos cpg que contienen analogos t hidrofobos con actividad inmunoestimuladora mejorada.
BRPI0719445A2 (pt) * 2006-09-27 2013-12-10 Coley Pharm Group Inc Composições de ligandos de tlr e antivirais.
WO2008057529A2 (en) * 2006-11-06 2008-05-15 Coley Pharmaceutical Group, Inc. Peptide-based vaccine compositions to endogenous cholesteryl ester transfer protein (cetp)
ES2544484T3 (es) * 2007-05-18 2015-08-31 Adiutide Pharmaceuticals Gmbh Análogos de oligonucleótidos modificados con fosfato con actividad inmunoestimulante
AU2008279509B2 (en) 2007-07-09 2011-07-21 Idera Pharmaceuticals, Inc. Stabilized immune modulatory RNA (SIMRA) compounds
BRPI0814260B8 (pt) * 2007-08-13 2021-05-25 Coley Pharm Gmbh composição compreendendo um polímero de fita única, método compreendendo contatar uma célula com tal polímero e uso de tal polímero
WO2009030254A1 (en) * 2007-09-04 2009-03-12 Curevac Gmbh Complexes of rna and cationic peptides for transfection and for immunostimulation
PT2176408E (pt) 2008-01-31 2015-04-23 Curevac Gmbh Ácidos nucleicos compreendendo a fórmula (nuglxmgnnv)a e os seus derivados como agentes/adjuvantes imunoestimuladores
US10383887B2 (en) * 2008-02-20 2019-08-20 New York University Preventing and treating amyloid-beta deposition by stimulation of innate immunity
KR101023194B1 (ko) * 2009-02-25 2011-03-18 사회복지법인 삼성생명공익재단 아토피 피부염 진단용 마커 및 그의 용도
CA2744346A1 (en) * 2009-03-17 2010-09-23 Gunther Hartmann Tlr 7 ligand and uses thereof
CA3033133C (en) 2009-03-25 2021-11-09 The Board Of Regents Of The University Of Texas System Compositions for stimulation of mammalian innate immune resistance to pathogens
WO2010138192A2 (en) 2009-05-27 2010-12-02 Selecta Biosciences, Inc. Nanocarriers possessing components with different rates of release
JP5854559B2 (ja) 2009-07-06 2016-02-09 ヴァリエーション バイオテクノロジーズ インコーポレイテッド 小胞を調製する方法及びこれから製造される製剤
CA2803282C (en) 2009-07-06 2018-05-01 David E. Anderson Methods for preparing vesicles and formulations produced therefrom
US20110110965A1 (en) 2009-08-26 2011-05-12 Selecta Biosciences, Inc. Compositions that induce t cell help
US20110053829A1 (en) 2009-09-03 2011-03-03 Curevac Gmbh Disulfide-linked polyethyleneglycol/peptide conjugates for the transfection of nucleic acids
WO2011061568A1 (en) * 2009-11-22 2011-05-26 Azure Vault Ltd. Automatic chemical assay classification
CA2798994A1 (en) 2010-05-26 2011-12-01 Selecta Biosciences, Inc. Multivalent synthetic nanocarrier vaccines
BR112013000394B8 (pt) 2010-07-06 2022-01-18 Variation Biotechnologies Inc Composição imunogênica, uso da mesma e método para preparar a referida composição
EA201390660A1 (ru) 2010-11-05 2013-11-29 Селекта Байосайенсиз, Инк. Модифицированные никотиновые соединения и связанные способы
CN107012149A (zh) * 2010-11-19 2017-08-04 艾德拉药物股份有限公司 调控基于toll‑样受体的免疫应答的免疫调节寡核苷酸(iro)化合物
US20120177701A1 (en) * 2010-12-31 2012-07-12 Selecta Biosciences, Inc. Compositions comprising immunostimulatory nucleic acids and related methods
BR112013017939B1 (pt) 2011-01-13 2022-11-16 Variation Biotechnologies Inc Composição imunogênica liofilizada termoestável, uso e método para preparação da mesma
WO2013009586A1 (en) * 2011-07-08 2013-01-17 The Research Foundation Of State University Of New York Topical minocycline ointment for suppression of allergic skin responses
EP2736537A4 (en) 2011-07-29 2015-04-15 Selecta Biosciences Inc SYNTHETIC NANOTRANSPORTERS FOR THE PRODUCTION OF HUMOROUS AND CYTOTOXIC T-LYMPHOCY (CTL) IMMUNE REACTIONS
US9636414B2 (en) 2011-12-15 2017-05-02 Biontech Ag Particles comprising single stranded RNA and double stranded RNA for immunomodulation
US10172960B2 (en) 2011-12-15 2019-01-08 Biontech Ag Particles comprising single stranded RNA and double stranded RNA for immunomodulation
EP2802353A4 (en) 2012-01-12 2015-12-02 Variation Biotechnologies Inc COMPOSITIONS AND METHOD FOR THE TREATMENT OF VIRUS INFECTIONS
CA2894467A1 (en) 2012-01-27 2013-08-01 Variation Biotechnologies Inc. Methods for preparing thermostable compositions comprising a lipid component and thermolabile therapeutic agents
WO2013113326A1 (en) 2012-01-31 2013-08-08 Curevac Gmbh Pharmaceutical composition comprising a polymeric carrier cargo complex and at least one protein or peptide antigen
US9228184B2 (en) 2012-09-29 2016-01-05 Dynavax Technologies Corporation Human toll-like receptor inhibitors and methods of use thereof
US9868955B2 (en) 2012-09-29 2018-01-16 Dynavax Technologies Corporation Human toll-like receptor inhibitors and methods of use thereof
KR20150127206A (ko) 2013-03-14 2015-11-16 프레지던트 앤드 펠로우즈 오브 하바드 칼리지 나노입자-기재 조성물
MX369469B (es) 2013-08-21 2019-11-08 Curevac Ag Vacuna contra el virus respiratorio sincitial.
EP3110401A4 (en) 2014-02-25 2017-10-25 Merck Sharp & Dohme Corp. Lipid nanoparticle vaccine adjuvants and antigen delivery systems
WO2015149944A2 (en) 2014-04-01 2015-10-08 Curevac Gmbh Polymeric carrier cargo complex for use as an immunostimulating agent or as an adjuvant
EA201692512A1 (ru) 2014-06-25 2017-07-31 Селекта Байосайенсиз, Инк. Способы и композиции для лечения синтетическими наноносителями и ингибиторами иммунной контрольной точки
US10286065B2 (en) 2014-09-19 2019-05-14 Board Of Regents, The University Of Texas System Compositions and methods for treating viral infections through stimulated innate immunity in combination with antiviral compounds
LU92821B1 (en) 2015-09-09 2017-03-20 Mologen Ag Combination comprising immunostimulatory oligonucleotides
CN105193836A (zh) * 2015-09-11 2015-12-30 陶烈晖 外用补充核苷酸的方法和制剂
GB2542425A (en) 2015-09-21 2017-03-22 Mologen Ag Means for the treatment of HIV
RU2713167C1 (ru) * 2018-11-21 2020-02-04 Артур Витович Жиурис Способ лечения гепатитов и состав для его осуществления
EP4104830A1 (en) 2021-06-16 2022-12-21 Burghardt Wittig Sequential innate and adaptive immune modulation for cancer treatment
WO2024028794A1 (en) 2022-08-02 2024-02-08 Temple Therapeutics BV Methods for treating endometrial and ovarian hyperproliferative disorders

Family Cites Families (114)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3854480A (en) 1969-04-01 1974-12-17 Alza Corp Drug-delivery system
US3906092A (en) 1971-11-26 1975-09-16 Merck & Co Inc Stimulation of antibody response
US4675189A (en) 1980-11-18 1987-06-23 Syntex (U.S.A.) Inc. Microencapsulation of water soluble active polypeptides
US4452775A (en) 1982-12-03 1984-06-05 Syntex (U.S.A.) Inc. Cholesterol matrix delivery system for sustained release of macromolecules
JPH0669953B2 (ja) 1985-08-16 1994-09-07 日産化学工業株式会社 脳脊髄系神経栄養剤
US5075109A (en) 1986-10-24 1991-12-24 Southern Research Institute Method of potentiating an immune response
US4950652A (en) 1987-03-23 1990-08-21 Hem Research, Inc. dsRNAs for combination therapy in the treatment of viral diseases
US5133974A (en) 1989-05-05 1992-07-28 Kv Pharmaceutical Company Extended release pharmaceutical formulations
US5407686A (en) 1991-11-27 1995-04-18 Sidmak Laboratories, Inc. Sustained release composition for oral administration of active ingredient
ATE226250T1 (de) * 1992-04-30 2002-11-15 Innogenetics Nv Polypeptide und peptide dafür kodierende nukleinsaüre und ihre verwendung im zusammenhang mit tumortherapie, entzündung oder immunology
US6342484B1 (en) 1993-06-30 2002-01-29 Board Of Regents, The University Of Texas Systems Method and compositions for promotion of wound treatment
AU7319994A (en) 1993-06-30 1995-01-24 Board Of Regents, The University Of Texas System Nucleotide preparation and uses thereof in wound healing
US5602109A (en) 1994-01-10 1997-02-11 Abbott Laboratories Method to enhance the immune system of a human
US5488039A (en) 1994-01-10 1996-01-30 Abbott Laboratories Method for the production of an enteral formula containing ribo-nucleotides
US5700590A (en) 1994-01-10 1997-12-23 Abbott Laboratories Nutritional formula with ribo-nucleotides
US5492899A (en) 1994-01-10 1996-02-20 Abbott Laboratories Infant nutritional formula with ribo-nucleotides
AU710504B2 (en) 1994-03-15 1999-09-23 Brown University Research Foundation Polymeric gene delivery system
US6727230B1 (en) 1994-03-25 2004-04-27 Coley Pharmaceutical Group, Inc. Immune stimulation by phosphorothioate oligonucleotide analogs
WO1995026204A1 (en) 1994-03-25 1995-10-05 Isis Pharmaceuticals, Inc. Immune stimulation by phosphorothioate oligonucleotide analogs
US6239116B1 (en) 1994-07-15 2001-05-29 University Of Iowa Research Foundation Immunostimulatory nucleic acid molecules
US6429199B1 (en) 1994-07-15 2002-08-06 University Of Iowa Research Foundation Immunostimulatory nucleic acid molecules for activating dendritic cells
US7935675B1 (en) 1994-07-15 2011-05-03 University Of Iowa Research Foundation Immunostimulatory nucleic acid molecules
WO1996002555A1 (en) 1994-07-15 1996-02-01 The University Of Iowa Research Foundation Immunomodulatory oligonucleotides
US20030050263A1 (en) 1994-07-15 2003-03-13 The University Of Iowa Research Foundation Methods and products for treating HIV infection
US20030026782A1 (en) 1995-02-07 2003-02-06 Arthur M. Krieg Immunomodulatory oligonucleotides
US6207646B1 (en) 1994-07-15 2001-03-27 University Of Iowa Research Foundation Immunostimulatory nucleic acid molecules
US5612060A (en) 1995-05-25 1997-03-18 Alexander; J. Wesley Enhancement of transplant graft survival through nutritional immunomodulation and immunosuppressive therapy
WO1997003702A1 (en) 1995-07-21 1997-02-06 Brown University Research Foundation A method for gene therapy using nucleic acid loaded polymeric microparticles
US5736152A (en) 1995-10-27 1998-04-07 Atrix Laboratories, Inc. Non-polymeric sustained release delivery system
FR2750435B1 (fr) * 1996-06-27 1998-08-28 Appligene Oncor Procede de formation de complexes d'hybridation dont la stabilite depend peu de la composition en base des deux molecules d'acides nucleiques hybridees
EP0855184A1 (en) 1997-01-23 1998-07-29 Grayson B. Dr. Lipford Pharmaceutical composition comprising a polynucleotide and an antigen especially for vaccination
AU738513B2 (en) 1997-02-28 2001-09-20 University Of Iowa Research Foundation, The Use of nucleic acids containing unmethylated CpG dinucleotide in the treatment of LPS-associated disorders
US6406705B1 (en) 1997-03-10 2002-06-18 University Of Iowa Research Foundation Use of nucleic acids containing unmethylated CpG dinucleotide as an adjuvant
US6339068B1 (en) 1997-05-20 2002-01-15 University Of Iowa Research Foundation Vectors and methods for immunization or therapeutic protocols
KR20010012770A (ko) * 1997-05-22 2001-02-26 세파론, 인코포레이티드 비타민 ｄ 유사체 및 그 뉴런 효과
EP1009440B1 (en) 1997-07-03 2008-09-17 MacFarlane, Donald E. Method for inhibiting immunostimulatory dna associated responses
JP2002510644A (ja) 1998-04-03 2002-04-09 ユニバーシティ オブ アイオワ リサーチ ファウンデーション 免疫治療用オリゴヌクレオチドおよびサイトカインを用いる免疫系刺激のための方法および産物
AU3884199A (en) 1998-05-06 1999-11-23 Ottawa Health Research Institute Methods for the prevention and treatment of parasitic infections and related diseases using cpg oligonucleotides
NZ508650A (en) 1998-05-14 2003-05-30 Coley Pharm Gmbh Regulating hematopoiesis using unmethylated C and G CpG-oligonucleotides with a phosphorothioate modification
DK1077722T3 (da) 1998-05-22 2006-11-27 Ottawa Health Research Inst Fremgangsmåder og produkter til induktion af mukosaimmunitet
US20040247662A1 (en) 1998-06-25 2004-12-09 Dow Steven W. Systemic immune activation method using nucleic acid-lipid complexes
EP1100807A1 (en) 1998-07-27 2001-05-23 University Of Iowa Research Foundation STEREOISOMERS OF CpG OLIGONUCLEOTIDES AND RELATED METHODS
AU777225B2 (en) 1998-09-03 2004-10-07 Coley Pharmaceutical Gmbh G-motif oligonucleotides and uses thereof
EP1177439B1 (en) 1999-04-29 2004-09-08 Coley Pharmaceutical GmbH Screening for immunostimulatory dna functional modifiers
EP1377554A1 (en) 1999-06-16 2004-01-07 University Of Iowa Research Foundation Antagonism of immunostimulatory cpg-oligonucleotides by 4-aminoquinolines and other weak bases
DE19935756A1 (de) 1999-07-27 2001-02-08 Mologen Forschungs Entwicklung Kovalent geschlossenes Nukleinsäuremolekül zur Immunstimulation
UA77152C2 (en) 1999-09-25 2006-11-15 Method for stimulation of immune response using nucleic acid-containing immunostimulating compositions, method for treatment of cancer and method for treatment or prophylaxis of allergy or asthma
DE60029460T3 (de) 1999-09-27 2011-02-10 Coley Pharmaceutical Gmbh Verfahren mittels durch nukleinsäuren induziertes immunostimulatorisches interferon
US6949520B1 (en) 1999-09-27 2005-09-27 Coley Pharmaceutical Group, Inc. Methods related to immunostimulatory nucleic acid-induced interferon
JP2003514791A (ja) 1999-11-02 2003-04-22 カイロン コーポレイション 二本鎖ＲＮＡレセプター（ｄｓＲＮＡ−Ｒ）およびそれに関連する方法
WO2001045750A1 (en) 1999-12-21 2001-06-28 The Regents Of The University Of California Method for preventing an anaphylactic reaction
CA2396871A1 (en) 2000-01-20 2001-12-20 Ottawa Health Research Institute Immunostimulatory nucleic acids for inducing a th2 immune response
US7585847B2 (en) 2000-02-03 2009-09-08 Coley Pharmaceutical Group, Inc. Immunostimulatory nucleic acids for the treatment of asthma and allergy
US7491805B2 (en) * 2001-05-18 2009-02-17 Sirna Therapeutics, Inc. Conjugates and compositions for cellular delivery
US20020156033A1 (en) 2000-03-03 2002-10-24 Bratzler Robert L. Immunostimulatory nucleic acids and cancer medicament combination therapy for the treatment of cancer
US20040131628A1 (en) 2000-03-08 2004-07-08 Bratzler Robert L. Nucleic acids for the treatment of disorders associated with microorganisms
US7102024B1 (en) * 2000-08-01 2006-09-05 Schwartz David A Functional biopolymer modification reagents and uses thereof
EP1292331A2 (en) 2000-06-07 2003-03-19 Biosynexus Incorporated Immunostimulatory rna/dna hybrid molecules
DE60139689D1 (de) 2000-06-22 2009-10-08 Univ Iowa Res Found Kombination von CpG und Antikörpern gegen CD19,CD20,CD22 oder CD40 zur Prävention oder Behandlung von Krebs.
US20020165178A1 (en) 2000-06-28 2002-11-07 Christian Schetter Immunostimulatory nucleic acids for the treatment of anemia, thrombocytopenia, and neutropenia
US20020198165A1 (en) 2000-08-01 2002-12-26 Bratzler Robert L. Nucleic acids for the prevention and treatment of gastric ulcers
US20020091097A1 (en) 2000-09-07 2002-07-11 Bratzler Robert L. Nucleic acids for the prevention and treatment of sexually transmitted diseases
DK1366077T3 (da) 2000-09-15 2011-09-12 Coley Pharm Gmbh Fremgangsmåde til screening i store mængder af CpG-baserede immunoagonister/-antagonister
DE60134421D1 (de) 2000-12-08 2008-07-24 Coley Pharmaceuticals Gmbh Cpg-artige nukleinsäuren und verfahren zu ihrer verwendung
AU2002248185A1 (en) 2000-12-14 2002-07-16 Coley Pharmaceutical Group, Inc. Inhibition of angiogenesis by nucleic acids
US20030050268A1 (en) 2001-03-29 2003-03-13 Krieg Arthur M. Immunostimulatory nucleic acid for treatment of non-allergic inflammatory diseases
AU2002318944A1 (en) 2001-08-01 2003-02-17 Coley Pharmaceutical Gmbh Methods and compositions relating to plasmacytoid dendritic cells
NZ531194A (en) 2001-08-17 2007-02-23 Coley Pharm Gmbh Combination motif immune stimulatory oligonucleotides with improved activity
CA2461315A1 (en) 2001-10-05 2003-04-17 Coley Pharmaceutical Gmbh Toll-like receptor 3 signaling agonists and antagonists
US20030139364A1 (en) 2001-10-12 2003-07-24 University Of Iowa Research Foundation Methods and products for enhancing immune responses using imidazoquinoline compounds
AU2002358616A1 (en) 2001-12-07 2003-06-17 Intercell Ag Immunostimulatory oligodeoxynucleotides
CN1694621A (zh) * 2002-04-04 2005-11-09 科勒制药股份公司 含有g,u的免疫刺激寡核糖核苷酸
US8153141B2 (en) 2002-04-04 2012-04-10 Coley Pharmaceutical Gmbh Immunostimulatory G, U-containing oligoribonucleotides
WO2003103586A2 (en) 2002-06-05 2003-12-18 Coley Pharmaceutical Group, Inc. Method for treating autoimmune or inflammatory diseases with combinations of inhibitory oligonucleotides and small molecule antagonists of immunostimulatory cpg nucleic acids
US7807803B2 (en) 2002-07-03 2010-10-05 Coley Pharmaceutical Group, Inc. Nucleic acid compositions for stimulating immune responses
US20040053880A1 (en) 2002-07-03 2004-03-18 Coley Pharmaceutical Group, Inc. Nucleic acid compositions for stimulating immune responses
US7576066B2 (en) 2002-07-03 2009-08-18 Coley Pharmaceutical Group, Inc. Nucleic acid compositions for stimulating immune responses
US7605138B2 (en) 2002-07-03 2009-10-20 Coley Pharmaceutical Group, Inc. Nucleic acid compositions for stimulating immune responses
US7569553B2 (en) 2002-07-03 2009-08-04 Coley Pharmaceutical Group, Inc. Nucleic acid compositions for stimulating immune responses
WO2004007743A2 (en) 2002-07-17 2004-01-22 Coley Pharmaceutical Gmbh Use of cpg nucleic acids in prion-disease
AR040996A1 (es) 2002-08-19 2005-04-27 Coley Pharm Group Inc Acidos nucleicos inmunoestimuladores
WO2004026888A2 (en) 2002-09-19 2004-04-01 Coley Pharmaceutical Gmbh Toll-like receptor 9 (tlr9) from various mammalian species
EA008777B1 (ru) 2002-10-29 2007-08-31 Коли Фармасьютикал Груп, Лтд. Способы и продукты, относящиеся к лечению и предупреждению инфекции вируса гепатита c
US7790867B2 (en) * 2002-12-05 2010-09-07 Rosetta Genomics Inc. Vaccinia virus-related nucleic acids and microRNA
JP2006512927A (ja) 2002-12-11 2006-04-20 コーリー ファーマシューティカル グループ，インコーポレイテッド ５’ｃｐｇ核酸およびその使用方法
WO2004087203A2 (en) 2003-04-02 2004-10-14 Coley Pharmaceutical Group, Ltd. Immunostimulatory nucleic acid oil-in-water formulations for topical application
EP1631687A2 (en) 2003-04-22 2006-03-08 Coley Pharmaceutical GmbH Methods and products for identification and assessment of tlr ligands
AU2004257149A1 (en) 2003-06-20 2005-01-27 Coley Pharmaceutical Gmbh Small molecule toll-like receptor (TLR) antagonists
US20050013812A1 (en) 2003-07-14 2005-01-20 Dow Steven W. Vaccines using pattern recognition receptor-ligand:lipid complexes
JP4989225B2 (ja) * 2003-09-25 2012-08-01 コーリー ファーマシューティカル グループ，インコーポレイテッド 核酸親油性接合体
US20050215501A1 (en) 2003-10-24 2005-09-29 Coley Pharmaceutical Group, Inc. Methods and products for enhancing epitope spreading
UA88457C2 (ru) 2003-10-30 2009-10-26 Коли Фармасьютикал Гмбх Иммуностимулирующая нуклеиновая кислота с улучшенной иммуностимулирующей эффективностью
US20050239733A1 (en) * 2003-10-31 2005-10-27 Coley Pharmaceutical Gmbh Sequence requirements for inhibitory oligonucleotides
US20050100983A1 (en) 2003-11-06 2005-05-12 Coley Pharmaceutical Gmbh Cell-free methods for identifying compounds that affect toll-like receptor 9 (TLR9) signaling
US20050256073A1 (en) 2004-02-19 2005-11-17 Coley Pharmaceutical Group, Inc. Immunostimulatory viral RNA oligonucleotides
JP2007531746A (ja) 2004-04-02 2007-11-08 コーリー ファーマシューティカル グループ，インコーポレイテッド Ｉｌ−１０応答を誘導するための免疫活性化核酸
AU2005326144A1 (en) 2004-06-08 2006-08-03 Coley Pharmaceutical Gmbh Abasic oligonucleotide as carrier platform for antigen and immunostimulatory agonist and antagonist
JP2008506683A (ja) 2004-07-18 2008-03-06 コーリー ファーマシューティカル グループ， リミテッド 先天免疫応答を誘導するための方法および組成物
KR100958505B1 (ko) 2004-07-18 2010-05-17 씨에스엘 리미티드 면역자극 복합체 및 향상된 인터페론-감마 반응을 유도하기위한 올리고뉴클레오티드 제제
US7582744B2 (en) 2004-08-10 2009-09-01 Alnylam Pharmaceuticals, Inc. Chemically modified oligonucleotides
MY159370A (en) 2004-10-20 2016-12-30 Coley Pharm Group Inc Semi-soft-class immunostimulatory oligonucleotides
EP1819365B1 (en) 2004-12-09 2014-07-02 Alnylam Pharmaceuticals Inc. Compositions and methods for inducing an immune response in a mammal and methods of avoiding an immune response to oligonucleotide agents such as short interfering RNAs
CA2598992A1 (en) 2005-02-24 2006-08-31 Coley Pharmaceutical Group, Inc. Immunostimulatory oligonucleotides
AU2006219717B2 (en) 2005-03-02 2009-05-21 The Secretary Of State For Defence Pharmaceutical composition
BRPI0610449A2 (pt) 2005-04-08 2012-01-10 Coley Pharm Group Inc métodos para tratar asma exarcebada por doença infecciosa
WO2006116458A2 (en) * 2005-04-26 2006-11-02 Coley Pharmaceutical Gmbh Modified oligoribonucleotide analogs with enhances immunostimulatory activity
EP1764107A1 (en) 2005-09-14 2007-03-21 Gunther Hartmann Compositions comprising immunostimulatory RNA oligonucleotides and methods for producing said RNA oligonucleotides
WO2007031322A1 (en) 2005-09-14 2007-03-22 Gunther Hartmann Compositions comprising immunostimulatory rna oligonucleotides and methods for producing said rna oligonucleotides
EA200801045A1 (ru) 2005-10-12 2008-10-30 Кэнсер Рисерч Текнолоджи Лтд. Способы и композиции для лечения иммунных нарушений
CN102517292B (zh) 2005-11-25 2014-12-24 佐蒂斯比利时股份有限公司 免疫刺激性寡核糖核苷酸
WO2007095316A2 (en) 2006-02-15 2007-08-23 Coley Pharmaceutical Gmbh Compositions and methods for oligonucleotide formulations
US8027888B2 (en) 2006-08-31 2011-09-27 Experian Interactive Innovation Center, Llc Online credit card prescreen systems and methods
WO2008033432A2 (en) 2006-09-12 2008-03-20 Coley Pharmaceutical Group, Inc. Immune modulation by chemically modified ribonucleosides and oligoribonucleotides
BRPI0719445A2 (pt) 2006-09-27 2013-12-10 Coley Pharm Group Inc Composições de ligandos de tlr e antivirais.

Also Published As

Publication number Publication date
AU2006318464B2 (en) 2011-02-17
PL1957647T3 (pl) 2015-07-31
WO2007062107A2 (en) 2007-05-31
ES2536103T3 (es) 2015-05-20
US20070142315A1 (en) 2007-06-21
US8354522B2 (en) 2013-01-15
AU2011202189A1 (en) 2011-06-02
CN102517292B (zh) 2014-12-24
AU2006318464A1 (en) 2007-05-31
JP2009517048A (ja) 2009-04-30
BRPI0622298A2 (pt) 2012-12-11
CA2630738A1 (en) 2007-05-31
US7662949B2 (en) 2010-02-16
US20100316659A1 (en) 2010-12-16
TW200738877A (en) 2007-10-16
CA2630738C (en) 2013-09-03
WO2007062107A3 (en) 2007-07-12
PT1957647E (pt) 2015-06-01
BRPI0618857B1 (pt) 2022-07-19
EP1957647B1 (en) 2015-03-04
JP4538522B2 (ja) 2010-09-08
EP1957647A2 (en) 2008-08-20
KR20080072934A (ko) 2008-08-07
BRPI0618857A8 (pt) 2016-04-05
SI1957647T1 (sl) 2015-04-30
CN102517292A (zh) 2012-06-27
BRPI0622298A8 (pt) 2016-04-05
AU2011202189B2 (en) 2012-05-17
BRPI0618857A2 (pt) 2011-09-13
EP2883957A1 (en) 2015-06-17
HK1210212A1 (en) 2016-04-15
US20110206719A1 (en) 2011-08-25

Similar Documents

Publication Publication Date Title
DK1957647T3 (da) Immunstimulerende oligoribonukleotider
US20100144846A1 (en) Oligoribonucleotides and uses thereof
US20060241076A1 (en) Modified oligoribonucleotide analogs with enhanced immunostimulatory activity
US8466124B2 (en) RNA sequence motifs in the context of defined internucleotide linkages inducing specific immune modulatory profiles
EP1928500A2 (en) Modulation of tlr-mediated immune responses using adaptor oligonucleotides
CA2790802C (en) Immunostimulatory oligoribonucleotides
MX2008006770A (en) Immunostimulatory oligoribonucleotides