DK174543B1 - Fremgangsmåde til fremstilling af 2-[2-[4-[[(4-chlorphenyl)phenylmethyl)]-1-piperazinyl]ethoxy]eddikesyre og dens dihydrochlorid og udgangsforbindelse til anvendelse ved fremgangsmåden - Google Patents

Fremgangsmåde til fremstilling af 2-[2-[4-[[(4-chlorphenyl)phenylmethyl)]-1-piperazinyl]ethoxy]eddikesyre og dens dihydrochlorid og udgangsforbindelse til anvendelse ved fremgangsmåden Download PDF

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Publication number
DK174543B1
DK174543B1 DK198905867A DK586789A DK174543B1 DK 174543 B1 DK174543 B1 DK 174543B1 DK 198905867 A DK198905867 A DK 198905867A DK 586789 A DK586789 A DK 586789A DK 174543 B1 DK174543 B1 DK 174543B1
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Prior art keywords
phenylmethyl
chlorophenyl
piperazinyl
ethoxy
dihydrochloride
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Application number
DK198905867A
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Danish (da)
English (en)
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DK586789A (da
DK586789D0 (da
Inventor
Jean Gobert
Guy Bodson
Eric Cossement
Genevieve Motte
Original Assignee
Ucb Sa
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Publication of DK586789D0 publication Critical patent/DK586789D0/da
Publication of DK586789A publication Critical patent/DK586789A/da
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Publication of DK174543B1 publication Critical patent/DK174543B1/da

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/088—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
DK198905867A 1988-11-23 1989-11-22 Fremgangsmåde til fremstilling af 2-[2-[4-[[(4-chlorphenyl)phenylmethyl)]-1-piperazinyl]ethoxy]eddikesyre og dens dihydrochlorid og udgangsforbindelse til anvendelse ved fremgangsmåden DK174543B1 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB8827391 1988-11-23
GB888827391A GB8827391D0 (en) 1988-11-23 1988-11-23 Process for preparation of 2-(2-(4-((4-chlorophenyl)phenylmethyl)-1-pipera-zinyl)ethoxy)-acetic acid & its dihydrochloride

Publications (3)

Publication Number Publication Date
DK586789D0 DK586789D0 (da) 1989-11-22
DK586789A DK586789A (da) 1990-05-24
DK174543B1 true DK174543B1 (da) 2003-05-19

Family

ID=10647347

Family Applications (1)

Application Number Title Priority Date Filing Date
DK198905867A DK174543B1 (da) 1988-11-23 1989-11-22 Fremgangsmåde til fremstilling af 2-[2-[4-[[(4-chlorphenyl)phenylmethyl)]-1-piperazinyl]ethoxy]eddikesyre og dens dihydrochlorid og udgangsforbindelse til anvendelse ved fremgangsmåden

Country Status (16)

Country Link
KR (1) KR970009728B1 (hu)
AT (1) AT398971B (hu)
CA (1) CA1317300C (hu)
CY (1) CY1671A (hu)
DK (1) DK174543B1 (hu)
ES (1) ES2021907A6 (hu)
FI (1) FI91862C (hu)
GB (2) GB8827391D0 (hu)
GR (1) GR1000553B (hu)
HK (1) HK95892A (hu)
HU (1) HU205094B (hu)
NO (1) NO172342C (hu)
PH (1) PH25982A (hu)
PL (1) PL161379B1 (hu)
PT (1) PT92364B (hu)
SG (1) SG89492G (hu)

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AU703690B2 (en) * 1992-09-24 1999-04-01 Sepracor, Inc. Methods for treating allergic disorders using optically pure (+)cetirizine
EP0885611A3 (en) * 1992-09-24 1999-01-07 Sepracor, Inc. Methods and compositions for treating allergic disorders using optically pure (+) cetirizine
EP0950412A3 (en) * 1992-09-24 2001-05-16 Sepracor, Inc. Compositions for treating allergic disorders using (-) cetirizine
GB9305282D0 (en) * 1993-03-15 1993-05-05 Ucb Sa Enantiomers of 1-(4-chlorophenyl)phenylmethyl)-4-(4-methylphenyl)sulphonyl)piperazine
US6469009B1 (en) 1996-04-08 2002-10-22 Ucb, S.A. Pharmaceutical compositions for the treatment of rhinitis
BE1010094A3 (fr) * 1996-04-10 1997-12-02 Ucb Sa Nouveaux [2-(1-piperazinyl)ethoxy] methyle substitues.
BE1010095A3 (fr) * 1996-04-10 1997-12-02 Ucb Sa Procede de preparation de l'acide 2-[2-[4-[(4-chlorophenyl)phenylmethyl]-1-piperazinyl] ethoxy]-acetique et de ses sels.
EP1020443B1 (en) 1997-06-04 2003-09-10 Azwell Inc. Process for producing piperazinesulfonamide derivatives and salts thereof
EP0919550A1 (en) * 1997-11-26 1999-06-02 Ucb, S.A. Pseudopolymorphic forms of 2-2-4-bis(4-fluorophenyl)methyl-1-piperazinyl-ethoxy acetic acid dihydrochloride
IL124195A (en) * 1998-04-23 2000-08-31 Chemagis Ltd Process for the preparation of esters of 2-¬4-¬4-chlorophenyl¾phenylmethyl¾-1-piperazinyl¬ethoxy¾acetic acid
GR990100135A (el) * 1999-04-22 2000-12-29 Genepharm �.�. Μεθοδος παρασκευης του 2-(2-[4-[4-χλωροφαινυλο)(φαινυλο)μεθυλο]πιπεραζινο]αιθοξυ) οξικου οξεος και του διυδροχλωρικου αλατος αυτου
JP2002249487A (ja) 2001-02-22 2002-09-06 Sumitomo Chem Co Ltd ４−（ｔｅｒｔ−ブトキシカルボニル）ピペラジン誘導体、その光学活性な酸付加塩、それらの製造法、およびそれらを用いる光学活性な１−［（置換フェニル）フェニルメチル］ピペラジンの製造法。
US6977301B1 (en) 2001-05-29 2005-12-20 Ucb, S.A. Process for preparing (S) and (R)—2-[4-(4-chlorobenzhydryl)piperazin-1-yl]-ethoxyacetamide
US7199241B1 (en) 2001-05-29 2007-04-03 Ucb, S.A. Process for preparing (S) and (R)-2-[4-(4-chlorobenzhydryl)piperazin-1-yl]-ethoxyacetamide
AU2004205494B2 (en) 2003-01-23 2009-04-30 Ucb Farchim Sa Piperazine derivatives and their use as synthesis intermediates
KR100503443B1 (ko) 2004-02-02 2005-07-22 한림제약(주) 광학적으로 활성인 세티리진 또는 그의 염의 제조방법
ES2326689T3 (es) * 2005-03-03 2009-10-16 Ucb Farchim, S.A. Sales de piroglutamato y su uso en la resolucion optica de intermedios para la sintesis de dextrocetirizana y levocetirizana.
HU227325B1 (en) * 2005-12-08 2011-03-28 Egis Gyogyszergyar Nyrt Process for the production of an intermediate of (dextro- and levo)- cetirizine
US8049011B2 (en) 2007-03-12 2011-11-01 Krka, Tovarna Zdravil, D.D., Novo Mesto Process for the preparation of levocetirizine and intermediates thereof
SI22489A (sl) * 2007-03-12 2008-10-31 Krka, Tovarna Zdravil, D.D., Novo Mesto Nov postopek za pripravo levocetirizina in njegovih intermediatov
EP2167479B1 (en) 2007-06-15 2013-09-11 Symed Labs Limited Process for preparation of substantially optically pure levorotatory and dextrorotatory enantiomers of cetirizine using novel intermediates
WO2009062036A2 (en) * 2007-11-09 2009-05-14 Dr. Reddy's Laboratories Ltd. Processes for preparing levocetirizine and pharmaceutically acceptable salts thereof
PL2062881T3 (pl) 2007-11-21 2011-07-29 Synthon Bv Sposób wytwarzania N-(difenylometylo)piperazyn
US7989623B2 (en) 2007-11-21 2011-08-02 Synthon Bv Process for making n-(diphenylmethyl)piperazines
AU2009254959B2 (en) 2008-06-02 2014-01-30 Cipla Limited Processes for the synthesis of levocetirizine and intermediates for use therein
EP2297122B1 (en) * 2008-06-11 2014-05-21 KRKA, tovarna zdravil, d.d., Novo mesto New process for the preparation of levocetirizine and intermediates thereof
KR100998067B1 (ko) 2008-09-08 2010-12-03 주식회사 삼오제약 비스(1-[(4-클로로페닐)페닐메틸]피페라진)-2,3-디벤조일 타르타르산 신규 중간체 염 및 이를 이용한 광학 활성적으로 순수한 1-[(4-클로로페닐)페닐메틸]피페라진을 분리하는 분리방법
WO2010046908A2 (en) 2008-09-17 2010-04-29 Calyx Chemicals And Pharmaceuticals Pvt. Ltd. Novel water based process for the preparation of substituted diphenylmethyl piperazines
WO2010107404A1 (en) 2009-03-16 2010-09-23 Mahmut Bilgic Stable pharmaceutical combinations
TR201007652A2 (tr) 2010-09-20 2012-04-24 Bi̇lgi̇ç Mahmut Sinerjik etki.
TR201009398A2 (tr) 2010-11-11 2012-05-21 Bi̇lgi̇ç Mahmut Fiziksel özellikleri geliştirilmiş tablet formülasyonları
WO2012101475A1 (en) 2011-01-27 2012-08-02 Jubilant Life Sciences Limited An improved process for the preparation of antihistaminic drugs via a novel carbamate intermediate
CN103044355A (zh) * 2011-10-13 2013-04-17 湖南九典制药有限公司 合成左西替利嗪的关键中间体及其制备方法
KR101418404B1 (ko) 2012-01-06 2014-07-10 한미약품 주식회사 레보세티리진 또는 이의 약학적으로 허용가능한 염 및 몬테루카스트 또는 이의 약학적으로 허용가능한 염을 함유하는 안정한 경구투여용 약학 제제
KR102226833B1 (ko) 2013-06-28 2021-03-12 한미약품 주식회사 레보세티리진 및 몬테루카스트를 포함하는 안정성이 개선된 복합 과립 제형
CN104045607B (zh) * 2014-05-21 2016-04-13 丽珠医药集团股份有限公司 一种盐酸西替利嗪的纯化方法
CN105924409B (zh) * 2016-05-12 2019-01-08 浙江永宁药业股份有限公司 一种(r)-1-((2-氯苯基)-(苯基)-甲基)-哌嗪的拆分方法
CN111205247B (zh) * 2020-04-22 2020-08-14 湖南九典宏阳制药有限公司 左旋西替利嗪的制备方法

Family Cites Families (1)

* Cited by examiner, † Cited by third party
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FI75816C (fi) * 1981-02-06 1988-08-08 Ucb Sa Foerfarande foer framstaellning av terapeutiskt aktiv 2-/4-(difenylmetyl)-1-piperazinyl/-aettiksyror eller dess amid.

Also Published As

Publication number Publication date
KR900007825A (ko) 1990-06-02
GR890100770A (en) 1990-12-31
NO894651D0 (no) 1989-11-22
FI895564A0 (fi) 1989-11-22
GR1000553B (el) 1992-08-26
FI91862B (fi) 1994-05-13
HK95892A (en) 1992-12-11
HU205094B (en) 1992-03-30
HUT53627A (en) 1990-11-28
SG89492G (en) 1992-12-04
GB2225321B (en) 1992-04-08
CA1317300C (en) 1993-05-04
GB8827391D0 (en) 1988-12-29
KR970009728B1 (ko) 1997-06-17
NO172342B (no) 1993-03-29
CY1671A (en) 1993-05-14
ATA266589A (de) 1994-07-15
PL161379B1 (pl) 1993-06-30
DK586789A (da) 1990-05-24
AT398971B (de) 1995-02-27
ES2021907A6 (es) 1991-11-16
DK586789D0 (da) 1989-11-22
PT92364A (pt) 1990-05-31
GB2225321A (en) 1990-05-30
PH25982A (en) 1992-01-13
FI91862C (fi) 1994-08-25
PT92364B (pt) 1995-07-18
HU896131D0 (en) 1990-02-28
NO172342C (no) 1993-07-07
GB8926243D0 (en) 1990-01-10
NO894651L (no) 1990-05-25

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