DK175266B1 - Fremgangsmåde til omdannelse af en human insulin-prækursor til humant insulin - Google Patents

Fremgangsmåde til omdannelse af en human insulin-prækursor til humant insulin Download PDF

Info

Publication number
DK175266B1
DK175266B1 DK198705284A DK528487A DK175266B1 DK 175266 B1 DK175266 B1 DK 175266B1 DK 198705284 A DK198705284 A DK 198705284A DK 528487 A DK528487 A DK 528487A DK 175266 B1 DK175266 B1 DK 175266B1
Authority
DK
Denmark
Prior art keywords
approx
human insulin
metal ion
ion
insulin precursor
Prior art date
Application number
DK198705284A
Other languages
Danish (da)
English (en)
Other versions
DK528487A (da
DK528487D0 (da
Inventor
Bruce Hill Frank
Richard Eugene Heiney
Walter Francis Prouty
Mark Robert Walden
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of DK528487D0 publication Critical patent/DK528487D0/da
Publication of DK528487A publication Critical patent/DK528487A/da
Application granted granted Critical
Publication of DK175266B1 publication Critical patent/DK175266B1/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/62—Insulins

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Endocrinology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Toxicology (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Diabetes (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DK198705284A 1986-10-14 1987-10-09 Fremgangsmåde til omdannelse af en human insulin-prækursor til humant insulin DK175266B1 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US91793986A 1986-10-14 1986-10-14
US91793986 1986-10-14

Publications (3)

Publication Number Publication Date
DK528487D0 DK528487D0 (da) 1987-10-09
DK528487A DK528487A (da) 1988-04-15
DK175266B1 true DK175266B1 (da) 2004-08-02

Family

ID=25439543

Family Applications (1)

Application Number Title Priority Date Filing Date
DK198705284A DK175266B1 (da) 1986-10-14 1987-10-09 Fremgangsmåde til omdannelse af en human insulin-prækursor til humant insulin

Country Status (26)

Country Link
US (1) US5457066A (ja)
EP (1) EP0264250B1 (ja)
JP (1) JP2634176B2 (ja)
KR (1) KR970003519B1 (ja)
CN (1) CN1029131C (ja)
AR (1) AR243608A1 (ja)
AT (1) ATE115962T1 (ja)
AU (1) AU595934B2 (ja)
CA (1) CA1339955C (ja)
CY (1) CY1830A (ja)
DE (1) DE3750897T2 (ja)
DK (1) DK175266B1 (ja)
EG (1) EG18520A (ja)
ES (1) ES2065321T3 (ja)
GR (1) GR3015143T3 (ja)
HK (1) HK39495A (ja)
HU (1) HU204572B (ja)
IE (1) IE65972B1 (ja)
IL (1) IL84110A (ja)
MX (1) MX168305B (ja)
NZ (1) NZ222082A (ja)
PH (1) PH26471A (ja)
PT (1) PT85892B (ja)
RU (1) RU1829939C (ja)
SG (1) SG14795G (ja)
ZA (1) ZA877505B (ja)

Families Citing this family (39)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5130236A (en) * 1989-12-07 1992-07-14 Eli Lilly And Company Process for producing des(64,65)-proinsulin
KR100188800B1 (ko) * 1990-09-05 1999-06-01 이센브룩, 라피세 프리프로인슐린을 인슐린으로 전환시키기 위한 효소적 방법
NZ245170A (en) * 1991-11-26 1994-07-26 Lilly Co Eli Insulin and proinsulin analogues with arg at b31, b32 and ao and pharmaceutical compositions
CA2102673A1 (en) * 1992-11-13 1994-05-14 Michael G. Greaney Expression vectors for bovine trypsin and trypsinogen and host cells transformed therewith
US6001604A (en) * 1993-12-29 1999-12-14 Bio-Technology General Corp. Refolding of proinsulins without addition of reducing agents
US6068993A (en) * 1997-07-02 2000-05-30 Biobras Sa Vector for expression of heterologous protein and methods for extracting recombinant protein and for purifying isolated recombinant insulin
US6087558A (en) * 1998-07-22 2000-07-11 Prodigene, Inc. Commercial production of proteases in plants
IL138990A0 (en) * 1999-02-12 2001-11-25 Biostream Inc Matrices for drug delivery and methods for making and using the same
US7169889B1 (en) * 1999-06-19 2007-01-30 Biocon Limited Insulin prodrugs hydrolyzable in vivo to yield peglylated insulin
US20020164712A1 (en) * 2000-12-11 2002-11-07 Tonghua Gantech Biotechnology Ltd. Chimeric protein containing an intramolecular chaperone-like sequence
KR20030005204A (ko) * 2000-12-25 2003-01-17 가부시키가이샤 시세이도 교감신경 활성화 향료 조성물
US7060675B2 (en) 2001-02-15 2006-06-13 Nobex Corporation Methods of treating diabetes mellitus
US6867183B2 (en) 2001-02-15 2005-03-15 Nobex Corporation Pharmaceutical compositions of insulin drug-oligomer conjugates and methods of treating diseases therewith
US7713932B2 (en) 2001-06-04 2010-05-11 Biocon Limited Calcitonin drug-oligomer conjugates, and uses thereof
US6835802B2 (en) * 2001-06-04 2004-12-28 Nobex Corporation Methods of synthesizing substantially monodispersed mixtures of polymers having polyethylene glycol moieties
US6828305B2 (en) 2001-06-04 2004-12-07 Nobex Corporation Mixtures of growth hormone drug-oligomer conjugates comprising polyalkylene glycol, uses thereof, and methods of making same
US6858580B2 (en) * 2001-06-04 2005-02-22 Nobex Corporation Mixtures of drug-oligomer conjugates comprising polyalkylene glycol, uses thereof, and methods of making same
US6828297B2 (en) 2001-06-04 2004-12-07 Nobex Corporation Mixtures of insulin drug-oligomer conjugates comprising polyalkylene glycol, uses thereof, and methods of making same
US6713452B2 (en) * 2001-06-04 2004-03-30 Nobex Corporation Mixtures of calcitonin drug-oligomer conjugates comprising polyalkylene glycol, uses thereof, and methods of making same
US7312192B2 (en) 2001-09-07 2007-12-25 Biocon Limited Insulin polypeptide-oligomer conjugates, proinsulin polypeptide-oligomer conjugates and methods of synthesizing same
US7196059B2 (en) 2001-09-07 2007-03-27 Biocon Limited Pharmaceutical compositions of insulin drug-oligomer conjugates and methods of treating diseases therewith
US6913903B2 (en) 2001-09-07 2005-07-05 Nobex Corporation Methods of synthesizing insulin polypeptide-oligomer conjugates, and proinsulin polypeptide-oligomer conjugates and methods of synthesizing same
US7166571B2 (en) 2001-09-07 2007-01-23 Biocon Limited Insulin polypeptide-oligomer conjugates, proinsulin polypeptide-oligomer conjugates and methods of synthesizing same
KR100925381B1 (ko) 2001-11-19 2009-11-09 노보 노르디스크 에이/에스 인슐린 화합물의 제조 방법
ATE487486T1 (de) * 2002-05-24 2010-11-15 Medtronic Inc Polypeptid-spaltungsprozess
CA2485698C (en) * 2002-05-24 2012-03-27 Jin Seog Seo Peptide amidation process
AU2003243316A1 (en) * 2002-05-24 2003-12-12 Nps Allelix Corp. Method for enzymatic production of glp-2(1-33) and glp-2-(1-34) peptides
AU2003236521A1 (en) * 2002-06-13 2003-12-31 Nobex Corporation Methods of reducing hypoglycemic episodes in the treatment of diabetes mellitus
DE10235168A1 (de) 2002-08-01 2004-02-12 Aventis Pharma Deutschland Gmbh Verfahren zur Reinigung von Preproinsulin
ES2380765T3 (es) * 2003-11-21 2012-05-18 Nps Pharmaceuticals, Inc. Producción del péptido 2 de tipo glucagón y análogos
DE602004025192D1 (de) * 2003-12-05 2010-03-11 Roche Diagnostics Gmbh Rekombinante Carboxypeptidase B und ihre Aufreinigung
UA91512C2 (ru) * 2004-07-19 2010-08-10 Биокон Лимитед Коньюгати олигомеров инсулина, их композиция (варианты) и применение
US9241908B2 (en) 2007-10-16 2016-01-26 Biocon Limited Orally administrable solid pharmaceutical composition and a process thereof
PL2307441T3 (pl) * 2008-08-07 2016-09-30 Sposób otrzymywania związków insuliny
WO2012104099A1 (en) * 2011-02-04 2012-08-09 Glucometrix Ag Process for the production of recombinant trypsin
WO2012115640A1 (en) 2011-02-23 2012-08-30 Elona Biotechnologies Liquid insulin- containing compositions and methods of making the same
JP2018531007A (ja) * 2015-09-24 2018-10-25 ハンミ ファーマシューティカル カンパニー リミテッド インスリンの製造方法
KR20200080747A (ko) * 2018-12-27 2020-07-07 주식회사 폴루스 인슐린 전구체의 인슐린 효소 전환용 조성물 및 이를 이용하여 인슐린 전구체를 인슐린으로 전환하는 방법
TW202409070A (zh) 2022-05-18 2024-03-01 美商普羅托莫科技公司 芳族含硼化合物及相關胰島素類似物

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5756878A (en) * 1980-09-22 1982-04-05 Sharp Corp Cleaning device
DK149824C (da) * 1982-01-22 1987-03-16 Carlsberg Biotechnology Ltd Fremgangsmaade til enzymatisk udskiftning af b-30 aminosyrer i insuliner

Also Published As

Publication number Publication date
JPS63105695A (ja) 1988-05-10
AU7952887A (en) 1988-04-21
IL84110A0 (en) 1988-03-31
GR3015143T3 (en) 1995-05-31
PT85892A (en) 1987-11-01
MX168305B (es) 1993-05-17
RU1829939C (ru) 1993-07-23
KR970003519B1 (ko) 1997-03-18
IL84110A (en) 1992-11-15
SG14795G (en) 1995-06-16
JP2634176B2 (ja) 1997-07-23
AR243608A1 (es) 1993-08-31
EP0264250A2 (en) 1988-04-20
ES2065321T3 (es) 1995-02-16
AU595934B2 (en) 1990-04-12
CN87107019A (zh) 1988-04-27
ATE115962T1 (de) 1995-01-15
HU204572B (en) 1992-01-28
DE3750897T2 (de) 1995-05-18
EP0264250B1 (en) 1994-12-21
CY1830A (en) 1995-12-01
DK528487A (da) 1988-04-15
DE3750897D1 (de) 1995-02-02
HUT46363A (en) 1988-10-28
EP0264250A3 (en) 1990-03-21
CA1339955C (en) 1998-07-14
PH26471A (en) 1992-07-27
ZA877505B (en) 1989-05-30
PT85892B (pt) 1990-07-31
IE872743L (en) 1988-04-14
CN1029131C (zh) 1995-06-28
KR880005262A (ko) 1988-06-28
NZ222082A (en) 1989-08-29
US5457066A (en) 1995-10-10
DK528487D0 (da) 1987-10-09
IE65972B1 (en) 1995-11-29
EG18520A (en) 1993-04-30
HK39495A (en) 1995-03-24

Similar Documents

Publication Publication Date Title
DK175266B1 (da) Fremgangsmåde til omdannelse af en human insulin-prækursor til humant insulin
US5698669A (en) Tri-arginine insulins
CA1162868A (en) Process for preparing insulin esters
PL191901B1 (pl) Sposób wytwarzania prekursorów insuliny i pochodnych insuliny
CA2464616C (en) Process for preparing insulin compounds
JPH02131594A (ja) デ‐ｂ３０‐インシュリンおよびデ‐ｂ３０‐インシュリン誘導体の製造方法
FI79853B (fi) Foerfarande foer framstaellning av insulinderivat.
EP0017938B1 (en) Process for preparing a b30-threonine insulin
Jering et al. Preparation and Characterization of the Active Derivative of Bovine Trypsin‐Kallikrein Inhibitor (Kunitz) with the Reactive Site Lysine‐15–Alanine‐16 Hydrolyzed
US4489159A (en) Process for preparing esters of human insulin
EP0037255B1 (en) Process for producing an insulin precursor
WO2000028067A1 (en) Enzymatic amidation of peptides
CA2050606C (en) Enzymatic process for the conversion of preproinsulins into insulins
EP0037256B1 (en) Process for producing an insulin
Gershagen et al. The genes for SHBG/ABP and the SHBG-like region of vitamin K-dependent protein S have evolved from a common ancestral gene
IL93115A (en) Process for the preparation of an insulin precursor
JPH05271283A (ja) インスリン同族体
Kumar et al. Improved pepsin inhibitor derived from activation peptide 1-16 of porcine pepsinogen
EP0557076A1 (en) Selective removal of N-terminal extensions from folded insulin precursors using dipeptidyl-aminopeptidase-1
CN1102409A (zh) 制备吲哚的方法
NO163531B (no) Beskyttet b30-thr(r1)(r2)-insulin egnet for fremstilling av et b30-threonininsulin.
ZA200102694B (en) Enzymatic amidation of peptides.
GB2149398A (en) N-benzyloxycarbonyl-l-aspartic acid

Legal Events

Date Code Title Description
PBP Patent lapsed

Country of ref document: DK