DK175103B1 - Hirudin-derivater, deres fremstilling og anvendelse - Google Patents

Hirudin-derivater, deres fremstilling og anvendelse Download PDF

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Publication number
DK175103B1
DK175103B1 DK198902707A DK270789A DK175103B1 DK 175103 B1 DK175103 B1 DK 175103B1 DK 198902707 A DK198902707 A DK 198902707A DK 270789 A DK270789 A DK 270789A DK 175103 B1 DK175103 B1 DK 175103B1
Authority
DK
Denmark
Prior art keywords
hirudin
lys
gly
carrier
glu
Prior art date
Application number
DK198902707A
Other languages
Danish (da)
English (en)
Other versions
DK270789A (da
DK270789D0 (da
Inventor
Rainer Obermeier
Paul Habermann
Klaus Sauber
Dominique Tripier
Peter Crause
Martin Kramer
Original Assignee
Aventis Pharma Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=6355879&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK175103(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Aventis Pharma Gmbh filed Critical Aventis Pharma Gmbh
Publication of DK270789D0 publication Critical patent/DK270789D0/da
Publication of DK270789A publication Critical patent/DK270789A/da
Application granted granted Critical
Publication of DK175103B1 publication Critical patent/DK175103B1/da

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K17/00—Carrier-bound or immobilised peptides; Preparation thereof
    • C07K17/02—Peptides being immobilised on, or in, an organic carrier
    • C07K17/10—Peptides being immobilised on, or in, an organic carrier the carrier being a carbohydrate
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/81—Protease inhibitors
    • C07K14/815—Protease inhibitors from leeches, e.g. hirudin, eglin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/61—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule the organic macromolecular compound being a polysaccharide or a derivative thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biophysics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Epidemiology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Hydrogenated Pyridines (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
DK198902707A 1988-06-04 1989-06-02 Hirudin-derivater, deres fremstilling og anvendelse DK175103B1 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE3819079 1988-06-04
DE3819079A DE3819079A1 (de) 1988-06-04 1988-06-04 Hirudin-derivate mit verzoegerter wirkung

Publications (3)

Publication Number Publication Date
DK270789D0 DK270789D0 (da) 1989-06-02
DK270789A DK270789A (da) 1989-12-05
DK175103B1 true DK175103B1 (da) 2004-06-01

Family

ID=6355879

Family Applications (1)

Application Number Title Priority Date Filing Date
DK198902707A DK175103B1 (da) 1988-06-04 1989-06-02 Hirudin-derivater, deres fremstilling og anvendelse

Country Status (21)

Country Link
US (1) US5538946A (ko)
EP (1) EP0345616B1 (ko)
JP (1) JP2804514B2 (ko)
KR (1) KR0140884B1 (ko)
AT (1) ATE130315T1 (ko)
AU (1) AU625215B2 (ko)
CA (1) CA1340197C (ko)
CY (1) CY2025A (ko)
DE (2) DE3819079A1 (ko)
DK (1) DK175103B1 (ko)
ES (1) ES2080732T3 (ko)
FI (1) FI98703C (ko)
GR (1) GR3018364T3 (ko)
HK (1) HK1006024A1 (ko)
HU (1) HU204851B (ko)
IE (1) IE72201B1 (ko)
IL (1) IL90507A0 (ko)
NO (1) NO177312C (ko)
NZ (1) NZ229402A (ko)
PT (1) PT90743B (ko)
ZA (1) ZA894180B (ko)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2000887A1 (en) * 1988-11-01 1990-05-01 Cecilia S.L. Ku Thromboresistant materials and methods for making same
EP0502962B1 (de) * 1989-12-01 1996-03-13 BASF Aktiengesellschaft Hirudin-Muteine und deren Polyalkylenglykolkonjugate
JP2975632B2 (ja) * 1990-03-30 1999-11-10 生化学工業株式会社 グリコサミノグリカン修飾プロテイン
GB2247239A (en) * 1990-08-22 1992-02-26 Ciba Geigy Ag Hirudin conjugates with polyoxyethylene
DE4041185A1 (de) * 1990-12-21 1992-06-25 Knoll Ag Verwendung von hirudin und dessen muteinen zur kombinationsbehandlung von tumoren
DE4437502A1 (de) * 1993-12-02 1995-06-08 Basf Ag Hirudin-Konjugate aus Hirudin und lipophilen Verbindungen
DE4342154A1 (de) * 1993-12-10 1995-06-14 Behringwerke Ag Amidinophenylalaninderivate, Verfahren zu deren Herstellung, deren Verwendung und diese enthaltende Mittel als Antikoagulantien
DE4404168A1 (de) * 1994-02-10 1995-08-17 Hoechst Ag Hirudinderivate und Verfahren zu deren Herstellung
DE19533817C2 (de) * 1995-09-13 1999-12-09 Max Planck Gesellschaft Komplex-gebundene Hemmstoffe aktivierbarer Stoffwechselenzyme als molekulare Marker zur Diagnostik und Therapieüberwachung
US6562781B1 (en) 1995-11-30 2003-05-13 Hamilton Civic Hospitals Research Development Inc. Glycosaminoglycan-antithrombin III/heparin cofactor II conjugates
US7045585B2 (en) 1995-11-30 2006-05-16 Hamilton Civic Hospital Research Development Inc. Methods of coating a device using anti-thrombin heparin
US6491965B1 (en) 1995-11-30 2002-12-10 Hamilton Civic Hospitals Research Development, Inc. Medical device comprising glycosaminoglycan-antithrombin III/heparin cofactor II conjugates
US5856452A (en) * 1996-12-16 1999-01-05 Sembiosys Genetics Inc. Oil bodies and associated proteins as affinity matrices
DE19915862A1 (de) * 1999-04-08 2000-10-12 Max Planck Gesellschaft Verwendung von molekulargewichtserweitertem Hirudin als Antikoagulans bei der extrakorporalen Nierenersatztherapie
US6809076B2 (en) * 2000-03-20 2004-10-26 Abbott Gmbh & Co. Kg Use of anticoagulant agents in the extracorporeal treatment of blood
US6818392B2 (en) 2000-12-06 2004-11-16 Abbott Laboratories Monoclonal antibodies to human immunodeficiency virus and uses thereof

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS55500091A (ko) * 1978-02-17 1980-02-14
DE2930542A1 (de) * 1979-07-27 1981-02-12 Hoechst Ag Neue insulinderivate und verfahren zu ihrer herstellung
CA1341414C (fr) * 1984-03-27 2002-12-31 Paul Tolstoshev Vecteurs d'expression de l'hirudine, cellules transformees et procede de preparation de l'hirudine
US4666884A (en) * 1984-04-10 1987-05-19 New England Deaconess Hospital Method of inhibiting binding of von Willebrand factor to human platelets and inducing interaction of platelets with vessel walls
DE3438296A1 (de) * 1984-04-18 1985-11-07 Hoechst Ag, 6230 Frankfurt Neue polypeptide mit blutgerinnungshemmender wirkung, verfahren zu deren herstellung bzw. gewinnung, deren verwendung und diese enthaltende mittel
EP0168342B1 (de) * 1984-06-14 1991-07-03 Ciba-Geigy Ag Verfahren zur Herstellung von Thrombin-Inhibitoren
DE3429430A1 (de) * 1984-08-10 1986-02-20 Hoechst Ag, 6230 Frankfurt Gentechnologisches verfahren zur herstellung von hirudin und mittel zur durchfuehrung dieses verfahrens
DE3500268A1 (de) * 1985-01-05 1986-07-10 Hoechst Ag, 6230 Frankfurt Praeparate mit verzoegerter wirkung, verfahren zu deren herstellung sowie entsprechende mittel zur human- bzw. veterinaermedizinischen anwendung
DE3506992A1 (de) * 1985-02-27 1986-08-28 Plantorgan Werk Heinrich G.E. Christensen, KG, 2903 Bad Zwischenahn Modifizierte hirudine, verfahren zu deren herstellung und pharmazeutische mittel, die diese wirkstoffe enthalten
FR2593518B1 (fr) * 1985-05-02 1989-09-08 Transgene Sa Vecteurs d'expression et de secretion de l'hirudine par les levures transformees
EP0209061B1 (de) * 1985-07-17 1994-01-12 Hoechst Aktiengesellschaft Neue Polypeptide mit blutgerinnungshemmender Wirkung, Verfahren zu deren Herstellung bzw. Gewinnung, deren Verwendung und diese enthaltende Mittel
DE3541856A1 (de) * 1985-11-27 1987-06-04 Hoechst Ag Eukaryotische fusionsproteine, ihre herstellung und verwendung sowie mittel zur durchfuehrung des verfahrens

Also Published As

Publication number Publication date
HU204851B (en) 1992-02-28
AU625215B2 (en) 1992-07-02
IE891815L (en) 1989-12-04
PT90743B (pt) 1994-10-31
HUT51298A (en) 1990-04-28
DE3819079A1 (de) 1989-12-07
DK270789A (da) 1989-12-05
DE58909493D1 (de) 1995-12-21
FI98703C (fi) 1997-08-11
EP0345616A3 (de) 1991-03-20
NO177312C (no) 1995-08-23
NO892267L (no) 1989-12-05
CA1340197C (en) 1998-12-15
GR3018364T3 (en) 1996-03-31
JP2804514B2 (ja) 1998-09-30
JPH0267300A (ja) 1990-03-07
AU3595589A (en) 1989-12-07
FI98703B (fi) 1997-04-30
HK1006024A1 (en) 1999-02-05
KR910001041A (ko) 1991-01-30
NZ229402A (en) 1992-05-26
EP0345616A2 (de) 1989-12-13
NO892267D0 (no) 1989-06-02
KR0140884B1 (ko) 1998-06-15
PT90743A (pt) 1989-12-29
US5538946A (en) 1996-07-23
ATE130315T1 (de) 1995-12-15
EP0345616B1 (de) 1995-11-15
FI892686A (fi) 1989-12-05
ZA894180B (en) 1990-02-28
ES2080732T3 (es) 1996-02-16
IL90507A0 (en) 1990-01-18
CY2025A (en) 1998-02-20
FI892686A0 (fi) 1989-06-01
NO177312B (no) 1995-05-15
IE72201B1 (en) 1997-04-09
DK270789D0 (da) 1989-06-02

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