GB8926243D0 - A process for the preparation of 2-(2-(4-((4-chlorophenyl)phenylmethyl)-piperazinyl)ethoxy)-acetic acid and its dihydrochloride - Google Patents
A process for the preparation of 2-(2-(4-((4-chlorophenyl)phenylmethyl)-piperazinyl)ethoxy)-acetic acid and its dihydrochlorideInfo
- Publication number
- GB8926243D0 GB8926243D0 GB898926243A GB8926243A GB8926243D0 GB 8926243 D0 GB8926243 D0 GB 8926243D0 GB 898926243 A GB898926243 A GB 898926243A GB 8926243 A GB8926243 A GB 8926243A GB 8926243 D0 GB8926243 D0 GB 8926243D0
- Authority
- GB
- United Kingdom
- Prior art keywords
- phenylmethyl
- dihydrochloride
- piperazinyl
- chlorophenyl
- ethoxy
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
- C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
- C07D295/088—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB888827391A GB8827391D0 (en) | 1988-11-23 | 1988-11-23 | Process for preparation of 2-(2-(4-((4-chlorophenyl)phenylmethyl)-1-pipera-zinyl)ethoxy)-acetic acid & its dihydrochloride |
Publications (3)
Publication Number | Publication Date |
---|---|
GB8926243D0 true GB8926243D0 (en) | 1990-01-10 |
GB2225321A GB2225321A (en) | 1990-05-30 |
GB2225321B GB2225321B (en) | 1992-04-08 |
Family
ID=10647347
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GB888827391A Pending GB8827391D0 (en) | 1988-11-23 | 1988-11-23 | Process for preparation of 2-(2-(4-((4-chlorophenyl)phenylmethyl)-1-pipera-zinyl)ethoxy)-acetic acid & its dihydrochloride |
GB8926243A Expired - Lifetime GB2225321B (en) | 1988-11-23 | 1989-11-21 | A process for the preparation of 2-(2-(4-((4-chlorophenyl)phenylmethyl)-1-piperazinyl)ethoxy)-acetic acid and its dihydrochloride |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GB888827391A Pending GB8827391D0 (en) | 1988-11-23 | 1988-11-23 | Process for preparation of 2-(2-(4-((4-chlorophenyl)phenylmethyl)-1-pipera-zinyl)ethoxy)-acetic acid & its dihydrochloride |
Country Status (16)
Country | Link |
---|---|
KR (1) | KR970009728B1 (en) |
AT (1) | AT398971B (en) |
CA (1) | CA1317300C (en) |
CY (1) | CY1671A (en) |
DK (1) | DK174543B1 (en) |
ES (1) | ES2021907A6 (en) |
FI (1) | FI91862C (en) |
GB (2) | GB8827391D0 (en) |
GR (1) | GR1000553B (en) |
HK (1) | HK95892A (en) |
HU (1) | HU205094B (en) |
NO (1) | NO172342C (en) |
PH (1) | PH25982A (en) |
PL (1) | PL161379B1 (en) |
PT (1) | PT92364B (en) |
SG (1) | SG89492G (en) |
Families Citing this family (38)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU703690B2 (en) * | 1992-09-24 | 1999-04-01 | Sepracor, Inc. | Methods for treating allergic disorders using optically pure (+)cetirizine |
CA2145413A1 (en) * | 1992-09-24 | 1994-03-31 | Nancy M. Gray | Methods and compositions for treating allergic disorders using optically pure (+) cetirizine |
ATE170749T1 (en) * | 1992-09-24 | 1998-09-15 | Sepracor Inc | USE OF (-)CETIRIZINE FOR THE TREATMENT OF ALLERGIC RHINITIS AND AND ASTHMA |
GB9305282D0 (en) * | 1993-03-15 | 1993-05-05 | Ucb Sa | Enantiomers of 1-(4-chlorophenyl)phenylmethyl)-4-(4-methylphenyl)sulphonyl)piperazine |
US6469009B1 (en) | 1996-04-08 | 2002-10-22 | Ucb, S.A. | Pharmaceutical compositions for the treatment of rhinitis |
BE1010094A3 (en) * | 1996-04-10 | 1997-12-02 | Ucb Sa | NEW [2- (1-piperazinyl) ethoxy] SUBSTITUTED. |
BE1010095A3 (en) * | 1996-04-10 | 1997-12-02 | Ucb Sa | METHOD OF PREPARATION OF ACID 2- [2- [4 - [(4-Chlorophenyl) phenylmethyl] -1-PIPERAZINYL] ETHOXY] acetic acid AND ITS SALTS. |
WO1998055459A1 (en) | 1997-06-04 | 1998-12-10 | Azwell Inc. | Process for producing piperazinesulfonamide derivatives and salts thereof |
EP0919550A1 (en) * | 1997-11-26 | 1999-06-02 | Ucb, S.A. | Pseudopolymorphic forms of 2-2-4-bis(4-fluorophenyl)methyl-1-piperazinyl-ethoxy acetic acid dihydrochloride |
IL124195A (en) * | 1998-04-23 | 2000-08-31 | Chemagis Ltd | Process for the preparation of esters of 2-¬4-¬4-chlorophenyl¾phenylmethyl¾-1-piperazinyl¬ethoxy¾acetic acid |
GR990100135A (en) * | 1999-04-22 | 2000-12-29 | Genepharm �.�. | Method of preparation 2-(2-{4-[(4-chlorophenyl)(phenyl)methhyl]piperasine}-ethoxy)acetic acid and its bihydrochloric salt |
JP2002249487A (en) * | 2001-02-22 | 2002-09-06 | Sumitomo Chem Co Ltd | 4-(tert-butoxycarbonyl)piperazine derivative, optically active acid addition salt of the same, method for producing them and optically active 1-[(substituted phenyl)phenylmethylpiperazine which uses them |
US7199241B1 (en) | 2001-05-29 | 2007-04-03 | Ucb, S.A. | Process for preparing (S) and (R)-2-[4-(4-chlorobenzhydryl)piperazin-1-yl]-ethoxyacetamide |
US6977301B1 (en) | 2001-05-29 | 2005-12-20 | Ucb, S.A. | Process for preparing (S) and (R)—2-[4-(4-chlorobenzhydryl)piperazin-1-yl]-ethoxyacetamide |
US7381821B2 (en) | 2003-01-23 | 2008-06-03 | Ucb, S.A. | Piperazine derivatives and their use as synthesis intermediates |
KR100503443B1 (en) | 2004-02-02 | 2005-07-22 | 한림제약(주) | Processes for preparing an optically active cetirizine or its salt |
ATE433444T1 (en) * | 2005-03-03 | 2009-06-15 | Ucb Farchim Sa | PYROGLUTAMAT SALTS AND THEIR USE IN THE OPTICAL SEPARATION OF INTERMEDIATE PRODUCTS FOR THE SYNTHESIS OF DEXTROCETIRIZINE AND LEVOCETIRIZINE |
HU227325B1 (en) * | 2005-12-08 | 2011-03-28 | Egis Gyogyszergyar Nyrt | Process for the production of an intermediate of (dextro- and levo)- cetirizine |
SI22489A (en) * | 2007-03-12 | 2008-10-31 | Krka, Tovarna Zdravil, D.D., Novo Mesto | New procedure for preparation of levocetirizine and its intermediates |
WO2008110586A2 (en) | 2007-03-12 | 2008-09-18 | Krka, Tovarna Zdravil, D.D., Novo Mesto | New process for the preparation of levocetirizine and intermediates thereof |
WO2008152650A1 (en) | 2007-06-15 | 2008-12-18 | Symed Labs Limited | Process for preparation of substantially optically pure levorotatory and dextrorotatory enantiomers of cetirizine using novel intermediates |
WO2009062036A2 (en) * | 2007-11-09 | 2009-05-14 | Dr. Reddy's Laboratories Ltd. | Processes for preparing levocetirizine and pharmaceutically acceptable salts thereof |
EP2062881B1 (en) | 2007-11-21 | 2011-02-23 | Synthon B.V. | Process for making N-(diphenylmethyl)piperazines |
US7989623B2 (en) | 2007-11-21 | 2011-08-02 | Synthon Bv | Process for making n-(diphenylmethyl)piperazines |
EP2307392A2 (en) | 2008-06-02 | 2011-04-13 | Cipla Limited | Processes for the synthesis of levocetirizine and intermediates for use therein |
EP2297122B1 (en) * | 2008-06-11 | 2014-05-21 | KRKA, tovarna zdravil, d.d., Novo mesto | New process for the preparation of levocetirizine and intermediates thereof |
KR100998067B1 (en) | 2008-09-08 | 2010-12-03 | 주식회사 삼오제약 | A novel Bis1-[4-chlorophenylphenylmethyl]piperazine-2,3-Dibenzoyl tartarate intermediate salt and the method for isolating optically active 1-[4-chlorophenylphenylmethyl]piperazine using thereby |
WO2010046908A2 (en) | 2008-09-17 | 2010-04-29 | Calyx Chemicals And Pharmaceuticals Pvt. Ltd. | Novel water based process for the preparation of substituted diphenylmethyl piperazines |
WO2010107404A1 (en) | 2009-03-16 | 2010-09-23 | Mahmut Bilgic | Stable pharmaceutical combinations |
TR201007652A2 (en) | 2010-09-20 | 2012-04-24 | Bi̇lgi̇ç Mahmut | Synergistic effect. |
TR201009398A2 (en) | 2010-11-11 | 2012-05-21 | Bi̇lgi̇ç Mahmut | Tablet formulations with improved physical properties |
WO2012101475A1 (en) | 2011-01-27 | 2012-08-02 | Jubilant Life Sciences Limited | An improved process for the preparation of antihistaminic drugs via a novel carbamate intermediate |
CN103044355A (en) * | 2011-10-13 | 2013-04-17 | 湖南九典制药有限公司 | Key intermediate for synthesizing levocetirizine and preparation method thereof |
KR101418404B1 (en) | 2012-01-06 | 2014-07-10 | 한미약품 주식회사 | Stable pharmaceutical formulation for oral administration comprising levocetirizine or a pharmaceutically acceptable salt thereof, and montelukast or a pharmaceutically acceptable salt thereof |
KR102226833B1 (en) | 2013-06-28 | 2021-03-12 | 한미약품 주식회사 | Complex granule formulation having improved stability comprising levocetirizine and montelukast |
CN104045607B (en) * | 2014-05-21 | 2016-04-13 | 丽珠医药集团股份有限公司 | A kind of purification process of cetrizine hcl |
CN105924409B (en) * | 2016-05-12 | 2019-01-08 | 浙江永宁药业股份有限公司 | The method for splitting of one kind (R) -1- ((2- chlorphenyl)-(phenyl)-methyl)-piperazine |
CN111205247B (en) * | 2020-04-22 | 2020-08-14 | 湖南九典宏阳制药有限公司 | Preparation method of levocetirizine |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DK154078C (en) * | 1981-02-06 | 1989-05-22 | Ucb Sa | METHOD OF ANALOGUE FOR THE PREPARATION OF 2- (2- (4- (DIPHENYL-METHYL) -1-PIPERAZINYL) ETHOXY) -ACETAMIDES OR ACID ADDITION SALTS. |
-
1988
- 1988-11-23 GB GB888827391A patent/GB8827391D0/en active Pending
-
1989
- 1989-09-29 CA CA000614709A patent/CA1317300C/en not_active Expired - Fee Related
- 1989-11-20 GR GR890100770A patent/GR1000553B/en not_active IP Right Cessation
- 1989-11-21 GB GB8926243A patent/GB2225321B/en not_active Expired - Lifetime
- 1989-11-21 PT PT92364A patent/PT92364B/en not_active IP Right Cessation
- 1989-11-22 DK DK198905867A patent/DK174543B1/en not_active IP Right Cessation
- 1989-11-22 PL PL1989282410A patent/PL161379B1/en unknown
- 1989-11-22 ES ES8903975A patent/ES2021907A6/en not_active Expired - Lifetime
- 1989-11-22 AT AT0266589A patent/AT398971B/en not_active IP Right Cessation
- 1989-11-22 NO NO894651A patent/NO172342C/en not_active IP Right Cessation
- 1989-11-22 HU HU896131A patent/HU205094B/en not_active IP Right Cessation
- 1989-11-22 FI FI895564A patent/FI91862C/en not_active IP Right Cessation
- 1989-11-23 KR KR1019890017040A patent/KR970009728B1/en not_active IP Right Cessation
- 1989-11-23 PH PH39570A patent/PH25982A/en unknown
-
1992
- 1992-09-05 SG SG894/92A patent/SG89492G/en unknown
- 1992-12-03 HK HK958/92A patent/HK95892A/en not_active IP Right Cessation
-
1993
- 1993-05-14 CY CY1671A patent/CY1671A/en unknown
Also Published As
Publication number | Publication date |
---|---|
GB2225321A (en) | 1990-05-30 |
KR900007825A (en) | 1990-06-02 |
FI895564A0 (en) | 1989-11-22 |
CY1671A (en) | 1993-05-14 |
NO894651D0 (en) | 1989-11-22 |
DK586789A (en) | 1990-05-24 |
ATA266589A (en) | 1994-07-15 |
HU205094B (en) | 1992-03-30 |
AT398971B (en) | 1995-02-27 |
CA1317300C (en) | 1993-05-04 |
ES2021907A6 (en) | 1991-11-16 |
SG89492G (en) | 1992-12-04 |
DK586789D0 (en) | 1989-11-22 |
DK174543B1 (en) | 2003-05-19 |
HU896131D0 (en) | 1990-02-28 |
GB8827391D0 (en) | 1988-12-29 |
NO172342B (en) | 1993-03-29 |
FI91862C (en) | 1994-08-25 |
HUT53627A (en) | 1990-11-28 |
PT92364A (en) | 1990-05-31 |
HK95892A (en) | 1992-12-11 |
KR970009728B1 (en) | 1997-06-17 |
GB2225321B (en) | 1992-04-08 |
PT92364B (en) | 1995-07-18 |
FI91862B (en) | 1994-05-13 |
GR1000553B (en) | 1992-08-26 |
PH25982A (en) | 1992-01-13 |
NO172342C (en) | 1993-07-07 |
NO894651L (en) | 1990-05-25 |
PL161379B1 (en) | 1993-06-30 |
GR890100770A (en) | 1990-12-31 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
732E | Amendments to the register in respect of changes of name or changes affecting rights (sect. 32/1977) | ||
PCNP | Patent ceased through non-payment of renewal fee |
Effective date: 20081121 |