DK175709B1 - Fremgangsmåde til fremstilling af kalium-clavulanat - Google Patents

Fremgangsmåde til fremstilling af kalium-clavulanat Download PDF

Info

Publication number
DK175709B1
DK175709B1 DK198800404A DK40488A DK175709B1 DK 175709 B1 DK175709 B1 DK 175709B1 DK 198800404 A DK198800404 A DK 198800404A DK 40488 A DK40488 A DK 40488A DK 175709 B1 DK175709 B1 DK 175709B1
Authority
DK
Denmark
Prior art keywords
potassium
clavulanate
isopropanol
solution
rosettes
Prior art date
Application number
DK198800404A
Other languages
Danish (da)
English (en)
Other versions
DK40488D0 (da
DK40488A (da
Inventor
Dennis Edward Clark
Shaukat Hussain Malik
Paul Gerard Butterly
Clive Elton Badman
Jeffrey David Haseler
Original Assignee
Beecham Group Plc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Beecham Group Plc filed Critical Beecham Group Plc
Publication of DK40488D0 publication Critical patent/DK40488D0/da
Publication of DK40488A publication Critical patent/DK40488A/da
Application granted granted Critical
Publication of DK175709B1 publication Critical patent/DK175709B1/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D503/00—Heterocyclic compounds containing 4-oxa-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. oxapenicillins, clavulanic acid derivatives; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)
DK198800404A 1987-01-29 1988-01-27 Fremgangsmåde til fremstilling af kalium-clavulanat DK175709B1 (da)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US878187A 1987-01-29 1987-01-29
US878187 1987-01-29
US7494487A 1987-07-17 1987-07-17
US7494487 1987-07-17

Publications (3)

Publication Number Publication Date
DK40488D0 DK40488D0 (da) 1988-01-27
DK40488A DK40488A (da) 1988-07-30
DK175709B1 true DK175709B1 (da) 2005-01-31

Family

ID=26678616

Family Applications (1)

Application Number Title Priority Date Filing Date
DK198800404A DK175709B1 (da) 1987-01-29 1988-01-27 Fremgangsmåde til fremstilling af kalium-clavulanat

Country Status (19)

Country Link
EP (1) EP0277008B1 (xx)
JP (2) JP2648321B2 (xx)
KR (1) KR960004535B1 (xx)
AT (1) AT399154B (xx)
AU (1) AU620538B2 (xx)
BE (1) BE1000734A3 (xx)
CA (1) CA1326486C (xx)
CH (1) CH677671A5 (xx)
DE (1) DE3853962T2 (xx)
DK (1) DK175709B1 (xx)
ES (2) ES2074048T3 (xx)
FR (1) FR2610196B1 (xx)
GB (1) GB2200355B (xx)
GR (1) GR1000035B (xx)
IE (1) IE880217L (xx)
IT (1) IT1227072B (xx)
LU (1) LU87123A1 (xx)
NZ (1) NZ223316A (xx)
PT (1) PT86631B (xx)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2435859A (en) * 1945-06-06 1948-02-10 John E Whitman Garment hanger
US2494711A (en) * 1946-06-28 1950-01-17 Kusher Hyman Garment hanger
US3474943A (en) * 1967-02-21 1969-10-28 Frank Mcbain Skirt hanger
SE7805391L (sv) * 1978-05-11 1979-11-12 Karner & Co Ab Kledhengare
AT400033B (de) 1992-03-10 1995-09-25 Biochemie Gmbh Neues verfahren zur isolierung und reinigung von clavulansäure und zur herstellung von pharmakologisch verträglichen salzen derselben
SE9401169L (sv) * 1994-04-08 1995-10-09 Corimed Gmbh Förfarande för framställning av ett antibekteriellt aktivt ämne samt användning därav
GB9426261D0 (en) 1994-12-24 1995-02-22 Spurcourt Ltd Clavulanic acid salts
GB9515809D0 (en) * 1995-08-02 1995-10-04 Smithkline Beecham Plc Process
AT403375B (de) * 1995-11-15 1998-01-26 Biochemie Gmbh Verfahren zur fällung von alkalisalzen der clavulansäure
US6414142B1 (en) 1996-06-13 2002-07-02 Smithkline Beecham Corporation Process for preparing potassium clavulanate
CN1209099C (zh) * 1999-04-01 2005-07-06 Dsm公司 结晶化附聚物
ATE273982T1 (de) 2000-05-13 2004-09-15 Smithkline Beecham Plc Verfahren zur reinigung eines salzes der clavulansäure
CA2528413A1 (en) * 2003-06-10 2004-12-23 Taisho Pharmaceutical Co., Ltd. Radial spherical crystallization product, process for producing the same and dry powder preparation containing the crystallization product
CN100384853C (zh) * 2004-05-10 2008-04-30 河北张药股份有限公司 替卡西林钠的合成方法
KR102459377B1 (ko) * 2022-03-18 2022-10-28 주식회사 에이치투뉴트리션 무알콜 단백질 맥주의 제조방법

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1508977A (en) * 1974-04-20 1978-04-26 Beecham Group Ltd Beta-lactam antibiotic from streptomyces clavuligerus
GB1504425A (en) * 1975-08-20 1978-03-22 Beecham Group Ltd Salts of clavulanic acid
GB2003863B (en) * 1977-09-01 1982-03-31 Beecham Group Ltd Chemical process
US4454069A (en) * 1979-08-24 1984-06-12 Beecham Group Limited Clavulanic acid salts and their preparation from the tertiary butyl amine salt
DE3063683D1 (en) * 1979-08-24 1983-07-14 Beecham Group Plc Amine salt of clavulanic acid, its preparation and use
DE3266580D1 (en) * 1981-12-02 1985-10-31 Beecham Group Plc Pharmaceutical formulation comprising beta-lactam antibiotics
FR2586561B1 (fr) * 1985-09-05 1988-05-20 Rhone Poulenc Sante Procede de preparation d'agglomerats spheriques de paracetamol et produits obtenus

Also Published As

Publication number Publication date
DE3853962D1 (de) 1995-07-20
KR890002166A (ko) 1989-04-08
PT86631A (pt) 1988-02-01
DK40488D0 (da) 1988-01-27
IT1227072B (it) 1991-03-14
GR1000035B (el) 1990-03-12
IT8847572A0 (it) 1988-06-27
ES2008418A6 (es) 1989-07-16
ATA16388A (de) 1994-08-15
FR2610196B1 (fr) 1991-06-28
IE880217L (en) 1988-07-29
JPH09169771A (ja) 1997-06-30
GB8801765D0 (en) 1988-02-24
ES2074048T3 (es) 1995-09-01
AU1092788A (en) 1988-08-04
AT399154B (de) 1995-03-27
PT86631B (pt) 1992-01-31
DE3853962T2 (de) 1996-02-08
DK40488A (da) 1988-07-30
GB2200355B (en) 1990-08-01
KR960004535B1 (ko) 1996-04-06
BE1000734A3 (fr) 1989-03-21
AU620538B2 (en) 1992-02-20
FR2610196A1 (fr) 1988-08-05
CA1326486C (en) 1994-01-25
CH677671A5 (xx) 1991-06-14
GB2200355A (en) 1988-08-03
JP2716966B2 (ja) 1998-02-18
GR880100031A (en) 1988-12-16
LU87123A1 (fr) 1988-05-03
JP2648321B2 (ja) 1997-08-27
JPS63270687A (ja) 1988-11-08
EP0277008A1 (en) 1988-08-03
EP0277008B1 (en) 1995-06-14
NZ223316A (en) 1989-10-27

Similar Documents

Publication Publication Date Title
DK175709B1 (da) Fremgangsmåde til fremstilling af kalium-clavulanat
US5463116A (en) Crystals of N- (trans-4-isopropylcyclohexlycarbonyl)-D-phenylalanine and methods for preparing them
CA2316841C (en) Crystallographically stable amorphous cephalosporin compositions and process for producing the same
US5288861A (en) Potassium clavulanate in rosette form
US5679789A (en) Pharmaceutical compositions comprising potassium clavulanate and methods of using them
Lee et al. Systematic evaluation and optimization of crystallization conditions for vancomycin purification
CN111233893A (zh) 舒巴坦钠的制备工艺
US5750685A (en) Process for preparing potassium clavulanate in rossette form
CN109748926A (zh) 一种头孢唑啉酸的纯化方法
AU712904B2 (en) Improved process for preparing potassium clavulanate
CN113105455B (zh) 晶型b阿维巴坦钠的制备方法
JP2003531147A (ja) 高結晶質セフォペラゾンナトリウムを調製するための方法
US4458070A (en) Process for the manufacture of crystalline sodium cefoperazone
US2871264A (en) Tetracycline extractions
US20020004595A1 (en) Process for preparing potassium clavulanate
US6984725B2 (en) Method for the separation of triglycoalkaloids
US2579455A (en) Crystallization of lysozyme from egg white
CN101647800B (zh) 一种头孢呋辛酸的组合物
CN106674217B (zh) 消旋山莨菪碱晶型及其制备方法
US3352859A (en) Process for improving crystal quality of a cephalosporin antibiotic
CN117980295A (zh) 一种依洛西巴特晶型ii及其制备方法
CN114159822A (zh) 一种药用级七水硫酸锌的制备方法
WO2011033470A1 (en) Crystalline form of montelukast sodium
CN110396101A (zh) 曲索芬头孢曲松钠药物制剂治疗细菌性内膜炎的新适应症
JPH04342590A (ja) エラグ酸の精製法

Legal Events

Date Code Title Description
PUP Patent expired