GR990100135A - Method of preparation 2-(2-{4-[(4-chlorophenyl)(phenyl)methhyl]piperasine}-ethoxy)acetic acid and its bihydrochloric salt - Google Patents

Method of preparation 2-(2-{4-[(4-chlorophenyl)(phenyl)methhyl]piperasine}-ethoxy)acetic acid and its bihydrochloric salt

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Publication number
GR990100135A
GR990100135A GR990100135A GR990100135A GR990100135A GR 990100135 A GR990100135 A GR 990100135A GR 990100135 A GR990100135 A GR 990100135A GR 990100135 A GR990100135 A GR 990100135A GR 990100135 A GR990100135 A GR 990100135A
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GR
Greece
Prior art keywords
chlorophenyl
piperasine
phenyl
ethoxy
bihydrochloric
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Application number
GR990100135A
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Greek (el)
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Genepharm �.�.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by Genepharm �.�. filed Critical Genepharm �.�.
Publication of GR990100135A publication Critical patent/GR990100135A/en

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Abstract

Method of preparation of the 2-(2-{4-[(4-chlorophenyl)(phenylmethyl]piperasine}-ethoxy)acetic acid (1) and its bihydrochloric salt (VII) where (4-chlorophenyl)(phenyl) methanol (II) reacts with triphenylphosphine and tetrachlorocarbon and is converted to chloro (4-chlorophenyl)(phenyl) methane which is processed with piperasine for yielding (4-chlorophenyl)(phenyl) piperasine methane which further reacts with 2-bromoethanol for yielding 2-(2-(2-{4-[(4-chlorophenyl)(phenyl)methyl]piperasine}-1-ethanol. The last compound is alkylated with chloroacetoonitrile for yielding 2-(2-(2-{4-[(4-chlorophenyl)(phenylmethyl]piperasine}-ethoxy)ethyl nitrile (VI) which is then hydrolysed towards 2-(2-{4-[(4-chlorophenyl)(phenyl)methyl]piperasine}-ethoxy)acetic acid. The acid which is isolated is finally converted to its bihydrochloric salt.
GR990100135A 1999-04-22 1999-04-22 Method of preparation 2-(2-{4-[(4-chlorophenyl)(phenyl)methhyl]piperasine}-ethoxy)acetic acid and its bihydrochloric salt GR990100135A (en)

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GR99100135 1999-04-22

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GR990100135A true GR990100135A (en) 2000-12-29

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GR990100135A GR990100135A (en) 1999-04-22 1999-04-22 Method of preparation 2-(2-{4-[(4-chlorophenyl)(phenyl)methhyl]piperasine}-ethoxy)acetic acid and its bihydrochloric salt

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GR (1) GR990100135A (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8049011B2 (en) 2007-03-12 2011-11-01 Krka, Tovarna Zdravil, D.D., Novo Mesto Process for the preparation of levocetirizine and intermediates thereof

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0058146A1 (en) * 1981-02-06 1982-08-18 U C B, S.A. 2-(4-(Diphenylmethyl)-1-piperazinyl)-acetic acids and their amides, process for their preparation and pharmaceutical compositions
GB2225321A (en) * 1988-11-23 1990-05-30 Ucb Sa Process for preparation of a 1-piperazine-ethoxyacetic acid

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0058146A1 (en) * 1981-02-06 1982-08-18 U C B, S.A. 2-(4-(Diphenylmethyl)-1-piperazinyl)-acetic acids and their amides, process for their preparation and pharmaceutical compositions
GB2225321A (en) * 1988-11-23 1990-05-30 Ucb Sa Process for preparation of a 1-piperazine-ethoxyacetic acid

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8049011B2 (en) 2007-03-12 2011-11-01 Krka, Tovarna Zdravil, D.D., Novo Mesto Process for the preparation of levocetirizine and intermediates thereof
EA016523B1 (en) * 2007-03-12 2012-05-30 Крка, Товарна Здравил, Д.Д., Ново Место New process for the preparation of levocetirizine and intermediates thereof

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