DK174986B1 - Anvendelse af purinderivater til fremstilling af et lægemiddel - Google Patents

Anvendelse af purinderivater til fremstilling af et lægemiddel Download PDF

Info

Publication number
DK174986B1
DK174986B1 DK199002649A DK264990A DK174986B1 DK 174986 B1 DK174986 B1 DK 174986B1 DK 199002649 A DK199002649 A DK 199002649A DK 264990 A DK264990 A DK 264990A DK 174986 B1 DK174986 B1 DK 174986B1
Authority
DK
Denmark
Prior art keywords
hydroxy
amino
compounds
acid
alkyl
Prior art date
Application number
DK199002649A
Other languages
Danish (da)
English (en)
Other versions
DK264990D0 (da
DK264990A (da
Inventor
Bjoern Gunnar Lindborg
Roelf Datema
Karl Nils Gunnar Johansson
Bo Fredrik Oeberg
Original Assignee
Medivir Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Medivir Ab filed Critical Medivir Ab
Publication of DK264990D0 publication Critical patent/DK264990D0/da
Publication of DK264990A publication Critical patent/DK264990A/da
Application granted granted Critical
Publication of DK174986B1 publication Critical patent/DK174986B1/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A61P31/22—Antivirals for DNA viruses for herpes viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
    • C07F9/65616—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings containing the ring system having three or more than three double bonds between ring members or between ring members and non-ring members, e.g. purine or analogs
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6564—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms
    • C07F9/6571—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and oxygen atoms as the only ring hetero atoms
    • C07F9/657163—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and oxygen atoms as the only ring hetero atoms the ring phosphorus atom being bound to at least one carbon atom
    • C07F9/657181—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and oxygen atoms as the only ring hetero atoms the ring phosphorus atom being bound to at least one carbon atom the ring phosphorus atom and, at least, one ring oxygen atom being part of a (thio)phosphonic acid derivative

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Virology (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Communicable Diseases (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Oncology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)
DK199002649A 1988-05-06 1990-11-05 Anvendelse af purinderivater til fremstilling af et lægemiddel DK174986B1 (da)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
SE8801729 1988-05-06
SE8801729A SE8801729D0 (sv) 1988-05-06 1988-05-06 Purine derivatives for use in therapy
PCT/SE1989/000255 WO1989010923A1 (en) 1988-05-06 1989-05-05 Derivatives of purine, process for their preparation and a pharmaceutical preparation
SE8900255 1989-05-05

Publications (3)

Publication Number Publication Date
DK264990D0 DK264990D0 (da) 1990-11-05
DK264990A DK264990A (da) 1990-11-05
DK174986B1 true DK174986B1 (da) 2004-04-13

Family

ID=20372263

Family Applications (1)

Application Number Title Priority Date Filing Date
DK199002649A DK174986B1 (da) 1988-05-06 1990-11-05 Anvendelse af purinderivater til fremstilling af et lægemiddel

Country Status (18)

Country Link
EP (1) EP0343133B1 (cs)
JP (1) JP2866688B2 (cs)
KR (1) KR0141913B1 (cs)
AT (1) ATE74603T1 (cs)
CA (1) CA1340909C (cs)
DE (1) DE68901153D1 (cs)
DK (1) DK174986B1 (cs)
ES (1) ES2033548T3 (cs)
FI (1) FI98729C (cs)
GR (1) GR3004482T3 (cs)
HU (1) HU207082B (cs)
IE (1) IE62066B1 (cs)
IL (1) IL90166A (cs)
MY (1) MY108541A (cs)
NZ (1) NZ229002A (cs)
PT (1) PT90478B (cs)
SE (1) SE8801729D0 (cs)
WO (1) WO1989010923A1 (cs)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8904855D0 (en) * 1989-03-03 1989-04-12 Beecham Group Plc Pharmaceutical treatment
US5728575A (en) * 1990-02-01 1998-03-17 Emory University Method of resolution of 1,3-oxathiolane nucleoside enantiomers
HU9300132D0 (en) * 1990-07-19 1993-04-28 Beecham Group Plc Method for producing phosphono-alkene-purine derivatives and medical preparatives of anti-viral effect containing them
GB9020932D0 (en) * 1990-09-26 1990-11-07 Wellcome Found Heterocyclic compounds
US5208221A (en) * 1990-11-29 1993-05-04 Bristol-Myers Squibb Company Antiviral (phosphonomethoxy) methoxy purine/pyrimidine derivatives
US5360714A (en) * 1992-08-28 1994-11-01 Fox Chase Cancer Center Hepadnavirus polymerase gene product having RNA-dependent DNA priming and reverse transcriptase activities and methods of measuring the activities thereof
US5334525A (en) * 1992-08-28 1994-08-02 Fox Chase Cancer Center Hepadnavirus polymerase gene product having RNA-dependent DNA priming and reverse transcriptase activities and methods of measuring the activities thereof
AU690587B2 (en) * 1993-09-17 1998-04-30 Gilead Sciences, Inc. Method for dosing therapeutic compounds
US5798340A (en) 1993-09-17 1998-08-25 Gilead Sciences, Inc. Nucleotide analogs
US5656745A (en) * 1993-09-17 1997-08-12 Gilead Sciences, Inc. Nucleotide analogs
DE19540798A1 (de) * 1995-11-02 1997-05-07 Hoechst Ag Alkylxanthinphosphonate und Alkylxanthinphosphinoxide und deren Verwendung als Arzneimittel
US20030040467A1 (en) 1998-06-15 2003-02-27 Mary Ann Pelleymounter Ig/ob fusions and uses thereof.
BR9612317A (pt) * 1995-12-29 2000-10-31 Gilead Sciences Inc Análogos nucleotìdeos.
US5717095A (en) * 1995-12-29 1998-02-10 Gilead Sciences, Inc. Nucleotide analogs
US6703394B2 (en) 1996-02-16 2004-03-09 Medivir Ab Acyclic nucleoside derivatives
US5869493A (en) * 1996-02-16 1999-02-09 Medivir Ab Acyclic nucleoside derivatives
US6184376B1 (en) 1997-02-10 2001-02-06 Mediver Ab Synthesis of acyclic nucleoside derivatives
JP2009298785A (ja) * 1997-02-10 2009-12-24 Medivir Ab 非環状ヌクレオシド誘導体の合成
JP4425352B2 (ja) * 1997-02-10 2010-03-03 メディヴィル・アクチボラグ 非環状ヌクレオシド誘導体の合成
US6753322B2 (en) 2000-06-06 2004-06-22 Pfizer Inc 2-aminocarbonyl-9H-purine derivatives
EP1440072A4 (en) 2001-10-30 2005-02-02 Conforma Therapeutic Corp PURINE ANALOGS HAVING HSP90 INHIBITORY ACTIVITY
TWI332507B (en) 2002-11-19 2010-11-01 Hoffmann La Roche Antiviral nucleoside derivatives
EP2145888A1 (en) 2003-09-18 2010-01-20 Conforma Therapeutics Corporation Deazapurine derivatives as HSP90-Inhibitors
CA2602257A1 (en) 2005-03-30 2006-10-05 Conforma Therapeutics Corporation Alkynyl pyrrolopyrimidines and related analogs as hsp90-inhibitors
AU2009276343A1 (en) 2008-08-01 2010-02-04 Bioxiness Pharmaceuticals, Inc. Methionine analogs and methods of using same
CN102250126A (zh) * 2010-05-18 2011-11-23 北京化工大学 一种双嘌呤类衍生物及其合成

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3376326D1 (en) * 1982-10-14 1988-05-26 Wellcome Found Antiviral purine derivatives
CS233665B1 (en) * 1983-01-06 1985-03-14 Antonin Holy Processing of isomere o-phosphonylmethylderivative of anantiomere racemic vicinal diene
IL73682A (en) * 1983-12-20 1991-08-16 Medivir Ab Antiviral pharmaceutical compositions containing 9-hydroxy aliphatic derivatives of guanine,some new such derivatives and process for their preparation
SE8406538D0 (sv) * 1984-12-21 1984-12-21 Astra Laekemedel Ab Novel derivatives of purine
MY101126A (en) * 1985-12-13 1991-07-31 Beecham Group Plc Novel compounds

Also Published As

Publication number Publication date
NZ229002A (en) 1997-05-26
FI98729B (fi) 1997-04-30
HU207082B (en) 1993-03-01
FI98729C (fi) 1997-08-11
WO1989010923A1 (en) 1989-11-16
HU893004D0 (en) 1991-09-30
KR0141913B1 (en) 1998-06-01
IL90166A0 (en) 1989-12-15
IL90166A (en) 1996-09-12
EP0343133A1 (en) 1989-11-23
JP2866688B2 (ja) 1999-03-08
DK264990D0 (da) 1990-11-05
AU626300B2 (en) 1992-07-30
GR3004482T3 (cs) 1993-03-31
HUT57767A (en) 1991-12-30
MY108541A (en) 1996-10-31
PT90478B (pt) 1994-08-31
IE891472L (en) 1989-11-06
ATE74603T1 (de) 1992-04-15
IE62066B1 (en) 1994-12-14
DE68901153D1 (de) 1992-05-14
AU3572689A (en) 1989-11-29
JPH03504243A (ja) 1991-09-19
CA1340909C (en) 2000-02-22
DK264990A (da) 1990-11-05
ES2033548T3 (es) 1993-03-16
FI905475A0 (fi) 1990-11-05
PT90478A (pt) 1989-11-30
SE8801729D0 (sv) 1988-05-06
EP0343133B1 (en) 1992-04-08

Similar Documents

Publication Publication Date Title
DK174986B1 (da) Anvendelse af purinderivater til fremstilling af et lægemiddel
JP7416365B2 (ja) アポトーシス誘発剤
US5055458A (en) Purine derivatives having antiviral activity
BG61493B2 (bg) Пуринови производни и фармацевтичната им употреба
JP2015164934A (ja) ヌクレオチドアナログ
CN106167504A (zh) 非环核苷磷酰胺d‑氨基酸酯衍生物及其盐的制备以及在抗病毒方面的应用
EP0915894B1 (en) Nucleotide analogs
CA2062299C (en) Cyclopropane derivatives
US5284837A (en) Derivatives of purine, process for their preparation and a pharmaceutical preparation
DK166823B1 (da) Purinforbindelser, fremgangsmaade til fremstilling heraf, samt anvendelse af forbindelserne som farmaceutika
AU3760793A (en) Antiviral phosphonic acid derivatives of purine analogues
EP0319228B1 (en) Novel compounds
HUT54697A (en) Process for producing sulfur- and phosphorus-containing purine derivatives and pharmaceutical compositions comprising same as active ingredient
AU626300C (en) Derivatives of purine, process for their preparation and a pharmaceutical preparation
JP3580377B2 (ja) ホスホナートヌクレオチドエステル誘導体
WO2012006680A1 (en) 7, 9-nitrogen radical-4-oxo-4h-pyrido[l,2-a]pyrimidine-2-carboxylic acid benzylamide anti-virals
NO177306B (no) Analogifremgangsmåte for fremstilling av terapautisk aktive purinderivater
EP0394346A1 (en) Pyrimidine and purine 1,2-butadiene-4-ols as anti-retroviral agents
US5252575A (en) Antiviral purine derivatives with improved gastrointestinal absorption
JPH04297463A (ja) 新規なシクロブタン誘導体
JPH06206880A (ja) 新規シクロペンテン誘導体

Legal Events

Date Code Title Description
PBP Patent lapsed

Country of ref document: DK