GR990100135A - Method of preparation 2-(2-{4-[(4-chlorophenyl)(phenyl)methhyl]piperasine}-ethoxy)acetic acid and its bihydrochloric salt - Google Patents
Method of preparation 2-(2-{4-[(4-chlorophenyl)(phenyl)methhyl]piperasine}-ethoxy)acetic acid and its bihydrochloric saltInfo
- Publication number
- GR990100135A GR990100135A GR990100135A GR990100135A GR990100135A GR 990100135 A GR990100135 A GR 990100135A GR 990100135 A GR990100135 A GR 990100135A GR 990100135 A GR990100135 A GR 990100135A GR 990100135 A GR990100135 A GR 990100135A
- Authority
- GR
- Greece
- Prior art keywords
- chlorophenyl
- piperasine
- phenyl
- ethoxy
- bihydrochloric
- Prior art date
Links
Landscapes
- Hydrogenated Pyridines (AREA)
Abstract
Method of preparation of the 2-(2-{4-[(4-chlorophenyl)(phenylmethyl]piperasine}-ethoxy)acetic acid (1) and its bihydrochloric salt (VII) where (4-chlorophenyl)(phenyl) methanol (II) reacts with triphenylphosphine and tetrachlorocarbon and is converted to chloro (4-chlorophenyl)(phenyl) methane which is processed with piperasine for yielding (4-chlorophenyl)(phenyl) piperasine methane which further reacts with 2-bromoethanol for yielding 2-(2-(2-{4-[(4-chlorophenyl)(phenyl)methyl]piperasine}-1-ethanol. The last compound is alkylated with chloroacetoonitrile for yielding 2-(2-(2-{4-[(4-chlorophenyl)(phenylmethyl]piperasine}-ethoxy)ethyl nitrile (VI) which is then hydrolysed towards 2-(2-{4-[(4-chlorophenyl)(phenyl)methyl]piperasine}-ethoxy)acetic acid. The acid which is isolated is finally converted to its bihydrochloric salt.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GR99100135 | 1999-04-22 |
Publications (1)
Publication Number | Publication Date |
---|---|
GR990100135A true GR990100135A (en) | 2000-12-29 |
Family
ID=10943800
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GR990100135A GR990100135A (en) | 1999-04-22 | 1999-04-22 | Method of preparation 2-(2-{4-[(4-chlorophenyl)(phenyl)methhyl]piperasine}-ethoxy)acetic acid and its bihydrochloric salt |
Country Status (1)
Country | Link |
---|---|
GR (1) | GR990100135A (en) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8049011B2 (en) | 2007-03-12 | 2011-11-01 | Krka, Tovarna Zdravil, D.D., Novo Mesto | Process for the preparation of levocetirizine and intermediates thereof |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0058146A1 (en) * | 1981-02-06 | 1982-08-18 | U C B, S.A. | 2-(4-(Diphenylmethyl)-1-piperazinyl)-acetic acids and their amides, process for their preparation and pharmaceutical compositions |
GB2225321A (en) * | 1988-11-23 | 1990-05-30 | Ucb Sa | Process for preparation of a 1-piperazine-ethoxyacetic acid |
-
1999
- 1999-04-22 GR GR990100135A patent/GR990100135A/en not_active IP Right Cessation
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0058146A1 (en) * | 1981-02-06 | 1982-08-18 | U C B, S.A. | 2-(4-(Diphenylmethyl)-1-piperazinyl)-acetic acids and their amides, process for their preparation and pharmaceutical compositions |
GB2225321A (en) * | 1988-11-23 | 1990-05-30 | Ucb Sa | Process for preparation of a 1-piperazine-ethoxyacetic acid |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8049011B2 (en) | 2007-03-12 | 2011-11-01 | Krka, Tovarna Zdravil, D.D., Novo Mesto | Process for the preparation of levocetirizine and intermediates thereof |
EA016523B1 (en) * | 2007-03-12 | 2012-05-30 | Крка, Товарна Здравил, Д.Д., Ново Место | New process for the preparation of levocetirizine and intermediates thereof |
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